• The Korean journal of internal medicine
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• 제39권2호
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• pp.295-305
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• 2024

Background/Aims: The prognosis of patients with idiopathic pulmonary fibrosis (IPF) and respiratory failure requiring mechanical ventilation is poor. Therefore, mechanical ventilation is not recommended. Recently, outcomes of mechanical ventilation, including those for patients with IPF, have improved. The aim of this study was to investigate changes in the use of mechanical ventilation in patients with IPF and their outcomes over time. Methods: This retrospective, observational cohort study used data from the National Health Insurance Service database. Patients diagnosed with IPF between January 2011 and December 2019 who were placed on mechanical ventilation were included. We analyzed changes in the use of mechanical ventilation in patients with IPF and their mortality using the Cochran-Armitage trend test. Results: Between 2011 and 2019, 1,227 patients with IPF were placed on mechanical ventilation. The annual number of patients with IPF with and without mechanical ventilation increased over time. However, the ratio was relatively stable at approximately 3.5%. The overall hospital mortality rate was 69.4%. There was no improvement in annual hospital mortality rate. The overall 30-day mortality rate was 68.7%, which did not change significantly. The overall 90-day mortality rate was 85.3%. The annual 90-day mortality rate was decreased from 90.9% in 2011 to 83.1% in 2019 (p = 0.028). Conclusions: Despite improvements in intensive care and ventilator management, the prognosis of patients with IPF receiving mechanical ventilation has not improved significantly.

• 농촌의학ㆍ지역보건
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• 제13권1호
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• pp.3-18
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• 1988

The general objective of this research is to study behavioral pattern of health care utilization and to measure the level of utilization of the traditional medicine. The specific objective is to study utilization pattern and content of folk medicine which is the indegenous medical technology recognized part of traditional medicine. This research was under taken to generate valid information that will provide basis data for formulating general direction for health education activities and for designing service package for general population. A social survey method was employed to obtain required information for the research activities, The survey field team consisted of 20 surveyors who all participated is an intensive 2 day training course. A total of 3091 households were visited and interviewed by the field team during the period 7 September to 6 October 1987. The major findings obtained from the information collected by the field survey are as follows ; 1) General characteristics of the study households 2562 households out of 3091 households visited were selected for final data process, 80.2 of the selected households were nuclear families ; 17.4%, extended families ; others 2.4%. Only 4.3 percent of the study population in the urban households indicated "no schooling" whereas 14.2% of the rural household members falls within this category. Study population in the urban areas are more protected against diseases by the national medical insurance system than those in rural areas. In their self appraisal of living standard, those who responded with low group are 39.6% and 50.3% respectively by urban and rural households. 2) Morbidity status Period prevalence rate for all diseases during the preceding 15 days before the date of the household interview v as 243,0 per 1,000 study population. For cases with the illness duration of within 15 days, the initial points of medical entry were diversied ; 56.9%, drug stores ; 30.9%, clinics and hospitals ; 4.6% folk medicine ; 1.7% clinics of Korean oriental medicine. Among the chronic case; with illness duration of over 90 days, 34.6% of these people utilized clinics and hospitals of modern medicine ; 31.6%, drug stores ; 18.6% clinics of Korean oriental medicine ; 6.8% folk medical techniques. Noticeable is the almost ten fold increase from the mere 0.9% in the utilization of Korean oriental medicine, whereas in the utilization of folk medicine, it is short of two-fold increase. 3) Folk medicine and its utilization Households that use folk medicine for relief and care of signs and symptoms commonly encountered in daily life, number 1969 households, which accounts for 76.9% of all the study households. This rather high level use of folk medicine is not different from rural to urban areas. The order of frequency of utilizing folk medicine among the study people are : the highest 14.3% for the relief of indigestion ; 8.6% for burns ; 5.1% for common cold ; 4.7% for hiccough ; and 4.2% for hordeolum. A present various procedures of folk medicine is being used to relieve all kinds of symptoms. 192 symptoms are identified at present. The most frequently used procedures of folk medicine appear to be based either on principles of the Korean oriental medicine or of scientific knowledge. Based on these survey findings, proposals for utilizing folk medicine are as follows First, this survey's findings will be feed back to both on the job training and on the spot guidance of community health practitioners, public health nurses and other peripheral work force in the health field, who are in daily contacts with community. This feed back will assure that the health personnel carry out their health education and information activities that are based on the utilization pattern of folk medicine as found in the survey result. Second, studies will be soon implemented that are designed to measure the efficiency and potency of these procedures and to improve these procedures of folk medicine were most frequently used by the community. Third, studies will continue to systematize medicinal plants and skills of Korean oriental medicine that are easily available at minimal cost in daily life for the prevention of diseases and management of emergency cases.

