• Journal of Pharmaceutical Investigation
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• v.35 no.6
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• pp.453-460
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• 2005

4-Aminopyridine (AP) is a potassium channel blocker used in the treatment of neurological disorders such as multiple sclerosis and Alzheimer disease. AP‘s window of therapeutic effect appears to correlate with its plasma halflife (3.5 hours). It demonstrates pH-dependent solubility because of a weakly basic drug. In addition, the resulting release from conventional matrix tablets decreases with increasing pH-milieu of the gastrointestinal tract. The aim of this study is to design sustained release matrix tablet containing AP, overcoming this problem. $Eudragit^{\circledR}$ L 100 (EuL) and sodium alginate were used in an effort to achieve pH independent drug release. The effect of sodium alginate and EuL on drug release from matrix tablet was investigated. The drug release behavior from the different tablets was analyzed by $t_{20%},\;t_{40%},\;t_{60%}$, The exponential diffusion coefficient n, kinetic constant K were calculated according to the Korsmeyer-Peppas equation. The drug release from matrix tablets prepared with sodium alginate was decreased with increasing the content of sodium alginate in pH 7.4 while there is no significant difference in pH 1.2. The exponent n values were determined to be approximately 0.5 and 0.8 respectively, in both pH 1.2 and 7.4. These values indicate diffusion-based anomalous mechanism and erosion-based anomalous mechanism, respectively. The drug release from sodium alginate matrix tablets prepared with solid dispersion of EuL containing drug showed a slow drug release in an acidic medium and a more fast drug release in phosphate medium, compared with sodium alginate matrix tablets prepared with physical mixture. These results may be attributed to the gel forming ability of sodium alginate and pH dependent solubility of EuL. Therefore, sustained-release AP matrix tablets using sodium alginate and EuL were successfully prepared.

• Journal of Computing Science and Engineering
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• v.6 no.3
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• pp.179-192
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• 2012

This paper presents novel statistical algorithms for protecting the iTrust information retrieval network against malicious attacks. In iTrust, metadata describing documents, and requests containing keywords, are randomly distributed to multiple participating nodes. The nodes that receive the requests try to match the keywords in the requests with the metadata they hold. If a node finds a match, the matching node returns the URL of the associated information to the requesting node. The requesting node then uses the URL to retrieve the information from the source node. The novel detection algorithm determines empirically the probabilities of the specific number of matches based on the number of responses that the requesting node receives. It also calculates the analytical probabilities of the specific numbers of matches. It compares the observed and the analytical probabilities to estimate the proportion of subverted or non-operational nodes in the iTrust network using a window-based method and the chi-squared statistic. If the detection algorithm determines that some of the nodes in the iTrust network are subverted or non-operational, then the novel defensive adaptation algorithm increases the number of nodes to which the requests are distributed to maintain the same probability of a match when some of the nodes are subverted or non-operational as compared to when all of the nodes are operational. Experimental results substantiate the effectiveness of the detection and defensive adaptation algorithms for protecting the iTrust information retrieval network against malicious attacks.

• Journal of KIISE:Computing Practices and Letters
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• v.13 no.2
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• pp.110-118
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• 2007

Due to the development of high speed Internet, a number of Internet users connect online to access web sites. However, there are several procedures required, before you actually find what you were looking for. These procedures are necessary to access Internet services you need, but it is somewhat inconvenient to users. The virtual portal system suggested in this paper is designed to solve such inconvenience. The virtual portal system described in this paper perceives personal computers as web service providing sites, so that it enables users to define customized services by themselves. Also, it makes an exclusive browser as a multiple browser window and provides features to navigate web sites. Therefore, this paper suggests methods for building a pesonalized virtual portal system, where users are able to access web services more conveniently.

• Journal of Advanced Navigation Technology
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• v.15 no.6
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• pp.1132-1137
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• 2011

In this paper, we propose Modified Multi CAMShift Algorithm(Modified Multi Continuously Adaptive Mean Shift Algorithm) that extracts skin color area and tracks several human body parts for real-time human tracking system. Skin color area is extracted by filtering input image in predefined RGB value range. These areas are initial search windows of hands and face for tracking. Gaussian background model prevents search window expending because it restricts skin color area. Also when occluding between these areas, we give more weights in occlusion area and move mass center of target area in color probability distribution image. As result, the proposed algorithm performs better than the original CAMShift approach in multiple object tracking and even when occluding of objects with similar colors.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 1999.05a
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• pp.420-424
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• 1999

