• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.282-282
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• 1996

The purpose of this study was to prepare the nifedipine dry elixir (NDE) and coated nifedipine dry elixir (CNDE) containing nifedipine ethanol solution for improving the dissolution rate and bioavailability of nifedipine. NDE containing nifedipine and ethanol in wall materials of dextrin was prepared using a spray-dryer and then NDE was coated with eudragit acrylic resin to make CNDE. Shape and size of the NDE and CNDE were monitored by scanning electron micrograph and laser particle size analyzer In vitro dissolution tests were performed in simulated gastric and intestinal fluid. Bioavailability of NDE and CNDE were compared with drug powder suspension and commercial soft capsule after oral administration of the preparations to rats. NDE and CNDE are spherical in shape. Cross-sectional view of dry elixirs indicates the large inter cavity containing ethanolic drug solution in shell. Geometric mean diameter of NDE and CNDE is about 6.64 and 8.70 $\mu\textrm{m}$, respectively. Drug dissolution rate within first 5 min from NDE increased dramatically irrespective of dissolution medium. However, CNDE showed a particularly retarded dissolution rate in pH 1.2 simulated gastric fluid compared with NDE. The bioavailability of nifedipine in the NDE was increased dramatically compared with drug powder suspension. CNDE reduced initial burst-out plasma peak compared with NDE. CNDE as a sustained release delivery system could reduce the initial burst-out plasma peak due to controlling the release rate of nifedipine from NDE and maintain the effective plasma level over a longer period within therapeutic window with enhanced bioavailability of nifedipine.

• Journal of the Korea institute for structural maintenance and inspection
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• v.13 no.5 s.57
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• pp.101-108
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• 2009

Mathematical basis of interpretation of data from nondestructive evaluation (NDE) methods in condition assessment of structures is presented. In structural inspection with NDE methods, NDE data are not directly used for the condition assessment. Instead, NDE data must be interpreted as condition of inspected element. Correct assessments of conditions depend on many factors such as the inaccuracy and the variability in NDE measurements and the uncertainty in correlation between attributes (what is measured) and conditions (what is sought in the inspection). A full description of the performance of NDE methods considers the relation of test data to conditions of elements. The quality of the test itself is important, but equally important is the interpretation that occurs after the test. The effects of variability in test data and uncertainty in correlations of attributes and conditions are presented in three examples of field testing methods.

• Proceedings of the Korea Concrete Institute Conference
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• 2001.11a
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• pp.803-808
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• 2001

Mathematical basis of interpretation of data from nondestructive evaluation (NDE) methods in bridge inspection is presented. In bridge inspection with NDE methods, NDE data are not assessments. NDE data must be interpreted as condition of element. Interpretation is then assessment. Correct assessments of conditions of bridge elements depend on the accuracy and variability in test data as well as on the uncertainty of correlations between attributes (what is measured) and conditions (what is sought in the inspection). Inaccuracy and variability in test data defines the qualify or NDE test. The qualify or test itself is important, but in view of condition assessment, the significance of uncertainty in correlations of attributes and conditions must be combined. NDE methods that are accurate in their measurements may still be found to be poor methods if attributes are uncertain indicators of condition of bridge elements. This paper reports mathematical presentation of inaccuracy and variability in test data and of uncertainty in correlation of attributes to element conditions with three examples of NDE methods.

• Journal of the Korea institute for structural maintenance and inspection
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• v.11 no.3
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• pp.167-175
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• 2007

The relations between data from test methods and conditions in structural elements are considered. NDE(Nondestructive Evaluation) methods are joint application of a test and a basis for interpretation of data obtained in the test. Correct assessments of conditions of elements depend on the inaccuracy and variability in the test data and on the uncertainty of correlations between attributes(what is measured) and conditions(what is sought in the inspection). A full description of the performance of NDE methods considers the relation of test data to condition of elements. The quality of the test data itself is important, but equally important is the interpretation that occurs after the test. To make the decision of the performance of NDE methods, this paper presents mathematical basis to measure the reliability of NDE methods.

• Proceedings of the Korean Magnestics Society Conference
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• 2005.12a
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• pp.6-6
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• 2005

• Radioisotope journal
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• v.2 no.1
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• pp.4-7
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• 1987

• Proceedings of the Korean Nuclear Society Conference
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• 2005.10a
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• pp.961-962
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• 2005

• Proceedings of the Korean Society For Composite Materials Conference
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• 2003.10a
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• pp.190-194
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• 2003

Two different types of nondestructive evaluation (NDE) techniques were employed to investigate the tensile behavior of ceramic matrix composites (CMCs). Two NDE methods, ultrasonic testing (UT) and infrared (IR) thermography, were used to assess defects and/or damage evolution before and during mechanical testing. Prior to tensile testing, a UTC-scan and a xenon flash method were performed to obtain initial defect information in light of UT C-scans and thermal diffusivity maps, respectively. An IR camera was used for in-situ monitoring of progressive damages. The IR camera measured temperature changes during tensile testing. This paper has presented the feasibility of using NDE techniques to interpret structural performance of CMCs.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2003.04a
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• pp.504-512
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• 2003

Simulation programs have been developed and used as an attempt to improve the accuracy of Non-Destructive Evaluation(NDE) techniques. The applicability of these programs is very limited, however, because it is difficult to describe the delicacy of the propagation of stress waves. To investigate the applicability of the finite element analysis for stress wave-based NDE techniques numerical simulation for Impact-Echo method and SASW method is performed. The numerical studies are performed to determine the essential parameters such as contact time of impact load, mesh size and time step size. These studies show that the choice of parameter is very important for improving the accuracy and confidence of the numerical procedure and, thereby, the applicability of the numerical analysis for stress wave-based NDE techniques

• Journal of Advanced Engineering and Technology
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• v.11 no.4
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• pp.245-251
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• 2018

Terahertz waves (T-ray) was extensively studied for the NDE (nondestructive evaluation) of characterization of trailing edges for a use of turbines composed with composite materials. The used NDE system were consisted of both CW(Continuous wave) and TDS (Time domain spectroscopy). The FRP composites were utilized for two kinds of both trailing edges of wind energy (non-conducting polymeric composites) and carbon fiber composites with conducting properties. The signals of T-ray in the TDS (Time domain spectroscopy) mode resembles almost that of ultrasound waves; however, a terahertz pulse could not penetrate a material with conductivity unlike ultrasound. Also, a method was suggested to obtain the "n" in the materials, which is called the refractive index (n). The data of refractive index (n) could be solved for the trailing edges. The trailing edges were scanned for characterization and inspection. C-scan and B-scan images were obtained and best optimal NDE techniques were suggested for complicated geometry samples by terahertz radiation. Especially, it is found that the defect image of T-ray corresponded with defect locations for the trailing edges of wind mill.