• Journal of Ginseng Research
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• 제42권4호
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• pp.571-576
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• 2018

Background: Korean Red Ginseng (KRG) has been used in Asia for its various biological effects, but no studies have investigated the safety of its long-term intake. Therefore, the present study evaluated the safety of KRG intake for 24 weeks. Methods: We randomized 1,000 participants in a 1:1 ratio into two groups, which were treated daily with 2 g of KRG or a placebo for 24 weeks. The primary endpoint was all adverse events and adverse drug reactions (ADRs) that occurred after KRG or placebo administration, which were reported at week 4, 12, and 24 after the baseline visit. Results: In total, 192 and 211 participants experienced adverse events in the KRG and placebo groups (39.2% and 42.0%, respectively; p = 0.361), and 59 and 57 KRG- and placebo-treated individuals reported ADRs (12.0% and 11.4%, respectively; p = 0.737). The frequently occurring ADRs were pruritus (2.0%), headache (1.6%), diarrhea (1.4%), and dizziness (1.2%) in the KRG group and pruritus (2.0%), headache (1.8%), dizziness (1.6%), rash (1.4%), and diarrhea (1.2%) in the placebo group. Discontinuation of drug administration due to ADRs was reported in 13 participants, six (1.2%) and seven (1.4%) in the KRG and placebo groups, respectively (p = 0.814). No significant abnormal changes were revealed by anthropometric, laboratory, and vital sign measurements in the KRG group compared with those in the placebo group. Conclusion: The present study confirms the safety and tolerability of daily intake of 2 g of KRG for 24 weeks by healthy adults.

• Korean Circulation Journal
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• 제54권9호
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• pp.534-544
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• 2024

Background and Objectives: Lipid lowering therapy is essential to reduce the risk of major cardiovascular events; however, limited evidence exists regarding the use of statin with ezetimibe as primary prevention strategy for middle-aged adults. We aimed to investigate the impact of single pill combination therapy on clinical outcomes in relatively healthy middle-aged patients when compared with statin monotherapy. Methods: Using the Korean National Health Insurance Service database, a propensity score match analysis was performed for baseline characteristics of 92,156 patients categorized into combination therapy (n=46,078) and statin monotherapy (n=46,078) groups. Primary outcome was composite outcomes, including death, coronary artery disease, and ischemic stroke. And secondary outcome was all-cause death. The mean follow-up duration was 2.9±0.3 years. Results: The 3-year composite outcomes of all-cause death, coronary artery disease, and ischemic stroke demonstrated no significant difference between the 2 groups (10.3% vs. 10.1%; hazard ratio [HR], 1.022; 95% confidence interval [CI], 0.980-1.064; p=0.309). Meanwhile, the 3-year all-cause death rate was lower in the combination therapy group than in the statin monotherapy group (0.2% vs. 0.4%; p<0.001), with a significant HR of 0.595 (95% CI, 0.460-0.769; p<0.001). Single pill combination therapy exhibited consistently lower mortality rates across various subgroups. Conclusions: Compared to the statin monotherapy, the combination therapy for primary prevention showed no difference in composite outcomes but may reduce mortality risk in relatively healthy middle-aged patients. However, since the study was observational, further randomized clinical trials are needed to confirm these findings.