In this paper, an optical switching circuit and several types of all-optical transmitter/receiver circuits which are configured with photodiodes, multiple quantum-well(MQW) optical modulators, and field-effect transistors(FETs) were simulated using PSPICE and their results of these are examined and discussed. 20 $\mu\textrm{m}$ ${\times}$ 20 $\mu\textrm{m}$ of window size was used for the optical modulators and 100 $\mu\textrm{m}$ wide FETs with the transconductance value of 55 mS/mm were used for the simulations. Simulation results clearly show that in order for the high speed operation of the all-optical circuits, the size of each device should be minimized to reduce the parasitic capacitance, the circuits should be designed to operate at the wavelength where the resposivity of photodiodes becomes the maximum peak, and the use of short, high-intensity input optical signal beams is very advantageous.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.7B
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• pp.667-674
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• 2004

The performance of transmission control protocol (TCP) is largely dependent upon its loss recovery. Therefore, it is a very important issue whether the packet losses may be recovered without retransmission timeout (RTO) or not. Although TCP SACK can recover multiple packet losses in a window, it cannot avoid RTO if a retransmitted packet is lost again. In order to alleviate this problem, we propose a simple change to TCP SACK, which is called TCP SACK+ in simple. We use a stochastic model to evaluate the performance of TCP SACK+, and compare it with TCP SACK. Numerical results evaluated by simulations show that SACK+ can improve the loss recovery of TCP SACK significantly in presence of random losses.

• The Journal of the Acoustical Society of Korea
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• v.14 no.1
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• pp.31-39
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• 1995

In this paper, we have constructed phoneme discriminant filters [PDF] according to the linear discriminant function. These discriminant filters do not follow the heuristic rules by the experts but the mathematical methods in iterative learning. Proposed system. is based on the piecewise linear classifier and error correction learning method. The segmentation of speech and the classification of phoneme are carried out simutaneously by the PDF. Because each of them operates independently, some speech intervals may have multiple outputs. Therefore, we introduce the unified coefficients by the output unification process. But sometimes the output has a region which shows no response, or insensitive. So we propose time windows and median filters to remove such problems. We have trained this system with the 549 monosyllables uttered 3 times by 3 male speakers. After we detect the endpoint of speech signal using threshold value and zero crossing rate, the vowels and consonants are separated by the PDF, and then selected phoneme passes through the following PDF. Finally this system unifies the outputs for competitive region or insensitive area using time window and median filter.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.7 no.6
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• pp.1194-1201
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• 2003

Measurements of network traffic have shown that self-similarity is a ubiquitous phenomenon spanning across diverse network environments. We have advance the framework of multiple time scale congestion control and show its effectiveness at enhancing performance for fast TCP prototype control. In this paper, we extend the fast TCP prototype control framework to window-based congestion control, in particular, TCP. This is performed by interfacing TCP with a large time scale control module which adjusts the aggressiveness of bandwidth consumption behavior exhibited by TCP as a function of "large time scale" network state. i.e., conformation that exceeds the horizon of the feedback loop as determined by RTT. Performance evaluation of fast TCP prototype is facilitated by a simulation bench-mark environment which is based on physical modeling of self-similar traffic. We explicate out methodology for discerning and evaluating the impact of changes in transport protocols in the protocol stack under self-similar traffic conditions. We discuss issues arising in comparative performance evaluation under heavy-tailed workload. workload.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.18 no.1
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• pp.15-21
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• 2018

Per-packet scheduling is more suitable than per-flow scheduling to reduce the flow completion time by efficiently utilizing resources in data center networks. Recently, many per-packet scheduling schemes utilizing multiple paths have been proposed. However, to mitigate the negative effect of packet reordering on TCP performance, most of the schemes require supplemental measures such as putting packets in order at the lower layer. In this study, we investigate how well DCTCP, which is a representative TCP for data center networks, performs with per-packet scheduling through simulation. Simulation results show that DCTCP keeps the queue length short but that DCTCP shows low fairness due to the way of reducing the congestion window by ECN.

• Journal of the Korean Institute of Telematics and Electronics S
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• v.36S no.6
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• pp.1-8
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• 1999

Multi-carrier CDMA is a transmission scheme where data symbols are spread in the frequency domain with a spread code then transmitted using multiple carriers. It is robust against narrowband interference because of its long symbol duration. However, due to large sidebands of the rectangular window frequency response, subchannels spectrally overlap with neighboring subchannels, which leads to substantial intercarrier interference in a dispersive channel. In this paper, we consider a mult-carrier CDMA system where subchannel spectral containment is achiveved by M-band cosine modulated filter bank (CMFB). In CMFB based MC-CDMA, subchannel spectral containment is achieved using the filter bank of longer impulse response than that of conventional discrete Fourier transform (DFT) filter bank. We show that spectral containment feature of the CMFB based fading channel is analyzed using computer simulations.