• 약학회지
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• 제55권4호
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• pp.338-344
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• 2011

This study aimed to identify the changes in the list of drugs covered by national health insurance(NHI) after the introduction of positive list system (PLS) in Korea in December, 2006. Six-year (pre-policy:2004-2006, post-policy:2007-2009) lists of the NHI reimbursable drugs filed from Health Insurance Review and Assessment Service (HIRA) were analyzed. The total number of listed drugs as well as drug ingredients, and the average number of listed drugs per manufacturer decreased annually after the introduction of PLS. More than 8,000 drugs were delisted in the year 2007 right after the policy change. Prescription-only drugs occupied more than 85% of NHI listed drugs. The percentage of oral type of listed drugs has been increased to more than 60% after the policy change. Korean pharmaceutical manufacturers occupied more than 90% of listed drugs than multinational firms. The gap between Korean and foreign manufacturer in terms of the average number of newly listed drugs per manufacturer in each year has decreased two years after the PLS (Korean 7.7 vs. foreign 6.3 in 2009) as the price negotiation power of foreign firms has increased. The total number of listed drugs is expected to decrease in the future as the Korean government makes an effort to delist the unnecessary drugs that do not show cost-effectiveness.

• 한국의류학회지
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• 제31권1호
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• pp.131-140
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• 2007

The purpose of this study was to clarify differences in consumer's advertising attitude related to type of mobile fashion advertising and level of apparel and advertising involvement groups. This study surveyed consumers who have an experience of receiving mobile fashion advertising. The subjects of this study were men and women aged 10-20 years of age, living in the metropolitan area and judgments sampling was employed. The data were obtained from 480 questionnaires. The measurement instruments were modified and made up by researcher on the basis of previous studies in the same field. Data were statistically analyzed using SPSS 11. Major statistical methods were Cronbach's ${\alpha}$, t-test, regression analysis, and descriptive statistics. The results were as follows: First, differences in effectiveness of fashion ads in both images ad and text messages ad were shown in this study. Respondents preferred images ad to left messages ad only. Also purchase intentions were more preferred by images ad. Second, the differences of consumer's advertising attitude were shown according to level of apparel and advertising involvement groups. The high apparel and ad involvement group was more likely to have a preferable attitude to the ads than the low apparel and ad involvement group. Third, consumer's purchase intentions were influenced by consumer's advertising attitude on two type's ad. The conclusion is that images ad will have great potential for fashion ads by mobile phones in the future. Also consumer attitude between other mobile advertising types must be studied in order to gain further insight into fashion advertising by mobile phone.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2012년도 학술발표회
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• pp.942-942
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• 2012

강우-유출에 대한 수문해석에 있어 유효강우량 산정방법으로는 여러 가지가 있으나 국내외로 미농무부(United States Department of Agriculture)에서 제안한 NRCS-CN 방법이 널리 사용되고 있다. SCS-CN 방법은 1개의 매개변수만을 사용하여 방법이 간략하고 유역 토양특성의 반영이 가능하다는 장점이 있으나 공간적 규모에 따른 효과반영이 불가하고 초기손실우량비를 0.2로 고정하는 가정의 문제점 등이 있다. 많은 연구자들이 SCS-CN 방법의 문제점을 보완하고자 다양한 방법을 제시하였으며 특히 Michel 등(2005)은 토양수분계산가정(Soil Moisture Accounting Procedure)에서 유출기준저류고를 새로운 매개변수로 제안하여 초기손실우량비 가정의 불합리성을 개선하고 새로운 AMC 조건식을 산정하였다. 그러나 범용적인 AMC 조건식을 제안하고자 140개 유역에 적용한 결과를 통해 유출기준저류고는 토양의 최대잠재보유수량의 1/3으로 일괄 적용하는 문제점이 있으며, 민감도분석을 통해 전체 결과의 효율이 좋은 값으로 선정하였다. 이에 본 연구에서는 일 단위 집중형 장기유출모형인 GR4J(Ge'nie Rural a' 4 parame'tres Journalier)를 Michel이 제안한 모형을 적용하기 위해 선정하였으며 토양수분계산과정에서 새로운 매개변수인 유출기준저류고를 최적화기법인 화음탐색법을 적용하여 결정하였다. 적용대상은 국내의 달방댐, 횡성댐, 섬진강댐, 청주댐, 대청댐유역에 적용하였으며 본 연구에서 제안한 방법이 강우-유출 결과의 정확성을 향상시키는 것을 볼 수 있었다. 최종적으로 최적화된 유출기준저류고와 유역크기와의 상관성분석을 통하여 관계식을 도출하였다. 토양수분과정에 대한 고려는 유출량을 산정하는 데 있어서 정확성을 높이는 데 기여할 수 있으며 더불어 본 연구에서 제안한 관계식을 통하여 유출기준저류고와 유역특성과의 연관성을 확인할 수 있었다.

