• 대한공업교육학회지
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• 제30권2호
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• pp.123-129
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• 2005

A Rayleigh-Benard problem with non-uniform wall temperatures of the form, $T_L=T_1+{\delta}{\Delta}T{\sin}kx$ and $T_U=T_2-{\delta}{\Delta}{\sin (kx)$, is numerically investigated. In the conduction-dominated regime with small a Rayleigh number, a two-tier structure appears with two counter-rotating rolls stacked on the top of each other. The flow becomes unstable with increase of the Rayleigh number, and multicellular convection occurs above a critical Rayleigh number. The multicellular flows at high Rayleigh numbers consist of approximetely square-shape cells. Four multiple flows and dual flows classified by the number of cells are found at k=0.5 and k=1, respectively.

• 미생물학회지
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• 제25권3호
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• pp.165-172
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• 1987

An expression vector in a mammalian cell was constructed using the origin of replication (OR) and the promoters of SV40. The plasmid pSVOE was constructed by inserting SV40 DNA fragment (1, 118bp) containing SV40 OR and promoters into pBR322-1, and then a multiple cloning sequence was inserted at the immediate downstream of the late promoter of SV40 in the pSVOE vector. The plasmid was named pSVML. As a selection marker, thymidine kinase gene of herpes simplex virus with its promoter was inserted into EcoRI site of pSVML and the recombinant was named pSVML-TKp. To test the expression capacity of foreigen gene inserted at the multiple cloning site of pSVML, the thymidine kinase gene without its own promoter was inserted at the BamHI site of pSVML. The recombinant was named pSVML-TK. These plasmids, pSVML-TKp and pSVML-TK, were transfected into COS cells with calcium phosphate precipitation method. The thymidine kinase activity was significantly increased in both transfected cells.

• Clinical Endoscopy
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• 제55권3호
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• pp.452-457
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• 2022

Colonic diffuse ganglioneuromatosis is an extremely rare disease in which multiple tumors derived from the ganglion cells, nerve fibers, and supporting cells are distributed in the colon. It is generally considered to be a benign neoplastic condition and is occasionally associated with rare hereditary conditions such as neurofibromatosis type I or multiple endocrine neoplasia type 2B. Here, we report a case of a patient in whom colon cancer developed 12 years after the initial diagnosis of colonic diffuse ganglioneuromatosis, which suggests a possible association between colonic diffuse ganglioneuromatosis and colorectal cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2389-2394
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• 2016

Background: Multiple myeloma (MM) is influenced by genetic and micro-environmental changes. Malignant plasma cells produce an abnormal monoclonal immunoglobulin, as well as cytokines, such as IL-10 and IL-6 which stimulate cells of the bone marrow microenvironment (BMM) and cause dysfunction and failure of many organs. B cell activating factor (BAFF), IL6, IL10 are known to influence the growth & survival of the malignant clone. Aim: The objectives of the present study were to investigate the circulating levels of BAFF, IL-10 and IL-6, correlate them with well-known parameters of disease activity in patients with MM, and to detect their impact on the patients' survival. Materials and Methods: This study was conducted on 89 newly diagnosed MM patients and seventy apparently healthy volunteers as a normal control group. BAFF, IL6, IL10 were measured by ELISA for both groups. Survival analysis was performed for all patients. Results: Studied markers were higher in the MM patients compared to the normal control subjects. Patients' survival was improved by high serum BAFF levels. Conclusions: High levels of BAFF were found to improve patients' survival. BAFF and IL-6 can be considered probable diagnostic markers for MM.

• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1351-1355
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• 2016

Background: Multiple myeloma (MM) is influenced by genetic and micro-environmental changes. Malignant plasma cells produce an abnormal monoclonal immunoglobulin, as well as cytokines, such as IL-10 and IL-6 which stimulate cells of the bone marrow microenvironment (BMM) and cause dysfunction and failure of many organs. B cell activating factor (BAFF), IL6 and IL10 are known to influence the growth and survival of malignant clones. Aim: The objectives of the present study were to investigate the circulating levels of BAFF, IL-10 and IL-6, correlate them with well-known parameters of disease activity in patients with MM, and to detect their impact on patients' survival. Materials and Methods: This study was conducted on 89 newly diagnosed MM patients and seventy apparently healthy volunteers as a normal control group. BAFF, IL6, IL10 were measured by ELISA for both groups and survival analysis was performed for all patients. Results: Studied markers were higher in the MM patients compared to the normal control subjects. Patients survival was improved by high serum BAFF levels. Conclusions: High levels of BAFF were found to improve patients' survival. BAFF and IL-6 can be considered probable diagnostic markers for MM.

• Journal of Acupuncture Research
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• 제20권3호
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• pp.1-14
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• 2003

