• 대한수학회논문집
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• 제32권1호
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• pp.29-38
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• 2017

The main objective of this paper is to establish certain unified integral formula involving the product of the generalized Mittag-Leffler type function $E^{({\gamma}_j),(l_j)}_{({\rho}_j),{\lambda}}[z_1,{\ldots},z_r]$ and the Srivastava's polynomials $S^m_n[x]$. We also show how the main result here is general by demonstrating some interesting special cases.

• IMMUNE NETWORK
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• 제3권1호
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• pp.61-68
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• 2003

Background: Fibroblast functions both as a structural element and as a vital immunoregulatory cell. Fibroblasts regulate inflammation through governing of chemokine expression. In order to elucidate the mechanisms by which the expressions of chemokines were regulated, the co-stimulatory effects of Th1 and proinflammatory cytokines were compared using nasal mucosal fibroblasts. Methods: Human nasal mucosa was obtained from surgery for septal deviation and the growth of fibroblasts was established. Fibroblasts from 4th to 6th passage were stimulated with various combinations of cytokines. To inhibit selected signaling pathways, fibroblasts were pretreated with cyclosporin A, wortmannin, staurosporine, and dexamethasone prior to the stimulation with cytokines. The supernatants were collected and chemokines were detected with a sandwich enzyme-linked immunosorbent assay. Results: $TNF-{\alpha}/IFN-{\gamma}$-induced production of RANTES was inhibited by all inhibitors used. MCP-1 was produced constitutively and $TNF-{\alpha}$-induced or $TNF-{\alpha}/IFN-{\gamma}$-induced production of MCP-1 was not inhibited by cyclosporin A or wortmannin, but by stauroporine or dexamethasone. All inhibitors used in this experiment inhibited $TNF-{\alpha}/IFN-{\gamma}$-induced or $IL-1{\beta}/IFN-{\gamma}$-induced production of MCP-2 in nasal mucosal fibroblasts. Although staurosporine or dexamethasone showed strong inhibitory effects, cyclosporin A or wortmannin did not inhibit the production of MCP-3 by $IL-1{\beta}/IFN-{\gamma}$ treatment. Conclusion: Chemokines were strongly induced by stimulation of cytokines in combination and showed different pattern of inhibition by the inhibitors. Therefore, it was assumed that cytokines acted on multiple pathways or on unknown pathways which converged to gene-specific transcription factors.

• 대한수학회논문집
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• 제28권2호
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• pp.297-301
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• 2013

When certain general single or multiple hypergeometric functions were introduced, their reduction formulas have naturally been investigated. Here, in this paper, we aim at presenting a very interesting reduction formula for the Srivastava's triple hypergeometric function $F^{(3)}[x,y,z]$ by applying the so-called Beta integral method to the Henrici's triple product formula for hypergeometric series.

• BMB Reports
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• 제34권5호
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• pp.484-488
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• 2001

STATs are proteins with a dual function: signal transducers in the cytoplasm and transcriptional activators in the nucleus. Among the six known major STATs (STAT1-6), STAT3 has been implicated in the widest range of signaling pathways that regulate cell growth and differentiation. As a part of our on-going investigation on the pleiotropic functions of STAT proteins, we examined the role of STAT3 as a molecular adaptor that links diverse cell growth signaling pathways. We observed that STAT3 can be specifically activated by multiple cytokines, such as IL-3, in transformed fibroblasts and IL-4 or IFN-$\gamma$ in primary immune cells, respectively. The selective activation of STAT3 in H-ras-transformed NIH3T3 cells is associated with an increased expression of phosphoserioe STAT3 in these cells, compared to the parental cells. Notably phosphoresine-STAT3 interacts with oncogenic ras, shown by immunoprecipitation and Western blots. The results suggest the role of STAT3 in rasinduced cellular transformation as a molecular adaptor linking the Jak/STAT and Ras/MAPK pathways. In primary immune cells, IL-4 and IFN-$\gamma$ each induced (in addition to the characteristic STAT6 and STAT1 homodimers) the formation of STAT3-containing complexes that bind to GAS probes, which correspond to the $Fe{\varepsilon}$ Rll and $Fe{\gamma}$ RI promoter sequences, respectively. Since IL-4 and IFN-$\gamma$ are known to counter-regulate the expression of these genes, the ability of STAT3 to form heterodimeric complexes with STAT6 or STAT1 implies its role in the fine-tuned control of genes that are regulated by IL-4 and IFN-$\gamma$.

