• The Journal of the Acoustical Society of Korea
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• v.41 no.6
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• pp.610-620
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• 2022

An acoustic vector sensor can simultaneously receive vector quantities, such as particle velocity and acceleration, as well as acoustic pressure at one location, and thus it can be used as a single input multiple output receiver in underwater acoustic communication systems. On the other hand, vector signals received by a single vector sensor have different channel characteristics due to the azimuth angle between the source and receiver and the difference in propagation angle of multipath in each component, producing different communication performances. In this paper, we propose a channel parameter-based weighting method to improve the performance of an acoustic communication system using a single vector sensor. To verify the proposed method, we used communication data collected from the experiment conducted during the KOREX-17 (Korea Reverberation Experiment). For communication demodulation, block-based time reversal technique which is robust against time-varying channels were utilized. Finally, the communication results showed that the effectiveness of the channel parameter-based weighting method for the underwater communication system using a single vector sensor was verified.

• Proceedings of the Korean Society of Crop Science Conference
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• 2022.10a
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• pp.312-312
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• 2022

Peanut hull as by-product has been discarded during peanut processing. However, peanut hull contains plenty of polyphenols that shows various physiological activities. The objectives of this study were to investigate anti-inflammatory and enzyme inhibitory activities of polyphenols from 'Sinpalkwang' peanut (Arachis hypogaea L.) hull. Compounds were isolated from methanol extracts of peanut hull by preparative-high performance liquid chromatography after identifying and quantifying polyphenols using Ultra performance liquid chromatography (UPLC) and UPLC-Quadrupole time-of-flight-mass spectrometry profiling. The structures of compounds were elucidated by one-dimensional [¹H, ¹³C] nuclear magnetic resonance (NMR) and two-dimensional NMR (correlated spectroscopy, heteronuclear single quantum coherence and heteronuclear multiple bond correlation). Three compounds were identified as 5,7-dihydroxy-4H-chromen-4-one (peak 2), luteolin (peak 4) and eriodictyol (peak 5). Significant differences in inflammatory mediator such as nitric oxide (NO), interleukin-6 (IL-6) and interleukin-1β (IL-lβ) in lipopolysaccharide stimulated Raw 264.7 macrophages and in enzyme (xanthine oxidase [XO] and α-glucosidase [AG]) inhibitory activities were observed between three compounds (p < 0.05). Peak 5 treated Raw 264.7 macrophages showed lower content of NO (16.4 uM), IL-6 (7.0 ng/mL), and IL-1β (60.6 pg/mL) than peak 2 (NO: 28.3 uM, IL-6: 11.3 ng/mL, IL-1β: 66.9 pg/mL) and peak 4 (NO: 24.7 uM, IL-6: 9.3 ng/mL, IL-1β: 62.6 pg/mL). Peak 5 showed higher XO inhibitory activity (84.7%) and higher AG inhibitory activity (52.4%) than peak 2 (XO inhibitory activity: 45.4%, AG inhibitory activity: 21.6%) and peak 4 (XO inhibitory activity: 37.9%, AG inhibitory activity: 37.5%) at concentration of 0.5mg/mL. This study suggests that peanut hull could be a potential source of anti-inflammatory and physiological materials while creating new use of discarded peanut hull as by-products concomitantly.

• The Journal of the Convergence on Culture Technology
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• v.9 no.5
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• pp.133-140
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• 2023

The origin of texts we refer to as literary or artistic may be imagination, but many are based on experiences. In fact, experiences can be the source of artistic imagination since imagination often builds upon experiences. Therefore, the act of verbalizing human experiences using them as raw material can become a great form of art. Transforming past experiences into stories and infusing them with vitality inevitably requires a creative process of reconstruction, which is essentially a literary process. As such, 'Personal Narrative' holds significance as a literary process that weaves facts into stories and shapes them into forms. Individual experiences are stored as personal memories, and these 'personal memories' continuously generate stories. Collections of individual stories are stored as multiple memories, which gradually form 'collective memories' with distinct social and cultural inclinations through the passage of time and invisible yet potent societal and cultural censorship. The problem lies in the fact that individuals may tend to align their own memories with the inclinations of collective memory rather than simply recalling what they personally experienced. In the context of actual history, personal memories and collective memories communicate with each other, producing non-fictional content close to reality and sometimes manifesting as fiction content enriched with imagination. 'Personal Narrative' holds a significant genre as one genre of non-fiction content within our culture.

• Convergence Security Journal
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• v.24 no.1
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• pp.51-57
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• 2024

Although industrial control systems (ICSs) recently keep evolving with the introduction of Industrial IoT converging information technology (IT) and operational technology (OT), it also leads to a variety of threats and vulnerabilities, which was not experienced in the past ICS with no connection to the external network. Since various control command messages are sent to field devices of the ICS for the purpose of monitoring and controlling the operational processes, it is required to guarantee the message integrity as well as control center authentication. In case of the conventional message integrity codes and signature schemes based on symmetric keys and public keys, respectively, they are not suitable considering the asymmetry between the control center and field devices. Especially, compromised node attacks can be mounted against the symmetric-key-based schemes. In this paper, we propose message authentication scheme based on double hash chains constructed from cryptographic hash function without introducing other primitives, and then propose extension scheme using Merkle tree for multiple uses of the double hash chains. It is shown that the proposed scheme is much more efficient in computational complexity than other conventional schemes.