• Toxicological Research
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• 제25권1호
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• pp.51-58
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• 2009

Carrageenan is a naturally-occurring sulfated polygalactan which has been widely used in the dairy industry and a gelling agent in non-dairy products. In this study, four short-term in vitro genotoxicity assays were investigated to evaluate the potential genotoxic effects of carrageenan. The mutagenicity of carrageenan was evaluated up to a maximum dose of 5 mg/plate in Ames test. There was no increase in the number of revertant colonies compared to its negative control at any dose in all of strains tested. To assess clastogenic effect, the in vitro chromosomal aberration assay was performed using Chinese hamster lung cells. Carrageenan was not considered to be clastogenic in this assay at up to the highest feasible concentration which could be evaluated. The in vitro comet assay and micronucleus test results obtained on L5178Y cells also revealed that carrageenan has no genotoxicity potential, although there was a marginal increase in micronuclei frequencies and DNA damage in the respective micronucleus and comet assays. Taken together, our results indicate that carrageenan was not genotoxic based on four in vitro genotoxicity results.

• Geomechanics and Engineering
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• 제13권5호
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• pp.715-742
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• 2017

Earth berms are often left in place to support retaining walls or piles in order to eliminate horizontal struts in excavations of soft soil areas. However, if the excavation depth is relatively large, an earth berm-supported retaining system may not be applicable and could be replaced by a multi-bench retaining system. However, studies on multi-bench retaining systems are limited. The goal of this investigation is to study the deformation characteristics, internal forces and interaction mechanisms of the retaining structures in a multi-bench retaining system and the failure modes of this retaining system. Therefore, a series of model tests of a two-bench retaining system was designed and conducted, and corresponding finite difference simulations were developed to back-analyze the model tests and for further analysis. The tests and numerical results show that the distance between the two rows of retaining piles (bench width) and their embedded lengths can significantly influence the relative movement between the piles; this relative movement determines the horizontal stress distribution in the soil between the two rows of piles (i.e., the bench zone) and thus determines the bending moments in the retaining piles. As the bench width increases, the deformations and bending moments in the retaining piles decrease, while the excavation stability increases. If the second retaining piles are longer than a certain length, they will experience a larger bending moment than the first retaining piles and become the primary retaining structure. In addition, for varying bench widths, the slip surface formation differs, and the failure modes of two-bench retained excavations can be divided into three types: integrated failure, interactive failure and disconnected failure.

• Steel and Composite Structures
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• 제35권2호
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• pp.261-278
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• 2020

In steel-concrete composite beams, to improve the cracking resistance of the concrete slab in the hogging moment region, a new type of connector in the interface, named uplift-restricted and slip-permitted screw-type (URSP-S) connector has been proposed. This paper focuses on the behavior of steel-concrete composite beams with URSP-S connectors. A total of three beam specimens including a simply supported beam with URSP-S connectors and two continuous composite beams with different connectors arrangements were designed and tested. More specifically, one continuous composite beam was equipped with URSP-S connectors in negative moment region and traditional shear studs in other regions. For comparison, the other one was designed with only traditional shear studs. The failure modes, crack evolution process, ultimate capacities, strain responses at different locations as well as the interface slip of the three tested specimens were measured and evaluated in-depth. Based on the experimental study, the research findings indicate that the larger slip deformation is allowed while using URSP-S connectors. Meanwhile, the tensile stress reduces and the cracking resistance of the concrete slab improves accordingly. In addition, the overall stiffness and strength of the composite beam become slightly lower than those of the composite beam using traditional shear studs. Moreover, the arrangement suggestion of URSP-S connectors in the composite beam is discussed in this paper for its practical design and application.

• 철학연구
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• 제117권
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• pp.399-418
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• 2011

이 논문은 초기 낭만주의 철학의 생성을 당대의 칸트 비판과 연관하여 살펴보고, 초기 낭만주의 철학의 토대를 구축한 야코비의 사상을 그의 "무제약자"와 "감정" 개념을 중심으로 재구성한 다음, "무한한 접근"을 강조하는 초기 낭만주의 철학의 특정을 노발리스를 통해 규명하는 것을 목적으로 한다. 야코비에게 무제약자는 지식의 가능근거이자 지식의 매개를 벗어나는 것이므로 "믿음"으로 간주된다. 무제약자는 지식의 조건이지만 의식의 영역을 초월하는 "존재"이다, 그러므로 야코비의 "무제약자" 내지 "근원-존재"는 칸트의 이원론을 극복하는 형이상학적 일원론의 토대이며 지식의 영역으로 환원되지 않는 실재론적 바탕이다. 노발리스에게 무제약자는 인간에게 주어져 있는 것이 아니며 동경과 노력의 대상이다. 여기서 철학은 무제약자를 향한 영원한 접근이 된다. 철학은 초월자와 접촉하는 감정의 근원적인 활동이며 근거를 인식하려는 끝없는 충동이다.

