• Environmental Engineering Research
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• 제23권3호
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• pp.309-315
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• 2018

Chlortetracycline (CTC) is one of the most important compounds in antibiotic production, and its distribution has been widely investigated due to health and ecological concerns. This study presents systematic approach to optimize the high-performance liquid chromatography-tandem mass spectrometry for analyzing CTC in a multiple reaction monitoring mode ($479{\rightarrow}462m/z$). One-factor-at-a-time (OFAT) test with response surface analysis (RSA) was used as optimization strategy. In OFAT tests, the fragmentor voltage, collision energy, and ratio of acetonitrile in the mobile phase were selected as major factors for RSA. The experimental conditions were determined using a composite in cube design (CCD) to maximize the peak area. As a result, the partial cubic model precisely predicted the peak area response with high statistical significance. In the model, the (solvent composition) and (collision $energy^2$) terms were statistically significant at the 0.1 ${\alpha}$-level, while the two-way interactions of the independent variables were negligible. By analyzing the model equation, the optimum conditions were derived as 114.9 V, 15.7 eV, and 70.9% for the fragmentor voltage, collision energy, and solvent composition, respectively. The RSA, coupled with the CCD, offered a comprehensive understanding of the peak area that responds to changes in experimental conditions.

• 보건행정학회지
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• 제12권3호
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• pp.1-22
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• 2002

건강은 개인과 가족의 행복, 그리고 국가 발전의 기본 조건이며 국민건강은 국력이다. 건강보호와 증진에 필수적인 의료서비스는 모든 국민이 누려야 할 기본권이며 국가는 이를 제공할 의무가 있다. 산업화로 환경오염의 심화, 국민생활수준의 향상, 생활양상의 변화, 노인 인구의 증가, 의료기술의 발달, 의료서비스에 대한 접근성 향상 등으로 감염성 질병은 감소 하고 암, 심장질환, 당뇨병과 같은 만성, 퇴행성 질환이 중요한 국민건강문제로 대두되었다. 이러한 질병들은 난치병으로 예방이 매우 중요하나 흡연, 음주, 운동, 스트레스 등 행태학적 요인이 중요한 위험인자이므로 예방을 위한 접근방법이 전염성 질병과는 다르다. 질병양상의 변화, 전국민건강보험의 도입, 의사와 의료기관의 증가로 의료공급량의 증가, 의료기술의 발달 등으로 의료이용량이 폭증하여 국민의료비가 연간 30조원을 넘어섰고, 앞으로 계속 증가할 전망이다. 정부는 국민건강수준을 향상하여 삶의 질을 높이는 것을 중요한 정책목표로 설정하였으며, 이를 위해 보건의료서비스 공급체계를 효율화하고 평생건강관리체계를 구축하고자 하였다. 이러한 목표달성을 위하여 공공보건사업을 강화하여 질병예방과 건강증진을 통하여 건강수준을 높이고, 질병치료에 필요한 의료비 증가를 억제해야한다. 주요 공공보건사업의 문제점은 공공보건사업을 위한 정책의 일관성 부재, 보건의료정보체계의 미비, 보건사업계획 및 평가의 합리성 결여, 보건요원의 업무수행능력 부족 등으로 보건사업이 비효율적으로 수행되어 자원이 낭비되고 있다. 지방자치제 하에서 광역자치단체는 능동적으로 보건시책을 세우고, 일선 보건요원들의 사없수행능력을 키우는 역할을 담당할 법적 의무가 있으므로 시 \ulcorner도보건과의 역할을 확대하고 기능을 강화해야 한다. 이를 위한 지방자치단체차원의 전략을 제시하면 다음과 같다. 광역자치단체 차원에서는 ${\circled}1$ 보건정책목표의 확립 : 평생건강관리체계 구축과 보건의료서비스 제공체계 효율화로 삶의 질 향상, ${\circled}2$ 보건사업기획 및 평가기능 강화, ${\circled}3$ 보건의료정보체계 및 주민건강/질병발생 감시체계 확립, ${\circled}41$ 보건요원의 훈련강화, ${\circled}5$ 건강증진센터(가칭) 설치 . 보건의료정보관리, 보건요원 훈련, 보건사업 기획 및 평가 업무담당, 그리고 ${\circled}6$ 지역대학과 협력체계 구축 등이다. 기초자치단체 차원에서는 ${\circled}1$ 보건소 기능의 재정립(전체 지역주민의 건강관리, 보건통계자료수집과 관리 및 주민건강/질병발생 감시, 지역보건사업 계획, 수행 및 평가, 안전하고 건강한 환경조성 및 식품위생관리, 취약계층을 위한 일차의료, 의약관리), ${\circled}2$ 보건소 조직 개편 및 민간의료기관과 협력체계 확립, ${\circled}3$ 전문인력 확보 및 인력구성 조정, 그리고 ${\circled}4$ 방문보건사업의 강화 등이다.

