• 대한두경부종양학회지
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• 제31권2호
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• pp.58-62
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• 2015

Benign symmetric lipomatosis, also known as Madelung's disease, Launois-Bensaude syndrome and multiple symmetric lipomatosis is a cutaneous condition characterized by extensive symmetric fat deposits in the neck, shoulders, and upper trunk. But symmetrical lipomatosis of the tongue is very rare and characterized by involvement exclusively of the tongue, invasiveness, and absence of encapsulation of the adipose tissue. A 75-year-old man presented with about a year history of painless tongue masses on both lateral border. Bilateral partial glossectomy was performed and subsequently was confirmed as symmetrical lipomatosis pathologically. We report this case with a review of the literatures.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제33권6호
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• pp.690-693
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• 2007

Benign symmetric lipomatosis(BSL) is a lesion characterized by symmetrical and diffuse growth of adipose tissue. It is commonly found in the posterior neck or upper trunk, manifesting itself as an entity known as Madelung disease or Lanoid-Bensaude syndrome. Lipomatosis affecting the tongue is very unusual. The etiology of BSL is unknown, but It can be associated with alcoholism, liver dysfunction, hypothyroidism. Because of its diffuse histologic feature, complete resection of the lesion is often difficult. Seventy one years old male patient, whose chief complaint was multiple nodules of tongue was referred to our department. The lesion was diagnosed histopathologically as BSL and subsequently removed surgically. So we report this rare case of BSL with literature review.

• 대한두개안면성형외과학회지
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• 제21권5호
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• pp.305-308
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• 2020

Madelung's disease (MD) otherwise known as Launois-Bensaude syndrome, multiple symmetrical lipomatosis, or benign symmetric lipomatosis, is a rare disease characterized by abnormal diffuse lipomatosis in proximal upper limbs and neck. Here, we report a rare case of MD. A 66-year-old man presented with massive growth of soft tissues in the cervico-occipital region of more than 2 years duration. Physical examination showed diffuse enlargement of the anterior neck (Madelung's collar) and three huge humps at the posterior neck. Under a diagnosis of MD, lipectomy via a single anterior transverse incision and liposuction were performed. This rare case report may be helpful for assessing patients with abnormal diffuse lipomatosis in the neck and proximal upper limbs.

• Journal of Yeungnam Medical Science
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• 제31권1호
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• pp.48-51
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• 2014

Multiple symmetric lipomatosis (MSL) is a rare disease characterized by symmetrical massive fatty deposits on the face, neck, shoulders, and upper trunk. We report a 74-year-old man who complained of painless subcutaneous nodules on his posterior neck that developed 3 weeks earlier. In a week, variably-sized similar lesions developed on both his shoulders and upper extremities. At the time of his hospital visit, several firm nodules as big as a walnut to a child's fist and with the normal-skin-hue were observed on his posterior neck, both shoulders, upper extremities, and trunk. The histological examination of his upper left arm revealed more mature adipocytes without encapsulation in the subcutaneous tissue. MSL was generally known to occur slowly over months or years. However, this is an unusual case that showed a fast-growing nature.

• Tuberculosis and Respiratory Diseases
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• 제47권1호
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• pp.97-102
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• 1999

다발성대칭성지방종증은 드문 질환이나 그 임상양상이 독특하여 진단이 어렵지는 않으나 증상이 없고 문헌에 잘 소개되지 않아 진단을 하지 못하는 경우가 있을 것으로 생각된다. 또한 다른 대사질환이나 악성종양을 동반하는 경우가 있어서 이에 대한 관심이 필요하며 지방종이 인후나 기관을 누르는 경우 호흡곤란을 유발하기도 하고, 종격동등 심부 조직에 침투하는 경우 예후가 나쁠 수 있다. 국내에서 극히 드문 다발성 대칭성지방종증 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Journal of Chest Surgery
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• 제29권2호
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• pp.244-247
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• 1996

다발성 대칭성 지방종증은 경부, 견갑부, 흉부, 복부 및 서혜부에 대칭적으로 피하지방종을 형성하는 드문 질환으로 최근에는 지각 및 자율신경계의 이상동반이 보고되 기도 하나, 현재까지는 원인이 화실하게 밝혀지지 않고 있다. 본 증례는 기관압박을 동반하는 종격동을 침범한 다발성 대칭성 지방종에 대한 증례이다. 환자는 55세 남자로 호흡곤란과 약 10년전부터 서서히 성장하는 경부, 견갑부, 흉부, 복부 및 서혜부의 종괴를 주소로 내원하였으며, 수십년의 심한 음주력이 있었다. 경부와 기관주위를 포함하는 종격동의 지방종괴는 transverse cervical incision을 통해 제거하였다. 그러나 기관주위의 불완전한 지방종괴의 제거로 인한 기관압박의 완화를 위해 술후 15일만에 재수술을 시행하였다. 술후 환자는 종격동기흥 및 피하기종이 심하여 2일 후 응급기관절개술을 시행받은 후, 영구기관절개술후 퇴원하였다.

• Archives of Plastic Surgery
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• 제34권4호
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• pp.478-484
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• 2007

Purpose: Multiple symmetric lipomatosis (MSL) is a relatively rare disorder characterized by presence of multiple, symmetric, nonencapsulated fat masses in face, neck, shoulder and other areas. There has been only a few cases reported in Korea. The main purpose of this research is to examine the Korean patients to see what kinds of special characteristics occurred due to this disease and to decide the proper treatment.Methods: A total of 16 patients were evaluated retrospectively. 5 patients were treated at our hospital. The other patients were reviewed from literature. We analyzed the biological characters of patients, location of fat deposit, morphologic characters of patients, clinical evidence of neuropathy, associated metabolic disorders and treatment modality.Results: All cases were male patient. The mean age of onset was 47.43 years. All patients were moderate to heavy alcoholics. The most common location of fat deposition was posterior neck and abdomen. In neurologic exam of 9 patients, 5 patients showed muscle weakness, tremor, pain and autonomic nerve dysfunction. In metabolic studies of 9 patients, total cholesterol values were higher in 1 patient. A glucose tolerance test was abnormal in 1 patient. In treatment modality, 14 patients were treated with surgical resection, 1 patient was treated with liposuction and surgical excision, 1 patient was treated only with liposuction. Conclusion: To treat MSL patients successfully, we should concentrate not only on the removal of the fatty tissue but also on neurologic abnormities, metabolic disorders and associated diseases.