• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4515-4520
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• 2015

GELOX (gemcitabine, oxaliplatin and L-asparaginase) regimen showed an impressive result in our previous study, but the effect of this new regimen is still dissatisfying for some patients, so it is necessary to identify which patients will benefit from this regimen. A total of fifty-one cases with nasal natural killer/T-cell lymphoma receiving initial GELOX chemotherapy were enrolled in this study. The ki-67 expression detected by immunohistochemistry (IHC) in the specimens ranged from 10% to 90%, with a median value of 70%, so cases higher than the median value (${\geq}70%$) were defined as high ki-67 expression, and the others were designated as low ki-67 expression. The response rate had no statistical difference between low ki-67 expression group and high ki-67 expression group (P=0.291) though the value in the former group was relatively high. After a median follow-up of 18.03 months, the 3-year progression-free survival (PFS) for patients with low ki-67 expression was significantly higher than those with high ki-67 expression (83.8% vs. 47.9%, P=0.038). In the stage I/II subgroup, 3-year PFS and overall survival (OS) were statistically higher in the patients with low ki-67 expression than those with high ki-67 expression. Multivariate analysis revealed high ki-67 expression was an independent prognostic factor for PFS. These results suggest that low ki-67 expression can predict a good response of GELOX in these patients, and the combination of ki-67 expression and early stage is helpful to identify an excellent prognosis subgroup from patients receiving GELOX in this disease.

• Asian Pacific Journal of Cancer Prevention
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• 제14권3호
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• pp.1965-1967
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• 2013

Background: To obtain the maximum additional information about the prognosis of gastric cancer, we compared CA-50 with other previously defined markers. Materials and Methods: This hospital based study was carried out in the Department of Biochemistry of Nepalese Army Institute of Health Sciences between $1^{st}$ July 2012 and $31^{st}$ December 2012. The variables collected were age, gender, AFP, CEA, CA19-9, and CA50, assayed with ELISA reader for all cases. The cut off values for serum AFP, CEA, CA19-9, and CA-50 were 10 ${\mu}g/l$, 10 ${\mu}g/l$, 37 U/ml, and 20 U/ml, respectively according to the manufacturer's instructions. Approval for the study was obtained from the institutional research ethical committee. Results: Of the 40 examined patients, 13 patients had tumors located in the upper third of the stomach, 6 patients had tumors in the middle third, 16 patients had tumors in the lower third, and 5 patients had tumors occupying two-thirds of the stomach or more. The distribution of lymph node staging of the patients was as follows: 7 patients belonged to N0, 9 patients to N1 stage, 10 patients to N2 stage, and 14 patients to N3 stage. The statistical method of Cox proportional hazards using multivariate analysis also illustrated that tumor markers including CEA (2.802), CA19-9 (2.690), CA50 (2.101), were independent prognostic factors, as tumor size (1.603), and lymph node stage (1.614). Conclusions: The tumour markers now available, like CEA, CA 19-9 and CA 50, chiefly perceive advanced gastric cancer. The preoperative rise in those tumour marker level have a prognostic significance and may be clinically helpful in choosing patients for adjuvant management.

• 한국환경과학회지
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• 제14권5호
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• pp.481-490
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• 2005

Surface sediments and seawater were sampled at Masan and Haengam Bays of Korea, to evaluate contamination by sewage-derived organic matter using fecal sterols, Six stream-water samples into Masan and Haengam Bays were also sampled. Total concentrations of eight sterols (coprostanol, epichloestanol, epicoprostanol, cholesterol, cholestanol, brassicasterol, stigmasterol and $\beta-sitosterol$) were in the range of $1,274\~4,768{\mu}g/g$ dry weight in suspended particulate from the stream-water, $292\~2,244{\mu}g/g$ dry weight in suspended particulate from the seawater and $4.5\~27.2{\mu}g/g$ dry weight in the sediments. Although sterol compositions in sediments, seawater and stream-water were different, cholesterol was the predominant sterol in all samples. The proportion and concentration of coprostanol, a sewage tracer, in stream-water was much higher than those in sediment and seawater. The sterol levels including coprostanol in the sediments and seawater were higher at inner basin than at the outer bay. Some molecular indices and multivariate statistical analysis were used to assess the origin of these sterols and sewage contamination in the study area. The sterol composition patterns in stream-water were mainly associated with contamination by sewage-derived organic matters and those of seawater were associated with the activities of marine-originated organisms. Sterol levels in the sediments were both from the sewage input through stream-water and the marine- originated organisms. This survey suggests that the main source/route of sewage-derived organic matters in Masan Bay is the input of stream-water into the bay.

