• 제목/요약/키워드: NOR-3

검색결과 1,696건 처리시간 0.029초

Impact of sperm DNA fragmentation on clinical in vitro fertilization outcomes

  • Choi, Hwa Young;Kim, Seul Ki;Kim, Seok Hyun;Choi, Young Min;Jee, Byung Chul
    • Clinical and Experimental Reproductive Medicine
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    • 제44권4호
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    • pp.224-231
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    • 2017
  • Objective: We studied the association between sperm DNA fragmentation (SDF) and several clinical in vitro fertilization outcomes. Methods: We retrospectively analyzed 169 consecutive fresh IVF cycles. Semen was collected on the day of oocyte retrieval, and we assessed standard semen parameters and the SDF level (by terminal deoxynucleotidyl transferase dUTP nick-end labeling). Poor ovarian response (POR) was defined as the collection of three or fewer mature oocytes. Oocytes were inseminated by the conventional method or intracytoplasmic sperm injection. Results: SDF did not affect the fertilization or pregnancy rate, but did have a significant effect on the miscarriage rate. In the miscarriage group (n = 10), the SDF level was significantly higher (23.9% vs. 14.1%) and number of mature oocytes was significantly lower (4.3 vs. 7.6) than in the live birth group (n = 45). Multiple regression analysis showed that SDF was an independent predictor of miscarriage (odds ratio, 1.051; 95% confidence interval, 1.001-1.104). The cutoffs for the SDF level and number of mature oocytes that could predict miscarriage were > 13% and ${\leq}3$, respectively. In the low-SDF group (${\leq}13%$), the miscarriage rate was similar in POR patients and those with a normal ovarian response (NOR; 14.2% vs. 4.3%). In the high-SDF group ( > 13%), the miscarriage rate was significantly higher in the POR group than in the NOR group (60.0% vs. 13.3%, p= 0.045). Conclusion: Our study demonstrated that a high SDF level ( > 13%) was associated with a high miscarriage rate, and that it mainly contributed to miscarriage in the POR group. The results suggest that SDF measurements should be considered in couples with POR in order to predict the prognosis of the pregnancy.

국내 배경지역 대기 미세먼지의 기류 이동경로별 조성변화: 2013년 측정 (Composition Variation of Atmospheric Fine Particulate Matters in Accordance with Air Mass Transport Pathways at Background Site of Korea in 2013)

  • 고희정;임은하;송정민;김원형;강창희;이해영;이철규
    • 한국대기환경학회지
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    • 제31권1호
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    • pp.15-27
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    • 2015
  • The collection of fine particulate matter samples was made at Gosan site of Jeju Island, one of the background sites of Korea, during a year of 2013, and their water-soluble ionic species were analyzed in order to examine the chemical compositions and pollution characteristics. The concentrations of $nss-SO_4{^{2-}}$, $NH_4{^{+}}$, $NO_3{^{-}}$, and $K^+$ had occupied 66.0% of water-soluble ionic species in $PM_{10}$, especially 94.3% in $PM_{2.5}$ fine mode, however the $nss-Ca^{2+}$ and $Na^+$ showed high concentrations in $PM_{10-2.5}$ coarse mode. $NO_3{^-}/nss-SO_4{^{2-}}$ concentration ratios in $PM_{10}$ and $PM_{10-2.5}$ were 0.30 and 0.13, showing less significant effect from automobile and local pollution sources. The sulfate and nitrate compounds were presumed to be long-range transported to Gosan area by the relatively high SOR and NOR values. The trajectory cluster analysis showed the higher concentrations of the major secondary pollutants ($nss-SO_4{^{2-}}$, $NO_3{^{-}}$, $NH_4{^{+}}$) and $nss-Ca^{2+}$ when the air masses had moved from China continent and Korean peninsula into Gosan area.

Common Misconceptions and Future Intention to Smoke among Secondary School Students in Malaysia

  • Caszo, Brinnell;Khair, Muhammad;Mustafa, Mohd Habbib;Zafran, Siti Nor;Syazmin, Nur;Safinaz, Raja Nor Intan;Gnanou, Justin
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권3호
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    • pp.1159-1164
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    • 2015
  • Background: The prevalence of smoking among secondary school children continues to remain unchanged over the last 3 decades even though awareness regarding the health effects of smoking is increasing. Common misconceptions about smoking and parental influence could be factors influencing future intentions to smoke among these students. Hence, we looked at the common misconceptions as well as student perceptions about their future intention to smoke among Form 4 students in Shah Alam, Malaysia. Materials and Methods: This study was conducted by distribution of a questionnaire developed as part of the Global Youth Tobacco Survey to Form 4 student in 3 schools at Shah Alam. Results: Prevalence of smoking (current smokers) was 7.5%. Almost half of the children came from families where one or both parents smoked and a third of the parents had no discussion regarding consequences of smoking with them. A large number of students were classified as "triers" as they had tried smoking and were unsure of whether they would not be smoking in the future. Contrary to our expectations, students generally felt smoking did make one feel more uncomfortable and helped one to reduce body weight. Most students seemed to be aware of the ill-effects of smoking on health. They felt they had received adequate information from school regarding the effects on smoking on health. Conclusions: Our study showed that even though Form 4 students in Shah Alam were knowledgeable about ill-effects of smoking and were taught so as part of their school curriculum, the prevalence of smoking was still high. Students in the "trier group" represent a potential group of future smokers and strategies targeting tobacco control may be aimed at tackling these vulnerable individuals. Efforts are also needed to help educate secondary school children about common misconceptions and dispel myths associated with cigarette smoking.

