• Molecules and Cells
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• 제25권4호
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• pp.531-537
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• 2008

Abnormal activation of nuclear factor kappa B ($NF-{\kappa}B$) probably plays an important role in the pathogenesis of Duchenne's muscular dystrophy (DMD). In this report, we evaluated the efficacy of curcumin, a potent $NF-{\kappa}B$ inhibitor, in mdx mice, a mouse model of DMD. We found that it improved sarcolemmic integrity and enhanced muscle strength after intraperitoneal (i.p.) injection. Histological analysis revealed that the structural defects of myofibrils were reduced, and biochemical analysis showed that creatine kinase (CK) activity was decreased. We also found that levels of tumor necrosis factor alpha ($TNF-\alpha$), interleukin-1 beta ($IL-1\beta$) and inducible nitric oxide synthase (iNOS) in the mdx mice were decreased by curcumin administration. EMSA analysis showed that $NF-{\kappa}B$ activity was also inhibited. We thus conclude that curcumin is effective in the therapy of muscular dystrophy in mdx mice, and that the mechanism may involve inhibition of $NF-{\kappa}B$ activity. Since curcumin is a non-toxic compound derived from plants, we propose that it may be useful for DMD therapy.

• 대한물리의학회지
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• 제6권3호
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• pp.311-321
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• 2011

Purpose : The purpose of this study was to determine effect of Medical Exercise therapy on walking ability and ankle muscles activation after stroke. Method : Participants were randomly divided into either MET training group(n=12) and control group(n=12). All of participants had been receving a traditional rehabilitation program, 5 days a week. MET training group have additionally undergone for six weeks, 3 days a week, the MET program. But control group was not received any additional program except the traditional rehabilitation program. The 10 mWT, F8WT and 2 MWT to measure walking ability were carried out twice before and after training. Muscular activity of the ankle was estimated by analyzing the RMS of action potential for EMG in terms of tibialis anterior muscle(TA), soleus(SO), gastrocnemius medial head(GM), gastrocnemius lateral head(GL). Rresults : At the walking ability, MET training group demonstrated a significant improvememt in the score of the 10 mWT(p<0.001), 2 MWT(p<0.05), but F8WT was not significant improvement(p>0.05). At the ankle muscle activation, MET training group demonstrated a significant improvememt in the RMS of the TA(p<0.01) and SO(p<0.05) but GM(p>0.05) and GL(p>0.05) were not significant improvement. Conclusion : From these results of this study, MET training for 6 weeks has an effect on improvement of walking ability and ankle muscles activation after stroke.

• 한국전문물리치료학회지
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• 제24권4호
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• pp.46-53
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• 2017

Background: The MLA is supported by both the abductor hallucis (ABH) and the extrinsic muscles. Insufficient muscular support may lower the MLA when the body's weight is applied to the foot. The short foot exercise (SFE) is effective in increasing the height of the MLA for people with flat feet. Most of the research related to the SFE has simply evaluated the efficiency of the exercise using enhanced ABH electromyography (EMG) activation. Since the tibialis anterior (TA), peroneus longus (PER), and ABH are all involved in supporting the MLA, a new experiment design examining the EMG of the selected muscles during SFE should be applied to clarify its effect. Objects: Therefore, this study aimed to clarify the effect of the SFE in different ankle position on the MLA angle and the activation of both the intrinsic and extrinsic muscles and to determine the optimal position. Methods: 20 healthy subjects and 12 subjects with flat feet were recruited from Yonsei University. The surface EMG and camera were used to collect muscle activation amplitude of TA, PER, and ABH and to capture the image of MLA angle during SFE. The subjects performed the SFE while sitting in three different ankle positions-neutral (N), dorsiflexion (DF) at 30 degrees, and plantar flexion (PF) at 30 degrees. Results: ABH EMG amplitudes were significantly greater in N and DF than in PF (p<.05). Muscle activation ratio of TA to ABH was the lowest in PF (p<.05). MLA angle in both groups significantly decreased in PF (p<.01). The TA and ABH was activated at the highest level in DF. However, in PF, subjects significantly activated the ABH and PER with relatively low activation of TA. Conclusion: Therefore, researchers need to discuss which SFE condition most effectively use the arch support muscle for flat foot.

