• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.2993-2999
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• 2014

Saccharina japonica is a family member of Phaeophyceae (brown macro-alga) and extensively cultivated in China, Japan and Korea. Here, the potential anti-cancer effect of n-hexane fraction of S. japonica was evaluated in SK-Hep1 human hepatocellular carcinoma cells. The N-hexane fraction reduced cell viability and increased the numbers of apoptotic cells in a both dose- and time-dependent manner. Apoptosis was activated by both caspase-dependent and independent pathways. The caspase-dependent cell death pathway is mediated by cell surface death receptors and activated caspase-8 amplified the apoptotic signal either through direct activation of downstream caspase-3 or pro-apoptotic proteins (Bad, Bax and Bak) subsequently leading to the release of cytochrome c. On the other hand, caspase-independent apoptosis appeared mediated by disruption of mitochondrial membrane potential and translocation of AIF to the nucleus where they induced chromatin condensation and/or large-scale DNA fragmentation. In addition, the n-hexane fraction induced endoplasmic reticulum (ER)-stress and cell cycle arrest. The results suggested that potential anti-cancer effects of n-hexane extract from S. japonica on SK-Hep1 cells.

• 한국안전학회지
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• 제30권3호
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• pp.1-6
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• 2015

Self-piercing riveting (SPR) is receiving more recognition as a possible and effective solution for joining automotive body panels and structures, particularly for aluminum parts and dissimilar parts. In this study, static strength and fatigue tests were conducted using coach-peel and cross-tension specimens with Al-5052 plates for evaluation of fatigue strength of the SPR joints. For the static experiment results, the fracture modes are classified into pull-out fracture due to influence of plastic deformation of joining area. During the fatigue tests for the coach-peel and cross-tension specimens with Al-5052, interface failure mode occurred on the top substrate close to the rivet head in the most cycle region. There were relationship between applied load amplitude $P_{amp}$ and life time of cycle N, $P_{amp}=715.5{\times}N^{-0.166}$ and $P_{amp}=1967.3{\times}N^{-0.162}$ were for the coach-peel and cross- tension specimens, respectively. The finite element analysis results for specimens were adopted for the parameters of fatigue lifetime prediction. The relation between SWT fatigue parameter and number of cycles was found to be $SWT=192.8N_f^{-0.44}$.

• 대한기계학회논문집
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• 제14권5호
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• pp.1349-1355
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• 1990

By examining the fatigue deformation properties of 12% Cr rotor steel which has been proved to have high fatigue and creep rupture strength around 600deg. C, authors reviewed major fatigue life prediction models such as Manson, Langer and Morrow equations, and following results were obtained. (1) A simple life prediction model for 12% Cr rotor steel was obtained as follows : DELTA..epsilon.$_{t}$ =2.18+.sigma.$_{u}$ /E+ $N^{-0.065}$+ $e^{0.6}$ $N^{-0.025}$ This equation shows that fatigue life, N, can be easily determined when total strain range, DELTA..epsilon.$_{t}$ and ultimate tensile strength, .sigma.$_{u}$ are known by simple tension test on the given test conditions. (2) Life prediction equation with equivalent maximum stress, DELTA..sigma./2, corresponding maximum strain in one cycle at room temperature is as follows: DELTA..sigma./w=-7.01logN+96.69+96.69

• 한국표면공학회지
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• 제48권6호
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• pp.283-291
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• 2015

The purpose of this study was to investigate effects of TiN coating on the fatigue fracture of dental implant system with various cyclic loads. TiN coated abutment screw, the fixture, and abutment of internal hex type were prepared for fatigue test. The fatigue test was carried out according to ISO 14801:2003(E) using tensile and compression tester with repeated load from 30% to 80% of static fracture force. Morphology and fractured surface was observed by field emission scanning electron microscope(FE-SEM) and energy dispersive X-ray spectroscope(EDS). The fracture cycle drastically decreased as repeated load increased. Especially, in the case of TiN-coated abutment screw, fracture cycle increased compared to non-coated abutment screw. The fatigue crack was propagated fast as repeated load increased. The plastic deformation region decreased, whereas, cleavage fracture region increased as repeated load increased.