• 응용통계연구
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• 제21권3호
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• pp.441-453
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• 2008

프로스포츠 선수들의 연봉은 선수들의 개인 성적과 팀에 대한 기여도 등으로 결정된다는 가정하에 프로농구와 프로야구 선수들의 전년도 성적으로 다음해 연봉을 예측 분석하였다. 분석에 있어서 data visualization 기법을 통해 변수사이의 관계, 이상점 발견, 모형진단등을 하였다. 다중선형회귀 모형(Multiple Linear Regression)과 트리모형(Regression Tree)을 이용해서 자료를 분석하고 모델간 비교를 했으며, Cross-Validation을 이용해서 최적모델을 선택하였다. 특히, 자동으로 변수선택을 하는 stepwise regression방법을 그냥 사용하기보다는 먼저 설명변수들 사이의 관계나 설명변수와 반응변수 사이의 관계등을 조사하고 나서 이를 통해 선택된 변수들을 가지고 stepwise regression과 regression tree 방법론을 이용해서 적절한 변수 및 최종 모형을 선택하였다. 분석결과, 프로농구의 경우에는 경기당 득점, 어시스트, 자유투 성공수, 경력 등이 중요한 변수였고, 프로야구 투수의 경우에는 경력, 9이닝 당 삼진 수, 방어율, 피홈런 수 등이 중요한 변수였고, 프로야구 타자의 경우에는 경력, 안타 수, FA(자유계약)유무 여부 등이 중요한 변수였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권4호
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• pp.1397-1401
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• 2015

Background: To determine the expressions of Tbx3, a member of subgroup belonging to T-box family, and its prognostic value in pancreatic carcinoma. Materials and Methods: We determined the expression levels of Tbx3 on both mRNA and protein levels in 30 pairs of fresh tumor tissues and paratumor tissues by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting, respectively. In addition, protein level of Tbx3 were identified using immunochemistry in 80 pairs of paraffin-embedded specimen. The correlations between Tbx3 expression and various clinicopathological parameters as well as overall survival were evaluated. Results: Tbx3 mRNA and protein levels in tumor tissues were significantly higher than in the paratumor tissues by qRT-PCR ($0.05{\pm}0.007$ vs. $0.087{\pm}0.001$, p<0.001) and western blotting ($1.134{\pm}0.043$ vs. $0.287{\pm}0.017$, p<0.001). The statistical analysis based on immunohistochemical evaluation suggested that Tbx3 aberrant expression was significantly associated with several conventional clinicopathological variables, such as gender, age, tumor position, preoperative CA19-9 level, pathological T staging and N staging. Univariate and multivariate analyses revealed that Tbx3 expression was an independent prognostic factor for overall survival (<0.001). Conclusions: Our results suggest that overexpression of Tbx3 is associated with poor prognosis of pancreatic cancer patients. However, additional clinical trials are needed to accurately validate this observation.

• 한국식품영양과학회지
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• 제43권2호
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• pp.179-186
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• 2014

대사체학이 질병, 약물, 스트레스, 식이, 생활습관, 유전적 차이, 장내 미생물 등에 의해서 발생하는 비정상적인 대사 메커니즘을 규명하고 관련 바이오 마커 발굴에 중요한 역할이 증명됨에 따라, 식품 영양학과 대사체학이 융합된 영양 대사체학의 역할이 더욱 중요해지고 있다. 특히 잘못된 식생활에 따른 미래의 질병 예측이 가능해지고 있어 향후 적절한 질병 예방이나 치료를 위한 적절한 식생활이나 식이에 대한 정보를 제공함으로써 건강 증진은 물론 개인별 맞춤식이나 맞춤약물 처방을 통한 개인 맞춤형 건강관리(personalized health care) 시대가 멀지 않았다. 또한 복잡한 식생활 패턴, 대사 반응에 대한 개인 간 차이 그리고 방대한 대사체 데이터와의 관계들을 효과적으로 밝혀낼 수 있는 기술에 대한 지속적인 개발과 영양 대사체학(nutritional metabolomics)이 유전체학(genomics or transcriptomics)과 단백체학(proteomics) 기술과 융합적으로 연구가 이루어질 때 질병과 식사 섭취 사이의 관계가 더욱 투명하게 규명될 것이다.

