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The Surgical Release of Dupuytren's Contracture Using Multiple Transverse Incisions

  • Lee, Hyunjic;Eo, Surak;Cho, Sanghun;Jones, Neil F.
    • Archives of Plastic Surgery
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    • 제39권4호
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    • pp.426-430
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    • 2012
  • Dupuytren's contracture is a condition commonly encountered by hand surgeons, although it is rare in the Asian population. Various surgical procedures for Dupuytren's contracture have been reported, and the outcomes vary according to the treatment modalities. We report the treatment results of segmental fasciectomies with multiple transverse incisions for patients with Dupuytren's contracture. The cases of seven patients who underwent multiple segmental fasciectomies with multiple transverse incisions for Dupuytren's contracture from 2006 to 2011 were reviewed retrospectively. Multiple transverse incisions to the severe contracture sites were performed initially, and additional incisions to the metacarpophalangeal (MCP) joints, and the proximal interphalangeal (PIP) joints were performed if necessary. Segmental fasciectomies by removing the fibromatous nodules or cords between the incision lines were performed and the wound margins were approximated. The mean range of motion of the involved MCP joints and PIP joints was fully recovered. During the follow-up periods, there was no evidence of recurrence or progression of disease. Multiple transverse incisions for Dupuytren's contracture are technically challenging, and require a high skill level of hand surgeons. However, we achieved excellent correction of contractures with no associated complications. Therefore, segmental fasciectomies with multiple transverse incisions can be a good treatment option for Dupuytren's contracture.

부유식 다수 풍력 발전기에 작용하는 비대칭 공력 하중의 영향 (Influence of Asymmetric Aerodynamic Loading on Multiple Unit Floating Offshore Wind Turbine)

  • 배윤혁
    • 한국해양공학회지
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    • 제29권3호
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    • pp.255-262
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    • 2015
  • The present study developed a numerical simulation tool for the coupled dynamic analysis of multiple turbines on a single floater (or Multiple Unit Floating Offshore Wind Turbine (MUFOWT)) in the time domain, considering the multiple-turbine aero-blade-tower dynamics and control, mooring dynamics, and platform motions. The numerical tool developed in this study was designed based on and extended from the single-turbine analysis tool FAST to make it suitable for multiple turbines. For the hydrodynamic loadings of floating platform and mooring-line dynamics, the CHARM3D program developed by the authors was incorporated. Thus, the coupled dynamic behavior of a floating base with multiple turbines and mooring lines can be simulated in the time domain. To investigate the effect of asymmetric aerodynamic loading on the global performance and mooring line tensions of the MUFOWT, one turbine failure case with a fully feathered blade pitch angle was simulated and checked. The aerodynamic interference between adjacent turbines, including the wake effect, was not considered in this study to more clearly demonstrate the influence of the asymmetric aerodynamic loading on the MUFOWT. The analysis shows that the unbalanced aerodynamic loading from one turbine in MUFOWT may induce appreciable changes in the performance of the floating platform and mooring system.

소프트웨어 제품라인의 출시 계획을 위한 최적해법 (An Exact Solution Approach for Release Planning of Software Product Lines)

  • 유재욱
    • 산업경영시스템학회지
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    • 제35권2호
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    • pp.57-63
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    • 2012
  • 소프트웨어 개발에 있어서 소프트웨어를 시장에 출시하는 계획을 수립하는 것은 소프트웨어를 이루고 있는 기능들을 구현하는 데 제약이 되는 조건들(기술, 자원, 위험, 예산 등)을 만족하면서 계획된 출시기간에 이들 기능들을 할당하는 일이다. 이와 같이 소프트웨어 출시를 계획하는 것은 소프트웨어 제품라인에 대해서 고려할 때 더욱 복잡해진다. 본 연구에서는 소프트웨어 제품라인에 있어서 소프트웨어 출시 계획을 수립하기 위한 문제를 우선순위 제약하의 다수 0-1 배낭문제로 수리 모형화하고, 이를 풀기 위한 최적해법이 개발된다. 최적해법은 동적 계획법이 주가 되고, 문제의 크기를 줄이기 위하여 휴리스틱과 축소방법이 이용된다.

