• 생명과학회지
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• 제18권9호
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• pp.1202-1206
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• 2008

본 연구에서 정상적인 baboon의 흉선조직 및 폐조직에서 HLA-DR과 PGP9.5항원에 대한 반응성을 나타내는 수지상세포 형태의 세포가 축적되는 것을 보았다. 하지만, 이런 세포들은 baboon 이 BPD즉 폐이형성증에 걸리게 되면 사라진다는 것을 확인하였다. 그리고 140일 제태기간보다 125일 제태 기간을 보낸 미성숙 baboon이 HLA-DR을 가지는 세포가 더 많아 진다는 것을 관찰할 수 있었고 이로 인해 BPD동물모델을 구축하는데 125일 제태 기간을 보낸 동물이 훨씬 적합하다는 것을 알았다. 또한 bombesin의 항체인 2A11을 처리한 baboon (125d-14d/PRN)의 폐조직에서는 정상수준의 HLA-DR positive세포들이 관찰되었다. 더욱이, Baboon의 흉선으로부터 분리한 thymocyte로 bombesin에 대한 chemotaxis를 수행한 결과 세포이동 반응성을 보였다. 이러한 결과들은 생체 내 BLP들을 차단하면 BPD에 의해 야기된 폐이형성증을 막을 수 있고 2A11항체가 수동 면역제로 폐이형성증을 치료할 수 있는 치료제로써의 가능성을 제시하는 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.5287-5290
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• 2012

Throughout human history, plant products have been used for many purposes including as medicines. Herbal products and spices can be used as preventive agents against cancer due to their antimicrobial, antioxidant and antitumorigenic properties. This study was designed to evaluate the potential protective effect of curcum in rats administered nitrosamine precursors; dibutylamine (DBA) and sodium nitrate (NaNO3); and infected with Escherichia coli (E. coli) and also to monitor changes in nuclear factor the Kappa B p65 (NF-${\kappa}B$ p56) pathway and its downstream products, Bcl-2 and interleukin-6 (IL-6), in parallel with nitrosamine precursors, E. coli and curcum treatment. Rats were divided into three groups (n=25 each; except of control group, n+20). Group I a normal control group, group II administered DBA/NaNO3 in drinking water and infected with E. coli and group III was administered DBA/NaNO3 in drinking water, infected with E. coli and receiving standard diet containing 1% curcum powder. Histopathological examination reflected that the curcum treated group featured a lower incidence of urinary bladder lesions, and lower levels of NF-${\kappa}B$, Bcl-2 and IL-6, than the group receiving nitrosamine precursor and infected with E. coli. These findings suggested that curcum may have a protective role during the process of bladder carcinogenesis by inhibiting the NF-${\kappa}B$ pathway and its downstream products.

• Archives of Plastic Surgery
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• 제40권5호
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• pp.621-626
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• 2013

Background Ever since lipoabdominoplasty was first developed to achieve better aesthetic outcomes and less morbidity, the rate of seroma formation, especially in obese patients, has disturbed plastic surgeons. The aim of this study was to evaluate the effect of fibrin sealant in the prevention of seroma formation after lipoabdominoplasty in obese patients. Methods Sixty patients with a body mass index (BMI) between 30 and 39.9 were assigned randomly to 1 of 2 groups (30 patients each). Group A underwent lipoabdominoplasty with fibrin glue, while group B underwent traditional lipoabdominoplasty; both had closed suction drainage applied to the abdomen. The patients' demographics and postoperative complications were recorded. Seroma was detected using abdominal ultrasound examinations at two postoperative periods: between postoperative days 10 and 12 and, between postoperative days 18 and 21. Results The age range was 31 to 55 years ($38.5{\pm}9.5$ years) in group A and 25 to 58 years ($37.8{\pm}9.1$ years) in group B, while the mean BMI was 31.4 to 39.9 $kg/m^2$ (32.6 $kg/m^2$) in group A and 32.7 to 37.4 $kg/m^2$ (31.5 $kg/m^2$) in group B. In group A, the patients had a complication rate of 10% in group A versus 43% in group B (P<0.05). The incidence of seroma formation was 3% in the fibrin glue group but 37% in the lipoabdominoplasty-alone group (P<0.05). Conclusions Lipoabdominoplasty with the use of autologous fibrin sealant is a very effective method that significantly reduces the rate of postoperative seroma.