• Journal of Animal Science and Technology
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• 제63권6호
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• pp.1453-1463
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• 2021

Feeding is the most important behavior that represents the health and welfare of weanling pigs. The early detection of feed refusal is crucial for the control of disease in the initial stages and the detection of empty feeders for adding feed in a timely manner. This paper proposes a real-time technique for the detection and recognition of small pigs using a deep-leaning-based method. The proposed model focuses on detecting pigs on a feeder in a feeding position. Conventional methods detect pigs and then classify them into different behavior gestures. In contrast, in the proposed method, these two tasks are combined into a single process to detect only feeding behavior to increase the speed of detection. Considering the significant differences between pig behaviors at different sizes, adaptive adjustments are introduced into a you-only-look-once (YOLO) model, including an angle optimization strategy between the head and body for detecting a head in a feeder. According to experimental results, this method can detect the feeding behavior of pigs and screen non-feeding positions with 95.66%, 94.22%, and 96.56% average precision (AP) at an intersection over union (IoU) threshold of 0.5 for YOLOv3, YOLOv4, and an additional layer and with the proposed activation function, respectively. Drinking behavior was detected with 86.86%, 89.16%, and 86.41% AP at a 0.5 IoU threshold for YOLOv3, YOLOv4, and the proposed activation function, respectively. In terms of detection and classification, the results of our study demonstrate that the proposed method yields higher precision and recall compared to conventional methods.

• 간호행정학회지
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• 제5권3호
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• pp.501-512
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• 1999

The aim of this study was to utilize the 20 steps in the three phases from the book, 'Twenty steps for developing a Healthy Cities Project $2^{nd}$ Ed., 1995, WHO/EURO' to survey Healthy Cities to identify the similarities and differences by implementation rates and perceived significances among Healthy Cities worldwide. For this study, a self-administered questionnaire was developed based on the book. The questionnaires were delivered by air-mail and e-mail to 213 Healthy City coordinators or directors in 43 nations from Jan 13 to Feb 10, 1999. The responses were gathered up until March 31 from 40 Healthy Cities in 17 nations, mostly in the USA and in the European regions. The main results are as follows; Overall the perceived significances were higher for healthy cities with higher implementation rates and there were significant differences for 'set-up office', 'plans strategy', 'increase health awareness', 'mobilize intersectoral action', and 'secure healthy public policy'. 1. According to national health system, the implementation rate, perceived significance and implementation ability of the 20 steps were higher in the healthy cities with a comprehensive-type health system as compared to those with an entreprenetrial & permissive health system. Overall there were significant differences in the steps 'mobilize intersectoral action', and 'secure healthy public policy'. steps which were predominant in the healthy cities with a comprehensive-type health system. There was no concordance in the ranks of implementation rate and perceived significant score. 2. According to the length of implementation time, the perceived significance and implementation ability were higher in healthy cities with more than 6 years compared to those with less than 6 years, although implementation rate was the same. Overall there was a significant difference in 'secure healthy public policy' the step which was predominant in the healthy cities with more than 6 years of implementation. 3. According to population covered by the Healthy City Project, the implementation rate and implementation ability were higher in healthy cities with more than a population of 100 thousand. There was no significant difference in perceived significance, but there were differences in the following, 'find finances', 'set-up office'. 'mobilize intersectoral action' in the implementation rate and implementation ability. These three steps were predominant in the healthy cities with a population of more than 100 thousand. 4. The population covered by the Healthy City Project was the only effective factor influencing the total implementation ability of each healthy city, and it was higher for those cities with a population of more than 100 thousand. In Conclusion, the implementation rate, the perceived significance and the implementation ability were higher in cities with a comprehensive -type health system, with more than 6 years of healthy city experience and with a population of more than 100 thousand. To increase the reliability and the validity of the questionnaire and the results of this study arising from lack of sufficient data, repeated study needs to be considered with a more refined questionnaire delivered to more healthy cities worldwide.

• Environmental Analysis Health and Toxicology
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• 제31권
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• pp.23.1-23.6
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• 2016

Objectives A stable follow-up participation rate is a very important factor for validity in a cohort study. This study analyzed the factors that affect the participation rate at one hospital-based birth cohort in South Korean. Methods The participants were recruited from the Mothers' and Children's Environmental Health study between 2006 and 2010. The analysis targeted 1751 mothers who participated in a birth cohort. We conducted analyses of general characteristics during pregnancy and those of infants at birth that affect the participation rate of the 6-month follow-up survey. Results The participation rate for the 6-month follow-up survey was 60.4%. The participation rate in the follow-up of the subsequent period decreased within a 5% to 10% range compared to the number of subjects. The participation rate of premature infants was 16.9% lower than that of a full-term infant (52.6% vs. 69.5%). Analysis showed a 16.7% difference between the participation rate of low-birthweight infants in follow-ups (53.7%) and the participation rate of infants with normal weight (70.4%). The participation rate of mothers who were employed during pregnancy was significantly lower for the 6-month follow-up compared to the participation rate of mothers who were unemployed during pregnancy. Conclusions In this study, factors such as premature birth, low-birthweight, and the employment status of the mother during pregnancy affected the participation rate of the follow-up survey for the birth cohort at six months. A specific strategy is needed to encourage survey participation for the high risk groups in the follow-ups.