• 한국과 국제사회
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• 제3권2호
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• pp.131-154
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• 2019

국가가 자주권을 행사하는 것은 전략문화와 강한 상관관계가 있지만 국가의 전략문화의 분류에 대해서는 학자마다 견해가 다르다. 중국 서부의 가장 중요한 인접국가 중 하나인 파키스탄은 중국의 든든한 파트너로서 파키스탄의 전략문화를 이해하는 것은 파키스탄의 국가정책과 국가가 자주권을 행사하는 행위를 이해하는 데 도움이 될 뿐만 아니라 중국과 파키스탄 양국의 협력관계를 심화시키는 데도 도움이 된다. 저자는 지리, 사회, 경제, 문화, 역사, 군사 등의 관점에서 볼 때 파키스탄의 전략적 문화 형성의 메커니즘은 주로 지정학적 환경, 생산방식, 생활방식, 문화적 전통, 역사적 경험과 대외 관계 등 네 가지 요인의 영향을 받는다. 분석 결과로 파키스탄의 전략 문화는 이슬람에 의해 형성되어 왔고, 대외 지향적인 전략 문화로 분류될 수 있으며 국가가 자주권을 행사하는 거도 이슬람적인 색채가 강하다.

• Journal of Veterinary Science
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• 제22권1호
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• pp.8.1-8.11
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• 2021

Background: Porcine circovirus type 2 (PCV2) is an important infectious pathogen implicated in porcine circovirus-associated diseases (PCVAD), which has caused significant economic losses in the pig industry worldwide. Objectives: A suitable viral vector-mediated gene transfer platform for the expression of the capsid protein (Cap) is an attractive strategy. Methods: In the present study, a recombinant adeno-associated virus 8 (rAAV8) vector was constructed to encode Cap (Cap-rAAV) in vitro and in vivo after gene transfer. Results: The obtained results showed that Cap could be expressed in HEK293T cells and BABL/c mice. The results of lymphocytes proliferative, as well as immunoglobulin G (IgG) 2a and interferon-γ showed strong cellular immune responses induced by Cap-rAAV. The enzyme-linked immunosorbent assay titers obtained and the IgG1 and interleukin-4 levels showed that humoral immune responses were also induced by Cap-rAAV. Altogether, these results demonstrated that the rAAV8 vaccine Cap-rAAV can induce strong cellular and humoral immune responses, indicating a potential rAAV8 vaccine against PCV2. Conclusions: The injection of rAAV8 encoding PCV2 Cap genes into muscle tissue can ensure long-term, continuous, and systemic expression.

• Geomechanics and Engineering
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• 제19권1호
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• pp.11-20
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• 2019

The use of electrokinetic dissipation method to study the fluid flow law in micro-pores is of great significance to reservoir rock microfluidics. In this paper, the micro-capillary theory was combined with the coupling model of the seepage field and the current field under the excitation of the harmonic signal, and the coupling theory of the electrokinetic effect under the first-order approximation condition was derived. The dissipation equation of electrokinetic dissipation and viscous resistance dissipation and its solution were established by using Green's function method. The physical and mathematical models for the electrokinetic dissipation of reservoir rocks were constructed. The microscopic mechanism of the electrokinetic dissipation of reservoir rock were theoretically clarified. The influencing factors of the electrokinetic dissipation frequency of the reservoir rock were analyzed quantitatively. The results show that the electrokinetic effect transforms the fluid flow profile in the pores of the reservoir from parabolic to wavy; under low-frequency conditions, the apparent viscosity coefficient is greater that one and is basically unchanged. The apparent viscosity coefficient gradually approaches 1 as the frequency increases further. The viscous resistance dissipation is two orders of magnitude higher than the electrokinetic effect dissipation. When the concentration of the electrolyte exceeds 0.1mol/L, the electrokinetic dissipation can be neglected, while for the electrolyte solution (<$10^{-2}M$) in low concentration, the electrokinetic dissipation is very significant and cannot be ignored.