• The Korean Journal of Quaternary Research
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• v.21 no.1
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• pp.27-36
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• 2007

The severe damage of cultural heritages induced by natural hazards like heavy rain has been dramatically increased since 1990. The number of the repair works of stone heritage of 2005 was six times as many as those of 1986 year. Especially the ratio of the repair works of Gyeongsang Province and Jeolla Province stood 63% of those of all over the country. Since 1990, the typhoons usually struck the southern part of Korea and went northward. The heavy damage of stone heritages in two provinces was caused by them. We made a preliminary survey the stone heritages that exposed to the natural hazards on the basis of repair works of them and a field survey. The analysis results indicate that the natural hazards such as landslide and soil disaster of the stone heritages related to a sloping surface stood 58% of all kind of natural hazards. The reasons are caused by the 59 % of all the stone heritages distributed in a sloping surface resulted in natural hazards like landslide and soil disaster. The bases of stone heritages can be easily eroded by the surface water with high energy induced by heavy rainfall. Most of the stone heritages like Maebul were engraved on a natural rock wall(outcrop). But some of them engraved on rolling stones are very vulnerable in a change of a base condition caused by erosion and ground subsidence and they can be tilted or fell down. The distribution of the stone heritages vulnerable in natural hazard is related to that of the rainfall distribution compounded five typhoons after 1990. Most of them are included in level two on the rainfall distribution map except those of Taean peninsula and some of Gyeonggi Province. They seem to be rather related to the rainfall distribution of the Typhoon Olga.

• Journal of Korean Society of Environmental Engineers
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• v.37 no.11
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• pp.619-630
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• 2015

This study was conducted to propose the methodology of human risk assessment specialized to domestic mine areas and to quantify the human risk of heavy metal (As, Cd, Cu, Pb, and Zn) contamination around two abandoned metal mines. To attain the goals, we established a relevant exposure scenario, including 7 exposure pathways and extracted a variety of exposure factors reflecting the characteristics of inhabitants around abandoned metal mine areas. Finally, carcinogenic and non-carcinogenic risks were compared between two areas, exposure pathways, heavy metal contaminants, and receptors. The total excess carcinogenic risks of two mine areas of concern were calculated to be larger than the acceptable carcinogenic risk ($1{\times}10^{-6}$), indicating those two areas are not safe for carcinogenic hazard. In addition, the hazard indices of two areas were computed to be higher than unit risk (1), suggesting that the areas of concern have non-carcinogenic risk. Ingestion of crop and intake of groundwater were evaluated to be main exposure pathways contributing to carcinogenic and non-carcinogenic risks within the areas. Also, the results show that carcinogenic and non-carcinogenic hazards were mostly attributed to As and As, Cd, and Pb, respectively.

• The Journal of Korean Society for School & Community Health Education
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• v.7
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• pp.51-58
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• 2006

Background & Objectives: This study investigates the recognition on the necessity of the use of radiation for both college students who are considered that they have a high knowledge level in radiation and proposes basic materials to change the recognition of the use of radiation. Also, the investigation was applied to average people who showed the most negative attitudes on radiation. Methods: A questionnaire was applied to 600 college students for five days from October 10 to 15, 2005 and used in statistical analysis. Results: The average value obtained in the recognition of the use of radiation was 76.60 points in which male respondents who were majored in natural science, health, and engineering department and respondents who have experienced radiation related education, radiation diagnosis, and radiation treatment demonstrated higher levels. Also, the average value obtained in the recognition of the radiation damage was 71.66 points in which respondents who were majored in natural sciences, humanities, engineering, and health department showed higher levels than that of respondents who were majored in art and physical department. Groups that exhibited higher recognition levels in the necessity of the use of radiation were male respondents and respondents who were majored in natural science, humanities, and health department and have experienced radiation diagnosis and radiation treatment. In the results of the correlation analysis on the necessity of the use of radiation and recognition of radiation damages, the recognition of radiation damages was presented as negative attitudes in the case of the higher recognition level in the necessity of the use of radiation. Conclusions: Regarding the frequency of the use of radiation in Korea, a 80.9% of university students who showed a high education level had no experiences in radiation related education. Although they showed a relatively high level of 76.6 points in the recognition level of the necessity of the use of radiation, the negative attitude on the radiation damage was also presented as a high level of 71.7 points. Because the providing chance of radiation related information was limited as compared to the atomic power used in Korea and dependancy of the use of radiation, it is necessary to provide the basic information related in the use of radiation to the public. In addition, various investigations on the use of radiation and such negative attitudes are required in future for the public. Also, the correct information of the radiation safety should be delivered to the public.

