• 한국측량학회:학술대회논문집
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• 한국측량학회 2003년도 춘계학술발표회 논문집
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• pp.81-92
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• 2003

웹 기반 GPS 자료처리 시스템의 프로토콜을 개발 하였다. 다양한 사용자가 획득한 GPS 자료를 웹을 통하여 전송하고 또한 결과를 전송 받을 수 있도록 하였으며, 특히 이기종(different operating system)의 클라이언트를 보유하는 다수의 사용자들의 GPS 자료를 수신 받아 사용자가 원하는 자료 처리 컴포넌트로 자료를 처리하여 결과를 사용자에게 전송하는 전형적인 ASP (Application Service Provider) 시스템으로 구성되었다. 또한 새로운 알고리즘의 업그레이드가 용이하도록 하였으며, 비 동기 방식의 자료 처리로 인하여 효과적인 다중 접속의 운용과 높은 사용자의 유연성을 구현하였다. 효율적인 GPS 자료의 관리 및 운용을 위한 데이터베이스 컴포넌트도 함께 개발 되어 향후 상시 관측소등의 자료를 활용할 수 있도록 하였다. 현재 자료처리 모듈은 코드를 이용한 절대 및 상대측위가 완성되었으며, 향후 사용자 자료의 질적조정, 반송파를 이용한 자료 처리 등의 다양한 자료처리 모듈이 포함될 예정이다.

• Bulletin of the Korean Chemical Society
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• 제33권1호
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• pp.177-182
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• 2012

A new composition of standardized Scutellariae Radix extract (HPO12) was developed for treatment of Alzheimer's disease. For the preclinical pharmacokinetic study of HPO12, a rapid, sensitive, and selective LCMS/MS method was developed and validated for the simultaneous determination of 4 bioactive compounds, baicalein, baicalin, wogonin, and wogonoside. After extraction with ethylacetate, chromatographic analysis was performed on a Thermo $C_{18}$ column ($150mm{\times}2.1mm$, $3{\mu}m$) with a mobile phase consisting of 0.1% formic acid (A) and 0.1% formic acid in 95% acetonitrile (B) by using gradient elution at a flow rate of $250{\mu}L/min$. Analytes introduced to a mass spectrometer were monitored by multiple reaction monitoring (MRM) in positive ion mode. Using $25{\mu}L$ of plasma sample, the method was validated over the following concentration ranges: 25-5000 ng/mL for baicalein, 20-40000 ng/mL for baicalin, 1-1000 ng/mL for wogonin, and 5-10000 ng/mL for wogonoside. The intra- and inter-day precision and accuracy of the quality control samples at the 4 concentrations showed $\leq$ 13.7% relative standard deviation (RSD) and 86.6-105.5% accuracy. The method was successfully applied to determine the concentrations of baicalein, baicalin, wogonin, and wogonoside in rat plasma after intraperitoneal and oral administrations of HPO12.

• Transactions on Electrical and Electronic Materials
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• 제3권1호
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• pp.30-37
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• 2002

A focusing grating coupler (FGC) was not fabricated by the 'Continuous Path Control'writing strategy but by an electron-beam lithography system of more general exposure mode, which matches not only the address grid with the grating period but also an integer multiple of the address grid resolution (5 nm). To more simplify the fabrication, we are able to reduce a process step without large decrease of pattern quality by excluding a conducting material or layer such as metal (Al, Cr, Au), which are deposited on top or bottom of an e-beam resist to prevent charge build-up during e-beam exposure. A grating pitch period and an aperture feature size of the FGC designed and fabricated by e-beam lithography and reactive ion etching were ranged over 384.3 nm to 448.2 nm, and 0.5 $\times$ 0.5 mm$^2$area, respectively. This fabrication method presented will reduce processing time and improve the grating quality by means of a consideration of the address grid resolution, grating direction, pitch size and shapes when exposing. Here our investigations concentrate on the design and efficient fabrication results of the FGC for coupling from slab waveguide to a spot in free space.

• 정보과학회 컴퓨팅의 실제 논문지
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• 제21권7호
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• pp.458-463
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• 2015

