• Radiation Oncology Journal
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• 제35권2호
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• pp.137-143
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• 2017

Purpose: To analyze the utilization and fractionation of extreme hypofractionation via stereotactic body radiotherapy (SBRT) in the treatment of prostate cancer. Materials and Methods: Data was analyzed on men diagnosed with localized prostate cancer between 2004-2012 and treated with definitive-intent radiation therapy, as captured in the National Cancer Database. This database is a hospital-based registry that collects an estimated 70% of all diagnosed malignancies in the United States. Results: There were 299,186 patients identified, of which 4,962 (1.7%) were identified as receiving SBRT as primary treatment. Of those men, 2,082 had low risk disease (42.0%), 2,201 had intermediate risk disease (44.4%), and 679 had high risk disease (13.7%). The relative utilization of SBRT increased from 0.1% in 2004 to 4.0% in 2012. Initially SBRT was more commonly used in academic programs, though as time progressed there was a shift to favor an increased absolute number of men treated in the community setting. Delivery of five separate treatments was the most commonly utilized fractionation pattern, with 4,635 patients (91.3%) receiving this number of treatments. The most common dosing pattern was $725cGy{\times}5fractions$ (49.6%) followed by $700cGy{\times}5fractions$ (21.3%). Conclusions: Extreme hypofractionation via SBRT is slowly increasing acceptance. Currently $700-725cGy{\times}5fractions$ appears to be the most commonly employed scheme. As further long-term data regarding the safety and efficacy emerges, the relative utilization of this modality is expected to continue to increase.

• 보건의료산업학회지
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• 제12권1호
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• pp.137-147
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• 2018

Objectives : The purpose of this study was to identify the post-traumatic stress, social support, and depression of Vietnam veterans and the effects of post-traumatic stress and social support on depression. Methods : This study was carried out from June 2017 to September 2017 with the cooperation of the Korean Society of Veterans' Affairs and 250 Vietnamese veterans from D city were randomly sampled and collected. The collected data were used by SPSS 24.0 Statistics Program. Results : Social support was inversely correlated with post-traumatic stress (r=-.268, p<.001) and depression (r=-.333, p<.001), and post-traumatic stress and depression (r=.592, p<.001) were positively correlated. Post-traumatic stress and social support of veterans had a significant effect on depression, and post-traumatic stress and social support showed an explanatory power of 37.7% in depression. Conclusions : It is necessary to improve soldiers' mental health by mediating their post-traumatic stress and reducing their depression level by establishing a social support system.

• International Journal of Advanced Culture Technology
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• 제5권4호
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• pp.26-30
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• 2017

The Ministry of Patriots and Veterans Affairs decided to designate Goesan County as a comprehensive venue for determining the geography of the land, the efficient management of land, the public opinion of local residents, and the establishment of a group of civic complaints. In the meantime, Goesan focused on attracting high-ranking government officials, including high-ranking government officials and high-ranking tourist attractions, to attract high-ranking government officials, including high-ranking officials of the National Guard, to promote the nation's bid to attract high-ranking government officials. In this paper, we intend to conduct a study centered on the controversy over the survival of the Korean National Guard. conflict between local governments is a non-authoritative administrative administrative body, it can be regarded as a matter of difficulty by intervening in any autonomous matter, and ultimately, it can be changed to judicial judgment. This is not to say that the residents of Goesan county will protest this time. Even though Goesan promotes regional development and development for local residents, it can not guarantee that the judgment of Goesan County will be held in the same situation. Thus, it should develop a win-win strategy based on the threat of sabotage. To this end, I would like to suggest the following measures.