• 미생물학회지
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• 제7권1호
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• pp.10-21
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• 1969

The effect of glucose and 2-thiobarbituric acid on the biosynthesis of cell constituents such as protein, carbohydrate, DNA, RNA, phospholipid and PCA-soluble phosphate compounds in Chlorella duing the life cycle was measured, and the changes in the content of these main cellular components of the algal cell were analyzed in connection with the nuclear and cytoplasmic divison. In the normal autotrophic synchronous culture the contents of protein, RNA, and DNA in the cell showed a chracteristic changes according to the progress of cell development, increasing more or less throughout all the life cycle. The synthesis of protein is more prominent in the division period nad that of DNA is more active in the ripening period, while the synthesis of RNA is more rapid in the growing and ripening periods than other developmental stages. The period of division cycle was little affected by glucose in the medium, although the synchrony of the growth and cellular division was disturbed and the n value increased. The cotents of protein, carbohydrate, RNA nad DNA of the cell were increased by the glucose treatment throughout all the life cycle. On the other hand, both of cellular growth and division were retarded severely and the n value was decreased by the 2-thiobarbituric acid treatment throughout all the life cycle. On the other hand, both of cellular growth and division were retarded severely and the n value was decreased by the 2-thiobarbituric acid treatment. The synthesis of protein, carbohydrate, DNA, RNA and phospholipid of the cell was also retarded by 2-thiobarbituric acid. In the autotrophic, mixotrophic and 2-thiobarbituric acid-treated cultures, each having different mode cytoplasmic division, a common general schema occurring in the cell during the life cycle may be drawn as follows. The ratio of RNA to protein attains maximum value in the $L_1$-cell stage prior to the nuclear division and thereafter decreases during the periods of ripening and division. The ratio of PCA-soluble phosphate compounds to protein increased from the begining of the culture to $L_4$-cell stage successively and thereafter decreased gradually during the division period, while the ratio of protein to DNA kept almost constant up to the division period and thereafter increased during the division period. Therefore, it is presumed that the increase in the ratio of RNA to protein is to be an inducer of nuclear division and that the cytoplasmic division is induced by the increase in the ratio of protein to DNA.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1999년도 제14차 학술회의논문집
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• pp.278-280
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• 1999

This paper proposes controlling of temperature in an oven by using 4 bits Integral - Cycle Binary Rate Modulation (IBRM) method and ac line with frequency 50 Hz. Microcontroller MCS-51 controls IBRM according to Proportional Integral controller (PI) function. Discrete signals are used in the system modeled by using Ziegler Nichols principle for analyzing the stability before designing the system. This procedure makes it easy to investigate system response. The system is implemented by 4 bits digital circuit which gives 320 patterns of ac signal fur controlling the generation of energy for 3,000 watts thermal coil every 20 ms of each cycle. We divide scan time (Ts$\sub$n/) in to 20 intervals, 1 ms interval is selected to generate 16 patterns IBRM. Because of this method gives the ripple lower than 2% it generates less noise fur system. Moreover, we can consider whole system from the time model of control procedure and IBRM algorithm at 40-200$^{\circ}C$ with ${\pm}$ 1$^{\circ}C$ error in the 1 cubic meter oven.

• 한국해양공학회지
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• 제4권2호
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• pp.100-111
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• 1990

In this paper, fatigue tests were carried out at stress test levels of 461 MPa, 441 MPa, and 431 MPa by using smooth specimen of$2_{1/4}$ Cr-1 Mo steel with the stress ratio(R) of 0.05. The initiation, growth and coalescense process of the major cracks and sub-cracks among the fatigue cracks on the smooth specimen are investigated and measured under each stress level at a constant cycle ratio by the replica technique with optical microscope. Some of the important results are as follows: In spite of the difference of stress levels, the major crack data gather into a small band in the curve of surface crack length and crack depth against cycle ratio N/Nf. The sub-crack data, however, deviate from the band of the major crack. The growth rates, da/dN, of major and sub-crack plotted against the stress intensity factor range, ${\Delta}K$, have the tendency to be compressed on a relatively small band. But it is more effective to predict fatigue life through major cracks. The propagation behavior of surface microcracks on the smooth specimens coincides with that of the specimen having an artificial small surface defect or through crack.