• The Journal of the Korea institute of electronic communication sciences
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• v.19 no.1
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• pp.65-76
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• 2024

With the recent activation of the offshore wind power industry, there has been a development of power plants with a scale exceeding 400MW, comparable to traditional thermal power plants. Renewable energy, characterized by intermittency depending on the energy source, is a prominent feature of modern renewable power generation facilities, which are structured based on controllable inverter technology. As the integration of renewable energy sources into the grid expands, the grid codes for power system connection are progressively becoming more defined, leading to active discussions and evaluations in this area. In this paper, we propose a method for selecting optimal reactive power compensation capacity when multiple offshore wind farms are integrated and connected through a shared interconnection facility to comply with grid codes. Based on the requirements of the grid code, we analyze the reactive power compensation and excessive stability of the 400MW wind power generation site under development in the southwest sea of Jeonbuk. This analysis involves constructing a generation site database using PSS/E (Power System Simulation for Engineering), incorporating turbine layouts and cable data. The study calculates reactive power due to charging current in internal and external network cables and determines the reactive power compensation capacity at the interconnection point. Additionally, static and dynamic stability assessments are conducted by integrating with the power system database.

• International Journal of Stem Cells
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• v.16 no.3
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• pp.281-292
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• 2023

Background and Objectives: Human induced pluripotent stem cell (hiPSC)-derived cardiomyocyte (CM) hold great promise as a cellular source of CM for cardiac function restoration in ischemic heart disease. However, the use of animal-derived xenogeneic substances during the biomanufacturing of hiPSC-CM can induce inadvertent immune responses or chronic inflammation, followed by tumorigenicity. In this study, we aimed to reveal the effects of xenogeneic substances on the functional properties and potential immunogenicity of hiPSC-CM during differentiation, demonstrating the quality and safety of hiPSC-based cell therapy. Methods and Results: We successfully generated hiPSC-CM in the presence and absence of xenogeneic substances (xeno-containing (XC) and xeno-free (XF) conditions, respectively), and compared their characteristics, including the contractile functions and glycan profiles. Compared to XC-hiPSC-CM, XF-hiPSC-CM showed early onset of myocyte contractile beating and maturation, with a high expression of cardiac lineage-specific genes (ACTC1, TNNT2, and RYR2) by using MEA and RT-qPCR. We quantified N-glycolylneuraminic acid (Neu5Gc), a xenogeneic sialic acid, in hiPSC-CM using an indirect enzyme-linked immunosorbent assay and liquid chromatography-multiple reaction monitoring-mass spectrometry. Neu5Gc was incorporated into the glycans of hiPSC-CM during xeno-containing differentiation, whereas it was barely detected in XF-hiPSC-CM. Conclusions: To the best of our knowledge, this is the first study to show that the electrophysiological function and glycan profiles of hiPSC-CM can be affected by the presence of xenogeneic substances during their differentiation and maturation. To ensure quality control and safety in hiPSC-based cell therapy, xenogeneic substances should be excluded from the biomanufacturing process.

• Korean Journal of Radiology
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• v.21 no.12
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• pp.1345-1354
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• 2020

Objective: To evaluate radiomics analysis in studies on mild cognitive impairment (MCI) and Alzheimer's disease (AD) using a radiomics quality score (RQS) system to establish a roadmap for further improvement in clinical use. Materials and Methods: PubMed MEDLINE and EMBASE were searched using the terms 'cognitive impairment' or 'Alzheimer' or 'dementia' and 'radiomic' or 'texture' or 'radiogenomic' for articles published until March 2020. From 258 articles, 26 relevant original research articles were selected. Two neuroradiologists assessed the quality of the methodology according to the RQS. Adherence rates for the following six key domains were evaluated: image protocol and reproducibility, feature reduction and validation, biologic/clinical utility, performance index, high level of evidence, and open science. Results: The hippocampus was the most frequently analyzed (46.2%) anatomical structure. Of the 26 studies, 16 (61.5%) used an open source database (14 from Alzheimer's Disease Neuroimaging Initiative and 2 from Open Access Series of Imaging Studies). The mean RQS was 3.6 out of 36 (9.9%), and the basic adherence rate was 27.6%. Only one study (3.8%) performed external validation. The adherence rate was relatively high for reporting the imaging protocol (96.2%), multiple segmentation (76.9%), discrimination statistics (69.2%), and open science and data (65.4%) but low for conducting test-retest analysis (7.7%) and biologic correlation (3.8%). None of the studies stated potential clinical utility, conducted a phantom study, performed cut-off analysis or calibration statistics, was a prospective study, or conducted cost-effectiveness analysis, resulting in a low level of evidence. Conclusion: The quality of radiomics reporting in MCI and AD studies is suboptimal. Validation is necessary using external dataset, and improvements need to be made to feature reproducibility, feature selection, clinical utility, model performance index, and pursuits of a higher level of evidence.

