• 한국문헌정보학회지
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• 제44권4호
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• pp.353-371
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• 2010

도서관 불안은 문헌정보학에서 이용자의 정서적 부분에 관한 대표적 연구로 인정 받아왔으며, 많은 도서관 이용자들이 정보이용 과정에서 도서관 불안을 경험하고 있으며 도서관 불안이 정보 활용에 제한요소로 작용하고 있음이 밝혀져 왔다. 오늘날 정보기술의 발전으로 가장 용이하게 접근할 수 있는 디지털도서관 환경은 전통적 도서관의 그것과 매우 달라졌음에도 불구하고 디지털도서관 불안에 관한 연구는 이루어지고 있지 않았다. 이에 본 연구에서는 통계적으로 신뢰성과 타당성을 인정받는 디지털도서관 불안척도(DLAS)를 개발함으로써 디지털도서관 불안의 개념과 하위영역 등을 파악하고 그 특성을 살펴보았다. DLAS는 탐색적 요인분석을 통해 정서적 문제, 자원, 이용지식, 보안, 언어, 기술적 문제, 과제 등 7개의 하위영역과 39문항으로 개발되었으며, 이 7개의 영역은 전체 디지털도서관불안의 51.165%를 설명하고 있는 것으로 분석되었다. 또한, 인구통계학적 변수와 이용 특성 변수를 사용하여 T검증과 분산분석을 실시함으로써 디지털도서관 불안의 특성을 살펴보고, 일반적 변인과 영향요인을 예측하였다.

• 한국의류학회지
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• 제23권1호
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• pp.78-89
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• 1999

Clothes enhance visual images through the interaction between space and background of the wearer. The influence of background is important as that of the clothes when the observer understands the images. We look at fashion pictures used as important as that various backgrounds are presented depending on the image of the clothes. The clothing the model wears in the pictures takes on shape and space which supports the clothes. The background interact to from the whole image. The background has an important influence on the delivery of image for the clothes. However when the clothes are presented in the background there are some cases that all or parts of clothes can be shown. We must consider the composition ratio of the clothes and background which influences the whole image of the clothing. These interactions and influences on the whole image in regards to clothing background and the ratio will be the focus of this study. clothing was Modern Mannish Casual, Feminine, Ground was decided artificial setting 1 natural setting 1, indoor setting 1, artificial setting 2, natural setting 2, indoor setting 2, Percentage of Clothing was 80% , 140%, 200%,. Thus visual stimulus were 72 pictures that were combined Clothing Ground and Percentage of Clothing, the main survey of questionary consisted of their evaluation of the Picture image combined Clothing and Ground by 30 semantic differential bi-polar scales and the subjects were 50 students majoring in clothing and textile. The data analyzed by factor analysis MCA, MDS, The major finding were as follows : 1) As a result of factor analysis, 5 factors -Attractiveness Hardness and softness Cuteness Attention Cool and Warm factor were found out as constructing factors the Picture image combined Clothing and Ground 2) According to multidimensional positioning map were presented in a stimulus position the perceptive image differed in degree of similarity as a ground construction of stimulus in spite of same clothing image. It will aid in choosing the most beneficial background for any clothing brand. It will enhance the picture images to their full potential in any advertising medium.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3543-3549
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• 2015

Background: Bladder cancer is one of the most common cancers worldwide. Gene expression profiling using microarray technologies improves the understanding of cancer biology. The aim of this study was to determine the gene expression profile in Egyptian bladder cancer patients. Materials and Methods: Samples from 29 human bladder cancers and adjacent non-neoplastic tissues were analyzed by cDNA microarray, with hierarchical clustering and multidimensional analysis. Results: Five hundred and sixteen genes were differentially expressed of which SOS1, HDAC2, PLXNC1, GTSE1, ULK2, IRS2, ABCA12, TOP3A, HES1, and SRP68 genes were involved in 33 different pathways. The most frequently detected genes were: SOS1 in 20 different pathways; HDAC2 in 5 different pathways; IRS2 in 3 different pathways. There were 388 down-regulated genes. PLCB2 was involved in 11 different pathways, MDM2 in 9 pathways, FZD4 in 5 pathways, p15 and FGF12 in 4 pathways, POLE2 in 3 pathways, and MCM4 and POLR2E in 2 pathways. Thirty genes showed significant differences between transitional cell cancer (TCC) and squamous cell cancer (SCC) samples. Unsupervised cluster analysis of DNA microarray data revealed a clear distinction between low and high grade tumors. In addition 26 genes showed significant differences between low and high tumor stages, including fragile histidine triad, Ras and sialyltransferase 8 (alpha) and 16 showed significant differences between low and high tumor grades, like methionine adenosyl transferase II, beta. Conclusions: The present study identified some genes, that can be used as molecular biomarkers or target genes in Egyptian bladder cancer patients.

