• Biomedical Science Letters
• /
• v.19 no.4
• /
• pp.348-352
• /
• 2013

microRNAs (miRNAs) play pivotal roles in controlling cell proliferation and differentiation. miRNA expression in human is becoming recognized as a new molecular mechanism of carcinogenesis. microRNA-34a (miR-34a), a member of the p53 network, was found to be regulated in multiple types of tumor. The purpose of this study was to define roles of miR-34a expression in cervical intraepithelial neoplasia with human papillomavirus infection, and its relationship with p53 protein expression. This study was performed to analyze expression of miR-34a by using qRT-PCR, and to evaluate p53 protein expression by using immunohistochemistry in 40 cases. Down-regulation of miR-34a expression was detected in 27 (67.5%) out of 40 cases and Immunoreactivity for p53 was found in 17 (42.5%) out of 40 cases. Nineteen (82.6%) of the 23 cases with a negative p53 expression showed a down-regulation miR-34a expression, there was a significant associations between miR-34a and p53 protein expression (P=0.04). These results suggest that miRNA-34a expression tend to be reduced depending on the advanced histologic grade, and down-regulation of miR-34a expression might be associated with inactivation of p53 protein expression by human papillomavirus infection.

• Journal of the East Asian Society of Dietary Life
• /
• v.21 no.3
• /
• pp.401-417
• /
• 2011

The purpose of this study was to investigate consumer concerns about hazardous elements on foods and recognition of the roles of government, food producers, and consumers in securing food safety. The data were collected from the 443 adult consumers living in Seoul, Busan, Daegu, Incheon, Kwangju and Daejeon through a self-administered questionnaire. Frequencies, t tests, analysis of variance and Duncan's multiple range tests were conducted using SPSS Windows. The results of the survey were as follows: (1) the respondents were worried about health risks related to hazardous elements on foods, (2) many respondents were more worried about preservatives of imported foods than those of domestic foods, and (3) most respondents mentioned that observance of enforcement regulations by producers was the most important factor for ensuring food safety in the future. These results imply that regulations regarding the safety of imported foods should be increased.

• The Journal of Asian Finance, Economics and Business
• /
• v.7 no.11
• /
• pp.499-506
• /
• 2020

The study examines the influence of individual characteristics, training content, and manager support on the effectiveness of on-the-job (OJT) training in the banking and finance industry. A simple random sampling technique was used to select the samples. Questionnaires were distributed to respondents in order to obtain the data. Using cross-sectional data obtained from 396 respondents in Bank A in Malaysia, the multiple regression results show that self-efficacy, motivation to learn, training content, and manager support have positive influence on OJT training effectiveness. Among all these factors, manager support is very highly correlated with OJT training effectiveness. The findings have given fruitful insight of the crucial roles of OJT training in the respective bank, particularly to bring forward the roles of systematic design and implementation of OJT training. This study is not only expanding knowledge in OJT and training, but offers managers practical insights in developing good OJT training program by considering employees need, capabilities, skills and job requirement. Furthermore, this study also provides a valuable framework in identifying the effectiveness of OJT training program for certain jobs. Further discussion of the research findings and its implications to theoretical knowledge of training and managers are promised at the end of the article.

• Journal of Korean Academy of Nursing Administration
• /
• v.20 no.3
• /
• pp.302-312
• /
• 2014

Purpose: The purpose of this study was to identify the roles of empowerment and emotional intelligence in the relationship between job embeddedness and turnover intension among general hospital nurses. Methods: The sample for this study consisted of 224 nurses from four general hospitals of less than 500 beds located in Seoul and Gyunggi Province. Data were analyzed using frequency, percentage, mean, standard deviation, t-test, ANOVA, Scheff$\acute{e}$ test, Pearson Correlation and Hierarchical Multiple Regression. Results: It was found that: (a) Job embeddedness and emotional intelligence had negative effects on turnover intension; (b) Emotional intelligence moderated the relationship between job embeddedness and turnover intension, but empowerment did not. Conclusion: Findings indicate a need to reduce the degree of turnover by enhancing job embeddedness among general hospital nurses. Further research needs to be done to refine this study.

• Molecules and Cells
• /
• v.37 no.5
• /
• pp.365-371
• /
• 2014

Recent findings, notably on adipokines and adipose tissue inflammation, have revised the concept of adipose tissues being a mere storage depot for body energy. Instead, adipose tissues are emerging as endocrine and immunologically active organs with multiple effects on the regulation of systemic energy homeostasis. Notably, compared with other metabolic organs such as liver and muscle, various inflammatory responses are dynamically regulated in adipose tissues and most of the immune cells in adipose tissues are involved in obesity-mediated metabolic complications, including insulin resistance. Here, we summarize recent findings on the key roles of innate (neutrophils, macrophages, mast cells, eosinophils) and adaptive (regulatory T cells, type 1 helper T cells, CD8 T cells, B cells) immune cells in adipose tissue inflammation and metabolic dysregulation in obesity. In particular, the roles of natural killer T cells, one type of innate lymphocyte, in adipose tissue inflammation will be discussed. Finally, a new role of adipocytes as antigen presenting cells to modulate T cell activity and subsequent adipose tissue inflammation will be proposed.

