• Journal of the Earthquake Engineering Society of Korea
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• v.3 no.1
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• pp.1-8
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• 1999

Dynamic elastoplastic LPM (lumped parameter mass) analyses are carried out in order to investigate the seismic resistant performance of a typical high-rise shear wall apartment subjected to several earthquakes. Three-dimensional nonlinear pushover analysis is adopted to estimate initial elastic stiffness, yielding strength and post-yielding stiffness of each story for the time history analysis of LPM shear model. For the hysteresis of each story, Clough and bilinear models are used with the input of four recorded earthquake ground motions of EI Centro 1940 NS, Taft 1952 EW, Hachinohe 1968 NS and Kobe 1995 NS, of which the amplitudes are scaled down to have the same maximum ground velocity of 12 kine. The result shows that yieldings take place in most storys of the building, i.e. the earthquake resistant capacity of this high-rise shear wall apartment is not sufficient at the event of earthquake M=5~6.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2007.10a
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• pp.187-191
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• 2007

This paper describes a 3.3V 10 bit CMOS digital-to-analog converter with a divided architecture of a 7 MSB and a 3 LSB, which uses an optimal Thermal-to-Binary Decoding method with monotonicity, glitch energy. The output stage utilizes here implements a return-to-zero circuit to obtain the dynamic performance. Most of D/A converters in decoding circuit is complicated, occupies a large chip area. For these problems, this paper describes a D/A converter using an optimal Thermal-to-Binary Decoding method. the designed D/A converter using the CMOS n-well $0.35{\mu}m$ process0. The experimental data shows that the rise/fall time, settling time, and INL/DNL are 1.90ns/2.0ns, 12.79ns, and a less than ${\pm}2.5/{\pm}0.7$ LSB, respectively. The power dissipation of the D/A converter with a single power supply of 3.3V is about 250mW.

• Genomics & Informatics
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• v.14 no.3
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• pp.104-111
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• 2016

Zika virus (ZIKV) is a mosquito borne pathogen, belongs to Flaviviridae family having a positive-sense single-stranded RNA genome, currently known for causing large epidemics in Brazil. Its infection can cause microcephaly, a serious birth defect during pregnancy. The recent outbreak of ZIKV in February 2016 in Brazil realized it as a major health risk, demands an enhanced surveillance and a need to develop novel drugs against ZIKV. Amodiaquine, prochlorperazine, quinacrine, and berberine are few promising drugs approved by Food and Drug Administration against dengue virus which also belong to Flaviviridae family. In this study, we performed molecular docking analysis of these drugs against nonstructural 3 (NS3) protein of ZIKV. The protease activity of NS3 is necessary for viral replication and its prohibition could be considered as a strategy for treatment of ZIKV infection. Amongst these four drugs, berberine has shown highest binding affinity of -5.8 kcal/mol and it is binding around the active site region of the receptor. Based on the properties of berberine, more similar compounds were retrieved from ZINC database and a structure-based virtual screening was carried out by AutoDock Vina in PyRx 0.8. Best 10 novel drug-like compounds were identified and amongst them ZINC53047591 (2-(benzylsulfanyl)-3-cyclohexyl-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one) was found to interact with NS3 protein with binding energy of -7.1 kcal/mol and formed H-bonds with Ser135 and Asn152 amino acid residues. Observations made in this study may extend an assuring platform for developing anti-viral competitive inhibitors against ZIKV infection.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.4
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• pp.691-698
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• 2008

This paper describes a 3.3V 10 bit CMOS digital-to-analog converter with a divided architecture of a 7 MSB and a 3 LSB, which uses an optimal Thermal-to-Binary Decoding method with monotonicity, glitch energy. The output stage utilizes here implements a return-to-zero circuit to obtain the dynamic performance. Most of D/A converters in decoding circuit is complicated, occupies a large chip area. For these problems, this paper describes a D/A converter using an optimal Thermal-to-Binary Decoding method. the designed D/A converter using the CMOS n-well $0.35{\mu}m$ process0. The experimental data shows that the rise/fall time, settling time, and INL/DNL are 1.90ns/2.0ns, 12.79ns, and a less than ${\pm}2.5/{\pm}0.7\;LSB$, respectively. The power dissipation of the D/A converter with a single power supply of 3.3V is about 250mW.

• Journal of Chest Surgery
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• v.26 no.1
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• pp.24-31
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• 1993

The long term clinical results following valve replacement with Hancock and Carpentier-Edwards bioprostheses were compared between tow valve models and between tow groups totaling 249 patients who were discharged after valve replacement from 1976 to 1986. The two groups of patients were treated with nonrandomized fashion. Follow-up was 87% complete. Cummulative duration of follow-up was 1909 patient-years, with maximum follow-up duration of 15 years. The actuarial survival for 122 patients with Hancock valves was 95.2%[\ulcornerstandard deviation] and 84.4% after 5 and 10 years of follow-up, respectively. Comparable figures for 127 patients undergoing valve replacement with Carpentier-Edwards valves were 87.3% and 76.4%, respectively[p=NS]. The probability of freedom from structural valve deterioration after 5 and 10 years of follow-up was 97.2% and 60.6%, respectively, with Hancock valves and 97.2% and 55.7%, respectively, with Carpentier-Edwards valves[p=NS]. Considering all 249 patients, multivariate [Cox model] regression revealed that ejection fraction was only significant predictor of structural valve deterioration. The probability of freedom from thromboembolism after 5 and 10 years of follow-up was 91.3% and 86.4%, respectively, with Hancock valves and 94.2% and 82.5%, respectively, with Carpentier-Edwards valves[p=NS]. Hence more strict control of anticoagulation should be done on patients with left atrial factors. In summary, there were no significant differences in actuarial survival rate and major valve related complications between tow valve models. These results suggests that its use should be confined to older patients or patients with a contraindication of anticoagulation.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.8B
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• pp.529-538
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• 2007