• 한국미생물학회:학술대회논문집
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• 한국미생물학회 2009년도 International Meeting of the Microbiological Society of Korea
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• pp.78-78
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• 2009

$^1H$ NMR spectroscopy coupled with multivariate statistical analysis was used for the first time to investigate metabolic changes in musts during alcoholic fermentation and wines during ageing. Three Saccharomyces cerevisiae yeast strains (RC-212, KIV-1116 and KUBY-501) were also evaluated for their impacts on the metabolic changes in must and wine. Pattern recognition (PR) methods, including PCA, PLS-DA and OPLS-DA scores plots, showed clear differences for metabolites among musts or wines for each fermentation stage up to 6 months. Metabolites responsible for the differentiation were identified to valine, 2,3-butanediol (2,3-BD), pyruvate, succinate, proline, citrate, glycerol, malate, tartarate, glucose, N-methylnicotinic acid (NMNA), and polyphenol compounds. PCA scores plots showed continuous movements away from days 1 to 8 in all musts for all yeast strains, indicating continuous and active fermentation. During alcoholic fermentation, highest levels of 2,3-BD, succinate and glycerol were found in musts with the KIV-1116 strain, which showed the fastest fermentation or highest fermentative activity of the 3 strains, whereas the KUBY-501 strain showed the slowest fermentative activity. This study highlights the applicability of NMR-based metabolomics for monitoring wine fermentation and evaluating the fermentative characteristics of yeast strains.

• 응용통계연구
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• 제29권1호
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• pp.61-73
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• 2016

본 논문에서는 다변량 시계열 모형 진단을 위해 잔차의 자기상관성 유무를 확인하기 위한 와일드 붓스트랩(wild bootstrap) Ljung-Box(LB) 검정통계량을 연구하였다. 일반적으로 LB 검정은 오차가 서로 독립이며 동일한 분포를 따른다는 IID 가정 하에 유도되는 점근적 카이제곱 분포를 이용한다. 한편 금융시계열 자료는 분산에 조건부 이분산성이 존재하기 때문에 오차의 IID 가정을 만족시키지 못하며 이에 따라 점근적 분포를 이용한 LB 검정은 제1종의 오류를 만족시키지 못하게 된다. 이를 극복하기 위해 와일드 붓스트랩을 이용한 LB 검정법을 제안하고 그 성질을 연구하고자 한다. 벡터자기회귀 모형과 벡터오차수정 모형 등의 다양한 다변량 시계열 모형을 이용하여 모의실험을 실시하는 한편, 코스피 200지수와 지수선물 자료를 이용한 실증분석을 통해 와일드 붓스트랩을 이용한 LB 검정법이 조건부 이분산성의 부정적인 영향을 효과적으로 제거할 수 있음을 입증하였다.

• Journal of Biosystems Engineering
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• 제40권2호
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• pp.124-136
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• 2015

Purpose: Grain quality is a general concept that covers many characteristics, ranging from physical to biochemical and physiochemical properties. Rice aging during storage is currently a challenge in the rice industry, and is a complicated process involving changes in all of the above properties. Spectroscopic techniques can be used to obtain information on the quality of rice samples in a non-destructive manner. Methods: The objective of this review was to highlight the factors that contribute to rice quality and aging, and to describe various spectroscopic modalities, particularly vibrational and hyperspectral imaging, for the assessment of rice quality. Results: Starch and protein are the main components of the rice endosperm, and are therefore key factors contributing to eating and cooking quality. While the overall starch, protein, and lipid content in the rice grain remains essentially unchanged during storage, structural changes do occur. These changes affect pasting and gel properties, and ultimately the flavor of cooked rice. In addition, grain quality is significantly affected by growing and environmental conditions, such as water availability, temperature, fertilizer application, and salinity stress. These properties can be evaluated using spectroscopic techniques, and rice samples can be discriminated by using multivariate statistical analysis methods. Conclusion: Hyperspectral imaging and vibrational spectroscopy techniques have good potential for determining rice quality properties in a non-invasive manner, i.e., not requiring the introduction of instruments into the rice grain.

• 대한지리학회지
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• 제44권4호
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• pp.532-543
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• 2009

외식산업 프랜차이즈는 외상 매출액의 비중이 작고 자금회전이 원활하여 국내에서 창업 선호도가 매우 높다. 이에 본 연구에서는 서울시지역 외식산업 프랜차이즈 1호점들의 입지분석을 통해 향후의 입지경향을 예측하는 데 목적을 두었다. 본 연구결과는 다음 세 가지로 요약된다. 첫째, 외식산업 프랜차이즈 1호점의 공간분포형태는 최근린지수(R) 0.16으로 집중된 분포패턴을 보인다. 둘째, 외식산업 프랜차이즈 1호점은 상관분석 결과 특히 금융기관수, 사업서비스업체수, 숙박 음식점업체수 등의 15개 변수와 상관성이 있다. 셋째, 다중회귀분석에 의해 최종적으로 선정된 입지요인은 설명력 64% 정도의 금융기관수이다. 이러한 본 연구결과에 의거하였을 때 금융기관수가 많은 서울시 강남구와 중구 지역은 향후에도 외식산업 프랜차이즈 1호점의 선점 장소가 될 것으로 예측된다.