• Journal of the Korean Institute of Telematics and Electronics B
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• v.31B no.4
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• pp.55-61
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• 1994

The multiple valued logic(MVL) circuit with ROM type using current mode CMOS is presented in this paper. This circuit is composed of the multiple valued-to-binary(MV/B) decoder and the selection circuit. The MV/B decoder decodes the single input multiple valued signal to N binary signal, and the selection circuits is composed N$\times$N array of the selecion cells with ROM types. The selection cell is realized with the current mirror circuits and the inhibit circuits. The presented circuit is suitable for designing the circuit of MVL functions with independent variables, and reduces the number of selection cells for designing the circuit of symmetric MVL functions as many as {($N^2$-N)/2}+N. This circuit possess features of simplicity. expansibility for array and regularity, modularity for the wire routing. Also, it is suitable for VLSI implementation.

• IE interfaces
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• v.19 no.1
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• pp.1-8
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• 2006

The mobile communication network has to offer good quality of services (QoS), high capacity, and more coverage at a lower cost. However, with the increase of cellular user, the shortage of capacity due to unbalanced call distribution and lack of QoS are common. This paper deals with dynamic sectorization for efficient resource management to solve load unbalancing among microcells in CDMA (Code Division Multiple Access) microcellular system. Dynamic load balancing can be effected by grouping micro-cells properly and grouping can be developed through a routing mechanism. Therefore, we use ants and their routes to choose the optimum grouping of micro-cells into sectors using Multiple Ant Colony System (MACS)in this paper.

• Journal of the Korean Operations Research and Management Science Society
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• v.31 no.3
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• pp.1-10
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• 2006

In this paper we deal with a cell planning issue arisen in a CDMA based multicast network. In a CDMA based wireless network, a terminal can significantly reduce the bit error rate via the cohesion of data streams from multiple base stations. In this case, multiple base stations have to be operated according to a common time line. The cells whose base stations are operated as such are called soft-combined cells. Therefore, a terminal can take advantage of error rate reduction, if the terminal is in a soft-combined cell and at least one neighboring cell is also soft-combined. However, as soft-combining operation gives heavy burden to the network controller, the limited number of cells can be soft-combined. Our problem us to find a limited number of soft-combined cells such that the benefit of the soft-combining operation is maximized.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.22 no.12
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• pp.1784-1795
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• 1998

Natural convection of low Prandtl number fluids with $Pr{\leq}0.2$ in a narrow horizontal annulus is numerically investigated. For $Pr{\leq}0.2$, hydrodynamic instability induces oscillatory multicellular flows consisting of multiple like-rotating cells. For a fluid with $Pr{\approx}0$, the region in which instability of conduction regime first forms is near the vertical section of annulus, and the multiple cells are distributed uniformly in the lower and upper regions of annulus. As Pr increases, however, the cells are shifted upwards. The like-rotating cells drift downward, as time goes on, and the speed of travel increases with increase of Pr. For a fluid with Pr=0.1, a flow with period-4 solution is observed between chaotic states.

• Korean Journal of Veterinary Research
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• v.46 no.3
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• pp.263-265
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• 2006

A 15-year-old intact female poodle dog was referred to a local animal clinic showing signs of dyspnea. A radiographic examination revealed multiple nodules in the lung. The following day, the animal died and a necropsy examination revealed multiple nodular masses of varying sizes in the lung. Microscopically, the tumor cells were composed of round to polygonal cells resembling adipocytes with little or no collagenous stroma. Most of the cells contained clear cytoplasmic vacuoles with the nucleus at the periphery while the other cells contained varying numbers of smaller vacuoles. The immunohisto-chemical evaluation yielded a positive reaction to S-100 and vimentin. Negative results were obtained for pancytokeratin, smooth muscle actin, desmin, epithelial membrane antigen and CD68. This case was diagnosed as a well-differentiated liposarcoma.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.36 no.9
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• pp.901-905
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• 2012

We present an electroporation and viability monitoring chip for lung cancer cells in a single channel with multiple electric field zones. Previous electroporation chips utilized multiple microchannels or electrodes to form multiple electric fields, thus resulting in complex structures. However, the present chip can generate multiple electric fields in a single stepwise microchannel between a pair of electrodes, thus achieving the analysis of both cell electroporation and viability with a simple structure. We demonstrate that the electric field of 0.4 kV/cm results in a maximum percentage of $51.4{\pm}3.0%$ and $26.6{\pm}0.7%$ of viable and electroporated human lung cancer cells, H23 and A549, respectively. The present chip has potential for use in integrated cell chips for transfection studies.