A Novel Monoclonal Antibody Induces Cancer Cell Apoptosis and Enhances the Activity of Chemotherapeutic Drugs

  • Xu, Heng;Tian, Yan-Na;Dun, Bo-Ying;Liu, Hai-Tao;Dong, Guang-Kuo;Wang, Jin-Hua;Lu, Shang-Su;Chen, Bo;She, Jin-Xiong
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권11호
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    • pp.4423-4428
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    • 2014
  • A novel monoclonal antibody (mAb), known as AC10364, was identified from an antibody library generated by immunization of mice with human carcinoma cells. The mAb recognized proteins in lysates from multiple carcinoma cell lines. Cell cytotoxicity assays showed that AC10364 significantly inhibited cell growth and induced apoptosis in multiple carcinoma cell lines, including Bel/fu, KATO-III and A2780. Compared with mAb AC10364 or chemotherapeutic drugs alone, the combination of mAb AC10364 with chemotherapeutic drugs demonstrated enhanced growth inhibitory effects on carcinoma cells. These results suggest that mAb AC10364 is a promising candidate for cancer therapy.

메탈 노트북 Dual 밴드 WiFi MIMO용 고효율 슬롯안테나 설계 및 구현 (Design and Implementation of High Efficiency Slot Antenna for the Metal Notebook Dual Band WiFi MIMO System)

  • 유영혁;이문희;손태호
    • 전기학회논문지
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    • 제67권10호
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    • pp.1338-1343
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    • 2018
  • MIMO(Multiple Input Multiple Output) slot antenna that operates on the dual WiFi band(2.401~2.495GHz, 5.18~5.825GHz), in this paper, was studied. The basic theory for the slot design is based on the coupling between adjacent slot, and slots are fed by the each microstrip lines. Two slot antennas for the MIMO operation are located on the left and the right side of top of the metal notebook, and grounds between a notebook and two microstrip feeding lines are connected. Measurement of return loss showed under -6dB on entire design band, and isolation was below than -30dB. Radiation efficiency, average gain and peak gain for the left and the right slot were measured in the anechoic chamber, and showed good performances as 57.25%, -2.42dBi, 5.64dBi and 55.35%, -2.61dBi, 6.42dBi for the 2.4GHz band and 55.89%, -2.58dBi, 7.3dBi and 53.79%, -2.8dBi, 7.54dBi for the 5GHz band.

Comprehensive Performance Analysis of Interconnect Variation by Double and Triple Patterning Lithography Processes

  • Kim, Youngmin;Lee, Jaemin;Ryu, Myunghwan
    • JSTS:Journal of Semiconductor Technology and Science
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    • 제14권6호
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    • pp.824-831
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    • 2014
  • In this study, structural variations and overlay errors caused by multiple patterning lithography techniques to print narrow parallel metal interconnects are investigated. Resistance and capacitance parasitic of the six lines of parallel interconnects printed by double patterning lithography (DPL) and triple patterning lithography (TPL) are extracted from a field solver. Wide parameter variations both in DPL and TPL processes are analyzed to determine the impact on signal propagation. Simulations of 10% parameter variations in metal lines show delay variations up to 20% and 30% in DPL and TPL, respectively. Monte Carlo statistical analysis shows that the TPL process results in 21% larger standard variation in delay than the DPL process. Crosstalk simulations are conducted to analyze the dependency on the conditions of the neighboring wires. As expected, opposite signal transitions in the neighboring wires significantly degrade the speed of signal propagation, and the impact becomes larger in the C-worst metals patterned by the TPL process compared to those patterned by the DPL process. As a result, both DPL and TPL result in large variations in parasitic and delay. Therefore, an accurate understanding of variations in the interconnect parameters by multiple patterning lithography and adding proper margins in the circuit designs is necessary.

Fine Structure of Cardiac Sarcomeres in the Black Widow Spider Latrodectus mactans

  • KIM, Hoon;MOON, Myung-Jin
    • Entomological Research
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    • 제48권5호
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    • pp.429-438
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    • 2018
  • Fine structural characteristics of the cardiac muscle and its sarcomere organization in the black widow spider, Latrodectus mactans were examined using transmission electron microscopy. The arrangement of cardiac muscle fibers was quite similar to that of skeletal muscle fibers, but they branched off at the ends and formed multiple connections with adjacent cells. Each cell contained multiple myofibrils and an extensive dyadic sarcotubular system consisting of sarcoplasmic reticulum and T-tubules. Thin and thick myofilaments were highly organized in regular repetitive arrays and formed contractile sarcomeres. Each repeating band unit of the sarcomere had three apparent striations, but the H-zone and M-lines were not prominent. Myofilaments were arranged into distinct sarcomeres defined by adjacent Z-lines with relatively short lengths of $2.0{\mu}m$ to $3.3{\mu}m$. Cross sections of the A-band showed hexagon-like arrangement of thick filaments, but the orbit of thin filaments around each thick filament was different from that seen in other vertebrates. Although each thick filament was surrounded by 12 thin filaments, the filament ratio of thin and thick myofilaments varied from 3:1 to 5:1 because thin filaments were shared by adjacent thick filaments.

