• Research in Plant Disease
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• v.18 no.4
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• pp.268-276
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• 2012

Broad bean wilt virus 2 (BBWV2), genus Fabavirus, subfamily Comovirinae, family Secoviridae, causes damage in many economically important horticultural and ornamental crops. Sequence alignments showed several conserved sequences in 5' non-coding regions (5' NCRs) of RNA 1 and RNA 2 in all BBWV2 strains characterized so far. Based on this observation, we generated a hpRNA construct (pIR-BBWV2) harboring an inverted repeat containing a 210 bp cDNA fragment homologous to 5' NCR portion of BBWV2 RNA 1 to investigate the silencing potential for its ability to interfere with a rapidly replicating BBWV2. Agrobacterium-mediated transient expression of the IR-BBWV2 had a detrimental effect on BBWV2 infection, showing no distinct symptoms in non-inoculated leaves of the agroinfiltrated Nicotiana benthamiana plants. BBWV2 genomic RNAs were not detected by RT-PCR from tissues of both the inoculated leaves and upper leaves of the agroinfiltrated plants. Accumulation of virus-derived small interfering RNAs was detected in the inoculated leaf tissues of N. benthamiana plants elicited by transient expression of IR-BBWV2 indicating that RNA silencing is responsible for the resistance to BBWV2.

• Korean Journal of Plant Resources
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• v.16 no.1
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• pp.82-88
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• 2003

Genomic RNA sequence of a tobamovirus infecting Eutrema wasabi plant(TMV-W) was determined. The RNA is composed 6,298 nucleotide and contains four OREs encoding the protein of 180KD(OREI), 130KD(ORE2),30KD(ORF3) and 18KD(coat protein, ORF4). ORE4, ORF 3, ORF 2 and ORF 1 are overlaped by 130, 20 and 40 nucleotides, and the overapping region can be folded into a stable hairpin styucture. This includes the 3'non-coding region of 238 nucleotides, coat protein gene(537 nucleotides,179 amino acid), 30KD movement protein gene(825 nucleotides, 275 amino acid), 13(IKD protein gene(1,896 nucleotides, 632 amino acid) and 180KD protein gene(2,958 nucleotides, 986 amino acid). The genomic RNA sequence was compared with homologous regions of eleven other tobamoviruses. TMV-WTE was similar to TMV-WSF(98.6%) in nucleotide sequence.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1421-1426
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• 2016

Background: There is a considerable lack of understanding of oral cancer incidence, especially its time trend in Iran. In this study, the authors aimed to analyze time trend of oral cancer incidence with a focus on differences by gender in a period of six years - from 2005 to 2010. Materials and Methods: Both population-based cancer registry and national cancer registry (NCR) data based on pathologic reports from 2005 to 2010 were obtained from the Ministry of Health and Medical Education (MOHME). Population data were also received from Statistical Centre of Iran. Age-standardized incidence rates (ASRs) based on the World Standard Population were then calculated. Finally, Negative Binomial regression was run for time trend analysis. Results: The maximum ASR for males was calculated as 2.5 per 100,000 person-years in 2008 and the minimum was observed as 1.9 per 100,000 person-years in 2005 and 2006. Meanwhile, the maximum ASR for females was estimated as 1.8 per 100,000 person-years in 2009 and the minimum was calculated as 1.6 per 100,000 person-years in 2005 and 2006. Additionally, in females, incidence risk ratio (IRR) did not show a clear decreasing or increasing trend during the six years. Nevertheless, in males an increasing trend was observed. The maximum IRR adjusted for age group and province, for females was reported in 2009 (IRR=1.05 95% CI: 0.90-1.23), and for males was estimated in 2010 (IRR=1/2 95% CI: 1.04 - 1.38). Conclusions: Our findings highlight disparities between oral cancer incidence trends in males and females over the six years from 2005 to 2010.

