• ALGAE
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• 제37권4호
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• pp.331-347
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• 2022

Atopic dermatitis (AD) is one of major skin inflammatory diseases characterized by excessive Th2-mediated immune responses. Recent evidence provides that interlukin-13 (IL-13) plays the role of a key Th2 cytokine that drives the inflammation underlining AD. Due to adverse effects of commercially available synthetic drugs, the need for treatments based on natural products is gaining much attention. Sargassum horneri is an edible brown algae known for beneficial bioactivities including anti-inflammation. We investigated if polyphenol-rich S. horneri extracts (SHE) could suppress AD-like skin lesions in NC/Nga mice and if that involved inhibition of the infiltration of Th2-mediated cytokine IL-13. We observed markedly increased infiltration of IL-13 positive cells in AD-like skin lesions of mice but SHE treatments decreased it. Also, the dermal expression of IL-13 was sufficient to cause inflammatory responses in mice skin resembling human AD. SHE suppressed the dermal infiltration of inflammatory cells where IL-13 plays a crucial role in skin tissues and in the recruitment of inflammatory cells. Furthermore, it was confirmed that SHE reduced T cell, dendritic cell, and macrophage populations in spleen. Moreover, SHE decreased the collagen deposition in skin and ear dermis resulting in reduced fibrosis that occurs in AD due to excessive collagen. Taken together, our results reveal that SHE suppressed the infiltration of inflammatory cells into skin dermis by decreasing the infiltration of IL-13 positive cells. Therefore, SHE could be taken as a useful therapeutic agent to alleviate AD.

• 대한기계학회논문집
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• 제6권4호
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• pp.341-345
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• 1982

The interpolator is usually built in hardware (logic circuitry), and the interpolator fabricated in a single LSI chip is recently made use of in most NC controllers, making the system more compact. However, the LSI interpolator not only has the technical difficulties but also requires high cost, in its fabrication. To solve these problems, we tried to find the method of interpolation by software, and succeeded in developing a program which, executed by INTEL's 8085 microprocessor, can distribute the input pulses of up to 4.0 [Kpps] for the linear interpolation and 3.0 [Kpps] for the circular interpolation. This paper presents the algorithm used to reduce the execution time and the flow chart of the interpolation program, and also shows the possibility of software interpolation. The interpolation program designed in assembly language is presented in the appendix.

• 한국산업융합학회 논문집
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• 제3권2호
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• pp.107-114
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• 2000

Recently the studies on the vibration and the noise of a helical gear transmission have been focused on the many researchers. The manufacturing error and the deformation of the tooth profile, which generates the vibration and the noise of the gear transmission, are main factors. The major purpose of this study is to develop an optimal design program for reducing the vibration and the noise of the helical gear. To obtain the these results, we restrain the helical gear from the deformation of the tooth profile and increase the contact ratio within the optimal design program. Furthermore we made the three-dimensional solid modeling of the helical gear from the AutoCAD and the Pro/Engineer. This model will be available to generate the finite element model and the NC code.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2003년도 춘계학술대회 논문집
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• pp.338-342
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• 2003

Hybrid machine is based on hardware technologies of machine tool and software technologies of open architecture controller. In machining technology, combination technology of turning, milling, and grinding and in machining energy technology. combination of mechanical, electrical, and chemical technology are developed. This paper describes hybrid machine technology for combination of machining, on-machine measurement, on-machine CAM, and on-machine remote monitoring and control in open architecture controller environment. For on-machine measurement, non-contact measurement technology based on CAD information is developed. For on-machine CAM, interactive CAM program for automatic NC program generation and tool path simulation is developed. For generation on-machine remote monitoring and control, suitable interface method between web program and CNC is proposed. The developed hybrid machine technology is implemented in 3 axes milling machine for evaluation of operablity.

• 한국정밀공학회지
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• 제16권9호
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• pp.143-148
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• 1999

G code has to be made after changing the drawing information to DXF file, the converting file. When the information is changed, the converted file had the unnecessary time of rapid feed during working and the large DATA capacity. It need for arranging the information ordered irregularly. This CAM program based AutoCAD can be decreased uncomfortableness in contrast to use of each system. Also it can be increased productivity by arranging information. And it can be used easily for the beginner of the minor enterprises. its program can be decreased system error between others by using one system and increased work efficiency by using DCL.

• 산업공학
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• 제10권1호
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• pp.135-143
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• 1997

The importance of training for NC, CNC and Machining Center has been greatly increased. This paper presents implementation of a DNC(Direct Numerical Control) operating software for educational system. This system is able to connect 8-32 CNCs to Control PC with RS232 multi-port serial card. Therefore, it allows much efficiency in training even after costs are considered. The KISCO DNC S/W for above system includes various communication functions, communication parameters setting, program editor and user-friendly environment. This software was developed with C and Windows programming. It was proved in function and stability by iterative field tests.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1996년도 한국자동제어학술회의논문집(국내학술편); 포항공과대학교, 포항; 24-26 Oct. 1996
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• pp.1328-1331
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• 1996

The importance of training for NC, CNC and Machining Center has been greatly increased. This paper presents implementation of a DNC system and operating software for educational purpose. This system is able to connect 8-32 CNCs to Control PC with RS232 multi-port serial card. Therefore, it allows much efficiency in training even after costs are considered. The KISCO DNC S/W for above system includes various communication function, communication parameter setting, program editor, tool management and user-friendly environment.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1988년도 한국자동제어학술회의논문집(국내학술편); 한국전력공사연수원, 서울; 21-22 Oct. 1988
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• pp.273-278
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• 1988

This paper represents the computer application techniques of initial and modification machining for dies with 3-dimensional scluptured surfaces. All procedures from die design to die machining and measurement are covered. The component of modelling is data management and modification (extrapolation and smoothing), surface modelling, and nc program preparation. Also this paper introduces the utility for successful and efficient operation of system such as map generation, data communication, tool path verification, contour map generation, graphic processing of extrapolation and smoothing results, and CAD/CAM system interface. Examples are given to illustrate the modelling.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 1992년도 추계학술대회 논문집
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• pp.335-338
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• 1992

To purpose of this study is to design and manufacturing of packing gland using CAD/CAM system. The computer system used in this study was constructed with CPU 80386, RAM memory 4M, VGA graphic card. We was composed with CAD/CAM system, with interface PC and NC milling machine. By using develop program, we designed packing gland and it's manufactured. The basic structure of automatic production system for packing gland was established.

• 한국공작기계학회:학술대회논문집
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• 한국공작기계학회 1998년도 춘계학술대회 논문집
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• pp.106-111
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• 1998

NC code has to be made after changing the drawing information to DXF file, the converting file. Arranging the information ordered irregularly when DXF file is made decrease the unnecessary time of rapid feed during working and the DATA capacity when the information is changed. This CAM program can be used easely for the beginner of the minor enterprises. The connection of operations and the use of GUI increase business efficiency.