• 한국산학기술학회논문지
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• 제14권9호
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• pp.4326-4334
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• 2013

본 연구는 보훈병원에 입원한 노인환자들의 약물정보인식, 약물사용 실태 및 약물오용상태를 파악하기 위해 시도된 서술적 조사연구이다. 연구기간은 2011년 5월부터 6월까지이며 연구대상자는 전국 5개 지역 보훈병원에서 약물을 사용하고 있는 만 65세 이상된 국가유공자 220명이다. 자료분석은 SPSS Win 18.0 프로그램을 이용하였고 영역별 분석은 평균과 표준편차, t-test와 ANOVA, 다중회귀분석으로 통계적 진술하였다. 연구결과로는 대상자의 일반적 특성인 연령, 결혼유형, 교육정도, 환자분류, 건강상태가 통계적으로 유의한 수준을 나타내었다. 약물정보인식 영역에 영향력 있는 변수는 '연령'으로 나타났으며 약물오용과 약물사용 실태 요인은 '건강상태'에 영향력을 보였다. 따라서 향후에는 보훈병원 입원 노인환자와 일반 노인환자를 대상으로 한 비교 연구가 필요하며, 또한 국가적 차원에서 전액 보상되는 치료비와 진료비는 보훈병원 입원 노인환자들의 약물의존도를 부추기는 경향으로 일부 작용하므로 보훈병원 입원 노인환자들에게 보훈의료제도의 합리적 지원방안에 관한 연구와 보훈의료 서비스의 질적인 향상을 위한 연구가 이루어져야 한다.

• 안보군사학연구
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• 통권9호
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• pp.283-311
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• 2011

The Republic of Korea, ranked as the 5th military power according to the size of its ground troops, discharges more than 200,000 manpower to the society annually; more than 13,000 of them are officers. The re-employment rate of discharged military personnels, who experience early retirement of 5 to 15 years compared to general public officers, is very low, only amounting to 53.2%. On the other hand, major developed countries exhibit great national scale of effort to take responsibility in helping the settlement of the soldiers who have dedicated their career for their countries. The re-employment rate amounts to 94%. Fully acknowledging such disparity, this paper examines various policies on discharged members support of developed countries, and aims to suggest developmental model on employment support designed for discharged members in the Republic of Korea.

• 대한예방의학회:학술대회논문집
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• 대한예방의학회 1994년도 교수 연수회(역학)
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• pp.324-331
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• 1994

To promote the inclusion of quality of life (QOL) end-points In clinical research on cancer, the National Cancer Institute (USA) sponsored a workshop on QOL assessment In cancer clinical trials In July, 1990. Experts In clinical trials and QOL research formed four working groups to Identify current areas of cancer treatment In which QOL end-points are most Important; to discuss methodologic problems In QOL assessment; to address common problems In Implementing clinical studies with QOL end-points; and to consider statistical Issues In design, Implementation, and data analysis. Recommendations made by the working groups are summarized in this paper.

• Biomolecules & Therapeutics
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• 제25권5호
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• pp.511-518
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• 2017

Ultraviolet (UV) irradiation is a relevant environment factor to induce cellular senescence and photoaging. Both autophagy- and silent information regulator T1 (SIRT1)-dependent pathways are critical cellular processes of not only maintaining normal cellular functions, but also protecting cellular senescence in skin exposed to UV irradiation. In the present studies, we investigated whether modulation of autophagy induction using a novel synthetic SIRT1 activator, heptasodium hexacarboxymethyl dipeptide-12 (named as Aquatide), suppresses the UVB irradiation-induced skin aging. Treatment with Aquatide directly activates SIRT1 and stimulates autophagy induction in cultured human dermal fibroblasts. Next, we found that Aquatide-mediated activation of SIRT1 increases autophagy induction via deacetylation of forkhead box class O (FOXO) 1. Finally, UVB irradiation-induced cellular senescence measured by $SA-{\beta}-gal$ staining was significantly decreased in cells treated with Aquatide in parallel to occurring SIRT1 activation-dependent autophagy. Together, Aquatide modulates autophagy through SIRT1 activation, contributing to suppression of skin aging caused by UV irradiation.