• Journal of Families and Better Life
• /
• v.20 no.6
• /
• pp.109-120
• /
• 2002

The purpose of this study is to investigate the level of role stress perceived by employed housewives working in sales departments, and further, to devise coping strategies that can help reduce stress resulting from their multiple roles The sample of this study consisted of married women who were working in sales departments, who have at least one child, and who live in the greater Seoul metropolitan area. A total of 343 out of 450 originally distributed questionnaires were used for the analysis in this study. The findings of the study are: 1 The housewives in sales departments felt stress most severely in their role as a mother. Next were the roles as a wife, housewife, daughter, daughter-in-law, and working woman, in that order. 2. It appeared that age and the motive for employment affected the overall level of role stress among housewives. The two variables (age and the motive for employment) explained about 23% of the variance. The younger they were the higher was the level of role stress. Also, if they were working for an economic reason (to support the family), they tended to be more stressed out. The results of this study could be utilized as baseline data for policy-making, consultation, and development of educational programs for housewives working in sales departments, an area that has hardly been explored.

• The Journal of Asian Finance, Economics and Business
• /
• v.6 no.2
• /
• pp.203-212
• /
• 2019

A system Integrator (SI) makes a consortium with multiple providers of hardware and software solutions to sell an information system. The success of information systems (IS) mainly depends on establishing a trustful relationship between SI supplier and client, and delivering high-quality system. However, the determinants of trust and system quality have been investigated mostly from the perspective of s ystem buyers rather than system sellers. This study examines the influence of key variables that SI can handle to improve trust and system quality which finally leads to user satisfaction toward SI. This study adopts resource complementarity, user participation and information sharing as the key variable then builds a research model to explain their relationships to user satisfaction. Respondents are recruited from 251 firms that have built any information system in recent two years in South Korea. Results of partial least square (PLS) modeling analysis show that both resource complementarity and information sharing have positive relationships with trust. Also the relationships between trust, system quality and user satisfaction toward S.I are supported. In addition, the mediating roles of trust and system quality are identified. We discussed some of the key managerial and theoretical implications of the paper and suggested further research directions.

• Journal of the Korean Society for Library and Information Science
• /
• v.53 no.3
• /
• pp.121-141
• /
• 2019

This research analyzed the characteristics of social capital and sharing economy, which are the new paradigm in the development of the entire society. In addition, it identified the social roles of a public library as a mediator that promotes the social benefit by conducting a survey questionnaire. As the results of the analysis through correlation analysis and hierarchical multiple regression analysis, social capital and sharing economy are the co-related societal phenomenon, and public libraries positively effect on the construction of social capital and the participation in sharing economy. From the perspective of the roles of a public library as a mediator between social capital and sharing economy, it was identified that various programs provided by public libraries positively effect on mediating social capital and sharing economy.

• Asia-Pacific Journal of Business
• /
• v.10 no.1
• /
• pp.87-103
• /
• 2019

In December 2017, the Moon Jae-in administration announced a major policy shift away from nuclear and coal, committing itself to the vision of creating a society where renewable sources account for 20% of its electricity generation by 2030. This energy transition involves not just a technical transition from conventional energy sources to renewable energy but also active participation of multiple stakeholders in the energy governance. While energy policy making has long been dominated by the central government in Korea with the aim of managing the supply for rapid industrialization and economic growth, the Moon administration aims to diffuse the central government's authority across various actors in society. Among those actors, this study focuses on the roles that local governments play in energy transition. Despite deepening local autonomy since 1995, Korean local governments have remained policy targets or recipients in the energy policy domain. This article discusses how such a traditional role has evolved under the new administration's energy transition policy and examines what challenges and limitations local governments face in creating a more decentralized energy governance system.

• Molecules and Cells
• /
• v.42 no.7
• /
• pp.523-529
• /
• 2019

mRNA quality is controlled by multiple RNA surveillance machineries to reduce errors during gene expression processes in eukaryotic cells. Nonsense-mediated mRNA decay (NMD) is a well-characterized mechanism that degrades error-containing transcripts during translation. The ATP-dependent RNA helicase up-frameshift 1 (UPF1) is a key player in NMD that is mostly prevalent in the cytoplasm. However, recent studies on UPF1-RNA interaction suggest more comprehensive roles of UPF1 on diverse forms of target transcripts. Here we used subcellular fractionation and immunofluorescence to understand such complex functions of UPF1. We demonstrated that UPF1 can be localized to the nucleus and predominantly associated with the chromatin. Moreover, we showed that UPF1 associates more strongly with the chromatin when the transcription elongation and translation inhibitors were used. These findings suggest a novel role of UPF1 in transcription elongation-coupled RNA machinery in the chromatin, as well as in translation-coupled NMD in the cytoplasm. Thus, we propose that cytoplasmic UPF1-centric RNA surveillance mechanism could be extended further up to the chromatin-associated UPF1 and co-transcriptional RNA surveillance. Our findings could provide the mechanistic insights on extensive regulatory roles of UPF1 for many cellular RNAs.