• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.559-562
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• 2012

Serum alpha-fetoprotein (AFP) is a significant marker for clinical diagnosis and prognosis evaluation in hepatocellular carcinoma (HCC) patients. However, some proportion of liver cancer patients are AFP-negative (AFP ${\leq}$20ng/ml). In order to study the differences between clinicopathological factors and prognosis of alpha-fetoprotein negative and positive patients, a total of 114 cases (41 AFP-negative and 73 AFP-positive) were selected for our research. By systematically statistical analysis, the results demonstrated that compared with AFP-negative patients, AFP-positive examples were more likely to feature cirrhosis nodules, non-complete neoplasm capsules, and a poor Edmondson-steiner grade. Furthermore, AFP-negative patients demonstrated a favorable long-term prognosis. By univariate analysis and multivariate analysis with Cox's proportional hazards model, multiple tumors were found to be independent risk factors for worse survival of AFP negative patients; however, less tumor-free margins, multiple tumors and Edmondson-steiner grades III/IV, proved to be independent risk factors leading to a poor prognosis of AFP positive cases. Finally, we can infer that high levels of AFP signify a highly malignant tumor and unfavorable prognosis.

• 한국조경학회지
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• 제30권1호
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• pp.29-43
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• 2002

The purpose of this paper is to examine atmospherical factors affecting user's satisfaction in natural park to answer the research question: what are the effects of atmosphere on user's satisfaction in natural parks(NP). After reviewing the literature, mechanism of NP, and use elements in NP, We constructed the conceptual framework and have formulated the hypothesis of this research. We had obtained data through a questionnaire, which surveyed 508 visitors at 6 of the 73 NP in Korea in 2001, based on stratified sampling method. We have analyzed the data using descriptive statistical methods, the mean difference test, Pearson's correlation analysis, and the multiple linear regression method. We found that 1) the five atmospheric variables, j.e., number of users(NOU), crowding, damage to park resources(DPR), and maintenance of park resources and facilities(MPRF), encounter level(EL) affecting user's satisfaction, have tuned out to be statistically significant at a five percent level. The direction of the relationship between user's satisfaction and MPRF, NOU, EL is the same as that of the dependent variable and the opposite of crowding, and BPR, 2) in bivariate analysis, the positive relationships between user's satisfaction and park resources, MPRF are fairly high and statistically significant. The higher the value of DPR, and crowing, the lower the degree of user's satisfaction, 3) in multivariate analysis, such variables as NOU, crowding, DPR, EL, and MPRF affecting user's satisfaction have been statistically significant at five percent level, and 4) the relative contribution of MPRF, park resources, park facilities, NOU, crowding, DPR, and size of activity space on user's satisfaction have been determined to have respectively 6.00, 4.78, 2.53, 1.83, 1.64, 1.59 and 2.03 times more important than that of EL. Among the atmospheric variables, MPRF is the most important at 1.26 times higher than that of park resources. The research results suggest that the development of devices for the increase in user's satisfaction and user management program based on the knowledge we have found, be recommended in the planning and development process of natural park. The approach adopted by this research is valid and useful for evaluation criteria of NP. It is recommended that more empirical studies by activity types, activity spaces, and seasons on atmospheric elements affecting user's satisfaction be performed in the future.

• Ocean and Polar Research
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• 제28권2호
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• pp.79-94
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• 2006

가막만에 분포하는 동물플랑크톤의 종조성과 분포 양상을 밝히고, 군집에 미치는 환경요인을 파악하기 위해 2003년 4월, 7월, 9월, 11월에 총 12개 정점에서 조사하였다. 동물플랑크톤은 총 43개의 분류군이었으며 평균 출현 개체수는 $270{\sim}1,803$ 개체/$m^3$의 범위를 보였지만 시 공간적인 변동폭이 다소 크게 나타났다. 우점종은 요각류 A. erythraea, E. pacifica, A. omorii, P. par편 s. 1, 지각류인 P. polyphemoides이었다. 동물플랑크톤 군집은 3개의 Group으로 구분되어졌으며, 정체성 해역인 소호 인근의 Group A, 가막만 중앙부해역인 Group B, 비교적 해수 소통이 원활한 남부해역인 Group C로 구분되었다. 군집으로 구분되는 세 Group간에 종수와 다양성 지수는 군집에 유의한 영향을 미치는 것으로 나타난 반면(p<0.05), 평균출현 개체수는 유의한 영향을 미치지 않았다(p>0.05). 본 연구에서 조사된 환경 자료를 이용하여 분석한 결과 동물플랑크톤의 군집에 미치는 환경요인을 분석한 결과는 수온, 염분, 용존산소로 나타났다. 결과적으로 가막만 동물플랑크톤의 군집 특성을 볼 때 소호 인근 해역은 급속한 산업화와 도시화로 인하여 지속적인 생활하수의 유입의 영향을 받고 있으며, 남부 해역의 군집은 계절에 따른 만 외수의 영향을 받아 계절에 따른 군집양상이 바뀌는 것으로 판단된다.

