• 제목/요약/키워드: NOTCH1

검색결과 616건 처리시간 0.024초

상고실 진주종의 형성에 관하여 (Concerning the Formation of the Acquired Cholesteatoma)

  • 장인원;이종원;정종진;조용범;국태진;이정헌;염시경;김종욱;조재식
    • 대한기관식도과학회:학술대회논문집
    • /
    • 대한기관식도과학회 1981년도 제15차 학술대회연제순서 및 초록
    • /
    • pp.39.3-40
    • /
    • 1981
  • 후천적진주종의 형성에 있어서 고막의 Shrapnell부분과 외이도후상부 상피의 상고 실내 침입 및 고막 중심성천공의 margin으로부터 상피가 침입하는 이른바 immigration설과 이밖에 metaplasia설이 있다. 임상적으로 진주종이 상고실에 형성된다는 사실은 알려져 왔으나 그 발생기전에 대한 해명은 충분하지 않는 실정이다. 연자 등은 최근에 중이수술을 시행한 진주종 170례에 대하여 검토를 가하였다. 수술소견에 있어서 진주종의 primary focus가 상고실에 있을 때 Shrapnell부위의 marginal 및 central perforation 2가지 형의 천공이 관찰되었으며 Prussak's space안으로 retraction 및 Rivinus notch의 골벽결손 등을 볼 수 있었고 진주종이 있었던 36례중 Shrapnell부위의 중심성천공을 동반한 경우 5례, Rivinus notch의 골벽이 결손된 경우와 Shrapnell부위의 후상부 marginal perforation이 있고 진주종을 형성한 경우 21례, 그중 Shrapnell부위의 중심성천공을 동반한 경우 3례였다. 결론적으로 상고실 진주종이 잘 생기는 이유는 1) 상고실은 염증성분필물을 배설하는 구씨관입구와의 거리가 있고 2) 고막 Shrapnell부위의 고유층은 collagen fiber가 긴장부에 비해서 엷고 탄력성섬유가 많기 때문에 표피층의 각화증식을 일으킬 경우 Prussak's space내로 retraction을 일으키기 쉽다. 3) Shrapnell부위의 상부에 위치한 Rivinus notch에 부착한 epidermis는 각화증식에 의하여 Rivinus notch margin과 여기에 부착하고 있는 고막연의 margin사이를 파괴하여 상고실로 상피가 침입하게 된다.

  • PDF

T Cells Development Is Different between Thymus from Normal and Intrauterine Growth Restricted Pig Fetus at Different Gestational Stage

  • Lin, Yan;Wang, Junjun;Wang, Xiaoqiu;Wu, Weizong;Lai, Changhua
    • Asian-Australasian Journal of Animal Sciences
    • /
    • 제26권3호
    • /
    • pp.343-348
    • /
    • 2013
  • This experiment was conducted to evaluate the development of T cells in intrauterine growth retarded (IUGR) piglets at different gestational stages, and tentatively explore the relationship between T cells development and the Notch signaling pathway. A total of 18 crossbred (Landrace${\times}$Large white) primiparous sows were mated at similar weights and estruses and euthanized at d 60, 90 and 110 of gestation with six replicates for each time point. One IUGR and one normal fetus were picked from each litter. The T-cell subsets, mRNA expression of Delta-like1, Delta-like4, Jagged1, and Notch2 genes in the thymus were investigated. Compared to normal piglets, $CD3^+CD4^-CD8^+$ cells in IUGR fetuses at d 90 was 0.13% lower (p<0.05). At d 110 of gestation $CD8^+$ T cells in IUGR fetuses was 0.19% lower (p<0.05). The percentage of $CD8^+$ T cells was 3.14% lower (p<0.05) of the total T cells in IUGR pigs at d 60. The abundance of Notch2 and Delta-like4 mRNA at d 110 was 20.93% higher and 0.77% (p<0.05) lower, and Delta-like1 mRNA at d 90 was 0.19% (p<0.05) higher compared to normal pigs. These results suggested that normal fetuses had a greater proportion of T-cell subsets at earlier gestation periods, and the Notch signaling pathway was likely partially responsible for these differences to some degree.

A Method for Estimating an Instantaneous Phasor Based on a Modified Notch Filter

  • Nam Soon-Ryul;Sohn Jin-Man;Kang Sang-Hee;Park Jong-Keun
    • Journal of Electrical Engineering and Technology
    • /
    • 제1권3호
    • /
    • pp.279-286
    • /
    • 2006
  • A method for estimating the instantaneous phasor of a fault current signal is proposed for high-speed distance protection that is immune to a DC-offset. The method uses a modified notch filter in order to eliminate the power frequency component from the fault current signal. Since the output of the modified notch filter is the delayed DC-offset, delay compensation results in the same waveform as the original DC-offset. Subtracting the obtained DC-offset from the fault current signal yields a sinusoidal waveform, which becomes the real part of the instantaneous phasor. The imaginary part of the instantaneous phasor is based on the first difference of the fault current signal. Since a DC-offset also appears in the first difference, the DC-offset is removed trom the first difference using the results of the delay compensation. The performance of the proposed method was evaluated for a-phase to ground faults on a 345kV 100km overhead transmission line. The Electromagnetic Transient Program was utilized to generate fault current signals for different fault locations and fault inception angles. The performance evaluation showed that the proposed method can estimate the instantaneous phasor of a fault current signal with high speed and high accuracy.