• Journal of the Korean Association of Geographic Information Studies
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• v.10 no.1
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• pp.47-59
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• 2007

Efficiency and limitations of HAZUS-MH, a GIS based systematic and informative system developed by FEMA and NIBS for natural hazard loss estimations, are discussed by means of a pilot study in the Korean Peninsula. Gyeongsang-do has been selected for the test after careful reviews of previous studies including historical and modern seismicity in the peninsula. A ShakeMap for the selected scenario earthquake with magnitude 6.7 in Gyeongju area is prepared. Then, any losses due to the scenario event have been estimated using HAZUS. Results of the pilot test show that the study area may experience significant physical, economic, and social damages. Detailed study in the future will provide efficient and crucial information to the decision makers and emergency agents to mitigate any disaster posed by natural hazards.

• 대한예방의학회:학술대회논문집
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• 1994.02a
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• pp.431-438
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• 1994

As currently conducted, standard rodent bioassays do not provide sufficient information to assess carcinogenic risk to humans at doses thousands of times below the maximum tolerated dose. Recent analyses indicate that measures of carcinogenic potency from these tests are restricted to a narrow range about the maximum tolerated dose and that information on shape of the dose-response is limited in experiments with only two doses and a control. Extrapolation from high to low doses should be based on an understanding of the mechanisms of carcinogenesis. We have postulated that administration of the maximum tolerated dose can increase mitogenesis which, in turn. increases rates of mutagenesis and, thus, carcinogenesis. The animal data are consistent with this mechanism, because about half of all chemicals tested are indeed rodent carcinogens, and about 40% of the positives are not detectably mutagenic. Thus, at low doses where cell killing does not occur, the hazards to humans of rodent carcinogens may be much lower than commonly assumed. In contrast, for high-dose exposures in the workplace, assessment of hazard requires comparatively little extrapolation. Nevertheless. permitted workplace exposures are sometimes close to the tumorigenic dose-rate in animal tests. Regulatory policy to prevent human cancer has primarily addressed synthetic chemicals, yet similar proportions of natural chemicals and synthetic chemicals test positive in rodent studies as expected from an understanding of toxicological defenses, and the vast proportion of human exposures are to natural chemicals. Thus, human exposures to rodent carcinogens are common. The natural chemicals are the control to evaluate regulatory strategies, and the possible hazards from synthetic chemicals should be compared to the possible hazards from natural chemicals. Qualitative extrapolation of the carcinogenic response between species has been investigated by comparing two closely related species: rats and mice. Overall predictive values provide moderate confidence in interspecies extrapolation; however, knowing that a chemical is positive at any site in one species gives only about a 50% chance that it will be positive at the same site in the other species.

• Journal of Environmental Policy
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• v.8 no.1
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• pp.129-143
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• 2009

In South Korea, Mine industries were encouraged to obtain the natural resource from 1960 to 1980. However, the depletion of natural resource and decreasing price have been caused by the voluntary closure of non-economical mines and a cut of their production since 1990. Harmful wastewater containing such heavy metals as iron, aluminum, arsenic, and cadmium are being discharged from abandoned pits and waste stone and tailing dumping sites following the closure of mines. Therefore, the objective of this paper suggests a policy of mine hazard prevention(PMHP) and method that allows the combination of new spatial data and as well as collected data on resources for the sustainable mine reclamation and management using EGIS/MGIS technique to develop an integrated plan and management techniques.

