• BMB Reports
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• v.51 no.9
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• pp.450-455
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• 2018

Tamoxifen (TAM) is commonly used to treat estrogen receptor (ER)-positive breast cancer. Despite the remarkable benefits, resistance to TAM presents a serious therapeutic challenge. Since several HOX transcription factors have been proposed as strong candidates in the development of resistance to TAM therapy in breast cancer, we generated an in vitro model of acquired TAM resistance using ER-positive MCF7 breast cancer cells (MCF7-TAMR), and analyzed the expression pattern and epigenetic states of HOX genes. HOXB cluster genes were uniquely up-regulated in MCF7-TAMR cells. Survival analysis of in slico data showed the correlation of high expression of HOXB genes with poor response to TAM in ER-positive breast cancer patients treated with TAM. Gain- and loss-of-function experiments showed that the overexpression of multi HOXB genes in MCF7 renders cancer cells more resistant to TAM, whereas the knockdown restores TAM sensitivity. Furthermore, activation of HOXB genes in MCF7-TAMR was associated with histone modifications, particularly the gain of H3K9ac. These findings imply that the activation of HOXB genes mediate the development of TAM resistance, and represent a target for development of new strategies to prevent or reverse TAM resistance.

• Journal of Technology Innovation
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• v.12 no.2
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• pp.67-97
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• 2004

Practical experience with technology implementation of the upgrading of very small village industries in India suggests that innovation failures are not merely a result of the lack of proper interaction between the users and suppliers of technologies under implementation, but also a result of adoption of the primitive conception of competitiveness in their practice of technology development. The approach of promoting the small producers to become individually competitive by using labour intensive, small-scale intermediate technologies is proving to be totally inadequate for the achievement of technological efficiency in a dynamic sense. Guided by a primitive notion of competitiveness, the suppliers of intermediated technologies are thus being led into limiting their technological efforts in the sectors of direct interest to the rural industrial clusters to the transitional objectives of mainly poverty alleviation. Consequently they have not been able to target the small producers of these village industries for the objectives of business growth. This paper posits that under competitive conditions the self-employed small producer has not only to come together for access to resources, but also has to emerge as a multi-sectoral collective of producers, co-operating in production. With the aim to draw lessons that are generic and have policy implications for the development of innovation systems for local economy based rural industrial clusters and value chains, the author analyses in this paper the experience of innovation in technological systems for the sectors of leather, fruits and vegetable processing and agro processing by the People's Science Movement with the help of the Ministry of Science and Technology and other sectoral ministries in India where rural poor were required to pool the resources and capabilities for raising the scale and scope of their collective production organization.

• Radiation Oncology Journal
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• v.20 no.1
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• pp.68-72
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• 2002

This study was done to implement intensity-modulated radiation therapy (IMRT) for the treatment of primary prostate cancer and to compare this technique with conventional treatment methods. A 72-year-old male patient with prostate cancer stage T2a was treated with IMRT delivered with dynamic multi-leaf collimation. Treatment was designed using an inverse planning algorithm, which accepts dose and dose-volume constraints for targets and normal structures. The IMRT plan was compared with a three-dimensional (3D) plan using the same 6 fields technique. Lower normal tissue doses and improved target coverage were achieved using IMRT at current dose levels, and facilitate dose escalation to further enhance locoregional control and organ movement during radiotherapy is an important issue of IMRT in prostate cancer.

• Korean Institute of Interior Design Journal
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• v.20 no.1
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• pp.117-127
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• 2011

Townhouse have been developed as alternative housing types for combining the characteristics of detached houses and high-rise apartments, Much research on townhouse have investigated physical environments of townhouse and provide a number of planning factors to be considered. However, these factors do not reflect the residents' experiences of the environments sufficiently. The aim of this research is to investigate residents' satisfactions in townhouse as an exploratory study which can be a basis for the improvement of residential environments in townhouse. First of all, we selected a target townhouse and conducted a field study to examine the existing state of the townhouse. Then a customized questionnaire was developed and distributed to residents in the townhouse for investigating their satisfactions on the residential environment. The questions included are divided into four categories; site environment, unit space, community area and housing management. Through the statistic analyses of the residents' responses, the residents' satisfactions of the residential environment were identified. Especially the residents' satisfaction on the community area, which revitalizes neighborhood relationships, is very high. They were also satisfied with the conditions of the sub-categories, 'a distinctive exterior' 'a private planning', 'outdoors' and 'landscapes', in townhouse. In conclusion, we suggested considerations for the improvement of the residential environments and the quality of life in townhouse.

• The KIPS Transactions:PartB
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• v.11B no.1
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• pp.35-44
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• 2004

Web contents created for desktop screens give rise to problems when they are to be displayed on the small screens of mobile terminals. While in some cases some of the objects of a page may not be displayable due to the lack of browser capability, the entire page may not be displayable due to the incompatibility with the browser in other cases. In this paper, we introduce a new mobile content adaptation approach based on web clipping, which transforms an original page into one that is optimally displayed on a mobile terminal. In this method, a source page is automatically clipped and transformed according to the clip specification made by the content provider using a clip editing tool. The clip editing tool allows the user to specify group clips, multi-level cups and dynamic clips as well as simple clips, and the presentation layout through a graphic user interface. Based on the clip specifications, each clip is transformed into an intermediate meta-language document, which in turn is transformed into a presentation page in the target markup language. Transcoding of image objects in major image file formats is also supported.