• Journal of Gastric Cancer
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• 제4권3호
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• pp.137-142
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• 2004

Purpose: There have been some controversies over the therapeutic principles of advanced gastric cancer, and the results of treatment have been variable, especially for stage III disease. This study was conducted to define the prognostic factors of stage III gastric cancer. Materials and Methods: This retrospective study was based on the medical records of 179 patients with stage III disease who received a gastrectomy from January 1990 to December 1994. The 5-year survival rate was analyzed according to the age, sex, tumor location, tumor size, Borrmann's type, depth of invasion, lymph-node metastasis, ratio of metastatic lymph nodes, type of surgical resection, extent of lymphnode dissection, curability of resection, postoperative chemotherapy, and pathological stage. The statistical analysis was done by using the Kaplan-Meier method, the log-rank test, and the Cox proportional hazards model. Results: The overall 5-year survival rate was $61.6\%$ the 5-year survival rates according to subgroup were $69.7\%$ for stage IIIa ($100\%$ for $T_{2}N_{2}$, $70.0\%$ for $T_{3}N_{1}$, $68.6\%$ for $T_{4}N_{0}$), and $54.1\%$ for stage IIIb ($T_{3}N_{2}$) (P<0.05). Among various clinicopathologic factors of stage III gastric cancer, the age of the patient, the tumor location, the gross type of tumor, the type of gastric resection, the extent of lymph-node dissection, the curability of resection, and the subgroups of stage III were statistically significant in the univariate survival analysis. The multivariate analysis defined the curability of resection, the extent of lymph-node dissection, the type of operation, the stage of disease, and the age of the patient as independent prognostic factors. Conclusion: A curative surgical resection and an extended lymph-node dissection are thought to be most important for improving the survival rate in stage III gastric cancer patients.

• Journal of Gastric Cancer
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• 제1권3호
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• pp.180-186
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• 2001

Purpose: The prognosis for early gastric cancer (EGC) is favorable, and the 10-year disease-specific survival rate is reported to be around $90\%$. The absolute number of recurred EGC is too small to assess the risk factors, so recruitment of a large number of cases for statistical analysis is very difficult. We carried out this study to analyze the incidence and the patterns of recurrence of EGC and to identify the clinicopathological risk factors for recurrence of EGC. Materials and Methods: The authors retrospectively investigated the follow-up records of 1418 patients who underwent a curative resection for EGC from Jan. 1984 to Dec. 1999 at the Korea Cancer Center Hospital and analyzed them with special reference to cancer recurrence. Results: In this retrospective study of 1418 cases, 43 patients died of a recurrence of gastric cancer, and 105 patients died of unrelated causes. The five-year and the ten-year overall survival rates were $89.6\%$ and $81.7\%$, respectively, while the five-year and the ten-year diseasespecific survival rates were $96.5\%$ and $94.3\%$, respectively. The recurrence patterns of the 45 recurred EGC were hematogenous metastasis (19 cases), lymph node (L/N) metastasis (8 cases), locoregional recurrence (2 cases), peritoneal seeding (3 cases), and combined form (13 cases). The mean time interval to recurrence was 38.6 months, and the number of delayed recurred cases after 5 years was 10 ($22.2\%$). Of the clinicopathologic factors, depth of invasion, L/N metastasis, macroscopic type, lymphatic invasion, and vessel invasion, were significant risk factors in the univariate analysis. However, in the multivariate analysis, only L/N metastasis was an independent prognostic factor. Conclusion: Based on the results of this study, L/N metastasis is an independent prognostic factor. Thus, in patients with node-positive disease, adjuvant therapy might be considered, and long-term close follow-up might facilitate early detection and treatment of recurrent disease due to delayed recurrence.