• Nutrition Research and Practice
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• 제13권4호
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• pp.333-343
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• 2019

BACKGROUND/OBJECTIVES: To compare five indices of adherence to the Mediterranean Diet (MD) among adults living in the Mediterranean region. SUBJECTS/METHODS: A total of 100 healthy Lebanese adults aged between 18 and 65 years. Face-to-face interviews to collect sociodemographic and medical information, to take anthropometric measurements, and to fill a validated, culturally adapted, food frequency questionnaire (FFQ). The score for each item was calculated following the recommendations for each corresponding index. The five MD indices were Mediterranean Diet Scale (MDScale), Mediterranean Food Pattern (MFP), MD Score (MDS), Short Mediterranean Diet Questionnaire (SMDQ), and the MedDiet score. RESULTS: Significant correlations were detected between items with P-values < 0.001. Minimal agreement was seen between MDScale and MedDiet score and maximal agreement between MDS and MedDiet score. Univariate and multivariate analyses showed that MDS and MedDiet scores had significant correlations with fiber and olive oil intake, main components of the MD. MDScale showed a significant correlation with waist-to-hip ratio and with total energy intake but none of the five indices was correlated to body mass index (BMI). CONCLUSIONS: The indices that showed the highest correlation with variables related to the MD are the MDScale and the MedDiet score; therefore, they can be used to assess our future study populations. Based on the current results, more than half of the study population was non-adherent to the MD and adherence to this diet did not appear to protect against being overweight ($BMI{\geq}30$).

• 플랜트 저널
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• 제17권4호
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• pp.53-60
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• 2021

본 연구에서는 국내 진동감시시스템 제작업체인 (주)나다와 발전소 회전기기 진동데이터 취득 및 분석에 효과적인 휴대용 진동분석기를 개발하고자 하였다. 개발된 휴대용 진동분석기의 하드웨어는 측정기기의 교정을 위한 측정 불확도를 통해 얻은 측정값을 시스템에서 보정함으로써 측정오차를 최소화하였고, 고속 데이터 처리로 높은 분해능을 가진 신호처리 장치로 구성되었다. 소프트웨어 구조는 다양한 진동 플롯을 구현하여 상세한 분석프로그램을 실행하며, 회전기기 운전 중 외란으로 발생하는 노이즈 측정 및 제거에 효과적인 알고리즘을 적용하였다. 개발품은 사용자의 이동 편의성 증대 및 고속 데이터 처리로 분해능을 높임으로써 성능향상은 물론, 국산화 개발에 따른 구입비용 절감에도 크게 기여하였다.

• 한국지반신소재학회논문집
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• 제22권3호
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• pp.71-86
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• 2023

본 연구에서는 암반 발파 시 발생하는 사면 재해를 방지하기위해 지중 관입형 변위센서를 이용한 암반 발파 시험을 수행하고 3차원 유한요소 수치해석을 통해 지중 관입형 변위센서의 적용성 검증 및 암반 발파 시 진동속도에 영향을 미치는 매개변수에 대해 고찰하였다. 암반 발파 시험 결과 지중 관입형 변위센서는 암반사면 거동 계측에 적용 가능한 시스템임을 확인하였으며, 수치해석 결과 암반 발파 시 진동속도에 가장 큰 영향을 미치는 매개변수는 단위중량인 것으로 분석되었다. 또한, 발파원과 멀어질수록 진동속도는 급격하게 줄어들고 발파원과 가까울수록 동탄성계수와 단위중량의 차이에 따라 최대 진동속도 차이는 크게 발생하며 내부마찰각과 점착력 변화에 따른 영향은 거의 없는 것으로 판단된다.

• Restorative Dentistry and Endodontics
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• 제47권2호
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• pp.24.1-24.15
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• 2022

Objectives: Regenerative endodontic treatment is a clinical procedure aimed at biologically regenerating damaged root canal tissue of immature permanent teeth. This study aimed to report the outcomes of regenerative endodontic treatment performed by endodontic postgraduate students. Materials and Methods: Clinical and radiographic data of 27 patients, aged 10-22 years, who underwent regenerative treatment of immature permanent teeth from 2015 to 2019 were followed up, wherein clinical and radiographic examinations were performed for each patient. Postoperative success rate and tooth survival were analyzed, and the postoperative radiographic root area changes were quantified. Results: A total of 23 patients attended the dental appointments, showing that all teeth survived and were asymptomatic. Specifically, 7 periapical pathosis cases were completely healed, 12 were incompletely healed, and 4 cases failed. Moreover, significant differences were found between discolored and non-discolored teeth, and between the presence or absence of periapical radiolucency. Additionally, 3 anterior teeth showed complete closure of the apical foramen, while the apical foramen width was reduced in 17 teeth and failed in 3 teeth. Root length was also found to have been increased in 7 anterior and 4 posterior teeth, and the average length ranged from 4.00-0.63 mm in the anterior teeth, 2.85-1.48 mm of the mesial root, and 2.73-2.16 mm of the molar teeth distal root. Furthermore, calcified tissue deposition was observed in 7 teeth. Conclusions: A favorable outcome of regenerative endodontic treatment of immature permanent teeth with necrotic pulp was achieved with a high survival rate.

