• Asian Pacific Journal of Cancer Prevention
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• v.15 no.9
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• pp.4039-4044
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• 2014

Background: The aim of this study was to investigate the anti-cancer effects and mechanisms of immunochemotherapy of 5-fluorouracil (5-FU) and interleukin-2 (IL-2) on non-small cell lung cancer (NSCLC) A549 cells. Materials and Methods: In order to detect whether 5-FU+IL-2 could effectively inhibit tumor growth in vivo, we established an A549-bearing nude mouse model. The cytotoxicity of natural killer (NK) cells was evaluated using a standard chromium release assay. To evaluate the relevance of NK cells in 5-FU+IL-2-mediated tumor inhibitory effects, we depleted NK cells in A549-bearing mice by injecting anti-asialo-GM-1 antibodies. Effects of 5-FU+IL-2 on the expression and promoter activity of NKG2D ligands (MICA/MICB) in A549 cells in vitro were also assessed. Results: In A549-bearing nude mice, combination therapy significantly inhibited tumor growth in comparison with monotherapy with 5-FU or IL-2 and enhanced the recognition and lysis of tumor cells by NK cells. Further study of mechanisms showed that NK cells played a vital role in the anticancer immune response of 5-FU+IL-2 immunochemotherapy. In addition, the combination therapy synergistically stimulated the expression and promoter activity of MICA/MICB. Conclusions: 5-FU and IL-2 immunochemotherapy significantly inhibited tumor growth and activated NK cytotoxicity in vivo, and these effects were partly impaired after depleting NK cells in tumor-bearing mice. Combination treatment of 5-FU and IL-2 upregulated the expression and the promoter activity of MICA/MICB in A549 cells, which enhanced the recognition of A549 cells by NK cells. All of the data indicated that immunochemotherapy of 5-FU and IL-2 may provide a new treatment option for patients with lung cancer.

• Journal of the Korean Society of School Health
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• v.11 no.2
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• pp.229-241
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• 1998

Because sexual awareness is changing, I have tried to classify university students' attitudes toward sex. This study examined male and female university students and used a Q-method to measure these attitudes. Out of a total of 202, 33 statements were abstracted, and a P-sample of 1-7 parties consisting of 26 persons were studied. I Q-sorted the statements with a standard of 9 points for normal distribution and analyzed the data by means of a Principal Component Analysis with a Quan PC Program. According to the result of this research, university students' attitudes toward sex are divided into three types. Type 1 are called open-minded open: They may have a surgical abortion in case of an unexpected pregnancy and sexual intercourse occurs when a man and woman feel love for each other. They don't see sexual intercourse as a means reproduction nor virginal purity as unconditional. It is remarkable that these students regard sexual intercourse as a natural thing and sex as a basic desire of human beings. In short, they show an open-minded attitude toward sex. Type 2 are supporters of virginal purity; They regard virginal purity with great importance. They insist that both man and woman should be chaste but that sexual intercourse before marriage is unfavorable only to the woman. They do not believe in sexual intercourse without love and emphasize purity in sex education. Differen from type 1, they are very negative about surgical abortion. Type 3 experss love through sex. They belive that sexual intercourse makes a couple happy and a way to express their affection for each other. In other words, the relationship between man and woman is improved through sexual intercourse. They do not think of sexual intercourse in terms of childbirth.

• Journal of the Korean association of regional geographers
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• v.18 no.1
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• pp.1-16
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• 2012

As the tourists of ecotourism are increasing, the supply for detailed information on tourist attraction is also significantly increasing. As a result of survey given to tourists, it showed that they are more interested in natural ecological resources rather than history or culture among resources of ecotourism and pointed out that more information on the region needs to be supplemented. In order to provide accurate, detailed and standardized information to tourists, ecotourism resources were categorized as experience type from the position of consumer and ecological resource type. And the category of experience is again divided into 4 types - nature, education, communication and adventure. Moreover, after developing the web-based homepage for it, the research proposed the cases of Tae-an area and Ulleungdo Island. If the problems from test operation are supplemented, it is expected to suggest the standard of mobile based digital storytelling technology in the field of ecotourism.