• Korean Circulation Journal
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• 제52권4호
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• pp.324-337
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• 2022

Background and Objectives: Identifying patients with high bleeding risk (HBR) is important when making decisions for antiplatelet therapy strategy. This study evaluated the impact of ticagrelor monotherapy after 3-month dual antiplatelet therapy (DAPT) according to HBR in acute coronary syndrome (ACS) patients treated with drug eluting stents (DESs). Methods: In this post-hoc analysis of the TICO trial, HBR was defined by 2 approaches: meeting Academic Research Consortium for HBR (ARC-HBR) criteria or Predicting Bleeding Complications in Patients Undergoing Stent Implantation and Subsequent DAPT (PRECISE-DAPT) score ≥25. The primary outcome was a 3-12 months net adverse clinical event (composite of major bleeding and adverse cardiac and cerebrovascular events). Results: Of the 2,980 patients without adverse events during the first 3 months after DES implantation, 453 (15.2%) were HBR by ARC-HBR criteria and 504 (16.9%) were HBR by PRECISE-DAPT score. The primary outcome rate was higher in HBR versus non-HBR patients (by ARC-HBR criteria: hazard ratio [HR], 2.87; 95% confidence interval [CI], 1.76-4.69; p<0.001; by PRECISE-DAPT score: HR, 3.09; 95% CI, 1.92-4.98; p<0.001). Ticagrelor monotherapy after 3-month DAPT was associated with lower primary outcome rate than ticagrelor-based 12-month DAPT regardless of HBR by ARC-HBR criteria, with similar magnitudes of therapy effect for HBR and non-HBR patients (p-interaction=0.400). Results were consistent by PRECISE-DAPT score (p-interaction=0.178). Conclusions: In ACS patients treated with DESs, ticagrelor monotherapy after 3-month DAPT was associated with lower rate of adverse clinical outcomes regardless of HBR, with similar magnitudes of therapy effect between HBR and non-HBR.

• Journal of Hospice and Palliative Care
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• 제18권2호
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• pp.128-135
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• 2015

목적: 2006년부터 가정산소치료 서비스에 대해 보장을 시작함에 따라, 기준에 부합하는 사람들은 가정산소 서비스이용에 대해 20%의 본인부담만을 지출하게 되었다. 이 같은 제도의 도입은 환자의 가정산소치료 서비스에 대한 부담을 경감시키게 됨에 따라 주요 이용자인 만성 폐쇄성 폐질환 환자들에게 긍정적인 효과를 미쳤을 것으로 예상된다. 하지만, 제도 도입 후 가정산소치료 서비스 제도의 효과에 대한 연구가 많지 않았고, 실증적 근거자료 또한 부족한 실정이다. 따라서, 본 연구는 제도 도입 후, 가정산소치료 서비스가 만성 폐쇄성 폐질환 환자들의 상태에 긍정적 영향을 미쳤는지를 알아보고자 한다. 방법: 만성폐쇄성 폐질환으로 2007년부터 2012년까지 병원을 방문한 사람(N=10,798)의 청구데이터를 분석에 이용하였으며, 가정산소치료 서비스 제도 적용의 기준인 호흡기장애등급에 따라 분포의 차이를 설명하기 위해 ${\chi}^2$ test을 하였다. 또한, 가정산소치료 서비스 이용에 대한 요인을 알아보고자 Multiple Logistic Regression Analysis을 하였으며, 가정산소치료 서비스 이용이 호흡기장애등급의 변화에 어떠한 영향을 주었는지 알아보고자 Generalized Linear Mixed Model 분석을 하였다. 결과: 분석대상 중 호흡기장애등급 1등급에 속하는 대상은 2,490명이었으며, 2/3등급에 속하는 대상은 8,308명이었다. 가정산소치료 서비스 이용에 대해서는 호흡기 장애등급 3등급이 1 또는 2등급에 비해 적게 이용하였다(OR: 0.33, 95% CI: 0.30~0.37). 또한, 가정산소치료를 이용함에 따라 환자의 상태의 변화에 대해 분석한 결과, 가정산소치료 이용자는 미이용자에 비해 상태의 완화 또는 유지에 대해 높은 값을 보였다(OR: 1.41, 95% CI: 1.23~1.61). 결론: 가정산소치료 서비스 이용은 만성 폐쇄성 폐질환 환자의 상태 악화방지에 대해서 긍정적인 영향을 준다.