• Asian Pacific Journal of Cancer Prevention
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• 제16권3호
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• pp.1063-1067
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• 2015

Background: Tumor associated fatigue (TAF) or cancer related fatigue (CRF) is not a new concept. Nonetheless, no real headway has been made in the quantitative analysis of its successful treatment via cognitive behavioral therapy. Since 20 to 30% of all breast cancer patients suffer from anxiety and/or depression within the first year of their diagnosis, this issue needs to be addressed and a standard treatment protocol has to be developed. This study focused on developing a simple, reproducible and short (8 weeks) protocol for the cognitive behavioral therapy support of tumor associated fatigue patients. Materials and Methods: Between the year 2011 and 2012, 23 breast cancer patients fulfilled the diagnosis TAF requirements and were introduced into this study. Our method focused on a psycho-oncological support group using a predetermined, highly structured and reproducible, cognitive behavioral therapy treatment manual. Eight weekly, 90 minute sessions were conducted and patients were evaluated before and after this eight session block. Tumor fatigue specific questionnaires such as the multidimensional fatigue inventory (MFI) as well as the hospital anxiety and depression scale (HADS) were used in order to quantitatively evaluate patient TAF. Results: Of the 23 patients enrolled in the study, only 7 patients fulfilled the TAF diagnostic criteria after the psycho-oncological group treatment. This represents a 70% reduction in diagnosable tumor associated fatigue. The HADS analysis showed a 33% reduction in patient anxiety as well as a 57% reduction in patient depression levels. The MFI scores showed a significant reduction in 4 of the 5 evaluate categories. With the exception of the "mental fatigue" MFI category all results were statistically significant. Conclusions: This study showed that a highly structured, cognitive behavioral therapy group intervention will produce significant improvements in breast cancer patient tumor associated fatigue levels after only 8 weeks.

• 한국콘텐츠학회논문지
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• 제16권4호
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• pp.195-203
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• 2016

본 연구에서는 커피 전문점 고객들의 구매 의사 결정 메커니즘에 대해 살펴보고자 한다. 고객들의 재구매 의도를 형성하는 주요 선행 요인으로 고객 만족, 인지된 가치, 브랜드 이미지를 고려하였다. 인지된 가치는 다차원 접근법을 바탕으로 실용적 가치, 유희적 가치, 사회적 가치로 구분하여, 각 가치 요인들이 고객들의 구매 의사 결정에 미치는 영향을 살펴보았다. 제안한 연구 모형은 커피 전문점을 자주 방문한 232명의 대학생들을 대상으로 분석하였으며, LISREL을 이용하여 구조방정식 모형을 검증하였다. 연구 분석 결과, 제안한 연구 모형은 재구매 의도 분산의 67%, 고객 만족 분산의 73%를 설명하였다. 고객 만족과 브랜드 이미지는 재구매 의도 형성에 핵심적인 역할을 담당하였다. 그리고 실용적 가치와 유희적 가치는 재구매 의도에 유의한 영향을 미쳤지만, 사회적 가치는 재구매 의도에 부정적인 영향을 미쳤다.

• Ocean and Polar Research
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• 제29권2호
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• pp.123-134
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• 2007

Distribution patterns of sandy bottom macrobenthic communities were studied around the Hupo coastal area. The seasonal surveys were conducted at 15 chosen sites within a depth range of 10 to 50 m along 10 km of the coastline using a Smith-McIntyre grab $(0.05\;m^2)$ in 2005. Overall depth distribution following the direction of the offshore become deeper parallel to the coastline. A total of 319 macrobenthic species were sampled with a mean density of $1,972\;ind./m^2$, and mean biomass was 82.5 wet-weight $g/m^2$. The major individual-dominant species were three polychaetes Spiophanes bombyx ($436\;ind./m^2$), Scoletoma longifolia ($250\;ind./m^2$) and Magelona japonica ($170\;ind./m^2$), and bivalve Adontorhina subquadrata ($73\;ind./m^2$). Cluster analysis and non-metric multidimensional scaling (nMDS) analysis based on Bray-Curtis similarity identified 2 major station groups which corresponded to macrobenthic faunal assemblages and their characteristic species. In addition, environmental conditions were significantly different between station groups. Group I contained mostly 20 and 50 m deep sites and was associated with sandy mud. Group I was characterized by high abundance of S. bombyx, S. longifolia, A. subquadrata. It was divided into two sub-groups (I-I and I-II) in relation to depth. Sub-group I-I was associated with deeper sites than sub-group I-II. Group II included mostly inshore area shallower than 15 m and was associated with coarse and medium sand. Group II was characterized by Lumbrinerides hayashii and Urothoe grimaldii japonica.