• Korean Institute of Interior Design Journal
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• v.21 no.1
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• pp.280-288
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• 2012

The purpose of this study is to deduct influence factors by analyzing preferences for public design that can increase user satisfaction through differentiated identity of regions. The study methods are as follows. First, consider a concept and semantic change of public design through the relevant literatures and precedent studies and then understand application status of domestic and overseas public design. Second, extract design elements for regional differentiation through precedent studies and reclassify regional resources that have an effect. Third, understand the necessity level of public design for regional differentiation by targeting experts and research the extracted design element and the degree of reflection about regionality. Lastly, understand a correlation between design elements and influence factors about territorial regionality of public design based on the researched contents, and analyze the degree of reflection between each other. As a result of this study, a plan that used 'material' and 'color' had high preference on the aspect of design elements and this is an important element that can show regional differentiation of regions. public design of showing regional differentiation. Thus, it is considered that various methods of using 'material' and 'color' must be planned. 'Public space' among design territories was most effective, and the following was 'public facility'. In particular, 'public space' has high preference of using 'natural resources' and 'industrial resources', and therefore an effect of a plan that uses these is judged to be positive. This study can use these results as basic data that suggested the standard for utilization of regional factors for regional differentiation of public design.

• Journal of the Korean Society of Safety
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• v.28 no.6
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• pp.49-56
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• 2013

The statistics of recent accidents in warehouses show that a heavy toll of lives were produced by various accidents, e.g. collision, overturn, fall, slip, exposure to harmful substances or environments, etc. Of significant concern amongst them is the collision, especially the collision between forklift and storage rack structure. Accordingly, this study focuses on behavioral characteristics of rack structure subjected to dynamic impact loading of a forklift. For this purpose, time-domain response analysis has been performed on a standard 2-bay six-story rack structure consisting of columns, beams and bracing members with perforated open section. In order to investigate the most critical scenario, the impact loads are applied in both down-aisle and cross-aisle directions, and the impact locations are also varied along the shelves of the palettes. In order to deal with storage distributions, three types of rack structures are further taken into account: original empty rack structure with no storage, half-loaded rack structure and fully-loaded rack structure. The numerical simulation results demonstrate that the dynamic characteristics of the rack structure are significantly dependent on the distribution of the storage goods and its natural period varies from 0.24sec to 1.06sec, approximately 4.4 times. Further, the parametric studies show that the forklift impact is most critical to the safety of the rack structure when it collides either at the base or at the top of the rack structure.

• The korean journal of orthodontics
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• v.20 no.1
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• pp.87-100
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• 1990

This study was designed to compare the craniofacial structure of orthodontic patients with that of normal adult. For that purpose, 61 male and 64 female adults with normal occlusion were selected and utilizing the cephalogram that had taken under the natural head position and computerized graphic image, the special position of each anatomical structure against true horizontal and vertical reference plane was investigated. The following results were obtained. 1. The absolute special positions of each anatomic structure were calculated. 2. The inclination of Sella-Nasion plane to true horizontal plane was $8.3^{\circ}{\pm}3.9$ in male and $9.3^{\circ}{\pm}3.2^{\circ}$ in female. 3. The inclination of Frankfort horizontal plane to true horizontal plane was $1.3^{\circ}{\pm}3.0^{\circ}$ in male and $1.7^{\circ}{\pm}3.0^{\circ}$ in female. 4. The dimensions of Nasion-sella and Nasion-Anterior nasal spine to be used as the basic units of mesh diagram were $70.7mm{\pm}3.1mm$, $61.8mm{\pm}2.7mm$ in male and $67.8mm{\pm}3.3mm$, $57.0mm{\pm}2.6mm$ in female respectively. 5. The standard templates of craniofacial structure of male and female adult normal group were constructed. 6. The mesh diagrams of craniofacial structure of male and female adult normal group were constructed.