• 한국지하수토양환경학회지:지하수토양환경
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• 제27권2호
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• pp.87-98
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• 2022

This study aims to prepare a technical protocol for identifying the source of nitrate in water using nitrogen (δ¹⁵N) and oxygen (δ¹⁸O) stable isotope ratios. The technical processes for nitrate sources identification are composed of site investigation, sample collection and analysis, isotope analysis, source identification using isotope characteristics, and source apportionment for multiple potential sources with the Bayesian isotope mixing model. Characteristics of various nitrate potential sources are reviewed, and their typical ranges of δ¹⁵N and δ¹⁸O are comparatively analyzed and summarized. This study also summarizes the current knowledge on the dual-isotope approach and how to correlate the field-relevant information such as land use and hydrochemical data to the nitrate source identification.

• 한국융합학회논문지
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• 제11권12호
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• pp.113-123
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• 2020

본 논문은 과거와 현재의 패션 트렌드와 패션 유행 주기에 관한 빅데이터 분석을 실시하였다. 패션 전문가나 패션쇼가 아닌 일반 사람들의 데일리룩을 위한 패션 트렌드를 분석하는데 집중하였다. 소셜 매트릭스 도구인 텍스톰을 활용하여 빈도수 분석, N-gram 분석, 네트워크 분석 및 구조적 등위성 분석을 수행하였다. 분석 결과, 첫째, 패션 전문가가 아닌 일반 사람들의 데일리 룩을 대상으로 과거(1980년대, 1990년대)와 현재(2019년, 2020년)의 패션 키워드를 도출하였다. 둘째, 과거의 패션이 현재의 패션으로 재현되는 순환성과 순환 주기가 30-40년 정도로 짧아졌음을 빅데이터 분석을 통해 과학적으로 검증하였다. 셋째, 도출된 패션 키워드들의 구조적 등위성 분석을 수행한 결과, 과거 패션에서는 청바지 패션, 레트로 코디, 애슬레저룩, 연예인 복고패션의 4개의 군집으로, 현재 패션에서는 레트로 청바지, 뉴트로, 레이디 쉬크, 레트로 퓨처리즘의 4개의 군집을 확인하였다. 넷째, 과거의 패션이 현재의 패션으로 재현되고 진화하는 네트워크 연결 관계를 확인하고 그 배경에 관한 이슈를 고찰하였다. 이와 같은 연구결과는 과거와 현재의 패션 키워드를 도출하고 이로부터 패션 유행의 순환 주기를 확인함으로써 과거를 통해 미래 패션을 예측하도록 하는데 의의가 있다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 1999년도 춘계학술대회 논문집
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• pp.133-136
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• 1999

We report on the electrochemical properly of LiZ $n_{x}$Mn $_{2-x}$ $O_4$ for different degrees of Zn substitution(x) Though all cathode material showed spinel phase based on cubic phase in X-ray diffraction, other peaks(M $n_2$ $O_3$ or M $n_3$ $O_4$) gradually exhibited and became intense with the increase of x vague in LiZ $n_{x}$Mn $_{2-x}$ $O_4$. In addtion, TG-DTA analysis exhibited that both LiM $n_2$ $O_4$ and LiZ $n_{0.1}$ M $n_{1.9}$ $O_4$ occurred the weight loss(TG) and the endothermic and exothermic reaction(DTA) until 80$0^{\circ}C$ When x=0.1 in LiZ $n_{x}$Mn $_{2-x}$ $O_4$ cathode materials showed the charge and discharge capacity of about 100mAh/g at first cycle and about 70mAh/g after tooth cycle.cle.e.cle.e.e.e.