안모수직 부조화에 따른 하악이부 형태에 관한 연구 (A STUDY OiM THE MORPHOLOGY OF CHIN IN RELATION TO VERTICAL DYSPLASIA OF CRANIOFACIAL COMPLEX)

  • 차봉근;서정훈
    • 대한치과교정학회지
    • /
    • 제20권1호
    • /
    • pp.135-156
    • /
    • 1990
  • This study was undertaken to investigate the difference of chin morphology and mandibular form in relation to different mandibular growth direction. The subject was divided into three group i.e., control group, vertical group, and horizontal group, according to the criteria of $Bj{\ddot{o}}rk$ sum, and each group was composed of 15 females and 15 males. Medial axis analysis in addition to the routine cephalometric analysis using P.I.A.S. (personal image analysing system) was carried out to find out the differences of mandibular morphology on each group. The results were as follows: 1. The area of symphysis was larger in horizontal growth group than that of vertical growth group. 2. Protruding chin area was also larger in horizontal growth group than that of vertical growth group. 3. There was a close correlationship between protruding chin area and other form of mandible. 4. Antegonial notch depth and ramus posterior contour depth was deeper in vertical growth group than in horizontal growth group, and antegonial notch depth was more influenced by anterior part of notch than posterior part of notch. 5. Mental medial axis and incisal medial axis length, in relation to corpus medial axis length was larger in vertical growth group than in horizontal growth group.

  • PDF

HSS-Co와 SM55C 이종 마찰용접재의 피로강도에 관한 연구(1) (A Study on fatigue Strength in the Friction Welded Joints of HSS-Co to SM55C Carbon Steel(I))

  • 서창민;서덕영;이동재
    • 대한기계학회논문집
    • /
    • 제19권4호
    • /
    • pp.918-928
    • /
    • 1995
  • This paper deals with the various mechanical properties and fatigue strength in the FRW1 (friction welded interface) of high speed steel (HSS-Co) to SM55C through the tensile test, hardness test and fatigue test. The data of FRW specimens are also compared with those of the base materials (HSS-Co and SM55C steel). Three kinds of specimens used in this study are the friction welded joints, HSS-Co and SM55C carbon steel with circumferential notch, saw notch and smooth, respectively. It is confirmed that the applied welding conditions are optimum methods in order to minimize the heat affected zone (HAZ) and hardness distribution at the HAZ. The fatigue strengths at N = 10$^{6}$ cycles of smooth, circumferential notch and saw notch specimens in the FRW joints are about 299.2 MPa, 123.8 MPa and 247.5 MPA, respectively. The fatigue strength of the friction welded joints is almost equal to that of the SM55C carbon steel in the optimum welding conditions. The fatigue cracks initiated at the welded zone are propagated along the side of SM55C steel.

노치 영역에서 유체 관성을 고려한 압력 평형형 베인 펌프의 압력 상승에 관한 연구 (A Study on the pressure Rising Considered Fluid inertia in the Notch Area of Balanced Type Vane Pump)

  • 조명래;한동철;문호지;박민호;배홍용
    • Tribology and Lubricants
    • /
    • 제13권1호
    • /
    • pp.14-20
    • /
    • 1997
  • This paper reports on theoretical study of the pressure overshoot in the delivery ports and pressure rising within balanced type vane pump. Pressure overshoot occur due to the accelerated fluid through the notch, so, result in pressure ripple, flow ripple, and noise. For calculating the pressure rising and fluctuations of pressure, we have modeled mathematically used continuity equation based on compressibility and momentum equation considered fluid inertia in the notch, and analyzed simultaneously. As a results of analysis, we have found oscillation of pressure and compression chamber pressure depend on the rotational speeds, notches. Using the model, notches have been shown to be important design factor in relaxing the rapid pressure rising and reducing the amplitudes of pressure overshoot.

고강도강 맞대기 용접 시험편의 루트갭 변경에 따른 피로강도 평가 (Fatigue Assessment of High Strength Steel with Butt Welded Joints for the Root Gap Difference)

  • 김호정;강성원;김명현
    • 대한조선학회논문집
    • /
    • 제48권1호
    • /
    • pp.56-61
    • /
    • 2011
  • In this study, a series of fatigue tests was conducted to evaluate fatigue strength for the root gap difference with high strength steel with butt welded joints. A finite element analysis using effective notch stress method was also performed to compare effective notch factors each other with butt welded specimens made by copper backing. The results of fatigue tests were classified according to the root gap difference. Fatigue life of butt welded specimens is presented for determining the root gap of high strength steel with butt welded joints in terms of fatigue strength. Then effective notch stress was applied to interpret fatigue strength of butt welded specimen model which is reflected actual measured dimensions. As a result, fatigue strength of high strength steel with butt welded specimens is increased by root gap gets longer in length.