• Imaging Science in Dentistry
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• 제53권4호
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• pp.313-323
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• 2023

Purpose: This study aimed to investigate the potential factors that could affect the reduction rate of odontogenic cysts following decompression using cone-beam computed tomography (CBCT) for 3-dimensional volumetric analysis. Materials and Methods: The study sample consisted of CBCT images of 41 individuals who underwent decompression of odontogenic cysts at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, between 2010 and 2022. Preoperative and postoperative CBCT results were collected, and a volumetric analysis was conducted to evaluate the differences in the reduction rate and the percentage of volume reduction of cystic lesions based on different parameters. Correlations between these parameters were analyzed to determine associations. Results: In this study, the average time of decompression for odontogenic cysts was 316 days. Males demonstrated a higher reduction rate than females (P<0.05). The reduction rate was directly proportional to initial cyst volume, with higher reduction rates for cysts with large initial volume than those with small initial volume (P<0.05). Spearman's rank correlation coefficient indicated a weak positive correlation between the initial cyst volume and the duration of decompression. Additionally, a strong positive correlation was observed between the initial volume and the reduction rate. Conclusion: Knowledge of the reduction rate of odontogenic cysts is vital for surgeons to evaluate the duration of decompression before enucleation and to determine a definitive treatment plan. Sex and initial lesion volume had significant effects on the reduction rate.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제27권1호
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• pp.37-42
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• 2024

Purpose: Limited data exist regarding outcome and morbidity associated with portosystemic shunts in the pediatric transplant population. Our study assesses the outcomes of pediatric patients who underwent a portosystemic shunt procedure, both with and without liver transplantation (LT). Methods: This study retrospectively reviewed the medical records of pediatric patients aged 0-19 years who underwent shunt placement between 2003 and 2017 at a tertiary care center. The analysis included cases of shunt placement with or without LT. Results: A total of 13 pediatric patients were included in the study with median age of 8.8 years. Among the cases, 11 out of 13 (84.6%) underwent splenorenal shunt, 1 (7.7%) underwent a mesocaval shunt, and another 1 (7.7%) underwent a Modified Rex (mesoportal) shunt. Additionally, 5 out of 13 (38.5%) patients had LT, with 4 out of 5 (80.0%) receiving the transplant before shunt placement, and 1 out of 5 (20.0%) receiving it after shunt placement. Gastrointestinal bleeding resulting from portal hypertension was the indication in all cases. A total of 10 complications were reported in 5 patients; the most common complication was anemia in 3 (23.1%) patients. At the most recent follow-up visit, the shunts were functional without encephalopathy, and no deaths were reported. Conclusion: Shunt placement plays a crucial role in the management of patients with portal hypertension. Our study demonstrates favorable long-term outcomes in pediatric patients who underwent shunt placement. Long term shunt outcomes were similar and unremarkable in patients with LT and without LT.

• 한국지반공학회논문집
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• 제36권11호
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• pp.119-133
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• 2020

지중공동구는 대표적인 개착식 지중구조물로, 지진시 지반의 변위로 인한 지진력이 작용하는 구조물이다. 시설안전기술공단에서는 2020년에 기존 시설물(공동구) 내진성능 평가요령을 제정하여 배포하였다. 본 논문에서는 내진성능평가요령에서 제시하고 있는 두 가지 성능평가방법인 응답변위법과 응답이력해석기법을 소개하고, 대표 공동구에 대해서 두 가지 내진성능평가방법을 적용하여 그 결과를 비교·검토 하였다. 평가에 사용된 공동구는 1988년 건설되어 내진설계가 적용되지 않은 공동구 이다. 응답변위법은 기반면 속도응답스펙트럼으로부터 단일코사인과 이중코사인 방법을 적용하여 내진성능평가를 실시하였다. 응답이력해석은 지반과 구조재료 모두 비선형 거동을 나타낼 수 있는 유한차분해석프로그램을 사용하여 2차원 평면변형율 해석을 시행하였다. 붕괴방지 수준의 지진에 대한 성능평가 결과 응답변위법은 구조물이 탄성범위내 거동하는 것으로 평가되는 반면, 응답이력해석은 구조물 일부에서 소성힌지가 발생하는 결과를 나타내었다.