• Title/Summary/Keyword: NICE-3

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FREE ARRANGEMENTS AND NICE PARTITIONS

  • Choi, Hyun-Hee;Lee, Ki-Suk
    • Communications of the Korean Mathematical Society
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    • v.17 no.3
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    • pp.439-449
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    • 2002
  • If an arrangement admits a nice partition, or an arrangement is free, then the characteristic polynomial of the arrangement can be factored. It is known that a free arrangement does not always admit a nice partition. We show that even an inductively free arrangement does not always admit a nice partition.

Up-regulation of NICE-3 as a Novel EDC Gene Could Contribute to Human Hepatocellular Carcinoma

  • Wei, Yuan-Jiang;Hu, Qin-Qin;Gu, Cheng-Yu;Wang, Yu-Ping;Han, Ze-Guang;Cai, Bing
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.9
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    • pp.4363-4368
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    • 2012
  • The epidermal differentiation complex (EDC) contains a large number of gene products which are crucial for the maturation of the human epidermis and can contribute to skin diseases, even carcinogenesis. It is generally accepted that activation of oncogenes and/or inactivation of tumor suppressor genes play pivotal roles in the process of carcinogenesis. Here, NICE-3, a novel EDC gene, was found to be up-regulated in human hepatocellular carcinoma (HCC) by quantitative real-time RT-PCR. Furthermore, overexpression of exogenous NICE-3 by recombinant plasmids could significantly promote cell proliferation, colony formation and soft agar colony formation in Focus and WRL-68 HCC cell lines. Reversely, NICE-3 silencing by RNA interference could markedly inhibit these malignant phenotypes in YY-8103 and MHCC-97H cells. Moreover, cell cycle analysis of MHCC-97H transfected with siRNA by flow cytometry showed that NICE-3 knockdown may inhibit cell growth via arrest in G0/G1 phase and hindering entry of cells into S phase. All data of our findings indicate that NICE-3 may contribute to human hepatocellular carcinoma by promoting cell proliferation.

Japanese Cancer Association Meeting UICC International Session - What is Cost-effectiveness in Cancer Treatment?

  • Akaza, Hideyuki;Kawahara, Norie;Roh, Jae Kyung;Inoue, Hajime;Park, Eun-Cheol;Lee, Kwang-Sig;Kim, Sukyeong;Hayre, Jasdeep;Naidoo, Bhash;Wilkinson, Thomas;Fukuda, Takashi;Jang, Woo Ick;Nogimori, Masafumi
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.1
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    • pp.3-10
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    • 2014
  • The Japan National Committee for the Union for International Cancer Control (UICC) and UICC-Asia Regional Office (ARO) organized an international session as part of the official program of the 72nd Annual Meeting of the Japanese Cancer Association to discuss the topic "What is cost-effectiveness in cancer treatment?" Healthcare economics are an international concern and a key issue for the UICC. The presenters and participants discussed the question of how limited medical resources can be best used to support life, which is a question that applies to both developing and industrialized countries, given that cancer treatment is putting medical systems under increasing strain. The emergence of advanced yet hugely expensive drugs has prompted discussion on methodologies for Health Technology Assessment (HTA) that seek to quantify cost and effect. The session benefited from the participation of various stakeholders, including representatives of industry, government and academia and three speakers from the Republic of Korea, an Asian country where discussion on HTA methodologies is already advanced. In addition, the session was joined by a representative of National Institute for Health and Care Excellence (NICE) of the United Kingdom, which has pioneered the concept of cost-effectiveness in a medical context. The aim of the session was to advance and deepen understanding of the issue of cost-effectiveness as viewed from medical care systems in different regions.

A Study on Third-trimester Gravidas' Konwledge of Infant Care Activity (임신 말기 임신부의 영아 돌보기 지식에 관한 연구)