• Animal cells and systems
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• v.14 no.3
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• pp.155-160
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• 2010

Extracellular signal-regulated kinases 1/2 (ERK1/2) play important roles in a variety of biological processes including cell growth and differentiation. We have previously reported that GAR-3 activates ERK1/2 via phospholipase C and protein kinase C, presumably through pertussis toxin (PTX)-insensitive Gq proteins, in Chinese hamster ovary (CHO) cells. Here we provide evidence that GAR-3 also activates ERK1/2 through PTX-sensitive G proteins, phosphatidylinositol 3-kinase (PI 3-kinase), and Src family kinases in CHO cells. We further show that in human embryonic kidney (HEK293) cells, epidermal growth factor receptor and Ras are required for efficient ERK1/2 activation by GAR-3. Taken together, our data indicate that GAR-3 evokes ERK1/2 activation through multiple signaling pathways in cultured mammalian cells.

• Journal of Microbiology and Biotechnology
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• v.31 no.2
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• pp.197-206
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• 2021

microRNA-361-3p (miR-361-3p) is involved in the carcinogenesis of oral cancer and pancreatic catheter adenocarcinoma, and has anti-carcinogenic effects on non-small cell lung cancer (NSCLC). However, its effect on multiple myeloma (MM) is less reported. Here, we found that upregulating the expression of miR-361-3p inhibited MM cell viability and promoted MM apoptosis. We measured expressions of tumor necrosis factor receptor-associated factor 6 (TRAF6) and miR-361-3p in MM cells and detected the viability, colony formation rate, and apoptosis of MM cells. In addition, we measured expressions of apoptosis-related genes Bcl-2, Bax, and Cleaved caspase-3 (C caspase-3). The binding site between miR-361-3p and TRAF6 was predicted by TargetScan. Our results showed that miR-361-3p was low expressed in the plasma of MM patients and cell lines, while its overexpression inhibited viability and colony formation of MM cells and increased the cell apoptosis. Furthermore, TRAF6, which was predicted to be a target gene of miR-361-3p, was high-expressed in the plasma of patients and cell lines with MM. Rescue experiments demonstrated that the effect of TRAF6 on MM cells was opposite to that of miR-361-3p. Upregulation of miR-361-3p induced apoptosis and inhibited the proliferation of MM cells through targeting TRAF6, suggesting that miR-361-3p might be a potential target for MM therapy.

• Journal of Microbiology and Biotechnology
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• v.31 no.11
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• pp.1559-1567
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• 2021

The root bark of Morus alba L. has cytotoxic activity against several types of cancer cells. However, little is known about its chemopreventive mechanisms and bioactive metabolites. In this study, we showed that M. alba L. root bark extracts (MRBE) suppressed β-catenin response transcription (CRT), which is aberrantly activated in various cancers, by promoting the degradation of β-catenin. In addition, MRBE repressed the expression of the β-catenin/T-cell factor (TCF)-dependent genes, c-myc and cyclin D1, thus inhibiting the proliferation of RPMI-8226 multiple myeloma (MM) cells. MRBE induced apoptosis in MM cells, as evidenced by the increase in the population of annexin VFITC-positive cells and caspase-3/7 activity. We identified ursolic acid in MRBE through LC/mass spectrum (MS) and observed that it also decreased intracellular β-catenin, c-myc, and cyclin D1 levels. Furthermore, it suppressed the proliferation of RPMI-8226 cells by stimulating cell cycle arrest and apoptosis. These findings suggest that MRBE and its active ingredient, ursolic acid, exert antiproliferative activity by promoting the degradation of β-catenin and may have significant chemopreventive potential against MM.

• Communications for Statistical Applications and Methods
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• v.7 no.3
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• pp.687-698
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• 2000

An identification method is proposed in order to detect more than one outlying cells in multi-way contingency tables. The iterative proportional fitting method is applied to get expected values of several suspected outlying cells. Since the proposed method uses minimal sufficient statistics under quasi log-linear models, expected counts of outlying cells could be estimated under any hierarchical log-linear models. This method is an extension of the backwards-stepping method of Simonoff(1988) and requires les iteration to identify outlying cells.