• The Korean Journal of Physiology
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• 제29권2호
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• pp.309-321
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• 1995

In the present study, the relationship between the somatosympathetic reflexes and arterial blood pressure responses to electrical stimulation of the peripheral nerve was investigated in cats anesthetized with ${\alpha}-chloralose$. Single sympathetic postganglionic fiber activities were recorded from the hindlimb muscle and skin nerves and also from the cervical and abdominal sympathetic chains. Effects of the morphine on responses of the sympathetic nerve and arterial blood pressure to activation of the peripheral $A{\delta}-$ and C-afferent nerves were analyzed. The following results were obtained. 1) Arterial blood pressure was depressed by peripheral AS-afferent stimulation (A-response) and was elevated during C-afferent activation (C-response). 2) Intravenously administered morphine enhanced the C-response while the A-response decreased insignificantly, Only the C-response was decreased by intrathecal morphine. 3) All the ten recorded cutaneous sympathetic fibers showed periodic discharge pattern similar to respiratory rhythm and five of them also showed cardiac-related rhythm. However, most of the muscular sympathetic fibers had cardiac-related rhythm and only four fibers showed respiratory rhythm. 4) Morphine decreased the sympathetic C-reflex elicited by the peripheral C-afferent activation and the abdominal sympathetic A-reflex was also decreased by morphine. From the above results, it was concluded that supraspinal mechanisms were involved in the enhanced arterial pressor response to peripheral C-afferent activation by intravenous morphine.

• 전자공학회논문지SC
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• 제46권4호
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• pp.77-83
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• 2009

본 연구는 자전거운동에서 슬관절 각도와 대퇴근 활성도의 관계를 확인하고자 하였다. 총 16명의 20대 남성을 대상으로 실험을 진행하였으며 대퇴근의 대퇴직근과 외측광근에서 EMG 신호를 측정하였다. 실험은 안장거리에 따라 총 5단계로 나누었으며 단계별로 1분씩 60RPM, 200W의 부하로 운동을 하였고 슬관절 각도는 동작분석 장비를 이용하여 측정하였다. 실험결과는 슬관절 각도와 대퇴직근 외측광근 각각은 상관관계가 Step 1에서만 높게 나타났으며 그 외에서는 나타나지 않았다. 이러한 이유는 개인의 습관에 따라 두 근육의 활성도가 다르기 때문으로 사료된다. 그러나 대퇴근의 근전도와 슬관절 각도를 비교한 결과 높은 상관관계가 나타났다.

• 대한물리치료과학회지
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• 제27권1호
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• pp.51-55
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• 2020

Background: A typical plank exercise (PE) strengthens the core muscles, stabilizes the spinal column, and provides stability around the pelvis and trunk when the trunk is aligned. However, because PE require that the hip joint be kept straight, they can activate the hamstring (HAM). Excessive HAM activation can induce tightness, which may cause low back pain. Therefore, it is necessary to explore PE methods that can minimize HAM activity while maximizing core muscle activity. Design: Cross-sectional study. Methods: This study included 30 healthy adults as subjects. We measured the activity of the HAM and the erector spinae (ES), rectus abdominis (RA), and external oblique (EO) muscles using surface electromyography during three PEs (typical PE, PE with balance pad, and PE with sling). Results: The RA, EO, and ES showed the highest muscular activity during PE with balance pad and the lowest during PE with sling; however, the differences were not significant. The HAM showed lower activity during PE with sling than during the other two PEs; however, these differences were also not significant. Conclusion: Although HAM activation was not significantly difference among PE positions, we should recognize altering activation of core and hamstring muscle according to PE postures.

• International Journal of Industrial Entomology and Biomaterials
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• 제5권1호
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• pp.109-122
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• 2002

The purpose of this investigation is to evaluate the effects of the Nuegra on enhancement of the masculine and physical activities in general through measuring changes of the testosterone, FSH and subjective symptoms like fatigue, insomnia, urinary stream, muscular weakness, libido and erectile dysfunction. Total 168 male subjects were enrolled from 12 urology, internal medicine clinics and general practitioner, During the 6-week investigational period, 2 capsules of Nuegra were given to the subjects right after meal for 4 weeks, and 1 capsule of Nuegra was added each time in subjects with no or minimal effect. Testoster-one and FSH levels were measured at first visit and last visit, for evaluating masculine activities. To avoid bias and standardize the test results, only one clinic was assigned as a central lab, and all blood samples were transferred. General information and subjective symptoms were evaluated at first visit and at 2 weeks interval, week 2, 4 and 6 using VAS (Visual Analogue Scale). The mean age of the subjects were 51.8${\pm}$8.2 years old (range: 36.1-82.1). Based on the subjects who were tested on testosterone and FSH levels at day l and week 6, the means were 4.4${\pm}$1.4 nmol/L (range: 2.6-7.7), 8.6${\pm}$9.6 mIU/mL (range: 0.3-40.4), respectively at day 1. At week 6, the results were 4.9 ${\pm}$1.6 (2.6-8.9 range), 9.4${\pm}$13.1 (1.0-53.9 range), respectively. Marginally significant difference between pre-dose and post-dose was present. Statistically significant differences were revealed in general assessment for subjective symptoms, fatigue, insomnia, erectile dysfunction, etc. In fatigue, response rates were 39.6, 65.4 and 76.4% at week 2, 4 and 6, respectively (P < 0.0001). Response vates for erectile dysfunction were 13.4, 41.2 and 72.7% at week 2, 4, and 6 (P < 0.0001), respectively, Response rates for libido were 13.6, 51.6 and 73.5% at week 2, 4, and 6 (P < 0.0001), respectively. For urinary stream response rates were 26.9, 44.7 and 66.8% at week 2, 4, and 6 (P < 0.0001), respectively. VAS for muscular weakness did not show significant results that response rates were 40, 60 and 80% at week 2, 4, and 6 from 8.2 (P ＝ 0.24), respectively. Response rates for insomnia were 50, 60, 100% at week 2, 4, and 6 (P < 0.0001), respectively. The results shows that Nuegra tends to enhance masculine activities including libido, erectile dysfunction and urinary stream and also effective for improving general conditions especially insomnia, muscular weakness and fatigue. In conclusion, this investigation has demonstrated that Nuegra does not only have tendency to increase masculine activities through increased secretion of the testosterone and FSH but also improve general conditions such as erectile dysfunction, libido, fatigue and muscular power.