와동 형태에 따른 5급 글라스 아이오노머 시멘트 수복물의 변연누출 비교 (COMPARISON OF MARGINAL LEAKAGE OF CLASS 5 GIC RESTORATIONS ACCORDING TO CAVITY DESIGNS)

  • 이선화;허복;이희주
    • Restorative Dentistry and Endodontics
    • /
    • 제23권1호
    • /
    • pp.296-303
    • /
    • 1998
  • The purpose of this study was to assess the effects of cavity designs on the marginal leakage of class 5 glass ionomer restorations. The five cavity designs were as follows ; notch shape(A group), notch shape with groove(B group), combined lesion(C group), combined lesion with groove and deep chamfer margin(D group) and combined lesion with groove and shoulder(E group), and each design had 10 cavities. After the cavities were restored with GIC, they were immersed in 0.5% basic fuchsin solution for 6 hours. The specimens were washed thoroughly and sectioned longitudinally in a buccolingual direction through the center of the restorations. The degree of marginal leakage was measured as the extent of dye penetration under the stereoscope. The results of this study were as follows 1. The enamel margins of all groups showed lesser leakage than dentin/cementum margins(p<0.05). 2. The combined lesion(C group) showed more leakage than notch shape(A group), but there was no siginificant difference(p>0.05). 3. In the notch shape, there was no influence on the marginal leakage by the groove preparation. 4. In the combined lesion, marginal leakage was decreased by the groove preparation and marginal modification.

  • PDF

Effects of the stiffness of an inclusion on the mechanical behavior of an aluminum alloy plate with a lateral notch

  • Moulgada Abdelmadjid;Zagane Mohammed El Sallah;Murat Yaylaci;Ait Kaci Djafar;Benouis Ali;Baltach Abdelghani;Sevval Ozturk;Mehmet Emin Ozdemir;Ecren Uzun Yaylaci
    • Steel and Composite Structures
    • /
    • 제51권1호
    • /
    • pp.63-72
    • /
    • 2024
  • This study delves into the interaction dynamics between lateral notches and inclusions, providing valuable insights for more effective engineering of structural components. By employing the finite element method, the research analyzes how inclusions affect the dimensions and contours of the plastic zone under confined plasticity conditions. Several parameters were investigated, including loading influence, the distance between the inclusion and notch tip, inclusion stiffness, and the distribution of Von Mises stress, as well as normal stresses σxx and σyy, and Comparison between different stresses. Examining stress distributions under varying loading conditions reveals a significant intensification, particularly near the crack tip. Moreover, the presence of an inclusion near the notch base reduces both the size and shape of the plastic zone. The distribution of the stresses for different loads knows an increase in intensity, especially near the crack head, which is the most requested by the tensile forces on its upper part, which can cause either the crack's initiation or opening, inducing significant stresses.

유효거리를 이용한 연소기관 노치부의 파손기준 해석 (Analysis of Failure Criterion for Combustion Pipe with Notch using Effective Distance)

  • 김덕회;김재훈;문순일
    • 대한기계학회:학술대회논문집
    • /
    • 대한기계학회 2004년도 춘계학술대회
    • /
    • pp.1-6
    • /
    • 2004
  • In this study, the intrinsic static/dynamic fracture toughness of Al 7175=T74 is evaluated from the apparent static/ dynamic toughness of notched specimen, The critical average stress fracture model is suggested to establish the relationship to predict the intrinsic fracture toughness from the apparent fracture toughness of a notched specimen. The critical average stress fracture model is established using the relation between the notch root radius and the effective distance calculated by finite element analysis. Also, effective distance is applied to estimate the failure criterion for the combustion pipe with notch. It is conclude that the true fracture toughness can be estimated from test results of apparent fracture toughness measured by using a notched specimen. Also, the effective In this study, the intrinsic static/dynamic fracture toughness of Al 7175=T74 is evaluated from the apparent static/ dynamic toughness of notched specimen, The critical average stress fracture model is suggested to establish the relationship to predict the intrinsic fracture toughness from the apparent fracture toughness of a notched specimen. The critical average stress fracture model is established using the relation between the notch root radius and the effective distance calculated by finite element analysis. Also, effective distance is applied to estimate the failure criterion for the combustion pipe with notch. It is conclude that the true fracture toughness can be estimated from test results of apparent fracture toughness measured by using a notched specimen. Also, the effective distance can be used to evaluate the failure criterion of structure with notch.

  • PDF