• Journal of Multimedia Information System
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• 제3권3호
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• pp.97-102
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• 2016

Deep learning enables machines to have perception and can potentially outperform humans in the medical field. It can save a lot of time and reduce human error by detecting certain patterns from medical images without being trained. The main goal of this paper is to build the optimal model for breast mass classification by applying various methods that influence the performance of Convolutional Neural Network (CNN). Google's newly developed software library Tensorflow was used to build CNN and the mammogram dataset used in this study was obtained from 340 breast cancer cases. The best classification performance we achieved was an accuracy of 0.887, sensitivity of 0.903, and specificity of 0.869 for normal tissue versus malignant mass classification with augmented data, more convolutional filters, and ADAM optimizer. A limitation of this method, however, was that it only considered malignant masses which are relatively easier to classify than benign masses. Therefore, further studies are required in order to properly classify any given data for medical uses.

• 한국비블리아학회지
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• 제24권4호
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• pp.281-299
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• 2013

이 연구의 목적은 KDC 제6판의 약학 분야 분류항목 전개에 대한 개선방안을 제시하는 것이다. 이를 위하여 첫째, 약학의 학문 영역과 체계를 살펴보았으며, 둘째, KDC초판부터 제6판까지 약학 분야에 사용된 용어를 분석하였으며, 셋째, KDC 약학 분야의 분류항목 전개의 변천과정을 분석하였으며, 넷째, KDC와 DDC, NLMC, 연구분야분류표에 전개된 약학 분야를 비교 분석하였다. 그 결과 KDC의 약학 분야는 제4판 이후 전혀 변화되지 않은 것으로 나타났다. 그래서 본표에 전개된 요목 및 세목에 관계된 새로운 주제들을 분류항목으로 추가 전개하여 관련 문헌들의 분류가 용이하도록 하였으며, 용어를 현대화하였다. 오늘날 새롭게 대두된 제약 산업분야, 항암관련 분야, 생물약학 분야를 미사용 중인 518.7-.8에 배정하여 분류할 수 있도록 하였다.

• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2010년도 심포지엄 및 추계학술발표회
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• pp.236-237
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• 2010

• 대한예방한의학회지
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• 제22권2호
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• pp.55-63
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• 2018

Objectives : This study was conducted to survey on the research trends of Pharmacopuncture in Korea. Methods : We searched Korean research database by using keyword 'Pharmacopuncture', 'Bee venom'. Korean research databases were Korean Studies Information Service System(KISS), Research Information Service System(RISS), National Digital Science Library(NDSL) and Korean Medicine Information System(OASIS). We classified articles identified by publish year, type of research and diseases. Results : We analyzed 533 studies. Clinical studies and non-clinical studies except literature studies were decreased from 2015. However, Literature studies had not shown particular change over the past decade. Pharmacopuncture treated disease was classified by Korean standard classification of disease(KCD), M-code (37.8%), G-code(18.4%) were frequently used. Conclusions : A variety of disease was treated by pharmacopuncture. It is necessary to increase the level of evidence of pharmacopuncture. through additional studies in the future.

• 동의신경정신과학회지
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• 제28권3호
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• pp.217-230
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• 2017

Objectives: This study was conducted to review studies on somatization disorder in traditional Chinese medicine. Methods: We reviewed studies in the China National Knowledge Infrastructure (CNKI) to 2017. Keywords were 軀體化障碍, Somatization disorder, somatic symptom disorder. We included Randomized Controlled Trial (RCT), and excluded non-Randomized Controlled Trial (nRCT), non-related somatization disorder or traditional Chinese medicine, non-clinical trials, dissertations for degrees. Jadad scale and Cochrane Library's Risk of Bias (RoB) were used for assessment of the quality of studies. Results: Twelve studies were selected. The Chinese Classification of Mental Disorders-3 (CCMD-3) was most frequently used as diagnostic criteria for somatization disorder. As for outcome measurement, Hamilton Rating Scale for Depression (HAMD) was used most commonly. Meta-analysis of 10 studies revealed effective rate of Chinese Herbal Medicine groups (CHM) was significantly higher than Western Medicine groups (WM) (RR: 1.14, 95% CI: 1.02 to 1.27, p=0.02, $I^2=40%$). There was no significant difference in effective rate of CHM+WM and WM (RR: 1.12, 95% CI: 0.84 to 1.49, p=0.46, $I^2=83%$). And also, effective rate of Acupuncture group (Acu) revealed no significant difference compared to that of WM (RR: 1.17, 95% CI: 0.95 to 1.44, p=0.13, $I^2=84%$). For HAMD, there was significant difference in CHM vs, WM group and Acu vs. WM group. Quality of selected 12 RCTs was low. Conclusions: Therapies practiced in traditional Chinese medicine may be effective options for somatization disorder. treatment. For further clinical studies in Korean medicine, this study could be groundwork for development of diagnosis and treatment on somatization disorder.

• 한국자원식물학회지
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• 제19권1호
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• pp.174-179
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• 2006

본 연구에서는 인삼 잎으로부터 정제한 mRNA를 이용하여 cDNA library를 제작하였다. 이 cDNA library로 부터 349개의 에너지 대사 관련 유전자를 선발 하였다. 에너지 대사 관련 유전자의 평균 사이즈는 0.49 kb이며, 에너지 관련 유전자들의 세부 기능별 발현을 분석한 결과 aerobic respiration(48.4%), accessory proteins of electron transport and membrane associated energy conservation(17.2%), glycolysis and gluconeogenesis(3.4%), electron transport and membrane associated energy conservation(2.9%), respiration(2.0%), glycolysis methylglyoxal byp-ass(1.7%), metabolism of energy reserves(0.6%)와 alcohol fermentation(0.3%)의 분포를 보였다. 인삼 잎에서 발현되는 유전자중 가장 많이 발현된 Chlorophyll a/b binding protein of IhcII type I(36.6%), Photosystem II oxygen-evolving complex protein(6.6%) 등이 발현되었다.