• Journal of Life Science
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• v.34 no.3
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• pp.170-178
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• 2024

Adipose-derived stem cells (ADSCs) are capable of differentiation into multiple lineages of cells, which has attracted attention for clinical therapy. However, ADSCs have poor proliferation capacity and a short life span in culture, which is an impediment in the application to clinical use. Previously, to overcome growth disadvantages, we had established an immortalized ADSC line (ADSC-T) by introducing the SV40 T antigen coding gene into primary human ADSC. In the present study, we evaluated the differentiation potential of this cell line and assessed the anti-inflammatory effect of its conditioned medium (CM). ADSC-T appeared to maintain the differentiation potential into adipocyte and chondrocyte. The CM of ADSC-T suppressed the NF-κB activity and its target gene expression of COX-2 and iNOS. Furthermore, the phosphorylations of MAPKs, including ERK, JNK and p38, were suppressed by the ADSC-T CM. The expressions of pro-inflammatory cytokines such as TGF-β, TNF-α, IL-6, and IL-13 were also suppressed by the CM of ADSC-T. In the Nc/Nga atopic model mice, the CM showed therapeutic effect on DNCB-induced atopic dermatitis. These results indicate that the immortalized ADSC-T maintains the beneficial properties of primary ADSC and could be a versatile cell source for not only research into ADSC but also for production of CM suitable for clinical application.

• Journal of Environmental Health Sciences
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• v.50 no.2
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• pp.157-167
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• 2024

Background: Several previous studies have shown that commuting is a source of stress for undergraduate students. However, few studies have investigated the effect of commuting on academic stress among undergraduate students, and there has been little awareness of the environmental impact of commuting. Objectives: To evaluate the associations between commute type and/or time and academic stress among undergraduate students in South Korea, focusing on environmental sustainability. Methods: We conducted an online survey and obtained information on commute types, commute times, and academic stress from 510 undergraduate students aged ≥19 years. Academic stress was comprised of five sub-categories of stress, and total academic stress ranged from 5 to 25 points. Multiple linear regression analysis was used to analyze the associations between commute type and commute time and academic stress. Furthermore, the students were grouped into 21 categories based on their transportation mode for commuting. CO₂ emission factors per each commuting category were calculated using the transportation type's CO₂ emission data from previous studies. Spearman's correlation analysis was used to confirm the correlation between CO₂ emission factors and total academic stress. Results: Students using home-to-school transportation without transfers (vs. walking) showed a significantly higher total academic stress of 2.19 points (95% CI: 0.58, 3.80). In contrast, students using school-to-home transportation without transfers (vs. walking) showed a significantly lower total academic stress of 1.96 points (95% CI: -3.55, -0.38). Moreover, students using transportation with lower CO₂ emission factors had lower academic stress scores (home-to-school: correlation coefficient = 0.507, p<0.001; school-to-home: correlation coefficient = 0.491, p<0.001). Conclusions: Our findings suggest that both commute type and time are significantly associated with academic stress among South Korean undergraduate students. When students select environmentally-friendly transportation, they may not only improve their mental health but also improve climate resilience.

• Journal of the Korean Society of Marine Environment & Safety
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• v.30 no.2
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• pp.165-175
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• 2024

Hydrogen is being touted as one of the energy sources to combat the climate change crisis. However, hydrogen can leak into enclosed spaces, rise to the ceiling, accumulate, and cause fires and explosions if it encounters an ignition source. In particular, ships that transport hydrogen or use it as a fuel comprise multiple enclosed spaces. Therefore, the dif usion characteristics within these spaces must be understood to ensure the safe use of hydrogen. The purpose of this study is to experimentally determine the diffusion characteristics of helium, which has similar properties to hydrogen, in a closed space on board a ship, and to determine the change in the oxygen concentration along the leakage direction as the air change per hour(ACH) increases to 25, 30, 35, 40, and 45 through CFD simulation. The study, results revealed that the oxygen concentration reduction rate was 2% for leakage in the -z direction and 1% for leakage in the +x and +z directions, and the ventilation time was 15 min 30 s for leakage in the -z direction, 7 min for leakage in the +x direction, and 9 min for leakage in the +z direction, showing that differences existed in the oxygen concentration and ventilation time depending on the leakage direction. In addition, no significant difference was observed in the rate of oxygen concentration reduction and ventilation time in all leakage directions from the ACH of 35 and above in the experimental space. Therefore, because the oxygen concentration and ventilation time were not improved by increasing the ACH, 35 was noted as the optimal ACH in this experimental environment.