• Journal of the Korean Chemical Society
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• v.51 no.2
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• pp.141-146
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• 2007

The present paper describes a procedure for separation, preconcentration and determination of trace amount of copper in natural water samples by using 2-mercaptobenzimidazol as the complexing agent. The proposed method is based on the surfactant aggregation formed on γ-alumina by mixing sodium dodecyl sulfate and γ-alumina in water; 2-mercaptobenzimidazol was incorporated into inner hydrophobic part of produced ad-micelles in acidic media to produce an assemble suitable for preconcentration and determination of copper ion. Optimum experimental conditions for adsorption of μg/ml levels of copper ions from aqueous solution by the adsorbent have been reported. The copper ions were quantitively adsorbed by the sorbent over the pH range of 7.1-8.0 and were quantitatively desorbed afterward by using sulfosalycilic acid as the eluent. The determination of copper was not interfered in the presence of common metal ions. The procedure was applied for analysis of river water sample. Relative standard deviation was found to be 4.91%.

• Management & Information Systems Review
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• v.16
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• pp.139-159
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• 2005

In many countries the demographics clearly informs us that an aging population represent a serious problem. To this extent senior citizens welfare does matter it has developed into a public debate and genuine concern. it seems that the social issues are focused on how the socity views the social welfare policies. In a modern welfare state where the emphasis lies in pursing a high standard of living and thereby high quality of life. This does not cover the very well the old people in society, but the government clearly carries an obligation to look after and care for the retired & old people in the society. This obligation the social and economic impact that an old person faces as he/she grows old. it is important ensure that their lives carries a meaning and that they as a group will not be estranged from the mainstream of society just because they are considered to be part of the aging population. The key issues that must be addressed are 1) The impact of reduced spending power from less income. a lower income stream; 2) increasing health problems and costs; 3) the natural degradation of ones physical & mental powers; 4) and thereby an isolation from the public in general. So clearly the social policy related to the old people in society should be developed with the consent of what they believe is important to them. To ensure their minimum income level that a beneficiary of an old person's pension will receive, the monthly pension should be reflected by the official price index and be adjusted accordingly. by making the job market open for the senior citizens, expending the mandatory retirement age, give companiesincentives to hire senior citizens, there maybe an opportunity to extend to the aging population the possibility to continue to participate in the society at large.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.18 no.6
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• pp.258-263
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• 2008

The fine aggregates of below 2 mm size was fabricated using by the vertical furnace in which the aggregates could be sintered at floating state and its physical properties were analyzed. The liquid formed at the surface of specimens sintered at $1200{\sim}l300^{\circ}C$ induced a gas in core to expand so the denser shell and porous core could be produced. The C series specimen fabricated by crushing an extruded body had an irregular shape and sharp edges but those became spheroidized by bloating due to gas expansion inside. The fine aggregates fabricated in this study was as light as floating in the water and had an apparent density of $0.68{\sim}1.08$. The absorption rate was proportioned to a porosity showing that the pores in core was not closed completely. The properties of fine aggregates fabricated in vertical furnace were similar with those of in an electric muffle furnace but the sticking-together phenomenon by surface fusion was not occurred in the vertical furnace. The aggregates fabricated in this study had a little lower impact resistance than that of natural aggregate but satisfied the unit volume weight standard specified in KS.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.17 no.4
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• pp.17-27
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• 2014

Wind power which is one of renewable energies is higher economical efficiency and technical maturity than other renewable energies. Recently, the government of ROK announced to increase the proportion of renewable energy through the National Energy Plan. Also, industry required to deregulate for large-scale wind power as Renewable Portfolio Standard (RPS) is introduced. Wind power whereas the eco-friendly energy, is a serious level of damage of the natural environment and topography when the wind power is located. Therefore, the study selected the indicators required for site selection of wind power and proposed the feasible area for wind power based on wind resource map. We selected the 15 indicators including 12 legal protected area, Ecology and Nature Map, rarity, and connectivity (National Ecological Network). After site selection, we should be considered slope and altitude at the stage of design for wind farm to mitigate the environmental impact. Results of analysis showed that 22.3% of wind resource map is available to locate wind power in real. Through the field survey we had verified the accuracy of the results was significantly correct.