• 동의생리병리학회지
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• 제23권5호
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• pp.1199-1205
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• 2009

The purpose of this case-control study was done to examine the relationship among the cerebral infarction, blood lipids and homocysteine. We compared the components of blood lipids and homocysteine between cerebral infarction patients group (n=127) and controls group (n=158). We performed Pearson's chi-square test and Student's t-test for univariate analysis, Binary logistic regression for multivariate analysis to evaluate risk factors of cerebral infarction and Pearson's correlation analysis to investigate correlation between blood lipids and homocysteine. The results were as follows. The blood levels of High density lipoprotein cholesterol(HDL-Chol) and Low density lipoprotein cholesterol (LDL-Chol) were significantly lower in patients group, while age, the blood levels of Triglyceride(TG) and homocysteine were significantly higher in patients group. Hypertension had a 4.62 odds ratio, $TG{\geq}150\;mg/d{\ell}$ had a 2.33 odds ratio, HDL-Chol ${\leq}40\;mg/d{\ell}$ had a 6.85 odds ratio, but sex, DM, T-Chol, LDL-Chol had no direct relationship with odds ratio(non significant). In addition, among T-Chol and TG , HDL-Chol, LDL-Chol, they had positive correlation each other. Between TG and HDL-Chol had negative correlation each other. Homocysteine was not correlated with blood lipids adjusted for age and sex. These results suggest that low HDL-Chol and high TG may be risk factor of cerebral infarction. The correlation between homocysteine and blood lipids was not proven.y urther reserch on the subject is needed.

• Safety and Health at Work
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• 제10권4호
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• pp.470-475
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• 2019

Background: There is a lack of statistical analysis investigating the relationship between sleep problems and commute time in Korea. We aimed to analyze the association between representative health symptoms, sleep disturbances, and commute time according to working hours in Korea. Methods: The 4th Korean Working Conditions Survey data were used for analysis, and unpaid family workers and workers who work fewer than three days in a week were excluded. Commute time, working hours, and sleep hours were assessed using self-reported questionnaires. Odds ratios (ORs) with 95% confidence intervals (CIs) for sleep problems were calculated using a multivariate logistic regression model with ≤10 min commute time as the reference group. Results: Among a total of 28,804 workers (men = 14,945, women = 13,859), 2.6% of men and 3.2% of women experienced sleep problems. In both sexes, long commute time (51-60 minutes and >60 minutes) showed an increased OR [men, 2.03 (CI = 1.32-3.13) and 2.05 (CI = 1.33-3.17); women, 1.58 (CI = 1.05-2.39) and 1.63 (CI = 1.06-2.50), respectively]. In stratification analysis of working hours, long commute time (51-60 and > 60 minutes) showed an increased OR in men working >40 hours/week [2.08 (CI = 1.16-3.71) and 1.92 (CI = 1.08-3.41), respectively]. Furthermore, long commute time (41-50, 51-60, and >60 minutes) showed an increased OR in women working >40 hours/week [2.40 (CI = 1.27-4.55), 2.28 (CI = 1.25-4.16), and 2.19 (CI = 1.17-4.16), respectively]. Moreover, commute time >60 minutes showed an increased OR in women working ≤40 hours/week [1.96 (CI = 1.06-3.62)]. Conclusion: This large cross-sectional study highlights that long commute time is related to sleep problems in both sexes. Shorter commute times and decreased working hours are needed to prevent sleep problems in workers.

• Advances in pediatric surgery
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• 제16권2호
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• pp.108-116
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• 2010