• 한국전자파학회논문지
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• 제26권11호
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• pp.966-977
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• 2015

본 논문에서는 새로운 변형된 동축 공동 공진기를 제안하고, 대역통과 여파기를 설계한다. 제안된 공진기는 하나의 캐비티 내부에 ${\Gamma}$-형 또는 곡선형의 4개의 접지된 도체 포스트로 구성되어 있다. 일반 동축 공동 공진기 여파기와 달리 도체 벽이 없기 때문에 공간 효율이 개선되어 품질계수가 약 15 % 이상 향상되며, 동일한 품질계수 대비 35 % 이상의 크기 소형화가 가능하다. 또한, 인접하지 않은 공진기와 입출력 교차결합을 통해 4개의 조절 가능한 전송영점이 생성되어 차단대역의 감쇄특성을 향상시킬 수 있다. 제안된 여파기와 설계법은 모의실험과 제작 및 측정을 통해 검증되었다.

• Biomolecules & Therapeutics
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• 제23권5호
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• pp.421-427
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• 2015

Imperatorin has been known to exert many biological functions including anti-inflammatory activity. In this study, we investigated the inhibitory effects of imperatorin on the production of inflammatory mediators in mouse bone marrow-derived mast cells (BMMC). Imperatorin inhibited degranulation and the generation of eicosanoids (leukotriene $C_4$ ($LTC_4$) and prostaglandin $D_2$ ($PGD_2$) in IgE/antigen (Ag)-stimulated BMMC. To elucidate the molecular mechanism involved in this process, we investigated the effect of imperatorin on intracellular signaling in BMMC. Biochemical analyses of the IgE/Ag-mediated signaling pathway demonstrated that imperatorin dramatically attenuated degranulation and the production of 5-lipoxygenase-dependent $LTC_4$ and cyclooxygenase-2-dependent $PGD_2$ through the inhibition of intracellular calcium influx/phospholipase $C{\gamma}1$, cytosolic phospholipase $A_2$/mitogen-activated protein kinases and/or nuclear factor-${\kappa}B$ pathways in BMMC. These results suggest that the effects of imperatorin on inhibition of degranulation and eicosanoid generation through the suppression of multiple steps of IgE/Ag-mediated signaling pathways would be beneficial for the prevention of allergic inflammation.

• 한국직업건강간호학회지
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• 제22권4호
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• pp.324-333
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• 2013

Purpose: This study was conducted to compare the changes in the levels of liver enzymes after providing health education to workers. Methods: Among 909 electronics-manufacturing workers, 96 (10.6%) workers had abnormal liver functions. Of these, male workers were randomly assigned into either the health education experimental group (48 [52.2%]) or the control group (44 [47.8%]). Depending on the level of participation in the health education, workers in the experimental group were classified into the participation (32 [34.8%]) and non-participation groups (16 [17.4%]). Changes in the levels of liver enzymes were compared among three groups. Results: The changes in the levels of gamma-glutamyltransferase (r-GTP) in the participation, non-participation, and control groups were $-25.3{\pm}54.5$ IU/L, $-4.4{\pm}24.1$ IU/L, and $-5.3{\pm}38.8$ IU/L, respectively (p=.036). Aspartate transaminase, alanine transaminase, waist circumference, body mass index, daily alcohol consumption, weekly exercise, and changes in smoking habits in the 3 groups did not differ significantly. In the multiple linear regression analysis, the variable of education participation revealed a significant regression coefficient of -25.10 when the change in r-GTP levels was the dependent variable. Conclusion: A brief health education targeted towards the management of liver disease among workers improved r-GTP levels.

