• Asian Pacific Journal of Cancer Prevention
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• v.17 no.12
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• pp.5189-5193
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• 2016

Objective: Dorema glabrum Fisch. & C.A. Mey is a perennial plant that has several curative properties. Anti-proliferative activity of seeds of this plant has been demonstrated in a mouse fibrosarcoma cell line. The aim of the present study was to evaluate cytotoxicity of D. glabrum root extracts in a human gastric adenocarcinoma (AGS) cell line and explore mechanisms of apoptosis induction, cell cycle arrest and altered gene expression in cancer cells. Materials and Methods: The MTT assay was used to evaluate IC50 values, EB/AO staining to analyze the mode of cell death, and flow cytometry to assess the cell cycle. Quantitative real-time polymerase chain reaction (qRT-PCR) amplification was performed with apoptosis and cell cycle-related gene primers, for cyclin D1, c-myc, survivin, VEGF, Bcl-2, Bax, and caspase-3 to determine alteration of gene expression. Results: Our results showed that n-hexane and chloroform extracts had greatest toxic effects on gastric cancer cells with IC50 values of $6.4{\mu}g/ml$ and $4.6{\mu}g/ml$, respectively, after 72 h. Cell cycle analysis revealed that the population of treated cells in the G1 phase was increased in comparison to controls. Cellular morphological changes indicated induction of apoptosis. In addition, mRNA expression levels of Bax and caspase-3 were increased, and of bcl-2 survivin, VEGF, c-myc and cyclin D1 were decreased. Conclusion: Our study results suggest that D. glabrum has cytotoxic effects on AGS cells, characterized by enhanced apoptosis, reduced cell viability and arrest of cell cycling.

• Archives of Pharmacal Research
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• v.26 no.12
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• pp.1055-1060
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• 2003

Lysophosphatidic acid (LPA) is a well-known mitogen in various cell types. However, we found that LPA inhibits melanocyte proliferation. Thus, we further investigated the possible signaling pathways involved in melanocyte growth inhibition. We first examined the regulation of the three major subfamilies of mitogen-activated protein (MAP) kinases and of the Akt pathway by LPA. The activations of extracellular signal-regulated protein kinase (ERK) and c-Jun N-terminal kinase (JNK) were observed in concert with the inhibition of melanocyte proliferation by LPA, whereas p38 MAP kinase and Akt were not influenced by LPA. However, the specific inhibition of the ERK or JNK pathways by PD98059 or D-JNKI1, respectively, did not restore the antiproliferative effect. We next examined changes in the expression of cell cycle related proteins. LPA decreased cyclin $D_1 and cyclin D_2$ levels but increased $p21^{WAF1/CIP1}$ (p21) and $p27^{KIP1}$ (p27) levels, which are known inhibitors of cyclin-dependent kinase. Flow cytometric analysis showed the inhibition of DNA synthesis by a reduction in the S phase and an increase in the $G_0/G_1$ phase of the cell cycle. Our results suggest that LPA induces cell cycle arrest by regulating the expressions of cell cycle related proteins.

• Journal of Information Technology and Architecture
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• v.10 no.3
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• pp.323-334
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• 2013

There are many studies on the project planning, project management and quality management. The cost of the new project takes only 20% of system's lifetime resource and the costs of the maintenance and infrastructure take more than 80%, so the study on the maintenance is much more important than the study on the new project. There has been many studies on the economic life cycle of the system using it's maintenance cost, but no studies on it's infrastructure cost. This paper provides how we can adapt infrastructure cost, which takes more than 40% of system's life cycle cost, to the economic life cycle of the system and its effects on the system's economic life cycle.

