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Pathologic Correlation of Serum Carcinoembryonic Antigen and Cytokeratin 19 Fragment in Resected Nonsmall Cell Lung Cancer

  • Lee, Seokkee;Lee, Chang Young;Kim, Dae Joon;Hong, Dae Jin;Lee, Jin Gu;Chung, Kyung Young
    • Journal of Chest Surgery
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    • v.46 no.3
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    • pp.192-196
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    • 2013
  • Background: This study focused on the association between preoperative serum carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (Cyfra 21-1) levels and pathologic parameters in patients with resected non-small-cell lung cancer (NSCLC). Materials and Methods: The records of 527 patients who underwent pulmonary resection of NSCLC were reviewed. The association between preoperative serum CEA and Cyfra 21-1 levels and variables that had p-values of less than 0.05 in a t-test or one-way analyses of variance was analyzed by multiple linear regression. Results: The mean serum CEA and Cyfra 21-1 levels prior to surgery were $6.8{\pm}23.1$ mg/dL (range, 0.01 to 390.8 mg/dL) and $5.4{\pm}12.3$ mg/dL (range, 0.65 to 140.2 mg/dL). The serum CEA levels were associated with tumor (T) and lymph node (N) stage and histology. The serum Cyfra 21-1 levels were associated with T stage, tumor size, and histology. Multiple linear regression indicated that serum CEA levels were associated with T (T3/4 vs. T1: ${\beta}$=8.463, p=0.010) and N stage (N2/3 vs. N0: ${\beta}$=9.208, p<0.001) and histology (adenocarcinoma vs. squamous cell: ${\beta}$=6.838, p=0.001), and serum Cyfra 21-1 levels were associated with tumor size (${\beta}$=2.579, p<0.001) and histology (squamous cell vs. adenocarcinoma: ${\beta}$=4.420, p=0.020). Conclusion: Serum CEA level was correlated with T and N stage, and Cyfra 21-1 with tumor size. CEA and Cyfra 21-1 showed histologic correlation. CEA is mainly elevated in adenocarcinoma and Cyfra 21-1 in squamous cell carcinoma. These results might be helpful for predicting pathologic status in preoperative NSCLC.

Singular Representation and Finite Element Methods

  • 김석찬
    • Proceedings of the Korean Society of Computational and Applied Mathematics Conference
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    • 2003.09a
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    • pp.9-9
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    • 2003
  • Let $\Omega$ be a bounded, open, and polygonal domain in $R^2$ with re-entrant corners. We consider the following Partial Differential Equations: $$(I-\nabla\nabla\cdot+\nabla^{\bot}\nabla\times)u\;=\;f\;in\;\Omega$$, $$n\cdotu\;0\;0\;on\;{\Gamma}_{N}$$, $${\nabla}{\times}u\;=\;0\;on\;{\Gamma}_{N}$$, $$\tau{\cdot}u\;=\;0\;on\;{\Gamma}_{D}$$, $$\nabla{\cdot}u\;=\;0\;on\;{\Gamma}_{D}$$ where the symbol $\nabla\cdot$ and $\nabla$ stand for the divergence and gradient operators, respectively; $f{\in}L^2(\Omega)^2$ is a given vector function, $\partial\Omega=\Gamma_{D}\cup\Gamma_{N}$ is the partition of the boundary of $\Omega$; nis the outward unit vector normal to the boundary and $\tau$represents the unit vector tangent to the boundary oriented counterclockwise. For simplicity, assume that both $\Gamma_{D}$ and $\Gamma_{N}$ are nonempty. Denote the curl operator in $R^2$ by $$\nabla\times\;=\;(-{\partial}_2,{\partial}_1$$ and its formal adjoint by $${\nabla}^{\bot}\;=\;({-{\partial}_1}^{{\partial}_2}$$ Consider a weak formulation(WF): Find $u\;\in\;V$ such that $$a(u,v):=(u,v)+(\nabla{\cdot}u,\nabla{\cdot}v)+(\nabla{\times}u,\nabla{\times}V)=(f,v),\;A\;v{\in}V$$. (2) We assume there is only one singular corner. There are many methods to deal with the domain singularities. We introduce them shortly and we suggest a new Finite Element Methods by using Singular representation for the solution.