복막전이를 동반한 위암에서 광범위절제의 효과 (Effect of Radical Removal of Primary and Metastatic Lesions in Gastric Cancer with Peritoneal Seeding)

  • 김영식;이상호;최경현
    • Journal of Gastric Cancer
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    • 제1권3호
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    • pp.136-143
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    • 2001
  • Purpose: The prognosis for gastric cancer with peritoneal seeding is very poor, and the role of surgical intervention is limited. We evaluated the effect of radical removal of primary and metastatic lesions on survival in gastric cancer with peritoneal seeding. Materials and Methods: From May 1989 to March 1999 at Kosin University Gospel Hospital, 115 patients revealed gastric cancer with peritoneal seeding but without liver or lung metastasis and without follow-up loss. The study group included 86 patients who underwent surgery for radical removal of primary gastric and metastatic peritoneal lesions. The control group included 29 patients who experienced incomplete removal of primary or metastatic lesions. Both groups received intraoperative intraperitoneal chemotherapy using mytomycin or cisplatin, and 25 patients underwent postoperative intravenous chemotherapy. Results: The median survival times in the study and the control groups were 13 months and 4 months, respectively (p<0.0001). The 1-year, 2-year, and 5-year survival rates were, respectively, $50.6\%,\;18.1\%$, and $11.3\%$ in the study group and $14.8\%,\;3.7\%$ and $0\%$ in the control group (p<0.0001). In the study group, neither postoperative intravenous chemotherapy nor microscopic invasion of the resection margin had any effect on survival, but intraoperative intraperitoneal chemotherapy and degree of peri-toneal seeding, especially the amount of peritoneal seeding, had an effect on survival. In the control group, neither intraperitoneal nor intravenous chemotherapy had any effect on survival, but resection of the primary gastric lesion improved survival. Conclusion: Radical removal of primary gastric and metastatic peritoneal lesions improved the survival rate for gastric cancer with peritoneal seeding. However, a randomized prospective study is needed to correctly evaluate the effect of intraperitoneal or intravenous chemotherapy.

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효모에서 발현된 유전자 재조합 탈메치오닌 인간 성장호르몬의 일반 약리작용 (General Pharmacology of Recombinant Human Growth Hormone without N-Terminal Methionine Expressed in Saccharomyces cerevisiae)

  • 이은방;신국현;김운자;윤기영;천선아;채윤정
    • 약학회지
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    • 제36권1호
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    • pp.17-25
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    • 1992
  • The general and some other pharmacological actions of growth hormone without N-terminal methionine(rhGH) were investigated in animals. The hormone had no influences on the central nervous system and on body temperature at a high oral dose of 40 IU/kg in animals. It had neither analgesic nor antiepileptic actions at the high doses. In the isolated ileum and trachea of guinea-pig and isolated stomach fundus and uterus of rat, it showed neither contractive nor relaxing effects at a concentration of $1{\times}10^{-3}\;IU/ml$ in bath, and no inhibitory action at a dose of $1{\times}10^{-3}\;IU/ml$ against the contractions produced by histamine ($5{\times}10^{-5}\;g/ml$), serotonin($1{\times}10^{-5}\;g/ml$), acetylcholine($1{\times}10^{-5}\;g/ml$) and oxytocin($5{\times}10^{-3}\;IU/ml$). Furthermore, the intravenous injection of 20 IU/kg rhGH had no influences on the normal blood pressure and respiration in rabbits. These negative results in pharmacological profile are thought that the hormone may not elicit serious side effects. On the other hand, the rhGH exhibited a weak inhibitory action of glucose tolerance in normal rats, significantly lowered the blood glucose contents in adrenalectomized rats 20 min after i.v. administration of 80 IU/kg, and showed a significant inhibitory effect on in vitro glycerol release in epinephrine-stimulated epididymal fat pad segments of rats.