최근 스트리밍 이용자는 자신이 처한 채널 상황에 따라 적응적으로 가장 적당한 비디오율(video rate)을 선택적으로 요청하여 서비스 받는 ABR(Adaptive Bitrate) 기법을 주로 이용하고 있다. 결과, 대부분의 ABR 비디오율 적응 기법 관련 연구는 채널 상황에 따른 실시간 비트율 적응에만 초점을 맞춘 나머지 모바일 기기의 배터리 의존성에 따른 에너지 제한적 특성을 놓치고 있다. 이는 모바일 장치의 중요한 특성을 고려하지 않은 것으로, 이에 따른 많은 에너지 소모는 궁극적으로 스트리밍 서비스 불만족의 원인이 될 수 있다. 본 논문에서는 ABR 적응 기법의 최신 연구인 버퍼 기반 비트율 적응 방법에 모바일 장치의 배터리 제한적 특성을 고려하여, 기존의 최신 연구와 동일한 성능을 내면서도 불필요하게 소모 되는 에너지를 절약하는 기법을 제안한다. 에너지 소비를 줄이기 위해 버퍼에 스트리밍이 충분히 있으면 에너지 전원을 끄고 (off), 버퍼에 스트리밍이 충분히 있지 않은 경우 에너지 효율적 Prefetching통해 동적 적응 비디오 스트리밍을 서비스한다. 성능평가 결과, 세계 평균 모바일 다운로드 속도에서 기존 기법에 비해 에너지 소비율이 60%절약됨을 보였다.

• Mass Spectrometry Letters
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• 제8권2호
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• pp.23-28
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• 2017

Arctigenin is the main active ingredient of Fructus Arctii, which has been reported with a variety of therapeutic activities including anti-cancer, anti-inflammation, anti-virus, and anti-obesity effects. In this study, a simple and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of arctigenin in rat plasma. The assay utilized a simple protein precipitation with methanol and the mobile phase consisted of 100% methanol and water containing 0.1% formic acid (65:35 v/v). Arctigenin and the internal standard (psoralen) were monitored using a positive electrospray turbo ionspray mode with multiple reaction monitoring transitions of m/z $373.2{\rightarrow}136.9$ and m/z $187.2{\rightarrow}130.9$, respectively, and total chromatographic run time was within 5 min. The lower limit of quantification (LLOQ) of arctigenin was 5 ng/mL in the rat plasma. The intra- and inter-day accuracy of arctigenin at LLOQ and matrix-matched quality control samples ranged 97.4 - 104.8% and 97.2 - 102.0%, respectively. The intra-day precision was within 4.80% and the inter-day precision was within 5.92%. Application of the present method was demonstrated through a pharmacokinetic study after intravenous and oral administration of arctigenin in male Sprague Dawley rats.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제16권2호
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• pp.445-466
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• 2022

As everything linking to the internet, people can subscribe to various services from a service provider to facilitate their lives through the Internet of Things (IoT). An obligatory thing for the service provider is that they should push the service data safely and timely to multiple IoT terminal devices regularly after the IoT devices accomplishing the service subscription. In order to control the service message received by the legal devices as while as keep the confidentiality of the data, the public key encryption algorithm is utilized. While the existing public encryption algorithms for push service are too complicated for IoT devices, and almost of the current subscription schemes based on push mode are relying on centralized organization which may suffer from centralized entity corruption or single point of failure. To address these issues, we design a secure subscription-push service scheme based on blockchain and edge computing in this article, which is decentralized with secure architecture for the subscription and push of service. Furthermore, inspired by broadcast encryption and multicast encryption, a new encryption algorithm is designed to manage the permissions of IoT devices together with smart contract, and to protect the confidentiality of push messages, which is suitable for IoT devices. The edge computing nodes, in the new system architecture, maintain the blockchain to ensure the impartiality and traceability of service subscriptions and push messages, meanwhile undertake some calculations for IoT devices with limited computing power. The legalities of subscription services are guaranteed by verifying subscription tags on the smart contract. Lastly, the analysis indicates that the scheme is reliable, and the proposed encryption algorithm is safe and efficient.

• Journal of Ginseng Research
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• 제46권2호
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• pp.290-295
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• 2022

Background: Dried and red ginseng are well-known types of processed ginseng and are widely used as healthy food. The dried and red ginseng quality may vary with the storage period of raw ginseng. Therefore, herein, the effect of the storage period of fresh ginseng on processed ginseng quality was evaluated through multicomponent quantification with statistical analysis. Methods: A method based on ultrahigh performance liquid chromatography coupled to triple quadrupole mass spectrometry in multiple-reaction monitoring mode (UPLC-MRM-MS) was developed for quantitation of ginsenosides and oligosaccharides in dried and red ginseng. Principal component analysis and partial least squares discriminant analysis were conducted to evaluate the dynamic distributions of ginsenosides and oligosaccharides after different storage periods. Results: Eighteen PPD, PPT and OLE ginsenosides and nine reducing and nonreducing oligosaccharides were identified and quantified. With storage period extension, the ginsenoside content in the processed ginseng increased slightly in the first 2 weeks and decreased gradually in the following 9 weeks. The content of reducing oligosaccharides decreased continuously as storage time extending, while that of the nonreducing oligosaccharides increased. Chemical conversions occurred during storage, based on which potential chemical markers for the storage period evaluation of fresh ginseng were screened. Conclusion: According to ginsenoside and oligosaccharide distributions, it was found that the optimal storage period was 2 weeks and that the storage period of fresh ginseng should not exceed 4 weeks at 0 ℃. This study provides deep insights into the quality control of processed ginseng and comprehensive factors for storage of raw ginseng.