• 셀메드
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• 제8권2호
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• pp.6.1-6.7
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• 2018

Myristica fragrans Houtt is commonly known as "nutmeg", it produces two spices: mace and nutmeg. Mace and nutmeg are strongly aromatic in nature and known as jowzabuwa and javetri/bisbasah respectively in the Unani system of medicine. M. fragrans was used as early as 700 BCE by Indian, however, ancient Greeks and Romans were not aware of it. Later Arab traders introduce M. fragrans into Europe followed by Portuguese and Dutch merchants. Mace is very useful medicine in the Unani system of medicine because of its therapeutic uses in salasal al-bawl (urinary incontinence), amrad-i-qalb (cardiac diseases), amrad-i-dimagh (central nervous system), zo'fe bah (sexual debility), amrad al-rahim (uterine diseases), and su-i-hazim (indigestion). The most important constituents of mace essential oil are ${\alpha}-pinene$, sabinene, myrcene, limonene, 1,8-cineole, terpinen-4-ol, myristicin, ${\gamma}-terpinene$, and safrole. The seed and mace extract of nutmeg contain quite high tannins, flavonoids, and terpenoids. Mace has pharmacological functions such as antibacterial and antifungal, anti-inflammatory, analgesic, antidiarrhea, antioxidant, chemoprotective, neuropharmacologic, and antidiabetic properties. To explore the correlation between the traditional uses and the same proven by recent researches, a comprehensive review is highlighted in this paper. Further, pharmacological activities which are not reported in classical texts are also discussed.

• 대한한방소아과학회지
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• 제21권2호
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• pp.1-12
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• 2007

Objectives : Allergic children have known to have multiple behavior problems. Among them, attentional ability disorder is one of the most common problems. This study is to examine relationship between learning ability and allergic rhinitis by analyzing EEG status of children. Methods : We analyzed cognitive functions of two different children groups; 21 children with allergic rhinitis and 19 normal children with CANS 3000(Central & Autonomic Nervous System, LAXTHA Inc., Korea), cognitive functions assessment program by EEG. Results : 1. According to mean active EEG rhythm of Theta, Alpha, SMR, M-beta, there were no significant difference between allergic rhinitis and the normal group. 2. According to mean active EEG rhythm of right H-beta, Gamma wave allergic rhinitis group's value was significantly higher than that of the normal group. 3. According to mean cognitive strength, response, concentration, left / right brain activity and learning ability score, there were no significant difference between allergic rhinitis and the normal group. 4. According to mean workload score, allergic rhinitis group's value was significantly higher than that of the normal group. Conclusions : It is likely that allergic rhinitis group, which showed relatively high frequency EEG rhythm, is more fragile to stress and less active on mental processing. Along side with physical examination, psychological assessment should also be conjugated on treating children with allergic rhinitis.

• 자원환경지질
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• 제36권3호
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• pp.243-255
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• 2003

유용광물자원탐사나 산사태 취약성 분석과 같은 지질학적 응용을 목적으로 GIS를 이용하여 다양한 지질자료를 통합하기 위한 수학적 모델이 개발되어 왔다. 여러 공간통합 방법 중에서 불확실한 정보를 효율적으로 다룰 수 있는 것으로 알려진 퍼지 이론을 이용한 지질정보의 통합에 대해서 논의하였다. 그동안 전문가의 의견에 의존하여 지질자료를 표현하는 목표 유도형 통합방법과 달리, 통합 목표와 지질자료 사이의 통계적 관계를 이용하는 자료 유도형 통합 방법을 제안하였다. 제안된 기법은 퍼지 소속함수로의 표현, 퍼지 연산자를 이용한 결합, 비퍼지화, 검증의 4단계로 구성된다. 자료 표현에는 우도비에 기반한 퍼지 소속함수를, 퍼지 소속함수들의 결합에는 퍼지 연산자 네트웍을, 통합결과의 상대적인 가능성값을 도시하기 위해 비퍼지화 단계를 각각 제안하였다. 최종적으로 통합 목표에 대한 의미있는 해석과 다양한 퍼지 연산자 네트웍의 정량적 비교를 위해 공간 분할에 기반한 검증 과정을 제안하였다. 지질학적 응용을 목적으로 제안한 방법론의 적용가능성, 실제 적용시의 제안점을 산사태 취약성 분석 적용연구를 통해 논의하였다. 적용연구 결과, 대상지역에서 산사태에 대한 취약한 지역을 구분하는데 제안기법이 효과적으로 이용될 수 있음을 확인할 수 있었으며, 검증을 통해 최종 퍼지 소속함수의 결합에 ${\gamma}$연산자를 사용한 경우가 최대, 최소 연산자를 사용한 경우에 비해 높은 예측능력을 나타내었다.