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Response of $I_{Kr}$ and hERG Currents to the Antipsychotics Tiapride and Sulpiride

  • Jo, Su-Hyun;Lee, So-Young
    • The Korean Journal of Physiology and Pharmacology
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    • 제14권5호
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    • pp.305-310
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    • 2010
  • The human $ether$-$a$-$go$-$go$-related gene ($hERG$) channel is important for repolarization in human myocardium and is a common target for drugs that prolong the QT interval. We studied the effects of two antipsychotics, tiapride and sulpiride, on hERG channels expressed in $Xenopus$ oocytes and also on delayed rectifier $K^+$ currents in guinea pig cardiomyocytes. Neither the amplitude of the hERG outward currents measured at the end of the voltage pulse, nor the amplitude of hERG tail currents, showed any concentration-dependent changes with either tiapride or sulpiride ($3{\sim}300{\mu}M$). However, our findings did show that tiapride increased the potential for half-maximal activation ($V_{1/2}$) of HERG at $10{\sim}300{\mu}M$, whereas sulpiride increased the maximum conductance ($G_{max}$) at 3, 10 and $100{\mu}M$. In guinea pig ventricular myocytes, bath applications of 100 and $500{\mu}M$ tiapride at $36^{\circ}C$ blocked rapidly activating delayed rectifier $K^+$ current ($I_{Kr}$) by 40.3% and 70.0%, respectively. Also, sulpiride at 100 and $500{\mu}M$ blocked $I_{Kr}$ by 38.9% and 76.5%, respectively. However, neither tiapride nor sulpiride significantly affected the slowly activating delayed rectifier $K^+$ current ($I_{Ks}$) at the same concentrations. Our findings suggest that the concentrations of the antipsychotics required to evoke a 50% inhibition of IKr are well above the reported therapeutic plasma concentrations of free and total compound.

모유수유중재의 산후 1, 3, 6개월 모유수유율에 대한 효과: 체계적 문헌고찰 및 메타분석 (Effects of Breastfeeding Interventions on Breastfeeding Rates at 1, 3 and 6 Months Postpartum: A Systematic Review and Meta-Analysis)

  • 박설희;류세앙
    • 대한간호학회지
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    • 제47권6호
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    • pp.713-730
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    • 2017
  • Purpose: This study was a systematic review and meta-analysis designed to evaluate the effects of breastfeeding intervention on breastfeeding rates. Methods: Based on the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), a systematic search was conducted using eight core electronic databases and other sources including gray literature from January 9 to 19, 2017. Two reviewers independently select the studies and assessed methodological risk of bias of studies using the Cochrane criteria. The topics of breastfeeding interventions were analyzed using descriptive analysis and the effects of intervention were meta-analyzed using the Review Manager 5.2 software. Results: A total of 16 studies were included in the review and 15 were included for meta-analysis. The most frequently used intervention topics were the importance of good latch-on and frequency of feeding and determining adequate intake followed. The pooled total effect of breastfeeding intervention was 1.08 (95% CI 1.03~1.13). In the subgroup analysis, neither pre-nor post-childbirth intervention was effective on the breastfeeding rates at 1, 3, and 6 months, and neither group nor individual interventions had an effect. Only the 1 month breastfeeding rate was found to be affected by the individual intervention with the persistent strategies 1.21 (95% CI 1.04~1.40). Conclusion: Effective breastfeeding interventions are needed to help the mother to start breastfeeding after childbirth and continue for at least six months. It should be programmed such that individuals can acquire information and specific breastfeeding skills. After returning home, there should be continuous support strategies for breastfeeding as well as managing various difficulties related to childcare.

CHARACTERIZATION OF THE HELICOID AS RULED SURFACES WITH POINTWISE 1-TYPE GAUSS MAP

  • Choi, Mie-Kyung;Kim, Young-Ho
    • 대한수학회보
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    • 제38권4호
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    • pp.753-761
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    • 2001
  • We introduce the notion of Gauss map of pointwise 1-type on ruled surfaces in the Euclidean 3-space for which vector valued functions is neither trivial nor it extends or coincides with the usual notion of 1-type, in general. We characterize the minimal helicoid in terms of it and give a complete classification of the ruled surfaces with pointwise 1-type Gauss map.

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홍삼 및 숙지황의 혼합추출물의 고혈당강하작용 (Hypoglycemic Effects of Extract Mixture of Red Ginseng and Steamed RehManiae Radix on Streptozotocin-induced Diabetic Rats)

  • 김학성;성연희
    • Journal of Ginseng Research
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    • 제21권3호
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    • pp.169-173
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    • 1997
  • The effects of extract mixture of red ginseng and steamed Rehmaniae radix prepared for antidiabetic activity was examined in streptozotocin-Induced diabetic rats. The increased blood glucosec level in the streptozotocin-induced diabetic rats was significantly decreased by the treatment with the mixture (800, 1600 mg/kg, p.o.). However, neither red ginseng extract nor steamed Rehmaniae radix extract alone showed significant hypoglycemic effects. The mixture prevented a weight loss in streptozotocin-induced diabetic rats. These results suggest that the mixture has the relieving action against streptozotocin-induced hyperglycemia.

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A NEW UDB-MRL TEST WITH UNKNOWN CHANCE POINT

  • Na, Myung-Hwan
    • 품질경영학회지
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    • 제30권3호
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    • pp.195-202
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    • 2002
  • The problem of trend change in the mean residual life is great Interest in the reliability and survival analysis. In this paper, a new test statistic for testing whether or not the mean residual life changes its trend Is developed. It is assumed that neither the change point nor the proportion at which the trend change occurs is known. The asymptotic null distribution of test statistic is established and asymptotic critical values of the asymptotic null distribution is obtained. Monte Carlo simulation is used to compare the proposed test with previously known tests.