• Journal of Advanced Navigation Technology
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• v.13 no.6
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• pp.957-963
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• 2009

It is necessary for the resource management system to manage for the resource in distributed networking environment. Because of increasing the complexity of vast computer system and business environment, needs of RMS is increasing. Based on the common information model to use of objected oriented technology, through analysis of the reference model for the resource management system of the SNIA, we intend to implement the application program to manage the NGS system that consist of SSD and DRAM. To visualize, it is use the GUI Interface. It is possible for application program(Client) to detect and manage the system that consist of the NGS system. Also, status information that is divided into three cataloges(Minor/Major/Critical) can be displayed and it provide support of configuration functionality to manage devices.

• Proceedings of the Korean Information Science Society Conference
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• 2011.06b
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• pp.466-469
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• 2011

최근에 등장한 Next Generation Sequencing(NGS)은 전통적인 방법에 비해 빠르고 저비용으로 대용량의 시퀀스 데이터를 이용한 차세대 시퀀싱 기술을 말한다. 이렇게 얻은 NGS 데이터를 분석하는 단계 중에서 alignment 단계는 시퀀서에서 얻은 대량의 read를 참조 염기서열에 맵핑하는 단계로 NGS 데이터 분석의 가장 기본이면서 핵심인 단계이다. alignment 도구는 긴 참조 염기서열을 색인화해서 짧은 read를 빠르게 맵핑하는 용도로 사용된다. 현재 많이 사용되고 있는 일반적인 alignment 도구들은 입력데이터에 대한 별도의 전처리 과정이 없으며 나열된 read를 순차적으로 맵핑하는 단순한 구조를 가지고 있다. 본 논문은 NGS 데이터의 특징 중에 특히 read간의 중복성이 존재하고 이를 이용한 read의 효율적 공통부분 서열을 찾는다. 중복이 가능한 read의 공통부분서열과 read의 관계를 그래프 이론의 Hitting Set 문제로 모델링하고 여러 read가 포함하는 공통 부분서열을 사용해서 alignment 단계의 효율을 높일 수 방법을 제안한다.

• Food Science and Industry
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• v.52 no.3
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• pp.220-228
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• 2019

Rapid development of next-generation sequencing (NGS) technology is available to study microbes in genomic level. This NGS has been widely used in DNA/RNA sequencing for genome sequencing, metagenomics, and transcriptomics. The food microbiology area could be categorized into three groups. Food microbes including probiotics and food-borne pathogens are studied in genomic level using NGS for microbial genomics. While food fermentation or food spoilage are more complicated, their genomic study needs to be done with metagenomics using NGS for compositional analysis. Furthermore, because microbial response in food environments are also important to understand their roles in food fermentation or spoilage, pattern analysis of RNA expression in the specific food microbe is conducted using RNA-Seq. These microbial genomics, metagenomics, and transcriptomics for food fermentation and spoilage would extend our knowledge on effective utilization of fermenting bacteria for health promotion as well as efficient control of food-borne pathogens for food safety.

• Journal of Life Science
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• v.25 no.3
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• pp.349-356
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• 2015

Thanks to recent advances in next-generation sequencing (NGS) technology, diverse livestock species have been dissected at the genome-wide sequence level. As for cattle, there are currently four Korean indigenous breeds registered with the Domestic Animal Diversity Information System of the Food and Agricultural Organization of the United Nations: Hanwoo, Chikso, Heugu, and Jeju Heugu. These native genetic resources were recently whole-genome resequenced using various NGS technologies, providing enormous single nucleotide polymorphism information across the genomes. The NGS application further provided biological such that Korean native cattle are genetically distant from some cattle breeds of European origins. In addition, the NGS technology was successfully applied to detect structural variations, particularly copy number variations that were usually difficult to identify at the genome-wide level with reasonable accuracy. Despite the success, those recent studies also showed an inherent limitation in sequencing only a representative individual of each breed. To elucidate the biological implications of the sequenced data, further confirmatory studies should be followed by sequencing or validating the population of each breed. Because NGS sequencing prices have consistently dropped, various population genomic theories can now be applied to the sequencing data obtained from the population of each breed of interest. There are still few such population studies available for the Korean native cattle breeds, but this situation will soon be improved with the recent initiative for NGS sequencing of diverse native livestock resources, including the Korean native cattle breeds.