• Plant Resources
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• v.1 no.2
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• pp.92-97
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• 1998

An isolate of barley yellow mosaic virus(BaYMV-HN) obtained from Haenam, Korea was compared with two BaYMV strains. BaYMV-Ⅱ-1 from Japan and BaYMV-G from Germany. The sequence of the 3'-terminal 3817nucleotides[excluding the poly (A) tail] of RNA 1 of BaYMV-HN was determined to start within a long open reading frame coding for a part of the NIa-VPg polymerase(26 amino acids). NIa-Pro polymerase (343 amino acids), NIb polymerase(528 amino acids) and the entire capsid protein(297 amino acids), which is followed by a noncoding region(NCR) of 235 nucelotides. In the partial ORFs, BaYMV-HN shows higher sequence homology with BaYMV-Ⅱ-1(99.5%) than BaYMV-G(92.7%). The 3' non-coding regions of BaYMV-HN(235nt) shows higher nucleotide sequence homology with BaYMV-G(235nt)(99.6%) than BaYMV-Ⅱ-1(231nt)(97.0%). The 3' NIa-Pro protein sequence of BaYMV-HN shows higher amino acid sequence homology with BaYMV-Ⅱ-1(95.0%) than BaYMV-G(93.6%), but, NIb protein sequence of BaYMV-HN shows same all amino acid sequence. The capsid protein sequence of BaYMV-HN(297aa) shows same with BaYMV-Ⅱ-1, and shows higher nucleotide sequence homology with BaYMV-UK (from United Kingdom)(97.3%) than BaYMV-G(96.9%) and G2(96.9%). Difference of capsid protein amino acid were 0-9 between the Japan, United Kingdom and Germany and were 2-6 between all Korean isolates. Many of the amino acid differences are located in the N-terminal regions of the capsid proteins from 1 to 74 amino acid positions.

• Journal of Korean Library and Information Science Society
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• v.52 no.4
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• pp.153-177
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• 2021

The revision of the Korean Cataloging Rules (KCR) is in progress in order to conform IFLA LRM conceptual model and to strengthen its internal stability. Religious works, along with musical works and legal works, have been treated as special and important in cataloging rules. This trend continues in the new cataloging rules that seek a bibliographic model that interconnects related materials. However since KCR2(1966), there are no rules for access points or specific rules on religious works. Under the circumstances, this study analyzed (1) the contents of religious works in the recently revised cataloging rules, (2) the access points and their functions for religious works implemented in online catalogs and authority system, and finally (3) the direction and scope of KCR revision. As a result of the study, this study suggested that it is necessary to prepare detailed rules for preferred title and authorized access points for various religious works in KCR. In conclusion, some issues for further discussion were summarized.

• Tunnel and Underground Space
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• v.31 no.6
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• pp.440-459
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• 2021

Roadheaders have begun to be adopted in Korean tunneling sites. The performance prediction models proposed by the manufacturer are used by Korean construction companies. The models use UCS (uniaxial compressive strength) value to predict the net cutting rate, but the rock specimens conducted for the uniaxial compression test have 1.0 of the diameter to length ratio. It has been reported that the specimen shape generally influences the rock strength. The previous references studying the shape effect were cited, and the UCS data of Korean rocks are also updated to analyze the shape effect on UCS. The cause of effect was discussed by previous theory. The change amount of UCS values of Korean rocks was estimated by the data, and the modified prediction model for NCR was finally suggested.

• Journal of Radiation Protection and Research
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• v.48 no.1
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• pp.1-8
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• 2023

