• Journal of Pharmaceutical Investigation
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• v.35 no.6
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• pp.411-416
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• 2005

The aim of the present work was to prepare the nanosuspension of inorganic pigment which shows light reflection and scattering as efficient sunscreen. The zinc oxide (ZnO) was chosen as an inorganic pigment, and high pressure homogenizer and bead mill have been used for the preparation of nanosuspension. The ZnO nanosuspensions were characterized by particle size, in vitro sun protection factor (SPF) and UV transmittance. ZnO nanosuspension prepared by bead mill showed the average diameter of $119{\pm}4\;nm$, resulting in the high value of SPF $(28.74{\pm}2.06,\;n=20)$, while that prepared by high pressure homogenizer showed the average diameter of $751{\pm}32\;nm$ with the relative lower value of SPF $(21.38{\pm}1.94\;n=20)$. In addition, the film of ZnO nanosuspension prepared by bead mill was showed a high visible ray (VIS) transmittance, indicating a high transparency. In conclusion, a physically stable ZnO nanosuspension in cyclomethicone was successfully prepared using bead mill for the suitable sunscreen preparations.

• Journal of Pharmaceutical Investigation
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• v.39 no.5
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• pp.359-366
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• 2009

In this study, paclitaxel-loaded lipid nanosuspension (PxLN) was prepared and the in vivo profiles after intravenous administration in rats were investigated. We compared the manufacturing processes depending on the temperature: PxLN-H for a hot homogenization process and PxLN-C for solidification of lipid-drug mixtures by liquid nitrogen. Both formulations showed submicron size distribution and the similar drug loading efficiency of about 70%. In vitro release of PxLNs and Taxol$^{(R)}$ performed by a dialysis diffusion method showed similar pattern for PxLN-H and Taxol$^{(R)}$, but the reduced release profile for PxLN-C. PxLN or Taxol$^{(R)}$ was intravenously administered to the rats at a dose of 5 mg/kg as paclitaxel. The drug in blood samples were assayed by the HPLC/MS/MS method. The AUC$_t$ of PxLN-H was 3.4-fold greater than that of Taxol$^{(R)}$. PxLN-H gave higher biodistribution in all tissues than did Taxol$^{(R)}$. In addition, it maintained the higher drug concentration for 12 h. This lipid nanosuspension might be a promising candidate for an alternative formulation for the parenteral delivery of poorly water-soluble paclitaxel.

• Journal of Powder Materials
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• v.9 no.6
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• pp.409-415
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• 2002

In this review the methods for production and processing of isolated or agglomerated nanoscale metal particles embedded in organic liquids (nanosuspensions) and polymer matrix composites are elucidated. Emphasis is laid on the techniques of inert gas condensation (IGC) and high pressure sputtering for obtaining highly porous metal powders ("nanopowder") as well as on vacuum evaporation on running liquids for obtaining nanosuspensions. Functional properties and post-processing are outlined in view of applications in the fields of electrically conductive adhesives and anti-microbially active materials for medical articles and consumer goods.mer goods.