In this paper, we have analyzed a simulation model of Slammer worm propagation process which caused serious disruptions on the Internet in the year of 2003 by using NS-2. Previously we had presented and analyzed Abstract Network to Abstract Network(AN-AN) model being modified from the Detailed Network to Abstract Network(DN-AN) of NS-2. However, packet analysis in AN-AN model had a problem of taking 240 hours to simulate the initial 300 seconds of infection. We have reduced the AN-AN model to save the simulation time and analyzed total 3.5 hours of the network congestions within 107 hours. Moreover, we have derived optimal quarantine rate of 0.0022 considering service outage of network devices caused by the heavy infected traffics, which was not taken into consideration in previous works. As the result of simulation, Although the inbound traffic at the Korean international gateway was back in normal conditions at 4,787 second, due to the revese direction saturation was maintained until 12,600 seconds, the service outage was persisted for 3.5 hours.

• Journal of Advanced Navigation Technology
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• v.23 no.5
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• pp.392-399
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• 2019

In this paper, we have studied wireless time division duplex(TDD) time synchronization technique considering the propagation delay between mobile vehicles. The existing IEEE 1588 precision time protocol(IEEE 1588 PTP) algorithm was applied and the time synchronization between the two nodes was achieved through the propagation delay and clock offset time correction calculated between master slave nodes during wireless TDD communication. The time synchronization process and procedure of IEEE 1588 PTP algorithm were optimized, thereby reducing the propagation delay error sensitivity for real-time moving vehicles. The sync flag signal generated through the time correction has a time synchronization accuracy of max +252.5 ns within 1-symbol(1.74 M symbol/sec, ${\pm}287.35ns$) through test and measurement, and it was confirmed that the time synchronization between master slave nodes can be achieved through sync flag signal generated during GPS disturbance.

• The Journal of the Korea institute of electronic communication sciences
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• v.14 no.5
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• pp.853-862
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• 2019

In this paper, we designed a 4.5kW X-band SSPA transmitter to replace the TWTA search radar transmitter with low MTBF and high maintenance cost. The transmitter is designed for the performance of over 520W average transmission output and 4.0kW maximum transmission output. In particular, by implementing a graceful degradation, it is designed to maintain better performance than conventional TWTA transmitter up to 40% (13 assembly modules) failure level of 200W power amplifier assembly. Through an experiment on the effective range of X-band, the performance of proposed transmitter verified the values of the maximum transmission output 6.1kW, spurious output 69.16dBc, RF pulse rising time 15.2ns and RF pulse falling time 16.3ns. The experiment confirmed the change of output power according to the graceful degradation due to fault injection.

• Journal of Microbiology and Biotechnology
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• v.30 no.12
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• pp.1801-1809
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• 2020

Chikungunya virus (CHIKV) was first identified in 1952 as a causative agent of outbreaks. CHIKV is transmitted by two mosquito species, Aedes aegypti and A. albopictus. Symptoms after CHIKV infection in human are typically fever and joint pain, but can also include headache, muscle pain, joint swelling, polyarthralgia, and rash. CHIKV is an enveloped single-stranded, positive-sense RNA virus with a diameter of approximately 70 nm. The pathogenesis of CHIKV infection and the mechanism by which the virus evades the innate immune system remain poorly understood. Moreover, little is known about the roles of CHIKV-encoded genes in the viral evasion of host immune responses, especially type I interferon (IFN) responses. Therefore, in the present study, we screened CHIKV-encoded genes for their regulatory effect on the activation of nuclear factor kappa B (NF-κB), a critical transcription factor for the optimal activation of IFN-β. Among others, non-structural protein 2 (nsP2) strongly inhibited melanoma differentiation-associated protein 5 (MDA5)-mediated induction of the NF-κB pathway in a dose-dependent manner. Elucidation of the detailed mechanisms of nsP2-mediated inhibition of the MDA5/RIG-I signaling pathway is anticipated to contribute to the development of virus-specific therapeutics against CHIKV infection.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.5B
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• pp.277-285
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• 2007

In this paper, we present a simulation model of Slammer worm propagation process which caused serious disruptions on Internet in the you of 2003 and analyze the process of Slammer by using NS-2. Recently introduced NS-2 modeling called "Detailed Network-Abstract Network Model" had enabled packet level analysis. However, it had deficiency of accommodating only small sized network. By extending the NS-2 DN-AN model to AN-AN model (Abstract Network-Abstract Network model), it is effectively simulated that the whole process from the initial infection to the total network congestion on hourly basis not only for the Korean network but also for the rest of the world networks. Furthermore, the progress of the propagation from Korean network to the other country was also simulated through the AN-AN model. 8,848 hosts in Korean network were infected in 290 second and 66,152 overseas hosts were infected in 308 second. Moreover, the scanning traffics of the worm at the Korean international gateway saturated the total bandwidth in 154 seconds for the inbound traffic and in 135 seconds for the outbound one.