Background: The purpose of this study is to evaluate the immunosuppressive and antioxidant effects of a novel radioprotective agent using the vitamin E derivative 2-(alpha-D-glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol (TMG) and its effect on tumors, and to study its usefulness. Materials and Methods: In this study, C57BL/6NCrSlc mice were divided into four groups (control, TMG, radiation therapy [RT], and RT+TMG), using 10 mice in each group. In the TMG and 2 Gy+TMG groups, 500 mg/kg TMG was administered. Two groups (2 Gy and 2 Gy+TMG) among RT and RT+TMG groups were irradiated with 2 Gy in a single fraction, while the other two groups (6 Gy and 6 Gy+TMG) were irradiated locally with 6 Gy in three fractions. Results and Discussion: TMG positively affected CD4+ and CD8+ T lymphocytes. Tumor volumes and growth inhibition rates were compared. In order to evaluate how TMG administration affected tumor growth, Ehrlich cancer cells were injected into the thigh of mice, and the tumor volume and growth suppression rate were compared. Not only RT but also TMG alone inhibited tumor growth. If RT conducted to the mice with TMG, TMG could increase the number of leukocytes, primarily that of lymphocytes. TMG also inhibited tumor growth in addition to RT. Tumor growth was significantly inhibited in the 6 Gy+TMG group. Conclusion: In conclusion, TMG exerted an immunopotentiating effect mainly by increasing the white blood cell numbers including that of lymphocytes. In addition to RT, TMG also inhibited tumor growth. Therefore, TMG is considered to be a useful radioprotective agent in radiotherapy without tumor growth induction.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1149-1154
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• 2014

Background: In Malaysia, data from the Malaysian Health Ministry showed colorectal cancer (CRC) to be the second most common type of cancer in 2007-2009, after breast cancer. The same was apparent after looking at males and females cases separately. In the present study, the Geographic Information System (GIS) was employed to describe the distribution of CRC cases in Kuala Lumpur (KL), Malaysia, according to socio-demographic factors (age, gender, ethnicity and district). Materials and Methods: This retrospective review concerned data for patients diagnosed with colorectal cancer in the years 1995 to 2011 collected from the Wilayah Persekutuan Health Office, taken from the cancer notification form (NCR-2), and patient medical records from the Surgical Department, Universiti Kebangsaan Malaysia Medical Centre (UKMMC). A total of 146 cases were analyzed. All the data collected were analysed using ArcGIS version 10.0 and SPSS version 19.0. Results: Patients aged 60 to 69 years accounted for the highest proportion of cases (34.2%) and males slightly predominated 76 (52.1%), Chinese had the highest number of registered cases at 108 (74.0%) and staging revealed most cases in the 3rd and 4th stages. Kernel density analysis showed more cases are concentrated up in the northern area of Petaling and Kuala Lumpur subdistricts. Spatial global pattern analysis by average nearest neighbour resulted in nearest neighbour ratio of 0.75, with Z-score of -5.59, p value of <0.01 and the z-score of -5.59. Spatial autocorrelation (Moran's I) showed clustering significant with p<0.01, Z score 3.14 and Moran's Index of 0.007. When mapping clusters with hotspot analysis (Getis-Ord Gi), hot and cold spots were identified. Hot spot areas fell on the northeast side of KL. Conclusions: This study demonstrated significant spatial patterns of cancer incidence in KL. Knowledge about these spatial patterns can provide useful information to policymakers in the planning of screening of CRC in the targeted population and improvement of healthcare facilities to provide better treatment for CRC patients.

• Journal of the Korean Society of Marine Environment & Safety
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• v.26 no.4
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• pp.412-418
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• 2020

Generally, the propeller shaft that constitutes the ship shaft system has different patterns of behavior due to the ef ects of engine power, propeller load and eccentric thrust, which increases the risk of bearing failure by causing local load variations. To prevent this, different studies of the propulsion shaft system have been conducted focused the relative inclination angle and oil film retention between the shaft and the support bearing, mainly with respect to the Rules for the Classification of Steel Ships. However, in order to secure the stability of the propulsion shaft via a more detailed evaluation, it is necessary to consider dynamic conditions, including the transient state due to sudden change in the stern wakefield. In this context, a 50,000 DWT vessel was analyzed using the strain gauge method, and the effects of propeller shaft movement were analyzed on the starboard rudder turn which is a typical transient state during normal continuous rate(NCR) operation in ballast draught condition. Analysis results confirm that the changed propeller eccentric thrust acts as a force that temporarily pushes down the shaft to increase the local load of the stern tube bearing and negatively affects the stability of the shaft system.