• 한국항공우주학회지
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• 제50권8호
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• pp.541-550
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• 2022

IMM 필터 및 GLRT 기법을 이용하여 무인기용 엔진의 효과적인 실시간 결함 진단 방안을 도출하였다. 이를 위해서 엔진 동적 사이클해석으로부터 선형 진단 모델을 유도하고 잔차 추정을 위한 칼만필터를 도입한 후 각 기법의 특성을 고찰하여 엔진 제어 구동기 및 센서의 결함 진단에 적용하였다. 이 과정에서 IMM 필터로부터 효과적인 FDI 방안을 도출하였고 구동기 결함으로 인한 상태변수의 반응값을 추정하였으며, GLRT로부터는 구동기 및 센서의 결함값 추정과 FDI 기능을 확인하였다. 수치 모의시험 결과를 통해서 FDI를 위한 IMM 필터의 효용성과 각 결함 모드의 결함값 추정을 위한 GLRT 기법의 효용성을 확인하였다.

• 응용통계연구
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• 제21권1호
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• pp.81-94
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• 2008

전달불균형 검정법(transmission and disequilibrium test)과 같은 가계중심(family-based) 검정법들은 질병 관련 유전자를 찾는 데 매우 유용한 방법으로 알려져 있다. 사례-대조군 연구와 달리 가계중심 검정법들은 집단혼합(population admixture)으로 인한 영향을 받지 않기 때문에 질병 관련 유전자와 표지자(marker) 사이의 집단 혼합으로 인한 가짜 연관성(spurious association)에 노출될 위험이 없다. 가계중심 검정법들은 대체로 표지자에 대한 부모의 유전자형(genotype) 정보를 필요로 한다. 그러나 고령층에서 발병하는 질병의 경우에는 발단자(proband) 부모의 유전자형을 구할 수 없는 상황에 종종 마주치게 된다. 본 논문에서는 이런 어려움을 극복하기 위해 부모의 유전자형 대신 질병에 노출되지 않은 발단자 형제나 자매의 유전자형을 이용한 검정법을 제안하고자 한다. 이를 위해 먼저 가능한 모든 일배체형(haplotype)에 대해 Mantel-Haenszel 형태의 통계량을 정의하고 그것에 기초한두 가지 검정통계량을 제안하였다. 모의실험 결과, 제안한 검정법은 집단 혼합으로부터 로버스트하고 유전 양식(mode of inheritance)에 관계 없이 상대위험(relative risk)이 증가함에 따라 단조적으로 증가하는 검정력을 갖는 것으로 나타났다. 제안한 검정법을 연세대학교 심혈관계질환 유전체연구센터로부터 수집한 자료에 적용하고 그 결과를 고찰하였다.

• Journal of Pharmaceutical Investigation
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• 제39권1호
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• pp.65-71
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• 2009

The aim of the present study was to evaluate the bioequivalence of two domperidone maleate tablets, Motilium-$M^{(R)}$ Tablet (Janssen Korea Ltd., reference product) and $Toriem^{(R)}$ Tablet (Daewon Pharm. Co., Ltd., test product). Domperidone was extracted by liquid-liquid extraction using tert-butyl methyl ether and separated in less than 3 min on $C_{18}$ reverse-phase column using an isocratic elution. A tandem mass spectrometer, as detector, was used for quantitative analysis in positive mode by a multiple reaction monitoring mode to monitor the m/z $426.1{\rightarrow}119.1$ and the m/z $837.4{\rightarrow}158.2$ transitions for domperidone and the internal standard (roxithromycin), respectively. Calibration curves, from $0.05{\sim}50$ ng/mL of domperidone, showed correlation coefficients (r) higher than 0.9941. Intra day and inter day precision (C.V. %) for quality control were ranged from 10.04 to 16.09% and from 10.87 to 18.69%, respectively. The lower limit of quantification (LLOQ) of domperidone was 0.05 ng/mL. The method described is precise and sensitive and has been successfully applied to the study of bioequivalence of domperidone in 24 healthy Korean volunteers. Twenty-four healthy male Korean volunteers received a single dose of each medicine ($2{\times}12.72\;mg$ domperidone maleate) in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of domperidone were monitored for over a period of 24 hr after the administration. $AUC_{0-t}$ (the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. The 90% confidence intervals for the log transformed data were within acceptable range of log 0.8 to log 1.25 (e.g., $log\;0.92{\sim}log\;1.05$ for $AUC_{0-t}$, $log\;0.81{\sim}log\;1.05$ for $C_{max}$). The major parameters, $AUC_{0-t}$ and $C_{max}$ met the criteria of KFDA for bioequivalence indicating that $Toriem^{(R)}$ tablet is bioequivalent to Motilium-$M^{(R)}$ tablet.