• Journal of the Korean Geographical Society
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• v.44 no.4
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• pp.497-509
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• 2009

Records on natural hazards such as droughts, floods, smallpox and attacks of grasshoppers are classified and analyzed during the Ancient Times(BC 57$\sim$AD 935) based on the Historical Records of the Three Kingdoms Age(Samguksaki main record), and influences on human activities and relationships of each natural hazard are studied. The strongest influences on the agricultural productivity were the drought and the influences of floods were weak. The most floods were not destructive hazards because the cultivated lands were distributed in the valley plains and the towns and villages were constructed in the area free from the floods during the Ancient Times. The attacks of grasshoppers have the high frequencies with the droughts. The smallpox of the Ancient Times has no relationships with the dearth, floods and droughts. This means that the waterborne infections happened periodically and after the unification, the infectious diseases happened continuously due to the urbanization leading the concentration of population on the capital. Two cycles of droughts are recognized, and they happened with the time intervals of approximately 500 years during approximately 1000 years in Shilla dynasty.

• Korean Journal of Clinical Pharmacy
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• v.34 no.3
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• pp.184-193
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• 2024

Background: Sunitinib, commonly used for metastatic renal cell carcinoma (mRCC), often induces hypothyroidism, affecting 27 to 85% of patients. There are clues suggesting an association between sunitinib-induced hypothyroidism and improved survival outcomes. This study aims to identify the predictive factors of sunitinib-induced hypothyroidism and evaluate whether the occurrence of overt or subclinical hypothyroidism predicts tumor outcome in patients with mRCC. Methods: Patients administered to sunitinib for mRCC was included in this retrospective study. Log-rank test and Cox proportional hazards model were conducted to identify predictive factors of hypothyroidism and prognostic factors of progression-free survival (PFS) and overall survival (OS). Results: A total of 156 patients with mRCC treated with sunitinib were included. Predictive factors of sunitinib-induced hypothyroidism were female (odds ratio (OR), 2.77), sunitinib-induced hypertension (OR, 2.99) and dose reduction of sunitinib due to intolerance (OR, 3.57). Sunitinib-induced overt hypothyroidism was a significant prognostic factor in predicting PFS and OS (hazard ratio, 0.38 and 0.23, respectively). Thyroid hormone replacement did not have an influence on PFS and OS. Conclusions: Female patients, patients who experienced sunitinib-induced hypertension and sunitinib dose reduction are at higher risk of hypothyroidism and need close monitoring. Overt hypothyroidism is a strong prognostic factor of sunitinib treatment outcome in mRCC patients and thyroid hormone replacement does not have a negative effect on tumor outcome.

• Earthquakes and Structures
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• v.7 no.4
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• pp.449-462
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• 2014

Seismically induced structural damage, as well as any damage caused by a natural catastrophic event, covers a wide area. This suggests to supervise the event consequences by vision tools. This paper reports the evolution from the results obtained by the project RADATT (RApid Damage Assessment Telematics Tool) funded by the European Commission within FP4. The aim was to supply a rapid and reliable damage detector/estimator for an area where a catastrophic event had occurred. Here, a general open-source methodology for the detection and the estimation of the damage caused by natural catastrophes is developed. The suitable available hazard and vulnerability data and satellite pictures covering the area of interest represent the required bits of information for updated telematics tools able to manage it. As a result the global damage is detected by the simple use of open source software. A case-study to a highly dense agglomerate of buildings is discussed in order to provide the main details of the proposed methodology.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.9
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• pp.4185-4197
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• 2016

Chronic arsenicosis is a major environmental health hazard throughout the world, including India. Animals and human beings are affected due to drinking of arsenic contaminated ground water, due to natural mineral deposits, arsenical pesticides or improperly disposed arsenical chemicals. Arsenic causes cancer with production of free radicals and reactive oxygen species (ROS) that are neutralized by an elaborate antioxidant defense system consisting of enzymes and numerous non-enzymatic antioxidants. Dietary antioxidant supplements are useful to counteract the carcinogenesis effects of arsenic. Oyster mushroom lectins can be regarded as ingredients of popular foods with biopharmaceutical properties. A variety of compounds have been isolated from mushrooms, which include polysaccharides and polysaccharopeptides with immune-enhancing effects. Lectins are beneficial in reducing arsenic toxicity due to anticarcinogenetic roles and may have therapeutic application in people suffering from chronic exposure to arsenic from natural sources, a global problem that is especially relevant to millions of people on the Indian subcontinent.