  • Lee, Su-Yeon
    • The Korean Nurse
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    • v.29 no.3
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    • pp.64-78
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    • 1990
  • The purpose of this study was to measure the degree of gravidas' knowledge of infant care activity, and to identify the factors influencing the difference of gravidas' knowledge. The subjects of this study consisted of 159 gravida visited 2 general hospitals, 2 OB/GY clinics and 2 midwives' clinics in J city for anenatal care. The data were collected from December 1 to 30, J.989. The instrument used for this study was true false type question which was developed by investigator through literature review. Data were analyzed by percentage, mean, t-test and ANOVA on significant difference with SPSS program. The results of this study were, summarized as follow: 1) The degree of gravidas' knowledge of infant care activity was 36.75, the degree of gravidas' know ledge of physical care activicy was 16.70, and the degree of gravidas' knowledge of psychosocial care activity was 20.00. 2) Among the physical care activity knowledge items, the diaper should be changed whenever it is soiled, $\lceil$shortly after feeding is over, bathing is bad$\rfloor$, $\lceil$gently patted or stroked on the back when bubbling$\rfloor$, $\lceil$10 minutes time in bathing is appropriate$\rfloor$, $\lceil$infant is crying whenever he is hungry per 3-4 hours$\rfloor$, and "room humidity controled 60 percent, more or less> were over a' percentage of 80 of right answer. Among the physical care, accivity knowledge items. $\lceil$a reason for burping was the air' he has swallowed will rise to the top of his stomach and be eructated$\rfloor$, $\lceil$burping is advisable after the feeding$\rfloor$, $\lceil$dressing of umbilical area is not necessary$\rfloor$, $\lceil$the thermometer should not be boiled for disinfection$\rfloor$, $\lceil$it is important chat the infant grasp the whole nipple within his mouth$\rfloor$, $\lceil$using alcohol sponge is bad whenever diaper is soiled", and $\lceil$when temperature is taken by the rectal method, infant legs shoud be grasped firmly_! were less than a percentage of 60 of right answer. 3) Among the psychosocial care activity knowledge items, $\lceil$it is nice, mother smile at bady frequently$\rfloor$, $\lceil$it is nice, mother praise a bady frequently$\rfloor$, $\lceil$it is nice, mother express bady's behavior$\rfloor$, $\lceil$talk frequently to the bady, the bady :should not be disturbed while feeding$\rfloor$, $\lceil$it is nice, mother see a baby face to face , $\lceil$it is nice, mother concentrate one's attention on her baby while playing$\rfloor$, $\lceil$it is nice, mother pat one's baby while he is feeding$\rfloor$, $\lceil$it is advisable, the baby is allowed to touch mother's breast while he is feeding$\rfloor$, $\lceil$it is advisable to stop feeding, if the baby protrudes one's tongue or cries while feeding$\rfloor$, $\lceil$baby is able to hear, see and smell$\rfloor$, $\lceil$it is nice, mother Concentrate one's attention on her baby while feeding$\rfloor$, and $\lceil$it is not advisable for mother to scold baby while he is crying out> were over a percentage of 80 of right answer. Among the psychosocial care activity knowledge items, $\lceil$Using' baby talks is bad when mother talks to baby> and $\lceil$it is nice, mother soothes the baby as soon as possible when he is crying I were less than a percentage of 60 of right answer. 4) There was statistically significant relationship between the degree of gravidas' knowledge of infant care activity and the demographic variables of gravida such as the age(p<0.01) and education level(p<0.01). From these results, it may be concluded that gravidas' knowledge of infant care activity is moderate level, and gravidas' knowledge of psychosocial care activity is greater than that of physical care activity. Also prenatal nursing educations should focus on subjects who have lower percentage of right answer in infant care activity knowledge items.dge items.

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Development of a Cybersecurity Workforce Management System (사이버 보안 분야 전문가 프로파일 관리 시스템 연구)

  • Ahn, Jun-young;Lee, Seung-hun;Park, Hee-min;Kim, Hyun-chul
    • Journal of the Semiconductor & Display Technology
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    • v.20 no.3
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    • pp.65-70
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    • 2021
  • According to the trend of increasingly sophisticated cyber threats, the need for technology research that can be applied to cyber security personnel management and training systems is constantly being raised not only overseas but also in Korea. Previously, the US and UK have already recognized the need and have been steadily conducting related research from the past. In the United States, by encouraging applications based on related research (NICE Cybersecurity Workforce Framework) and disclosing successful use cases to the outside, it is laying the groundwork for profiling cyber security experts. However in Korea, research on cyber security expert training and profiling is insufficient compared to other countries. Therefore, in this study, in order to create a system suitable for the domestic situation, research and analysis of cases in the United States and the United Kingdom were conducted over the past few years, and based on this, a prototype was produced for the study of profiling technology for domestic cyber security experts.