• 대한인간공학회지
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• 제29권5호
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• pp.789-795
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• 2010

This study aimed to investigate the effect of differing heel height on static balance and muscle activation of ankle joint during standing. Twenty-one young females volunteered to participate in this study. To measure balance function and EMG activity of tibialis anterior and gastrocnemius muscles, the subjects were asked to perform 1-min standing with eyes open and closed state under 3 different heel heights: barefoot, 3cm, and 7cm each. During the standing, postural sway distance and area, and EMG activity of tibialis anterior and gastrocnemius muscles were significantly augmented with increasing heel height (p<0.05). For comparison between eyes open and closed in terms of postural sway area and EMG activity of tibialis anterior muscle, barefoot and 7cm height conditions respectively showed significant differences as well. The findings indicate that high-heeled shoes may have disadvantages in maintaining balance function because of extra-muscular effort of ankle joint. This study provides useful information that will inform future studies on how heel height affects muscle activity around the ankle joint in aspects of static and dynamic balance.

• PNF and Movement
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• 제18권3호
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• pp.315-321
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• 2020

Purpose: Recent studies have indicated that applying different inclination angles and suspension devices could be a useful way of performing exercises that include the co-activation of the trunk muscles. Present study was to examine the influences of changes in the inclination angle during trunk muscle activity while engaging in a bridge exercise with a suspension device. Methods: 18 healthy, physically active male volunteers completed three trunk inclination angles (15°, 30°, and 45°) for bridge exercise variations. The surface electromyography responses of the rectus abdominis, internal oblique (IO), erector spinae (ES), and rectus femoris (RF), as well as the subjective difficulty (Borg RPE score), were investigated during these bridge exercises. Results: The bridge with a 45° inclination angle suspension significantly increased the muscular activities of the RA and RF and increased the Borg RPE scores (p<0.05). The bridge with a 15° suspension significantly elevated the ES activities when compared to the other conditions. Conclusion: The present study demonstrated that a higher inclination angle could not activate the overall trunk muscles during the bridge exercise. The RA and RF produced greater activation during the bridge exercise with the higher inclination angle. On the other hand, the activities of the erector spine were greater during the bridge exercise with the lower inclination angle. The present study suggests that applying a low trunk inclination angle for the supine bridge exercise is suitable for activating the erector spine muscles.

• PNF and Movement
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• 제22권1호
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• pp.151-158
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• 2024

Purpose: The present study investigated how variations in diagonal exercises affect shoulder muscle activity, examining changes in neuromuscular activation during scapular and shoulder diagonal patterns of exercises. Furthermore, we explored whether the exercise phase affects muscle activation. Methods: Sixteen asymptomatic male participants were recruited. Four diagonal pattern exercises (scapular anterior elevation, posterior elevation, flexion-adduction-external rotation, flexion, abduction-external rotation), and two exercise phases (concentric and eccentric) were administered. Surface electromyography data were collected. Results: Upper trapezius activity was significantly higher during the concentric phase of scapular posterior elevation exercises compared with the others (p<0.05). The serratus anterior, anterior deltoid, and infraspinatus activities were significantly higher during shoulder diagonal pattern exercises compared with the scapular diagonal pattern exercises (p<0.05). Except for the lower trapezius, muscular activities during the concentric phase were significantly greater compared with the eccentric phase (p<0.05). Conclusion: The current study suggests that the diagonal pattern of exercise may contribute to selective strengthening of the shoulder complex muscles and that the form of exercise should be tailored to the subject. It also suggests that diagonal exercises with concentric contractions tend to be more beneficial than eccentric contractions for overall muscle recruitment, but the effects vary for specific diagonal patterns.