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SET7-mediated TIP60 methylation is essential for DNA double-strand break repair

  • Song Hyun, Kim;Junyoung, Park;Jin Woo, Park;Ja Young, Hahm;Seobin, Yoon;In Jun, Hwang;Keun Pil, Kim;Sang-Beom, Seo
    • BMB Reports
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    • v.55 no.11
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    • pp.541-546
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    • 2022

  • The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is crucial for maintaining genomic integrity and is involved in numerous fundamental biological processes. Post-translational modifications by proteins play an important role in regulating DNA repair. Here, we report that the methyltransferase SET7 regulates HR-mediated DSB repair by methylating TIP60, a histone acetyltransferase and tumor suppressor involved in gene expression and protein stability. We show that SET7 targets TIP60 for methylation at K137, which facilitates DSB repair by promoting HR and determines cell viability against DNA damage. Interestingly, TIP60 demethylation is catalyzed by LSD1, which affects HR efficiency. Taken together, our findings reveal the importance of TIP60 methylation status by SET7 and LSD1 in the DSB repair pathway.

  • https://doi.org/10.5483/BMBRep.2022.55.11.080 인용 PDF KSCI

Korean Dependency Parsing Using Sequential Parsing Method Based on Pointer Network (순차적 구문 분석 방법을 반영한 포인터 네트워크 기반의 한국어 의존 구문 분석기)

  • Han, Janghoon;Park, Yeongjoon;Jeong, Younghoon;Lee, Inkwon;Han, Jungwook;Park, Seojun;Kim, Juae;Seo, Jeongyeon
    • Annual Conference on Human and Language Technology
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    • 2019.10a
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    • pp.533-536
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    • 2019

  • 의존 구문 분석은 문장 구성 성분 간의 의존 관계를 분석하는 태스크로, 자연어 이해의 대표적인 과제 중 하나이다. 본 논문에서는 한국어 의존 구문 분석의 성능 향상을 위해 Deep Bi-Affine Network와 Left to Right Dependency Parser를 적용하고, 새롭게 한국어의 언어적 특징을 반영한 Right to Left Dependency Parser 모델을 제안한다. 3개의 의존 구문 분석 모델에 단어 표현을 생성하는 방법으로 ELMo, BERT 임베딩 방법을 적용하고 여러 종류의 모델을 앙상블하여 세종 의존 구문 분석 데이터에 대해 UAS 94.50, LAS 92.46 성능을 얻을 수 있었다.

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