• Food Science and Industry
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• v.50 no.1
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• pp.2-10
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• 2017

Human have eaten various traditional fermented foods for a numbers of million years for health benefit as well as survival. The beneficial effects of fermented foods have been resulted from complex microbial communications within the fermented foods. Therefore, the holistic approaches for individual identification and complete microbial profiling involved in their communications have been of interest to food microbiology fields. Microbiome is the ecological community of microorganisms that literally share our environments including foods as well as human body. However, due to the limitation of culture-dependent methods such as simple isolations of just culturable microorganisms, the culture-independent methods have been consistently developed, resulting in new light on the diverse non-culturable and hitherto unknown microorganisms, and even microbial communities in the fermented foods. For the culture-independent approaches, the food microbiome has been deciphered by employing various molecular analysis tools such as fluorescence in situ hybridization, quantitative PCR, and denaturing gradient gel-electrophoresis. More recently, next-generation-sequencing (NGS) platform-based microbiome analysis has been of interest, because NGS is a powerful analytical tool capable of resolving the microbiome in respect to community structures, dynamics, and activities. In this overview, the development status of analysis tools for the fermented food microbiome is covered and research trend for NGS-based food microbiome analysis is also discussed.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.23 no.2
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• pp.1-7
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• 2023

Inherited metabolic disorders (IMD) are a group of disorders involving various metabolic pathways. Genetic diagnosis of IMD has been challenging because of extremely heterogeneous nature and extensive laboratory and/or phenotype overlap. Conventional genetic diagnosis was a gene-by-gene approach that needs a priori information on the causative genes that might underlie the IMD. Recent implementation of next-generation sequencing (NGS) technologies has changed the process of genetic diagnosis from a gene-by-gene approach to simultaneous analysis of targeted genes possibly associated with the IMD using gene panels or using whole exome/genome sequencing (WES/WGS) covering entire human genes. Clinical NGS tests can be a cost-effective approach for the rapid diagnosis of IMD with genetic heterogeneity and are becoming standard diagnostic procedures.

• 축산식품과학과 산업
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• v.9 no.2
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• pp.26-35
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• 2020

• Proceedings of the Korea Information Processing Society Conference
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• 2013.11a
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• pp.103-106
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• 2013

SAMtools는 NGS 데이터의 alignment 결과에 대해 사실상의 표준으로 쓰이고 있는 SAM 포맷의 데이터를 다루는 많은 연구자들에게 애용되는 tool 들을 포함하고 있는 SW 이다. 최근 멀티코어 처리장치 HW 기술이 적용된 alignment SW 들이 속속 공개되어 성능향상을 보여주고 있으나, SAMtools 는 그렇지 못한 실정이어서 점점 더 NGS 데이터 처리의 병목구간으로 작용하고 있다. 이러한 문제를 해결하기 위하여 본 논문에서는 멀티코어 CPU 를 효과적으로 활용한 고성능의 MC-SAMtools SW를 제시하고자 한다.

• Proceedings of the Korea Contents Association Conference
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• 2019.05a
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• pp.469-470
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• 2019

차세대염기서열분석법(NGS, Next Generation Sequencing) 기술은 하나의 유전체를 무수히 많은 조각으로 분해하여 각 조각을 동시에 읽어낸 뒤, 전산기술을 이용하여 조합함으로써 방대한 유전체 정보를 빠르게 해독하는 방법이다. 한편, 액체 생검(LB, liquid biopsy)이란 암세포가 깨지면서 생기는 미량의 DNA 조각을 말초혈액 속에서 찾아내 암을 진단하는 기술로 조직 생검(tissue biopsy)에 비해 비침습적이다. 본 논문은 NGS와 LB 기술을 접목했을 때 확진이 가능하고 예후 및 치료경과의 예측이 가능함을 제언하였다.

• Information and Communications Magazine
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• v.20 no.8
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• pp.14-20
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• 2003

인터넷에 대한 의존성이 증가하면서 온라인상에서도 다양한 형태의 사이버 위협이 상존하고 있으며, 특히 시스템의 취약성을 공격하는 해킹방식은 대규모의 트래픽을 발생하여 네트워크 자체에 대해 큰 위협이 되고 있다. 지난 1.25 인터넷 침해사고 이후 전역통신망 차원에서의 네트워크에 대한 침입을 능동적으로 탐지하고 대응할 수 있는 고성능 네트워크 정보보호시스템 개발이 절실히 요구되고 있는 실정이다. 본 고에서는 세계의 네트워크 기술과 보안 기술 발전 추세에 발맞추어 추진 중인 정책 기반의 실시간 침입 탐지, 대응 및 예측 기능이 복합적으로 융합된 종합 솔루션인 NGSS에 대해서 기술개발 추진의 타당성, 시스템의 주요 특징을 소개하고자 한다.