Air reduction is a safe, effective, and fast initial treatment for pediatric intussusception. There is low dose radiation exposure. Factors affecting outcomes of air reduction were analyzed by reviewing the clinical features and results of treatment. A total of 399 out of 485 patients with pediatric intussusceptions were treated at the Seoul National University Children's Hospital from 1996 to 2009. All of the patients received air reduction as the first line of treatment. Clinical features such as gender, age, seasonal variation, symptoms, signs, types, pathologic leading point, and treatment results including success rate, complication, recurrence, NPO time, and duration of hospitalization were reviewed. The Pearson chi-square, student T-, and logistic regression tests were used for statistical analysis. P-value less than 0.05 was considered to be statistically significant. The prevalent clinical features were: male (65.4 %), under one-year of age (40.3 %), ileocolic type (71.9 %), abdominal pain (85.4 %), and accompanying mesentery lymph node enlargement (2.2 %). The overall success rate for air reduction was 78.4 % (313 of 399 patients), and the perforation rate during reduction was 1.5 %. There were 23 recurrent cases over 21.6 months. All were successfully treated with re-do air reduction. Reduction failures had longer overall NPO times (27.067hrs vs. 43.0588hrs; p=0.000) and hospitalization durations (1.738d vs. 6.975d; p=0.000) compared to the successful cases. The factors affecting success rates were fever (p=0.002), abdominal distension (p=0.000), lethargy (p=0.000) and symptom duration (p=0.000) on univariate analysis. Failure rates were higher in patients with symptom durations greater than 24 hours (p=0.023), and lethargy (p=0.003) on multivariate analysis. Air reduction showed high success rates and excellent treatment outcomes as the initial treatment for pediatric intussusception in this study. Symptom duration and lethargy were significantly associated with reduced success rates.

• 한국과학교육학회지
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• 제36권5호
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• pp.729-737
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• 2016

자연선택개념은 진화론의 핵심개념으로 다양한 생물학적 문제를 해결하기 위해 이해해야 될 필수 개념이다. 이 연구는 한국예비생물 교사들의 자연선택개념의 이해 수준을 조사하기 위하여 중국, 미국, 독일의 생물전공자와 비교하는 것을 목적으로 한다. 특히 이 연구에서는 자연선택개념의 두 개념요소인 생태개념과 유전개념으로 구분하여 예비생물교사의 자연선택개념을 분석하였다. 우리나라 예비생물교사 376명을 포함하여 1226명의 한국, 중국, 미국, 독일의 생물전공 예비교사의 자료를 토대로 분석하였다. 검사도구는 생태개념과 유전개념문항 각 10개씩을 포함하고 있는 Conceptual Inventory of Natural Selection의 20문항을 라쉬모델, 다변량분산분석, 일변량분산 분석을 활용하여 분석하였다. 그 결과 우리나라 예비생물교사의 자연선택개념 수준은 중국과 비슷하고 미국, 독일에 비하여 낮았다. 생태개념과 유전개념으로 구분하여 살펴보면, 우리나라 예비생물교사 1학년의 경우 중국과 독일에 비하여 유전개념이 유의미하게 낮았으며, 4학년의 경우 미국과 독일에 비하여 생태개념이 유의미하게 낮았다. 3년간의 예비생물교사 교육과정 동안 유전개념에 대한 교육은 성공적이었으나, 생태개념의 교육은 성공적이지 못하였다. 이 연구결과를 토대로 자연선택개념의 이해를 위한 예비생물 교사교육에 대해서 논의한다.

• 한국지역지리학회지
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• 제10권3호
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• pp.642-653
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• 2004

본 연구는 곡성군에서 개최되는 곡성심청축제를 사례로 축제만족도 결정요인을 고찰하였다 곡성심청축제는 2000년부터 개최되어 2004년 현재 제5회 개최를 앞두고 있다. 곡성심청축제가 타축제 프로그램과 구별되는 독특한 면은 심청의 "효"의 의미를 되새기고 섬진강의 자연생태를 통한 "환경"의 중요성을 인식하는 다양한 볼거리와 체험행사로 구성되었다는 점이다. 본 연구에서는 지역축제 방문객의 만족도 결정요인을 고찰하기 위하여 17개의 지역축제 방문객의 만족요인 항목을 구성하여 설문조사를 통한 실증분석을 하였다. 연구자료는 세가지 통계기법(신뢰도분석, 요인분석, 다중회귀분석)을 사용하여 분석되었으며, 요인분석 후 4개의 요인(기념품과 음식, 행사내용, 홍보안내, 편의시설)이 도출되었다. 본 연구의 결과로 지역축제 방문객의 만족과 재방문. 그리고 권유의사에 가장 큰 영향을 미치는 유의한 축제만족요인은 '행사내용'요인으로 밝혀졌다. 지역축제 방문객 만족을 위해서는 무엇보다 축제 행사내용의 다양함과 재미, 체험프로그램을 통한 해당 지역의 문화 인지가 중요함을 알 수 있다. 지역축제의 관리자나 기획자는 지역축제의 만족요인에 지속적인 관심을 가져야 할 것이다.