• 한국사회복지학
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• 제53권
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• pp.285-310
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• 2003

국민연금제도 도입 11년만인 1999년에 전국민연금화를 위한 적용확대 과정이 마무리되면서, 이미 40년 역사를 가진 공적직역연금을 포함한 공적연금이 전국민 노령소득보장체계의 주축으로서 온전히 자리매김하게 되었다. 그로부터 4년이 지난 현재, '전국민연금화'라는 슬로건에 걸맞지 않게 국민연금제도에 가입하여 보험료를 납부하면서 연금수급자격을 갖추어 나가는 경우가 국민연금 적용대상인구의 절반에 불과한 것으로 나타나고 있다. 말하자면, 절반의 국민을 대상으로 공적연금제도가 운영되고 있을 뿐이고, 나머지 절반의 국민들은 공적연금의 사각지대에 놓여져 있다고 할 수 있다. 본 논문에서는 공적연금 사각지대의 규모와 특성을 분석하고 그 원인을 진단함으로써, 사각지대 문제의 해결을 위한 정책방안을 모색하고자 하였다. 현재 연금수급세대인 노령계층의 공적연금 사각지대 규모는 60세 이상 노령인구 대비 무려 86%에 이르고 있으며, 미래 연금수급세대인 근로연령계층의 공적연금 사각지대 규모도 18-59세 총인구 대비 61%에 이르는 것으로 나타났다. 현 연금수급세대의 경우 연령이 높을수록, 여성일 경우 사각지대에 노출될 확률이 높은 것으로 나타났고, 미래 연금수급세대의 경우 연령별로는 18-29세 연령층에서, 성별로는 여성의 경우 사각지대에 놓여질 가능성이 높은 것으로 나타났다. 또한 미래 연금수급자 증심으로 공적연금보험료 납부여부를 가지고 공적연금 사각지대 결정요인을 분석해 보면, 연령이 낮을수록, 학력이 낮을수록, 취업상태가 무직 임시일용직 등 불안정할수록, 종사산업이 농림어업, 건설업, 도소매음식숙박업, 금융보험부동산업에 종사하는 경우 제조업 종사에 비하여, 종사직업이 단순노무직, 전문기술교육직, 판매서비스직, 생산직, 고위행정관리직에 종사하는 경우 일반사무직에 비하여 공적연금의 사각지대에 놓여질 확률이 커지는 것으로 나타났다. 현재 연금수급자인 노령계층의 공적연금 사각지대는 제도역사가 짧아 노령으로 공적연금 가입기회를 갖지 못한 경우가 많으므로, 공적연금 성숙단계까지 경로연금 등 타 공적소득보장제도의 보완적 역할을 강화함으로써 현 노령계층의 공적연금의 사각지대 문제를 해결해 나가는 정책접근이 필요할 것으로 보여진다. 한편 미래 연금수급자인 근로연계층의 공적연금 사각지대 개선은 노동시장 및 가족 등 경제 사회적 여건의 심대한 변화에 조응안 보다 근본적인 제도체계의 재편이 이루어져야 할 것으로 보여진다. 현행 1소득자 1연금에서 1인 1연금 체계로의 전환과 이를 실질적으로 뒷받침한 시민권적 급여의 원리가 공적연금에 결합되어 공적연금의 기초보장적 성격의 강화가 이루어져야만, 비로소 공적연금이 보편적인 1차 노령소득보장의 안전망으로서의 역할을 수행하고 미래 연금수급자의 사각지대 문제가 궁극적으로 해결될 수 있을 것으로 보여진다.

• 한국산학기술학회논문지
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• 제14권7호
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• pp.3390-3399
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• 2013

본 연구는 2009년 한 해 동안 건강보험심사평가원의 요양급여 전체 청구자료를 통계적으로 표본 추출 한 환자표본자료를 이용하여 의료기관 종류 별 욕창 발생현황과 이중 요양병원 환자의 욕창 발생에 영향을 주는 요인을 규명하기 위해 시도되었다. 전체 의료기관 입원환자의 3.2%(n=25,339)에서 욕창이 발생하였다. 의료기관 종별로는 요양병원 입원환자의 8.2%(n=11,895)에서 욕창이 발생하여 종합병원(2.7%, n=8,052), 일반병원(1.7%, n=5,059) 보다 상대적으로 높은 비율을 보였다. 요양병원 입원환자(n=144,523)의 욕창발생에 영향을 주는 요인을 분석한 결과 의학적 진단 중 요실금을 가진 환자 군이 가지지 않은 군에 비해 욕창 발생이 2.46배 유의하게 높게 나타났다(Odds ratio(OR)=2.462, 95% confidence interval(CI)=2.038-2.974). 더하여, 고혈압질환(OR=1.456, CI=1.400-1.515), 말초혈관 질환(OR=1.357, CI=1.200-1.534)군 순으로 욕창 발생에 영향을 미쳤다. 진단 수(OR=1.193, CI=1.187-1.199)와 나이(OR=1.011, CI=1.009-1.012) 및 100침상 당 의사 수(OR=1.063, CI=1.035-1.091)가 증가할수록, 의료기관의 전체 침상수(OR=.889, CI =.869-.909)가 적을수록 욕창발생은 유의하게 높은 것으로 나타났다.

