• Journal of Food Hygiene and Safety
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• v.25 no.2
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• pp.148-152
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• 2010

Domestic studies for identification of causality between children exposure to toxic chemicals, such as arsenic (As) and resulted hazardous effects were not implemented. This study was conducted to probabilistically estimate dietary As intake and health risk assessment for young children and all age-specific populations from the consumption of As-contaminated rice of Korea. Arsenic intakes for young children (1 to 6 years old) from As-contaminated rice were higher than other age-specific groups, based on a dose-per-body weight basis. Based on the current EPA cancer slope factor for As, estimated cancer risks (to the skin cancer) associated with dietary intake of As-contaminated rice for 1 to 2 years old group and 3 to years old group are 1.76 per 10,000 and 3.16 per 10,000, respectively, at the 50th percentile. Based on possible reference levels (0.005 mg/kg/day) for children, mean and $95^{th}$ percentile value of HQ from rice for young children are very below 1.0, which is a regulatory limit of non-carcinogenic risks for human.

• Journal of the Korean Society of Marine Environment & Safety
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• v.21 no.6
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• pp.704-711
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• 2015

In this study, we have conducted a survey of AHP technique through the ocean experts to derive new items and revise assessment items and indices for risk of sunken ships based on the survey results. As a result of the survey, two new items such as accident cause and tidal current are derived. And it shows that existing items such as toxic liquid substance, remaining oil and explosive gas which were evaluated as one group are desirable to be evaluated respectively. Accordingly, we analyze the indices of the new eleven assessment items adjusted from the existing seven assessment items. As a result, the indices are ordered by toxic liquid substance, possibility of leaking, explosive gas, carrying capacity of fuel oil, sensitivity of sea environment, marine traffic environment, cause of accident, tidal current, keel clearance, ship type, and ship size. Especially, as compared with the indices of existing assessment items, the indices of sensitivity of sea environment and possibility of leaking are higher and the index of keel clearance is lower.

• Nuclear Engineering and Technology
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• v.51 no.3
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• pp.692-701
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• 2019

Recently, instrumentation and control (I&C) systems in nuclear power plants have undergone digitalization. Owing to the unique characteristics of digital I&C systems, the reliability analysis of digital systems has become an important element of probabilistic safety assessment (PSA). In a reliability analysis of digital systems, fault-tolerant techniques and their effectiveness must be considered. A fault injection experiment was performed on a safety-critical digital I&C system developed for nuclear power plants to evaluate the effectiveness of fault-tolerant techniques implemented in the target system. A software-implemented fault injection in which faults were injected into the memory area was used based on the assumption that all faults in the target system will be reflected in the faults in the memory. To reduce the number of required fault injection experiments, the memory assigned to the target software was analyzed. In addition, to observe the effect of the fault detection coverage of fault-tolerant techniques, a PSA model was developed. The analysis of the experimental result also can be used to identify weak points of fault-tolerant techniques for capability improvement of fault-tolerant techniques

• Mass Spectrometry Letters
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• v.10 no.2
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• pp.43-49
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• 2019

The aim of this study was conducted to develop an analytical method to determine the concentration of ceftiofur residue in eel, flatfish, and shrimp. For derivatization and extraction, the sample was hydrolyzed with dithioerythritol to produce desfuroylceftiofur, which was then derivatized by iodoacetamide to obtain desfuroylceftiofur acetamide. For purification, the process of solid phase extraction (Oasis HLB) was used. The target analytes were confirmed and quantified in $C_{18}$ column using liquid chromatography-tandem mass spectrometry with 0.1% formic acid in water (A) and 0.1% formic acid in acetonitrile (B) as the mobile phase. The linearity of the standard calibration curve was confirmed by a correlation coefficient, $r^2>0.99$. The limit of quantification for ceftiofur was 0.002 mg/kg; the accuracy (expressed as the average recoveries) was 80.6-105%; the precision (expressed as the coefficient of variation) was below 6.3% at 0.015, 0.03, and 0.06 mg/kg. The validated method demonstrated high accuracy and acceptable sensitivity to meet the Codex guideline requirements. The developed method was tested using market samples. As a results, ceftiofur was detected in one sample. Therefore, it can be applied to the analysis of ceftiofur residues in fishery products.