고추 풋마름병.역병 복합 저항성 계통육성 (Breeding Lines with Multiple Resistance to both Bacterial Writ and Phytophthora Blight in Pepper(Capsicum annuum L.))

  • 한정혜;김주영;황희숙;김병수
    • Current Research on Agriculture and Life Sciences
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    • 제18권
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    • pp.9-17
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    • 2000
  • 풋마름병과 역병에 복합저항성인 계통을 육성하기 위한 노력으로서 앞서 역병 저항성으로 육성한 계통(16-2-3-2 = 역병 저항성 '칼미초', 19-1-3-7-1-1, 19-2-4-5-3-2 = 역병 저항성 '수비초', 김 등, 1996)과 풋마름병 저항성 계통(KC350 = MC 4, KC353 = PBC631)을 교배하여 육성한 $F_5$$BC_1F_4$, $F_6$$BC_1F_5$ 세대에 대해 1999년과 2000년에 각각 풋마름병과 역병에 대한 복합저항성을 검정하였다. 풋마름병과 역병에 복합 저항성을 보인 개체를 선발하여 다음 세대의 종자를 채종하였다.

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Evolution and Identification of Thermo-Tolerant Hybrids in the Silkworm, Bombyx mori L.

  • Begum, A.Naseema;Rekha, M.;Basavaraja, H.K.;Ahsan, M.M.
    • International Journal of Industrial Entomology and Biomaterials
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    • 제6권2호
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    • pp.171-178
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    • 2003
  • Four thermo-tolerant lines of silkworm, Bombyx mori, (L.) viz., A HT, B HT (Chinese type) and F HT, G HT (Japanese type) were evolved by utilizing the breeding resource material (identified from initial screening at a temperature of 31 ${\pm} 1^{\circ}C$ and relative humidity 85 ${\pm}$ 5%) through conventional breeding. These tolerant lines were crossed with productive breeds and forty four hybrids were evaluated on eight economic traits by the Multiple Trait Evaluation Index Method. Ten hybrids were short-listed based on the average evaluation index value larger than 50 for eight economic traits studied. The identified ten hybrids recorded higher index values (> 50) for most of the traits studied. Single hybrid G ${\times}$ CSR12 indicated average index value larger than 50 for six traits viz., pupation number (58), cocoon weight (67), shell weight (65), average filament length (74), raw silk % (69), reelability % (51) except for shell ratio % (41). The standard deviation of the cocoons in the above hybrid was 8.41 in the hybrid cocoon length and width measurement. However, two selected hybrids viz., A ${\times}$ CSR5 and G ${\times}$ CSR13 recorded average index value larger than 50 for all the traits viz., pupation number (57, 60), cocoon weight (50, 54), shell weight (56, 57), shell ratio percentage (59, 53), average filament length (55, 60), raw silk percentage (63, 67) and reelability percentage (53, 53). The standard deviation of the cocoons in the two selected hybrids viz., A ${\times}$ CSR5 and G ${\times}$ CSR13 was 8.41 and 8.06 respectively in the cocoon length and width measurement.

다중 파라메트릭 변환곡선 기반 선수 선형 변환기법 연구 (Study on Hull Form Variation of Fore Body Based on Multiple Parametric Modification Curves)

  • 박성우;김승현;이인원
    • 대한조선학회논문집
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    • 제59권2호
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    • pp.96-108
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    • 2022
  • In this paper, we propose a systematic hull form variation technique which automatically satisfies the displacement constraint and guarantees a high level of fairness. This method is possible through multiple parameter correction curves. The present method is to improve the hull form variation method based on parametric modification function and consists of two sub-categories: SAC variation and section lines modification. For SAC variation, the utilization of two B-Spline curves satisfying GC1 condition led to the satisfaction of displacement constraint and high level of fairness at the same time. Section lines modification methods involves in using two fuctions: the first is the waterplane modification function combining two cubic splines. the other function is the sectional area modification function consisting of 2nd order polynomial over the DLWL(Design Load Waterline) and 3rd order polynomial below the DLWL, This function enables not only the fundamental U-V section shape variation but also systematically modified section lines. The present method is expected to be more useful in the hull form optimization process using CFD compared to the existing method.