• The Journal of the Korea Contents Association
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• v.14 no.5
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• pp.8-17
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• 2014

Petascale systems(so called supercomputers) have been mainly used for supporting communication-intensive and tightly-coupled parallel computations based on message passing interfaces such as MPI(HPC: High-Performance Computing). On the other hand, computing paradigms such as High-Throughput Computing(HTC) mainly target compute-intensive (relatively low I/O requirements) applications consisting of many loosely-coupled tasks(there is no communication needed between them). In Korea, recently emerging applications from various scientific fields such as pharmaceutical domain, high-energy physics, and nuclear physics require a very large amount of computing power that cannot be supported by a single type of computing resources. In this paper, we present our HTCaaS(High-Throughput Computing as a Service) which can leverage national distributed computing resources in Korea to support these challenging HTC applications and describe the details of our system architecture, job execution scenario and case studies of various scientific applications.

• Journal of Sensor Science and Technology
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• v.7 no.6
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• pp.418-425
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• 1998

Stereo cameras are the most widely used sensing systems for automated machines including robots to interact with their three-dimensional(3D) working environments. The position of a target point in the 3D world coordinates can be measured by the use of stereo cameras and the camera calibration is an important preliminary step for the task. Existing camera calibration techniques can be classified into two large categories - linear and nonlinear techniques. While linear techniques are simple but somewhat inaccurate, the nonlinear ones require a modeling process to compensate for the lens distortion and a rather complicated procedure to solve the nonlinear equations. In this paper, a method employing a neural network for the calibration problem is described for tackling the problems arisen when existing techniques are applied and the results are reported. Particularly, it is shown experimentally that by utilizing the function approximation capability of multi-layer neural networks trained by the back-propagation(BP) algorithm to learn the error pattern of a linear technique, the measurement accuracy can be simply and efficiently increased.

• Structural Engineering and Mechanics
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• v.56 no.4
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• pp.569-588
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• 2015

A comprehensive methodology is proposed for design of metallic dampers in seismic retrofit of earthquake-damaged frame structures. It is assumed that the metallic dampers remain elastic and only provide stiffness during frequent earthquake (i.e., earthquake with a 63% probability of exceedance in 50-year service period), while in precautionary earthquake (i.e., earthquake with a 10% probability of exceedance in 50-year service period), the metallic dampers yield before the main frame and dissipate most of the seismic energy to either prevent or minimize structural damages. Therefore by converting multi-story frame to an equivalent single-degree-of-freedom system, the added stiffness provided by metallic dampers is designed to control elastic story drifts within code-based demand under frequent earthquake, and the added damping with the combination of added stiffness influences is obtained to control structural stress within performance-based target under precautionary earthquake. With the equivalent added damping ratio, the expected damping forces provided by metallic dampers can be calculated to carry out the configuration and design of metallic dampers along with supporting braces. Based on a detailed example for retrofit of an earthquake-damaged reinforced concrete frame by using metallic dampers, the proposed design procedure is demonstrated to be simple and practical, which can not only meet current China's design codes but also be used in retrofit design of earthquake-damaged frame with metallic damper for reaching desirable performance objective.

• Structural Engineering and Mechanics
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• v.45 no.4
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• pp.543-568
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• 2013

This study explores the floor micro-vibrations induced by the automated guided vehicles (AGVs) in liquid-crystal-display (LCD) factories. The relationships between moving loads and both the vehicle weights and speeds were constructed by a modified Kanai-Tajimi (MKT) power spectral density (PSD) function whose best-fitting parameters were obtained through a regression analysis by using experimental acceleration responses of a small-scale three-span continuous beam model obtained in the laboratory. The AGV induced floor micro-vibrations under various AGV weights and speeds were then assessed by the proposed regressional MKT model. Simulation results indicate that the maximum floor micro-vibrations of the target LCD factory fall within the VC-B and VC-C levels when AGV moves at a lower speed of 1.0 m/s, while they may exceed the acceptable VC-B level when AGV moves at a higher speed of 1.5 m/s. The simulated floor micro-vibration levels are comparable to those of typical LCD factories induced by AGVs moving normally at a speed between 1.0 m/s and 2.0 m/s. Therefore, the numerical algorithm that integrates a simplified sub-structural multi-span continuous beam model and a proposed regressional MKT moving force model can provide a satisfactory prediction of AGV-induced floor micro-vibrations in LCD factories, if proper parameters of the MKT moving force model are adopted.

• Journal of the Korean Society of Hazard Mitigation
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• v.10 no.2
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• pp.111-122
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• 2010

As the Jamsu-bridge and the floodplains of the Han River can be flooded during the rainy season, the exact prediction of the peak flood time is very important for mitigation of flood hazard. This study analyzes the effect of outflow of Paldang Dam and tide of Yellow Sea on the Han River. A target area is from the Paldang dam to Jeonryu gauging station. Water level of Jeonryu as a downstream boundary condition was estimated through multi linear regression analysis with outflow of Paldang dam and tide level of Incheon, because it was influenced by both a tide of Yellow Sea and outflow of Paldang dam. In this study, Water Level Rising Travel Time of the Jamsu-bridge and some floodplains in the Han River are estimated. Also, The second order polynomial expressions for relationships of outflow of Paldang Dam and Water Level Rising Travel Time were developed considering the outflow of Paldang dam and tide of Yellow Sea.