• The Korean Journal of Physiology and Pharmacology
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• v.11 no.3
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• pp.113-119
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• 2007

Developmental disability shows life-long behavioral abnormality with no significant physical malformation. This study was undertaken to develop an animal model for developmental disability by using two-factor approach. Lipopolysaccharide (LPS), a bacterial toxin, and NAN-190, a $5-HT_{1A}$ receptor antagonist, were administered to Sprague-Dawley rats on postnatal day (PND) 5 to induce inflammation and an altered 5-HT system, respectively. Long-term alteration of behavior occurred in the drug-treated groups. The LPS-treated group showed impaired motor coordination in the Rota-rod test. The LPS- treated or both LPS and NAN-190-treated groups showed impaired fore-paw muscle power in the wire maneuver test. These groups also showed decreased white matter volume and increased serotonergic fibers. The LPS and NAN-190-treated group also exhibited neurologic deficit in the placing reaction test and impaired equilibrium function in the tilt table test. The results showed that a variety of altered behaviors can be generated by two factor model, and suggested that combination of important etiologic factors and possible underlying defects is a promising strategy of establishing an animal model for developmental disabilities.

• Journal of Korean Medicine Rehabilitation
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• v.19 no.4
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• pp.219-228
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• 2009

Objectives : This study was performed to report the effect of oriental medical treatment in the paraplegia and pain after epidural nerve block. Methods : A 39-year-old woman who underwent epidural nerve block at a local clinic was admitted with motor weakness of lower limbs, severe lower radiating pain and decreased sensation when voiding and defecating. We treated her by acupuncture, a herbal medicine, a bee venom injection, moxibustion and cupping treatment and physical theraphy from 11th July 2008 to 14th October 2008. Results : After treatment, most symptoms decreased, VAS(Visual Analog Scale) score changed from 9 to 2. and examinated muscle power changed from 2-3 to 4-5. Conclusions : Our study suggested that oriental medical treatments are significantly effective in the paralplegia and pain after epidural nerve block. And further studies will be aid to identify underlying mechanism of treatment.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.5
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• pp.2678-2688
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• 2014

The purpose of this study is to examine the explanatory power of factors similar change to see what the value of the child's father give faith, grow, grow what kind of participation in the developmental characteristics of infants affected. 1,802 people infants born in 2010, the study is his father, I used the data for the next fiscal year 3 Panel Korea Policy Institute childcare children that target it. Analysis of the data, we have carried out frequency analysis using SPSS18.0, The value of the infant's father a child problem-solving skills, fine motor activity been found to affect the activity. Muscle activity for the father of the infant did not influence variables are. And the infant's communication, personal-social variables that affect the independence turned out to be a father involved in parenting.

• Journal of Dental Rehabilitation and Applied Science
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• v.29 no.1
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• pp.1-9
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• 2013

This study examined the effects of the occlusal stability and a partial coverage mouthguard on physical fitness and motor capacity to determine the importance of the occlusal stability as a possible action mechanism of mouthguards on physical performance. Twenty physical education students were included for measurements of their handgrip strength, back strength, whole body reaction time, flexibility, sidestep test, stork stand test and jumping test according to the following 5 different occlusal conditions: mouth closed position without a mouthguard, with a full coverage mouthguard, with a right partial coverage mouthguard, with a left partial coverage mouthguard and with anterior partial mouthguard. The results revealed no significant difference in any of the measured physical factors between the occlusal conditions with and without a full-coverage mouthguard. On the other hand, a significant difference was observed in whole body reaction between the occlusal conditions with and without the partial coverage mouthguards. Therefore, isokinetic muscle tests on both knee joints and the Wingate anaerobic power test should be performed under the following five occlusal conditions: with or without full-coverage maxillary custom-made mouthguard, with a unilateral right or left partial-coverage maxillary mouthguard and with an anterior partial-coverage maxillary mouthguard. These results suggest that the partial coverage mouthguard had a short-term beneficial effect on agility rather than full coverage mouthguard.

• Journal of Acupuncture Research
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• v.24 no.4
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• pp.225-235
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• 2007

Amyotrophic Lateral Sclerosis(ALS) is Motor Neuron Disease(MND) that reveals muscle relaxation, bulbar palsy, extremities weakness, Pneumonia, in severe case, leads to death. Objectives : Amyotrophic Lateral Sclerosis is one of the incurable disease. In Oriental medicine, Wei symptom is similar as Amyotrophic Lateral Sclerosis, so we diagnosed it as Wei symptom and treated in Oriental medical system. Methods : The patient was treated by acupunture, moxibustion, herb medication, physical treatment. The improvement of the patient was judged by Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS), Grasping power on right arm, circumference of thigh and calf. Result : The patient had better condition for a while but the sputum irritated breathing and the day before he discharged vital sign was not stable and could not breath well. Conclusion : It is necessary to have more examination about the incurable syndromes such as Amyotrophic Lateral Sclerosis, and keep the patient's life better and expand their lives.

• Journal of Biomedical Engineering Research
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• v.25 no.6
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• pp.479-487
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• 2004

Biopotential signals have been used as command in systems using electrical stimulation of motor nerves to restore movement after an injury to the central nervous system (CNS). In order to use the voluntary EMG (electromyography) among the biopotentials as a control signal for the electrical stimulation of the same muscle for CNS injury patients, it is necessary to remove M-wave of having high magnitude from raw data. We designed an optimal filter for removing the M-wave and preserving the voluntary EMG and showed that the optimal filter is eigen filter. We also proved that the previous method using the prediction error filter(PEF) is a suboptimal filtering in the sense of preserving the voluntary EMG. On basis of the data obtained from a model for M-wave and voluntary EMG and from actual CNS injury patients, with false-positive rate analysis, the proposed adaptive filter showed a very promising performance in comparison with previous method.

• Clinical and Experimental Pediatrics
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• v.49 no.11
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• pp.1158-1166
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• 2006

Purpose : The purpose of this study is to make a diagnostic classification and discuss a diagnostic strategy of floppy infants by investigating clinical, neurological, electrophysiological, and genetic analysis of infants admitted to intensive care units with the complaint of hypotonia. Methods : A retrospective study was performed from Jan. 1993 to Dec. 2005 in neonatal and pediatric intensive care units of Seoul National University Children's Hospital. Clinical features and all tests related to hypotonia were investigated. Results : There were 21 cases of floppy infants admitted to intensive care units. Final diagnosis was classified as centra (7 cases[33.3 percent]), peripheral (11 cases [52.4 percent]), and unspecified (3 cases [14.3 percent]). Among the central group, three patients were diagnosed as hypoxic ischemic encephalopathy, two patients as Prader-Willi syndrome, one patient as chromosomal disorder, and one patient as transient hypotonia. Among the peripheral group, four patients were diagnosed as myotubular myopathy, three patients as SMA type 1, two patients as congenital myotonic dystrophy, one patient as congenital muscular dystrophy, and one as unspecified motor-neuron disease. Motor power was above grade 3 on average, and deep tendon reflex was brisk in the central group. Among investigations, electromyography showed 66 percent sensitivity in the peripheral group, and muscle biopsy was all diagnostic in the peripheral group. Brain image was diagnostic in the central group, and Prader-Willi FISH or karyotyping was helpful in diagnosis in central group. Morbidity and mortality was more severe in the peripheral group Conclusion : Classification of diagnosis by clinical characteristics in this study, and application of investigations step by step, may provide an effective diagnostic strategy.