• 한국자기공명학회논문지
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• 제20권2호
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• pp.56-60
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• 2016

Adenylate kinase (AK) enzyme which acts as the catalyst of reversible high energy phosphorylation reaction between ATP and AMP which associate with energetic metabolism and nucleic acid synthesis and signal transmission. This enzyme has three distinct domains: Core, AMP binding domain (AMPbd) and Lid domain (LID). The primary role of AMPbd and LID is associated with conformational changes due to flexibility of two domains. Three dimensional structure of human AK1 has not been confirmed and various mutation experiments have been done to determine the active sites. In this study, AK1R138A which is changed arginine[138] of LID domain with alanine[138] was made and conducted with NMR experiments, backbone dynamics analysis and mo-lecular docking dynamic simulation to find the cause of structural change and substrate binding site. Synthetic human muscle type adenylate kinase 1 (hAK1) and its mutant (AK1R138A) were re-combinded with E. coli and expressed in M9 cell. Expressed proteins were purified and finally gained at 0.520 mM hAK1 and 0.252 mM AK1R138A. Multinuclear multidimensional NMR experiments including HNCA, HN(CO)CA, were conducted for amino acid sequence analysis and signal assignments of $^1H-^{15}N$ HSQC spectrum. Our chemical shift perturbation data is shown LID domain residues and around alanine[138] and per-turbation value(0.22ppm) of valine[179] is consid-ered as inter-communication effect with LID domain and the structural change between hAK1 and AK1R138A.

• 품질경영학회지
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• 제45권4호
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• pp.629-648
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• 2017

Purpose: The world faces a great turning point fundamentally rebuilding the future, and human lives, by embracing the 4th industrial revolution era. This paper aims to seek new and various business models in the 4th industrial revolution era, and to examine the evolution of quality management in the changing of the industrial ecosystem. Methods: This paper examines the various strategies of approaching the 4th industrial revolution in Germany, the USA, Japan, China, and Korea. This paper also draws detailed items by classifying the six major items of Malcolm Baldridge into large, medium, and small scale classifications, researches items from the technical perspective by applied fields, and the four major factor perspectives of quality management, as well as analyzes the relevant items in a multidimensional method. After a questionnaire survey targeting 200 quality experts was conducted, the important quality management factors were selected by applying the Analytic Hierarchy Process (AHP) method. Results: The importance of the general criteria was analyzed in the order of customers, MAKM (measurement, analysis, and knowledge management), workforce, strategy, operations, and leadership. As for the importance analysis results of the secondary subcriteria, the following items are highly analyzed: senior leadership, searching business model's innovation opportunity, customer satisfaction improvement, big data utilization, systematic management of workforce, and, planning and design quality. Conclusion: In the era of the Internet of everything, when complexity increases, this study presented a quality management direction suitable for new business methods challenging existing orders by drawing on quality management priorities.

• Journal of Preventive Medicine and Public Health
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• 제43권5호
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• pp.411-422
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• 2010

Objectives: This study aims to investigate the factors related to Korean physicians' trust in the government. Methods: We used structured questionnaires that were composed of multidimensional scales for each of the various categories. Results: The recognition levels of trust of the government by Korean physicians were not high, and they ranged from 3.6 to 4.8 for ten scales. The factors related to trust in the government were categorized into seven factors on the basis of a factor analysis. On the regression analysis, a positive relationship was found between "the individual propensity to trust" and trust in the government, while a negative relationship was found between "the recognition level regarding the government as an authoritarian power" and trust in the government. "Confidence about participation in the policy process" as internal efficacy and "belief in governmental ability and motivation toward public demand" as external efficacy also showed a strong positive relationship with trust in the government. Conclusions: From these results, we can draw the conclusion that making efforts to improve the recognition level of trust in the government among physicians is an important policy task. To increase the trust level, participation of physicians in the policy process in various ways and open communication between the physicians' associations and the government should be facilitated.

• 대한조선학회논문집
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• 제49권6호
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• pp.461-468
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• 2012

In this study, a Cartesian-grid method based on finite volume approach is applied to simulate the ship motions in large amplitude waves. Fractional step method is applied for pressure-velocity coupling and TVD limiter is used to interpolate the cell face value for the discretization of convective term. Water, air, and solid phases are identified by using the concept of volume-fraction function for each phase. In order to capture the interface between air and water, the tangent of hyperbola for interface capturing (THINC) scheme is used with weighed line interface calculation (WLIC) method which considers multidimensional information. The volume fraction of solid body embedded in the Cartesian grid system is calculated using a level-set based algorithm, and the body boundary condition is imposed by a volume weighted formula. Numerical simulations for the two-dimensional barge type model and Wigley hull in linear waves have been carried out to validate the newly developed code. To demonstrate the applicability for highly nonlinear wave-body interactions such as green water on the deck, numerical analysis on the large-amplitude motion of S175 containership is conducted and all computational results are compared with experimental data.