• Journal of the Korean Data and Information Science Society
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• 제22권3호
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• pp.467-476
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• 2011

우리나라의 건강보험제도권 내 해당되지 않은 상해상병 진료건 중 국민건강보험으로 부당 잘못 청구되는 진료건을 적발하여, 환수조치하기 위해서는 정확한 상해상병 조사대상자 선정이 필요하다. 그러나, 국민건강보험공단의 한정된 인력으로 증가하는 상해조사관련 업무량을 보다 효율적으로 대처하고, 수행하기 위해서는 상해요인조사 업무 효율화 및 환수 결정율 제고를 위한 조사대상자 발췌기준의 고도화 방안을 마련해야 한다. 이에 본 연구에서는 상해상병 유형에 대해 일정금액 이상 진료건의 발췌 등과 같은 과거의 발췌기준에서 데이터마이닝 기법과 같은 통계적 모형과 업무규칙을 함께 적용한 하이브리드 모형으로서 상해상병 조사대상자 선정기준을 제시하고자하였다.

• Journal of Preventive Medicine and Public Health
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• 제34권1호
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• pp.80-88
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• 2001

Objectives : In an epidemiologic study on the health impact of Agent Orange exposure, the valid estimation of exposure level is the most important step. Based on recent studies, we examined the correlation between exposure levels categorized by personal exposure estimates and serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD, Dioxin), exploring the possibility of utilizing the exposure level as a surrogate for the estimate of exposure to agent orange. Methods : During the study period (Jan 1996-Feb 1996), blood specimens of 745 subjects taken randomly among 1,329 persons and kept frozen, were analyzed for 2,3,7,8-TCDO and six other dioxin congeners. The serum dioxin and congeners were measured in 1998 by CDC, adjusted for serum lipids. We categorized the total exposure scores into five groups based on Agent Orange exposure data collected by interview and military records. Pearson and Spearman's correlation coefficients & multiple regression analysis were used to identify the relationship of the exposure level categorized with serum concentration of 2,3,7,8-TCDD, and six other dioxin congeners. Results : Dioxin and the other congeners, except 1,2,4,6,7,8-HpCDD, showed significant correlations to exposure categories (p<0.005): 2,3,7,8-TCDD and OCDD showed positive correlations, whereas the other congeners did negative. The values of 2,3,7,8-TCDD differed according to exposure category and proportionally increased from the low exposure group to the high, a dose-response relationship, even after other possible confounding variables were adjusted for. In multiple regression analysis, age$(\beta=0.033)$, dioxin$(\beta=0.433)$, 1,2,3,7,8-PeCDD$(\beta=-0.998)$, 1,2,3,4,7,8-HxCDD$(\beta=-0.773)$, 1,2,3,6,7,8-HxCDD$(\beta=0.255)$, 1,2,3,7,8,9-HxCDD$(\beta=-3.468)$, 1,2,3,4,6,7,8-HpCDD$(\beta=0.109)$ we re found to be significantly related to the total exposure score(p<0.005). Conclusion : This study demonstrated that the use of such categorizations as a surrogate measure of agent orange exposure in identifying exposure degrees in a health impact study is valid.

• BMB Reports
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• 제46권1호
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• pp.25-30
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• 2013

Gap junctions and their structural proteins, connexins (Cxs), have been implicated in carcinogenesis. To explore the involvement of Cx32 in gastric carcinogenesis, immunochemical analysis of Cx32 and proliferation marker Ki67 using tissue-microarrayed human gastric cancer and normal tissues was performed. In addition, after Cx32 overexpression in the human gastric cancer cell line AGS, cell proliferation, cell cycle analyses, and $p21^{Cip1}$ and $p27^{Kip1}$ expression levels were examined by bromodeoxyuridine assay, flow cytometry, real-time RT-PCR, and western blotting. Immunohistochemical study noted a strong inverse correlation between Cx32 and Ki67 expression pattern as well as their location. In vitro, overexpression of Cx32 in AGS cells inhibited cell proliferation significantly. $G^1$ arrest, up-regulation of cell cycle-regulatory proteins $p21^{Cip1}$ and $p27^{Kip1}$ was also found at both mRNA and protein levels. Taken together, Cx32 plays some roles in gastric cancer development by inhibiting gastric cancer cell proliferation through cell cycle arrest and cell cycle regulatory proteins.