• Journal of Korean Medical Science
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• 제33권43호
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• pp.272.1-272.12
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• 2018

Background: In Korea, the breastfeeding (BF) rate of infants aged 6 months or more is drastically decreasing, and this phenomenon is particularly worrisome for the future health of the population. The present study aimed to identify an antenatal strategy for initiation and continuation of human BF, and to identify how Baby-Friendly Hospitals (BFHs) may positively influence the intention to breastfeed. Methods: A total of 414 pregnant Korean antenatal women were surveyed using questionnaires to determine current knowledge of the benefits of human breast milk, whether they planned to breastfeed after delivery, to continue BF after reinstatement in the workforce, are willing to abide by rooming-in care for infants, and plan to give birth at BFHs. Results: We found that planning room-in care, greater awareness of BF benefits for infant and mother, participation in antenatal education programs, and provision of BF facilities in the workplace were positively associated with plans for exclusive breastfeeding (EBF) and longer BF duration. The mothers who planned to give birth at BFHs also desired to breastfeed immediately after birth, implement in-room care, continue BF at their workplace, participate in antenatal BF educational programs, and were more aware of the benefits of BF. Conclusion: If the beneficial effects of BFHs were well known to individuals, these would enhance the success rate of BF in Korea. Antenatal education and consequent acquisition of better knowledge of the benefits of BF are important for increasing the rate of BF practices.

• Journal of Korean Medical Science
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• 제33권52호
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• pp.346.1-346.11
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• 2018

Background: To evaluate the therapeutic benefits of the treat-to-target (T2T) strategy for Asian patients with early rheumatoid arthritis (RA) in Korea. Methods: In a 1-year, multicenter, open-label strategy trial, 346 patients with early RA were recruited from 20 institutions across Korea and stratified into 2 groups, depending on whether they were recruited by rheumatologists who have adopted the T2T strategy (T2T group) or by rheumatologists who provided usual care (non-T2T group). Data regarding demographics, rheumatoid factor titer, anti-cyclic citrullinated peptide antibody titer, disease activity score of 28 joints (DAS28), and Korean Health Assessment Questionnaire (KHAQ) score were obtained at baseline and after 1 year of treatment. In the T2T group, the prescription for disease-modifying antirheumatic drugs was tailored to the predefined treatment target in each patient, namely remission (DAS28 < 2.6) or low disease activity (LDA) ($2.6{\leq}DAS28$ < 3.2). Results: Data were available for 163 T2T patients and 162 non-T2T patients. At the end of the study period, clinical outcomes were better in the T2T group than in the non-T2T group (LDA or remission, 59.5% vs. 35.8%; P < 0.001; remission, 43.6% vs. 19.8%; P < 0.001). Compared with non-T2T, T2T was also associated with higher rate of good European League Against Rheumatism response (63.0% vs. 39.8%; P < 0.001), improved KHAQ scores (-0.38 vs. -0.13; P = 0.008), and higher frequency of follow-up visits (5.0 vs. 2.0 visits/year; P < 0.001). Conclusion: In Asian patients with early RA, T2T improves disease activity and physical function. Setting a pre-defined treatment target in terms of DAS28 is recommended.

• 환경정책연구
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• 제7권2호
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• pp.67-90
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• 2008