Household Over-indebtedness and Financial Vulnerability in Korea: Evidence from Credit Bureau Data

  • KIM, YOUNG IL;KIM, HYOUNG CHAN;YOO, JOO HEE
    • KDI Journal of Economic Policy
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    • v.38 no.3
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    • pp.53-77
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    • 2016
  • Financial soundness in the household sector matters for financial stability and for the real economy. The level of household debt in Korea raises concern about the financial soundness of the household sector due to its size, growth rate and quality. Against this backdrop, we assess the financial vulnerability of borrowers based on an analysis of credit bureau (CB) data, in which the actual credit activities of most individuals are recorded at a high frequency in Korea. We construct over-indebtedness indicators from the CB data and then assess the predictability of forthcoming defaults. Based on the over-indebtedness indicators, we show how borrowers are distributed in terms of over-indebtedness and how the over-indebted differ from average borrowers in terms of their characteristics. Furthermore, we show how the aggregate credit risk in the household sector would change under macroeconomic distress by analyzing how each borrower's credit quality would be affected by adverse shocks. The findings of this paper may contribute to assessing household debt vulnerability and to enhancing regulatory and supervisory practices for financial stability.

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Treatment of Latent Tuberculosis Infection and Its Clinical Efficacy

  • Kim, Hyung Woo;Kim, Ju Sang
    • Tuberculosis and Respiratory Diseases
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    • v.81 no.1
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    • pp.6-12
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    • 2018
  • The role of the treatment for latent tuberculosis infection (LTBI) has been underscored in the intermediate tuberculosis (TB) burden countries like South Korea. LTBI treatment is recommended only for patients at risk for progression to active TB-those with frequent exposure to active TB cases, and those with clinical risk factors (e.g., immunocompromised patients). Recently revised National Institute for Health and Care Excellence (NICE) guideline recommended that close contacts of individuals with active pulmonary or laryngeal TB, aged between 18 and 65 years, should undergo LTBI treatment. Various regimens for LTBI treatment were recommended in NICE, World Health Organization (WHO), and Centers for Disease Control and Prevention guidelines, and superiority of one recommended regimen over another was not yet established. Traditional 6 to 9 months of isoniazid (6H or 9H) regimen has an advantage of the most abundant evidence for clinical efficacy-60%-90% of estimated protective effect. However, 6H or 9H regimen is related with hepatotoxicity and low compliance. Four months of rifampin regimen is characterized by less hepatotoxicity and better compliance than 9H, but has few evidence of clinical efficacy. Three months of isoniazid plus rifampin was proved equivalence with 6H or 9H regimen in terms of efficacy and safety, which was recommended in NICE and WHO guidelines. The clinical efficacy of isoniazid plus rifapentine once-weekly regimen for 3 months was demonstrated recently, which is not yet introduced into South Korea.

Effect of Paddy and Upland Conditions on Yield and Storage of Onion Bulbs (논밭 재배지 조건에 따른 양파 채종용 모구의 수량 및 저장력 변화)

  • Cho Sang-Kyun;Lee Eul-Tai;Oh Young-Jin;Choi In-Hu;Kim Young-Jin;Kim Jung-Gon
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.51 no.5
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    • pp.401-407
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    • 2006
  • This study was conducted to investigate the effect of onion cultivation under paddy and upland condition on the yield and storage of onion bulbs. In comparison of soil conditions, nitrogen, phosphate, potassium content and average temperature in upland condition were higher than those of paddy condition, but calcium, magnesium, sodium and water content in paddy condition were higher than those of upland condition. The growth of aerial part was better in upland cultivated condition. It showed that bulb formation in paddy cultivated condition was faster during in early growth stage, but was slower during in late growth stage. Average bulb size and weight were higher in upland cultivated condition, but dry weight per 100 g fresh weight and bulb hardness were higher in paddy cultivated condition. Sugar contents, inorganic compounds, nitrogen, phosphate and potassium content of onion were higher in upland cultivated condition, but calcium, magnesium and sodium content of onion were higher in paddy cultivated condition. In distribution of onion bulb size, most of large sized onions were produced in upland cultivated condition. Average bulb production for seed harvesting were $63{\sim}70%$ higher in paddy cultivated condition than that of upland cultivated condition. The rotted rate of onion was about $27.2{\sim}34.6%$ in paddy, $37.5{\sim}51.4%$ in upland cultivated condition respectively, showed favorable result as the difference of $8.7{\sim}24.2%$ in paddy cultivated condition.