• Nuclear Engineering and Technology
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• v.41 no.6
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• pp.785-796
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• 2009

A KALIMER-600 concept which is a type of sodium-cooled fast reactor, has been developed at KAERI. It uses sodium as a primary coolant and is a pool-type reactor to enhance safety. Also, a supercritical carbon dioxide ($CO_2$) Brayton cycle is considered as an alternative to an energy conversion system to eliminate the sodium water reaction and to improve efficiency. In this study, a simplified model for analyzing the thermodynamic performance of the KALIMER-600 coupled with a supercritical $CO_2$ Brayton cycle was developed. To develop the analysis model, a commercial modular modeling system (MMS) was adopted as a base engine, which was developed by nHance Technology in USA. It has a convenient graphical user interface and many component modules to model the plant. A new user library for thermodynamic properties of sodium and supercritical $CO_2$ was developed and attached to the MMS. In addition, some component modules in the MMS were modified to be appropriate for analysis of the KALIMER-600 coupled with the supercritical $CO_2$ cycle. Then, a simplified performance analysis code was developed by modeling the KALIMER-600 plant with the modified MMS. After evaluating the developed code with each component data and a steady state of the plant, a simple power reduction and recovery event was evaluated. The results showed an achievable capability for a performance analysis code. The developed code will be used to develop the operational strategy and some control logics for the operation of the KALIMER-600 with a supercritical $CO_2$ Brayton cycle after further studies of analyzing various operational events.

• Nuclear Engineering and Technology
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• v.27 no.5
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• pp.721-729
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• 1995

The Korean optimal nuclear fuel cycle strategy from the year 2000 to 2030 is derived using linear programming. The fuel cycle cost, the cost uncertainty, and the natural uranium consumption are used as the criteria for the optimization. These objectives are compromised by fuzzy decision-making technique which maximizes the minimum degree of satisfaction among the three objectives. The options for the back-end fuel cycle are direct disposal, reprocessing, and DUPIC. The optimal fuel cycle strategy of Korea is to start reprocessing in around 2010 and increase its capacity with the maximum of 800 tHM in around 2025, and to star DUPIC processing in 2025. The cot uncertainty and the natural uranium consumption of the optimal fuel cycle strategy are reduced by 7.1％ and 6.1％, respectively, at the cost penalty of 5.4％ compared with the cost-only optimal solution.

• Communications of the Korean Mathematical Society
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• v.12 no.1
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• pp.27-36
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• 1997

A matrix whose entries consist of the symbols +, -, 0 is called a sign-pattern matrix. We characterize the $n \times n$ irreducible sign-pattern matrices that are sign tripotent.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2008.06a
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• pp.193-194
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• 2008

• Communications of the Korean Mathematical Society
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• v.28 no.4
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• pp.857-863
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• 2013

In this paper, we prove that the total domination number of a $P_6$-free graph of order $n{\geq}3$ and minimum degree at least one which is not the cycle of length 6 is at most $\frac{n+1}{2}$, and the bound is sharp.

• Kyungpook Mathematical Journal
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• v.60 no.4
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• pp.831-837
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• 2020

Let M be the exterior of a hyperbolic link K ∪ L in a homology 3-sphere Y, such that the linking number lk(K, L) is non-zero. In this note we prove that if γ is a slope in ∂N(L) such that the manifold ML(γ) obtained by γ-Dehn filling along ∂N(L) contains a Klein bottle, then there is a bound on Δ(μ, γ), depending on the genus of K and on lk(K, L).

• Journal of KIISE:Computer Systems and Theory
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• v.29 no.1
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• pp.22-34
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• 2002

In this paper, we consider ring embeding problem in faulty (n,k) star graphs which is recently proposed as an alternative interconnection network topology, By effectively utilizing such strategies as series of dimension expansions and even distribution of faulty nodes into sub-stars in graph itself. we prove that it is possible to construct a maximal fault-free ring excluding only faulty nodes when the number of faults is no more than n-3 and $n-k{\geq}2$, and also propose an algorithm which can embed the corresponding ring in (n.k)-star graphs This results will be applied into the multicasting applications that the underlying cycle properties on the multi-computer system.