• 한국콘텐츠학회논문지
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• 제15권6호
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• pp.290-296
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• 2015

본 연구는 일개병원에서 시행된 년간 소아 두부 CT 검사에 대한 CT 선량지표(CTDI)를 국내 진단참고 준위와 비교하여 분석함으로써 제안점을 도출하고 피폭 방사선량 저감화 방안을 제시하고자 하였다. 이를 위하여 2014년 1월부터 12월까지 두부 손상으로 소아 두부 CT 검사를 의뢰 받은 10세 미만의 소아 231명을 후향적으로 조사하였다. 조사 방법은 선량 보고서와 의료전자차트를 참조하여 일반적 특성, 관전압(kVp), 관전류(mA), 검사 범위, $CTDI_{vol}$, DLP를 조사하여 분석하였다. 결과적으로 $CTDI_{vol}$은 전체 연구대상자의 7.4%(17명)가 국내 진단참고준위를 초과한 것으로 나타났으며 DLP의 경우 41.6%(96명)가 초과 되어 $CTDI_{vol}$ 보다 비교적 높게 나타났다. DLP는 한국식품의약품안전처에서 제시한 CT 선량 지표보다 대부분 약 60% 이상 초과되었으며 건강보험심사평가원에서 제시한 기준 검사 범위보다 약 30%이상 증가된 검사 범위가 DLP가 높게 나타난 원인으로 분석되었다. 결론적으로 임상에서 CT 검사 시 건강보험심사 평가원에서 제시하는 소아 두부 CT 검사의 기준 검사 범위를 준수하여 검사하고 프로토콜을 적절히 조절한다면 피폭선량을 상당히 낮출 수 있을 것으로 판단된다.

• Journal of Korean Neurosurgical Society
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• 제62권5호
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• pp.502-518
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• 2019

Objective : Since less invasive endovascular treatment was introduced to South Korea in 1994, a considerable proportion of endovascular treatments have been performed by neuroradiology doctors, and endovascular treatments by vascular neurosurgeons have recently increased. However, few specific statistics are known regarding how many endovascular treatments are performed by neurosurgeons. Thus, authors compared endovascular treatments collaboratively performed by vascular neurosurgeons with all cases throughout South Korea from 2013 to 2017 to elucidate the role of neurosurgeons in the field of endovascular treatment in South Korea. Methods : The Society of Korean Endovascular Neurosurgeons (SKEN) has issued annual reports every year since 2014. These reports cover statistics on endovascular treatments collaboratively or individually performed by SKEN members from 2013 to 2017. The data was requested and collected from vascular neurosurgeons in various hospitals. The study involved 77 hospitals in its first year, and 100 in its last. National statistics on endovascular treatment from all over South Korea were obtained from the Healthcare Bigdata Hub website of the Health Insurance Review & Assessment Service based on the Electronic Data Interchange (EDI) codes (in the case of intra-arterial (IA) thrombolysis, however, statistics were based on a combination of the EDI and I63 codes, a cerebral infarction disease code) from 2013 to 2017. These two data sets were directly compared and the ratios were obtained. Results : Regionally, during the entire study period, endovascular treatments by SKEN members were most common in Gyeonggido, followed by Seoul and Busan. Among the endovascular treatments, conventional cerebral angiography was the most common, followed by cerebral aneurysmal coiling, endovascular treatments for ischemic stroke, and finally endovascular treatments for vascular malformation and tumor embolization. The number of endovascular treatments performed by SKEN members increased every year. Conclusion : The SKEN members have been responsible for the major role of endovascular treatments in South Korea for the recent 5 years. This was achieved through the perseverance of senior members who started out in the midst of hardship, the establishment of standards for the training/certification of endovascular neurosurgery, and the enthusiasm of current SKEN members who followed. To provide better treatment to patients, we will have to make further progress in SKEN.