• Congress of the korean instutite of fire investigation
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• 2011.04a
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• pp.77-97
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• 2011

In this paper, we studied risk assessments of electrical fire and shock of LED lightings for outdoor. We examined national regulations about the LED lighting for outdoor and analyzed the appearances and compositions of LED lightings. And, We experimented about water proof, line to line fault, line to line breakdowm, overvoltage, line to line leakage in overhead line or water of LED lighting. From experimental results, we know that there are risks of electrical fire and shock by abnormal conditions at the LED lighting. Therefore, the uses of protective devices and insulated type of converter are required for the electrical safety. We expect that the results of this study would be helpful for the improvement of regulations and standards for electrical safety and for the investigations of electrical accidents of LED lightings.

• The Journal of Internal Korean Medicine
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• v.30 no.1
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• pp.181-190
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• 2009

It is important to establish the safety of herbal medicine because of its frequent and widespread use in Korea. Several studies on the safety of herbal medicine have been performed and there have been rare serious adverse drug reactions from those reports in Korea. However, the results are not strongly supported because of not adopting appropriate enough research methodology as to make the safety issue clear. For improving the quality of the safety research on herbal medicine. including investigations of drug induced liver injury (DILl). the aim of this study was to suggest herbal medicine-induced liver injury investigation forms for performing reasonable safety research. After a systematic review of the preceding studies regarding herbal safety in Korea was performed in 2008, we assessed the quality and the limitations of the primary studies. Two investigation forms for herbal safety research were made as a following step. one a basic investigation form for herbal safety research and the other an advanced investigation form for suspected DILl cases, Those forms include the essential informations and data needed to make an appropriate assessment of whether DILl occurred during or after the use of herbal medicine. Guidelines for using those forms and other recommendations were also suggested. More rigorous studies are required for answering the safety issue of herbal medicine as well as the efficacy issue. We hope for wide use and improvement of those investigation forms in the study of herbal safety by many researchers for establishing better evidences in Korea.

• Korean Journal of Clinical Pharmacy
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• v.29 no.3
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• pp.173-185
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• 2019

Objective: To gather inputs from clinical experts on selecting and prioritizing research topics, to address unmet vaccine safety needs. Methods: A questionnaire containing 15 vaccine safety assessment research proposals was sent to 28 vaccine experts chosen from various domestic medical association boards, and the rationale for each of the proposals was provided by presenting the following information: 1) a brief summary of the clinical safety studies on the vaccine, conducted by the Clinical Immunization Safety Assessment (CISA) project group, supervised by the United States Center for Disease Control (U.S. CDC), and 2) a summary of recently published studies that address vaccine safety issues. The experts were instructed to select and rank 5 topics in the order of preference, and the preference score for each proposed topic was calculated by assigning points on a scale of 1 to 5. Results: All 28 experts responded to the questionnaire, and the following topics were selected according to their calculated preference scores: 1) Human papillomavirus vaccine safety profile in the Korean female adolescents; 2) A signal detection of adverse events following Influenza vaccination: comparison between the US and South Korea; 3) Incidence of anaphylaxis following National Immunization Program vaccines between 2008 and 2017; 4) Safety of quadrivalent influenza vaccines compared to trivalent influenza vaccines; and 5) Pneumococcal vaccine safety profile in the general population. Conclusion: Five research topics addressing vaccine safety were selected, for which well-constructed research protocols need to be promptly developed to address current unmet vaccine safety needs in South Korea.

• Proceedings of the Korean Nuclear Society Conference
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• 2003.10a
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• pp.165.1-165.1
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• 2003

• Safe Food
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• v.6 no.3
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• pp.17-23
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• 2011

• Journal of the Korean Society of Safety
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• v.23 no.4
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• pp.47-52
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• 2008

Many researches on fire risk for normal electric wiring have been pursued in advanced countries such as the USA and Japan, but comparative studies of the partial disconnection and normal state of electric wires have not been conducted. Detection system for the cause of partial disconnection is not developed and prevention countermeasure for electrical fire by the cause is not effective. Therefore, in this paper, partial disconnection characteristics on electric wires were derived and analyzed by experiment and electrical-thermal finite element method(Flux 3D) on the model wires which consist of VCTF(PVC insulated PVC sheathed Cap Tyre Flexible Cord, KS C 3304) and IV(lndoorwire PVC, KS C 3302). VCTF is used in wiring portable electric appliances and the IV is used indoors. Interrelationships between partial disconnection premonitory symptom and current were derived and analyzed by the characteristics based on experiments and thermal analysis for electric wire according to current under normal state and 200% overload state of rated current.