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Apparent Dominance of Regenerated Primary Production in the Yellow Sea

  • Park, Myung-G.;Yang, Sung-R.;Shim, Jae-H.;Hong, Gi-H.;Chung, Chang-S.;Yang, Dong-B.;Cho, Byung-C.
    • Journal of the korean society of oceanography
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    • v.39 no.1
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    • pp.20-25
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    • 2004
  • The Yellow Sea is known to be a very productive region in terms of fisheries. However, its trophic status seems to be highly variable, ranging from oligotrophic to eutrophic, based on new production (NP) values. The NP and regenerated production (RP) values estimated from $^{15}N$-labelled nitrate and ammonium uptake in spring (April 1996) and winter (February 1997) during this study ranged from 0.05 to 19.8 mg $N m^{-2} d^{-1}$ and from 0.1 to 22.8 mg $N m^{-2}d^{-1}$, respectively. Our measurements and earlier observations suggested that NP in the Yellow Sea varied over the four orders of magnitude (range 0.05-180.9 mg $N m^{-2} d^{-1}$) temporally and spatially, and that RP (range 0.1-507.5 mg $N m^{-2}d^{-l}$) based on ammonium predominated during most period of the year, except in winter when both productions were low. The significant nitrogen uptake by phytoplankton below the euphotic zone and episodic entrainment of phytoplankton from below the euphotic zone into the euphotic zone, and nitrite excretion and dissolved organic nitrogen release during nitrate uptake might explain the apparent dominance of RP in the Yellow Sea.

Distal Hereditary Motor Neuropathy Type V (dHMN-V) With N88S Mutation in BSCL2 Gene (BSCL2유전자의 N88S돌연변이가 확인된 제5형 원위유전운동신경병증(dHMN-V))

  • Chung, Hwa Kyoung;Chung, Ki Wha;Park, Jin-Mo;Koo, Hye soo;Choi, Kyoung-Gyu;Park, Kee Duk;Choi, Byung-Ok
    • Journal of the Korean neurological association
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    • v.30 no.4
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    • pp.333-336
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    • 2012
  • Berardinelli-Seip congenital lipodystrophy 2 (BSCL2) gene is known to be associated with different clinical phenotypes; Silver syndrome, Charcot-Marie-Tooth type 2 with a dominant hand involvement and distal hereditary motor neuropathy type V (dHMN-V). Up to now, only two heterozygous mutations (N88S and S90L) in BSCL2 have been reported. We identified a N88S BSCL2 mutation in a dHMN-V family with a spastic gait by whole-exome sequencing. To our knowledge, this is the first report of a N88S BSCL2 mutation in Korean patient.

3차원 물체인식을 위한 신경회로망 인식시트메의 설계

  • 김대영;이창순
    • Journal of Korea Society of Industrial Information Systems
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    • v.2 no.1
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    • pp.73-87
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    • 1997
  • Multilayer neural network using a modified beackpropagation learning algorithm was introduced to achieve automatic identification of different types of aircraft in a variety of 3-D orientations. A 3-D shape of an aircraft can be described by a library of 2-D images corresponding to the projected views of an aircraft. From each 2-D binary aircraft image we extracted 2-D invariant (L, Φ) feature vector to be used for training neural network aircraft classifier. Simulations concerning the neural network classification rate was compared using nearest-neighbor classfier (NNC) which has been widely served as a performance benchmark. And we also introduced reliability measure of the designed neural network classifier.

STUDIES ON THE EARLY PREGNANCY DETERMINATION IN COWS BY USING THE ENZYME-IMMUNOASSY AND RADIO-IMMUNOASSAY IN MILK

  • Lee, J.M.;Kim, H.S.;Jeong, S.G.;Jung, J.K.
    • Asian-Australasian Journal of Animal Sciences
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    • v.9 no.3
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    • pp.299-302
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    • 1996
  • Milk samples(n = 78) were taken 19d, 20d, 21d, 22d after artificial insemination(AI) for early pregnancy diagnosis by using the Enzyme immunoassay(EIA) kit. The progesterone ($P_4$) concentration in the whole milk was measured on the same day of pregnancy diagnosis. Rectal palpation(RP) was accomplished between 60d and 70d after AI to estimate the ovary condition and pregnancy status. Milk progesterone concentrations measured by Radio-immunoassay(RIA) method, in the pregnant cows at 17d, 19d, 21d after insemination were $17.10{\pm}0.91$, $17.60{\pm}0.46$, and $18.43{\pm}0.79nmol/l$, whereas those in the not-pregnant cows were $6.57{\pm}1.03$, $2.63{\pm}0.29$, and $0.67{\pm}0.08nmol/l$, respectively. When the progesterone concentration was less than 7 nmol/l, the color of the EIA kit was lighter and when the progesterone concentration was ${\geq}16nmol/l$, the color of the EIA kit was darker compared to the standard color. The detection rates of error by judging the color differences were 5.1% and 20.7%, respectively. In the early pregnancy diagnosis by the EIA kit and RIA method, the accuracy rates in the pregnancy of cows were 82% and 87%, and those in not-pregnant cows were 86% and 91%, respectively. For ovarian status estimated by the RIA method and certified by RP, the accuracy rates of the ovarian atrophy, follicular cyst and luteal cyst were 80, 91 and 83% and the progesterone concentrations were 2.51, 2.03, and 26.7 nmol/l, respectively.