• 한국문헌정보학회지
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• 제53권2호
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• pp.223-246
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• 2019

본 연구에서는 한의학 연구 데이터 관리 및 공유를 위한 메타데이터 요소를 설계하고 한국한의학연구원에서 생산되는 연구 데이터를 대상으로 요소검증을 수행하였다. TTAK.K0-10.0976 표준과 DataCite 메타데이터 스키마, 한국과학기술정보연구원의 국가 연구 데이터플랫폼 스키마를 대상으로 메타데이터 요소를 도출하였다. 최상위 요소로서 Identifier를 포함한 27개 요소가 도출되었으며, 필수요소 29개, 권고요소 13개, 선택요소 31개를 도출하였다. 한의학 관련 분야별 전문가 6인을 대상으로 도출요소에 대한 필요성 정도를 조사하였으며, 추가적인 메타데이터 요소를 제안 받아 검토하였다. 한의학 연구 데이터 주제 분류를 제안하였으며, 최종 제안하는 메타데이터 요소로 현재 운영 중인 시스템의 메타데이터 수용여부를 검증하였다. 본 연구결과는 향후 한국한의학연구원에 구축되는 데이터 리포지터리에 아이템과 파일을 기술하기 위한 메타데이터 스키마로 활용될 수 있다.

• Korean Journal of Acupuncture
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• 제37권4호
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• pp.231-244
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• 2020

Objectives : This study was conducted to introduce the types and contents of books related to acupuncture published in North Korea that can be identified in South Korea, and to understand the general characteristics of North Korean acupuncture. Methods : Firstly, we identified books related to acupuncture in the Information Center on North Korea of the National Library of Korea. Specialized books on treatment interventions such as acupuncture, moxibustion, cupping, electrotherapy, and manual therapy including acupressure which stimulate acupoints were included in the study. Two authors reviewed the title, table of contents, and contents of each book in the order of publication year for the searched books. Based on this, the characteristics and trends of North Korean acupuncture were comprehensively examined. Results : The included 18 books were published between 1964 and 2018. One of them was considered a Chinese book translated into Korean and published in China, and another was a North Korean book republished by a South Korean publisher. Except for these, all were published in North Korea, two of which were translations of Chinese books. Most of them were books on the theory and clinical applications of acupuncture, but some of them focused on specific treatment interventions such as auricular acupuncture, fire needling, manual therapy, cupping, or electrotherapy. Also, there was a book about the mechanism of acupuncture analgesia in a neurophysiological way. Conclusions : Since the mid-1960s, North Korea has been steadily attempting to combine acupuncture and Western medicine by applying the disease name and classification system of Western medicine, using modern diagnostic technique, and explaining the mechanism of acupuncture based on the latest research. After the 2000s, the standard international acupuncture nomenclature by World Health Organization was used. In recent years, there has been a tendency to publish and widely disseminate specialized books on non-pharmacological treatment such as cupping, electrotherapy, and fire needling.

• Korean Journal of Acupuncture
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• 제34권4호
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• pp.191-208
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• 2017

Objectives : The purpose of this study was to analyze the trend of pharmacopuncture in Korean patent in order to establish database for patent technology. Methods : Electronic literature searches for Korean patents related to pharmacopuncture were performed in two electronic databases (Korea Intellectual Property Right Information Service and National Digital Science Library) to June 2017. Patents that were not Korean ones, did not use medicinal herb, only described method of manufacture, or had nothing to do with pharmacopuncture were excluded in this study. The status and application date of patents, Medicinal herb, target diseases, International Patent Classification (IPC), model of experiment and extracting methods were analyzed. Results : A total of 379 patents were retrieved. Based on our inclusion/exclusion criteria, 297 patents were excluded. Of 82 included patents, 27 patents did not include experiments using pharmacopuncture, and 9 patents were invented for treating animals such as pig or calf. In IPC analysis, Bee Venom, Panax (ginseng), Angelica, and Paeoniaceae were used frequently. Musculoskeletal diseases were the most targeted diseases followed by nervous diseases. For extracting, hot water extraction, distillation extraction, and solvent extraction using alcohol, ethanol, or methanol for solvent were commonly used. Conclusions : These data are useful for inventing new patent and extending range of pharmacopuncture in clinical use, however, more systematically analyzed patent studies and pharmacopuncture-related studies for new application on various diseases are needed in further studies.

• 한국문헌정보학회지
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• 제52권3호
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• pp.193-214
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• 2018

이 연구는 중국의 고문헌 관리 법제화에 대한 조사 분석을 목적으로 진행하였다. 우선 중국의 법체계와 고문헌 관리 정책을 살피고, 4종의 법률과 6종의 행정법규, 4종의 부문규장 및 13종의 행정규범성문건을 조사하였다. 그중 고문헌 관리 내용을 다루고 있는 1) 2013년의 법률 '중국문물보호법', 2) 1981년의 행정법규 '중국고문헌정리지시', 3) 1986년의 부문규장 '중의고문헌 연구정리출판 관리세칙', 4) 2001년의 부문규장 '문물소장품 등급결정 표준', 5) 2003년의 부문규장 '문물경매관리 임시규정'을 분석하였다. 이를 바탕으로 1) 고문헌 관리 정책의 중요성, 2) 국가 차원의 고문헌 관리, 3) 교육 확대와 인적자원의 양성, 4) 고문헌 관리 전문기구의 설치, 5) 중의고문헌 부문의 특별 관리 등의 중국 고문헌 관리의 시사점을 도출하였다.