본 연구의 목적은 실내 공기내의 유해화학물질의 농도 수준에 영향을 줄 수 있는 요소들을 통합적으로 고려하여 실내 공기질의 관리 전략을 수립하는 것이다. 이러한 목적으로 서울대에서는 실내 공기내의 유해화학물질의 농도 예측을 위한 '통합적 실내 공기질 모델(IIAQ)'을 개발한 바 있다. 본 연구에서는 IIAQ 모델을 사용하여 실내 공기내 유해화학물질의 농도를 도출하고 이 결과를 바탕으로 연구에서 제시된 시나리오에 따른 인체 위해성 평가를 수행하였다. IIAQ 모델을 통해 예측된 톨루엔과 포름알데히드의 10년 평균 농도는 실내에서 207.3 $ug/m^3$, 36.4 $ug/m^3$, 실외에서의 측정값은 55.9 $ug/m^3$, 8.62 $ug/m^3$으로 현재 실내 공기질 기준에 이하인 것으로 나타났다. 그러나 위해성 평가 결과, 포름알데히드의 노출로 인해서 예상 가능한 발암 위해도가 성인 남성 그룹에서 최대 1.05E-03인 것으로 나타났으며, 모든 수용체 그룹에서 자연적인 암 발생률인 1E-06을 초과하는 것으로 나타났다. 반면, 톨루엔에 대한 비발암 위해도는 모든 수용체 그룹에 대해서 1보다 작은 것으로 나타나, 심각하게 우려할 만한 비 발암 위해성이 나타날 가능성은 낮은 것으로 생각된다. 한편 본 연구에서 수행된 신축 공동주택에서 신축 후 10년간의 관심 화학물질인 톨루엔 및 포름알데히드에 농도 변화에 대한 모델링 결과 실내 오염원이 실외 오염원에 비해 실내 공기 오염에 더 큰 비중을 차지하는 것으로 나타나, 유해물질 위해도를 저감하기 위해서는 우선적으로 주요 실내 공기 오염원을 감소시킬 수 있는 전략이 수립되어야 할 필요가 있는 것으로 생각된다. 그리고 위해성 평가 결과는 현재의 실내 공기오염 기준치에 준하게 노출되었을 경우에 발암 위해성이 있을 수 있으므로, 현재의 실내 공기오염 기준치는 실내 외 오염원으로부터의 모든 노출 경로에 대한 총 노출량을 감안하여 총 노출 및 위해성을 감소시킬 수 있는 적절한 기준치로 재정립 되어야 할 필요가 있는 것으로 생각된다.

• Parasites, Hosts and Diseases
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• 제53권5호
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• pp.515-524
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• 2015

The objectives of this study was to conduct a survey on schistosomiasis and soil-transmitted helminth (STH) infections in order to come up with feasible control strategies in Lake Victoria basin, Tanzania. Depending on the size of the school, 150-200 schoolchildren were recruited for the study. Duplicate Kato-Katz stool smears were prepared from each child and microscopically examined for Schistosoma mansoni and STHs. Urine specimens were examined for Schistosoma haematobium eggs using the filtration technique. After the survey, mass drug administration was done using praziquantel and albendazole for schistosomiasis and STHs infections, respectively. A total of 5,952 schoolchildren from 36 schools were recruited for the study and had their stool and urine specimens examined. Out of 5,952 schoolchildren, 898 (15.1%) were positive for S. mansoni, 754 (12.6%) for hookworms, 188 (3.2%) for Ascaris lumblicoides, and 5 (0.008%) for Trichuris trichiura. Out of 5,826 schoolchildren who provided urine samples, 519 (8.9%) were positive for S. haematobium eggs. The results revealed that intestinal schistosomiasis, urogenital schistosomiasis, and STH infections are highly prevalent throughought the lake basin. The high prevalence of intestinal and urogenital schistosomisiasis in the study area was a function of the distance from Lake Victoria, the former being more prevalent at localities close to the lake, whilst the latter is more so away from it. Control of schistosomiasis and STHs in the study area requires an integrated strategy that involves provision of health education to communities, regular treatments, and provision of adequate safe water supply and sanitation facilities.

• Environmental Analysis Health and Toxicology
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• 제20권4호통권51호
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• pp.311-325
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• 2005

A chemical ranking and scoring system, CRS - Korea, has recently been developed and proposed to use to prioritize on a screening level the toxic chemicals for monitoring and risk assessment. As CRS-Korea requires rigorous assessments prior to its wide application, an assessment was conducted in this study by examining the contribution of individual parameter score to the final chemical score or ranking. The sensitivity of the system to the default values for various parameters of missing data was also tested. The chemical ranking/score was round to depend primarily on the score of a single parameter, i. e., the chemical release, while toxicity scores show little correlation with the priority Further analysis indicated that the dominating effect of the chemical release results from i) its multiplicative relationship with the other two exposure parameters (biodegradation and persistent) and ii) the fact that a maximum score of 10 was assigned to the chemical release parameter while 5 was assigned for all others. AE the fraction of the data that are missing exceeded $70\%$ for various toxicity parameters at compared to less than $10\%$ for exposure parameters, the sensitivity of the ranking to the default value was not significant (rank correlation coefficient = 0.98) for toxicity parameters. Bated on this assessment, an improved CRS system (CRS - Korea II) was proposed in which the impact of the chemical release was properly adjusted by changing the multiplicative relationship to additive one and the maximum score to 5. Chemical priority was derived for each of 16 provinces by using CRS-Korea II. The chemical priority was found to significantly vary among the provinces. It was concluded that not only the national chemical priority but the local chemical priority should be taken into account in setting the nationwide chemical monitoring and risk assessment strategy.