Effect of Plant Growth Regulators on Callus Induction and Plant Regeneration from Mature Seeds of Red Top Bentgrass (Agrostis alba L.) (식물생장조절물질이 레드 톱 밴트그래스 (Agrostis alba L.)의 종자로부터 캘러스 유도와 식물계 재분화에 미치는 영향)

  • Park, Choong-Hoon;Kim, Kyung-Hee;Lee, Dong-Gi;Alam, Iftekhar;Lee, Ki-Won;Lee, Sang-Hoon;Kim, Ki-Yong;Won, Sung-Hye;Lee, Byung-Hyun
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.28 no.4
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    • pp.273-280
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    • 2008
  • In order to develop a simple and reproducible protocol for red top bentgrass (Agrostis alba L.), effect of different growth regulators was investigated for embrogenic calli induction and subsequent plant regeneration using mature seeds. MS medium containing 2 mg/L 2,4-D was optimal for embryogenic callus induction from mature seeds. The highest plant regeneration frequency (64.4%) was showed when the embryogenic callus tissues were cultured on N6 medium supplemented with 0.5 mg/L 2,4-D and 2 mg/L BA. Regenerated plantlets were grown normally when shoots transplanted to the soil. A high-frequency and efficient regeneration system from mature seeds would be helpful for molecular breeding of new variety of red top bentgrass through Agrobacterium-mediated genetic transformation.

Studies on the Optical Resolution of DL-Amino Acids by Aminoacylase Immobilized on Chitosan: Properties and Reactivity of Immobilized Aminoacylase (Chitosan 고정화 Aminoacylase 를 이용한 DL 아미노산의 광학적 분할에 관한 연구 : 고정화 Aminoacylase의 성질 및 반응성)

  • Lee, Sang-Hyun;Lee, Young-Chun
    • Korean Journal of Food Science and Technology
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    • v.20 no.4
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    • pp.547-552
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    • 1988
  • Aminoacylase immobilized on chitosan was applied for optical resolution of DL-amino acids. Optimun pH's for hydrolysis of N-ac DL Met, N-ac DL Try and N-ac DL Phe by immobilized aminoacylase were 8.0, 7.0, and 7.5, respectively. The pH stability of immobilized aminoacylase was less than that of soluble enzyme, while there was no difference in thermostability between immibilized and soluble enzymes. The reaction rate of immobilized enzyme was maximum, when concentrations of N-ac DL Met, N-ac DL Try and N-ac DL Phe were 0.05, 0.03 and 0.05M, respectively. Continuous resolution of M/20 N-ac DL amino acids with immobilized aminoacylase packed in a column resulted in 100% hydrolysis upto space velocity $2.0\;at\;45^{\circ}C$, and the half-life of the column at space velocity 5.0 was about 25 days. The yield of L-Met, L-Try and L-Phe recovered from 2 liter of column effluent were 57%, 52% and 52%, respectively.

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Une lecture du film d'animation do Christian Volckman (크리스티앙 볼크만(Christian Volckman)의 장편 애니메이션 <르네상스(Renaissance)> 의 해석에 대한 방법적 시도)

  • Han, Sang-Jung
    • Cartoon and Animation Studies
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    • s.13
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    • pp.199-210
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    • 2008
  • Nous tentons ici d'une analyse esthetique sur le film d'animation francais "Renaissance". Le film d'animation est un genre du recit d'images. L'on no peut donc le traiter simplement comme les chaines des images sans I'histoire, ni comme I'histoire sans les images. Nous essaions de trouver dans notre etude, un meddle d'analyse sur le film d'animation. L'acces y est commece par expliquer le context du film et son resume de I'histoire. Ensuite, nous travaillons sur les caracteristiques produites par des images(noir et blanc) et des techniques(motion capture). Elles sont considerees comme les traits expressifs, ou les trails formels. Troisiement, on analysr des codes des genres et des sens implicites qui sont presentes dans le film. Apres aborder tous ces prises on comptes, nous les synthetisons dans ie principe d'esthetique. lci, celui-ci est figure comme un accord entre les caractedristiques formelless et les contenus traites. Mais le film n'arrive pas a cette concordance. L'avancee technique et le plaisir visuel que le film nous donne ne sont pourtant pas meprisable memo si I'objectif esthetique du film no s'acheve sur un echec. Notre etude est un peu large afin d'analyser les detailes du film. Nous laisssons cette faiblesss a un autre travail du futur, on etant content sur l'etude qui pout servir a analyser un film d'animation, mame un peu grossierement.

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