Objective : The aim of the study was to investigate the preventive effect of Acanthopanax senticosus(AS) aqua-acupuncture into Sinsu(BL23) of the multiple low-does strepozotocin(STZ)-induced diabetic rats. Methods : The experimental animals were divided into 4 groups : normal group of rats, control group of multiple low-does STZ-induced diabetic rats, NSAA group with 0.4ml normal saline(NS) aqua-acupunctured subcutaneously into Sinsu in multiple low-does STZ-induced diabetic rats, and ASAA group with 0.4ml of 20% AS aqua-acupunctured subcutaneously into Sinsu in multiple low-does STZ-induced diabetic rats. Each of AS and NS aqua-acupuncture was done subcutaneously into both loci of Sinsu taking turns everyday for 3 weeks. Thereafter the levels of serum glucose, body weight, index of kidney hypertrophy, urine glucose, urinary albumin excretion, creatinine clearance, mesangial cell and TGF-${\beta}1$ expression in glomeruli and tubular cells were measured on the determined day. Conclusions : 1. Both ASAA and NSAA groups decreased the serum glucose levels in multiple low-dose STZ-induced diabetic rats as compared to the cintrol group, and ASAA group showed more significant decreases than NSAA group. 2. Both ASAA and NSAA groups prevented the development of diabetes in multiple low-dose STZ-induced diabetic rats as compared to the control group, and ASAA group prevented more markedly the development of diabetes than NSAA group. 3. Both ASAA and NSAA groups prevented the reduction of body weight in multiple low-dose STZ-induced diabetic rats as compared to the control group, and ASAA group showed the same as the normal group. 4. Both ASAA and NSAA groups did not show any changes of the creatinine clearance in multiple low-does STZ-induced diabetic rats. 5. Both ASAA and NSAA groups prevented the excretion of urinary glucose and albumin in multiple low-dose STZ-induced diabetic rats as compared to the cintrol group, and ASAA group showed more significant prevention than NSAA group. 6. Both ASAA and NSAA groups prevented the expansion of glomerular cells and the protein expression of transforming growth factor-${\beta}1$ in multiple low-dose STZ-induced diabetic rats as compared to the cintrol group, and ASAA group prevented more significantly than NSAA group.

• 전력전자학회논문지
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• 제9권2호
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• pp.187-193
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• 2004

PDA, 스마트폰, USP 및 전기자동차와 같은 전기적 장치의 전력공급을 위하여 배터리가 직렬로 연결된 다중 셀을 만들어 일반적으로 사용한다. 이 경우 개별 셀 전압의 편차가 발생되면 배터리의 수명과 용량은 낮아지게 된다. 셀에서 전압의 안정화상태를 유지하기 위한 셀 전압을 안정화시키는 효율적인 방범은 없어서는 안 될 중요한 사항이다. 본 논문에서는 휴대형 가전기기에 적용하기 위해 마이크로컨트롤러를 사용한 다중 셀용 밸런싱 회로의 설계에 대하여 제안한다. 밸런싱 시스템은 충전되는 주기 동안 밸런싱 동작을 이행하며 마이크로컨트롤러로서 제어된다. 제안된 방법은 충전기와 레코드를 사용하여 실험을 통해 증명하였다. 실험결과에서 개별 배터리의 용량, 수령, 성능이 향상됨을 보여준다.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제14권4호
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• pp.431-435
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• 2008

기존의 CDP(Congestion Driven Placement) 기법[1]은 배선 밀집도에 크게 기여하는 넷에 속한 모든 셀들을 옮길 때 가능한 방향을 모두 고려하기 때문에 CPU 시간을 많이 소모한다. 본 논문에선 배선 밀집도를 완화하기 위한 빠른 배치 기법, 즉 ICDGP(Improved Congestion Driven Global Placement)라 불리는 개선된 기법을 제안한다. ICDGP는 밀집된 지역에 있는 넷에 속한 셀들의 이동 목표 지점을 정하기 위해 force-directed 기법을 사용하며, 각 셀은 이동 목표 지점으로만 옮기는 것을 고려한다. ICDGP는 또한 셀을 하나씩 옮기는 것보다 다수의 셀을 동시에 같이 옳기는 것이 낫다고 판단되면 같이 옮긴다. 실험 결과에 의하면 CDP보다 ICDGP가 배선 밀집도 면에서 좋은 배치를 생성한다. 특히 CPU 시간은 평균 36% 개선되었다.

• Journal of Plant Biotechnology
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• 제37권1호
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• pp.57-66
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• 2010

Programmed cell death systems are important for an active type of cell deaths. Among them, a type of programmed cell death, autophagy is activated in cancer cells in response to multiple stresses and has been demonstrated to promote tumor cell survival and drug resistance. Thus, in the area of cancer, over the time frame form around the 1940s to date, of the 155 small molecules, 73% are other than "synthetic", with 47% actually being either "natural products" or "directly derived therefrom". Autophagy has multiple physiological functions in multicellular organisms, including protein degradation and organelle turnover. Genes and proteins that constitute the basic machinery of the autophagic process were first identified in the yeast system and some of their mammalian orthologues have been characterized as well. Numerous oncogenes, including Akt1, Bcl-2, NF1, PDPK1, class I PI3K, PTEN, and Ras and oncosuppressors, inculuding Bec-1, Bif-1, DAPK-1, p53 and UVRAG suppress or promote the autophagy pathway. Regulation of autophagy in tumors is governed by similar principles of the normal cells, only in a much more complicated manner, given the frequently observed abnormal PI3K activation in cancer and the multitude of interactions between the PI3K/AKT/mTOR pathway and other cell signaling cascades, often also deregulated in tumor cells. Autophagy induction by some anticancer agents underlines the potential utility of its induction as a new cancer treatment modality of development for natural medicines.

• 전력전자학회논문지
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• 제26권6호
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• pp.390-396
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• 2021

Lithium-ion batteries have been designed and used as battery packs with series and parallel combinations that are suitable for use. However, due to its internal electrochemical properties, producing the battery's condition at the same value is impossible for individual cells. In addition, the management of characteristic deviations between individual cells is essential for the safe and efficient use of batteries as aging progresses with the use of batteries. In this work, we propose a method to manage deviation properties and detect abnormal behavior in the configuration of a combined battery pack of these multiple battery cells. The proposed method can separate and detect probabilistic low-frequency information according to statistical information based on Z-score. The verification of the proposed algorithm was validated using experimental results from 10S3P battery packs, and the implemented algorithm based on Z-score was validated as a way to effectively manage multiple individual cell information.