• Bulletin of Food Technology
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• v.16 no.3
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• pp.19-72
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• 2003

고도의 정보사회가 될 것으로 예견되는 21세기 전 세계는 창의적이고 원천적인 과학기술을 지속적으로 창출하면서 선진적 우위확보를 위해 치열한 경쟁을 벌이고 있다. 우리나라도 지금까지 이룩한 경제성장을 발판으로 이제부터는 더욱 생산적이고 독창적인 세계 일류 지식과 과학기술을 창출해 내야 할 위치에 있다. 세계적으로 새로운 지식은 대부분 학술지와 도서를 통해 발표되고 있으며, 미국의 과학정보기구인 ISI(Institute for Scientific Information)는 세계의 우수 학술지를 평가하여 그 중에서 가장 영향력이 높은 3~4%의 학술지를 SCI(Science Citation Index), SSIC(Social Science Citation Index), AHCI(Arts and Humanities Citation Index)로 전별하여 발표하고 있음은 잘 알려진 바와 같다. 우리 학계에서도 수 년 전부터 연구업적 등의 평가에 이들 분류를 적극 활용하고 있으며, 개개의 연구자들도 연구성과를 SCI 등에 등재된 학술지에 발표하기 위한 노력을 배가하고 있는 실정이다. 그러나 안타까운 것은 우리나라에서 발간되는 학술지 중 과학기술 분야 단 5종만이 SCI에 등재되어 있을 뿐이어서 우리의 학문이 세계적으로 교류되고 인정받는데 상대적으로 불리한 위치에 있다는 사실이다. 국내 학술지가 이들Index에 등재될 경우 우리의 연구성과가 보다 빠르고 쉽게 국제적으로 소개.인정되며, 이는 우리의 과학기술 수준을 한 단계 높이는데 첩경이 될 것이라는 점은 의심의 여지가 없다. 과학기술 평가과정은 측정 가능한 연구투자와 연구결과 현상으로 간주할 수 있는데, 일반적으로 연구투자는 연구투자에 필요한 모든 요소들이 실체적이며 평가하는 데에 있어서 인력, 재정 자원, 장비, 재료, 건물 등과 같이 구체적이고 경험을 요구하지 않기 때문에 그 모든 연구결과보다 평가하기가 용이하나 과학기술의 연구결과는 연구 과정을 통해 보다 비실체적이고 양적으로 측정하기 어려운 지식으로 구성되어 있어 평가하는데 어려움이 뒤따른다. 과학기술 연구결과를 양적이나 질적으로 측정하는데 있어 일반적으로 이용되는 시스템은 없으나 국가의 과학기술 수준은 보통 그 나라 과학기술 활동의 연구결과를 과학기술 생산성이나 연구결과물 즉 논문 등의 출판을 통한 배포나 인용분석 등에 기초한 양적 평가지표를 이용해 측정하는 서지적 방법에 의해 평가되고 있다.연구활동 결과로 발표된 연구논문은 새로운 연구논문의 자료로 인용되게 되는데, 일반적으로 인용이 많이 된 논문일수록 질적인 가치가 높다고 하므로 논문의 발표량과 인용된 횟수는 연구활동을 평가하는 척도로 활용점에 따라 과학기술분야 논문의 국가별, 기관별, 분야별 논문수와 피인용도는 과학기술 수준 평가의 척도가 될 수 있으며 이러한 평가는 과학기술 정책 수립 및 투자, 연구활동에 대한 평가 등의 중요한 자료로 활용될 수 있다. 과학기술분야 전반에 걸친 SCI 기반의 NSI, NCR 데이터베이스를 분석하여 우리나라 과학기술분야의 수준을 평가할 수 있는 지표를 산출하여 우리나라의 과학기술 수준을 정확히 파악하고, 세계 추세를 분석하여 앞으로 나아갈 정책방향을 설정하는데 도움이 되도록 하며, 국내 기관별, 분야별 분석을 통하여 과학기술 수준을 평가할 수 있는 객관적인 자료를 제공함과 동시에 국내 연구 인력간의 건전한 경쟁을 유도하여 과학기술 발전에 기여하고자 한다.