• Journal of the Korean Wood Science and Technology
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• v.32 no.3
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• pp.52-58
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• 2004

The use of N-hydroxyphthalimide (NHPI) as a mediator for laccase has proven to be comparable to N-hydroxybenzotriazole (HBT) for the delignification of kraft pulp, and the transformation of a number of industrial dyes. The advantages of NHPI derivatives are the biodegradation of these compounds compared to HBT, which has been shown to be recalcitrant in the environment, and the more reasonable cost of synthetic process.

• Bulletin of the Korean Chemical Society
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• v.33 no.2
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• pp.459-463
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• 2012

N-hydroxyphthalimide (NHPI) and copper chloride ($CuCl_2$) were first utilized for aerobic oxidation of ${\alpha}$-isophorone (${\alpha}$-IP) to ketoisophorone (KIP) and the effects of co-catalysts, temperature, reaction time, solvent, amount of $CuCl_2$ and pressure of oxygen were investigated extensively. NHPI/$CuCl_2$ turned out to be highly efficient to this oxidation with up to 91.3% conversion and 81.0% selectivity under mild conditions. And various hydrocarbons including benzylic compounds, cycloalkene and its derivatives were also oxidized smoothly under optimized conditions. Moreover, the possible reaction mechanism was proposed and verified by FT-IR spectra.