• Korean Journal of Biological Psychiatry
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• v.27 no.1
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• pp.18-26
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• 2020

Objectives The aim was to find effective vectorization and classification models to predict a psychiatric diagnosis from text-based medical records. Methods Electronic medical records (n = 494) of present illness were collected retrospectively in inpatient admission notes with three diagnoses of major depressive disorder, type 1 bipolar disorder, and schizophrenia. Data were split into 400 training data and 94 independent validation data. Data were vectorized by two different models such as term frequency-inverse document frequency (TF-IDF) and Doc2vec. Machine learning models for classification including stochastic gradient descent, logistic regression, support vector classification, and deep learning (DL) were applied to predict three psychiatric diagnoses. Five-fold cross-validation was used to find an effective model. Metrics such as accuracy, precision, recall, and F1-score were measured for comparison between the models. Results Five-fold cross-validation in training data showed DL model with Doc2vec was the most effective model to predict the diagnosis (accuracy = 0.87, F1-score = 0.87). However, these metrics have been reduced in independent test data set with final working DL models (accuracy = 0.79, F1-score = 0.79), while the model of logistic regression and support vector machine with Doc2vec showed slightly better performance (accuracy = 0.80, F1-score = 0.80) than the DL models with Doc2vec and others with TF-IDF. Conclusions The current results suggest that the vectorization may have more impact on the performance of classification than the machine learning model. However, data set had a number of limitations including small sample size, imbalance among the category, and its generalizability. With this regard, the need for research with multi-sites and large samples is suggested to improve the machine learning models.

• Journal of Sasang Constitution and Immune Medicine
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• v.17 no.1
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• pp.67-83
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• 2005

1. Objectives The purpose of this study lies on the objectification of the Sasang Constitutional diagnosis. This study was analyzing the constitutional characteristic of adult men voices by PSSC-2004. 2. Methods The study was conducted on the subjects inputted /a/ 2.5-3 sec of 231 adult men voices to PSSC-2004. The statistical analyses are applied to three groups: total group, under 55 year-old group, over 55 year-old group. The group of total 231 was composed with 5 Taeyangins, 32 Soyangins, 102 Taeumins and 92 Soeumins. The under 55 years old group was composed with 4 Taeyangins, 23 Soyangins, 83 Taeumins and 77 Soeumins. The over 55 year-old group was composed with 1 Taeyangin, 9 Soyangins, 19 Taeumins and 15 Soeumins. 3. Results 1) In total group, the Soeumin's mean value of center pitch(4)$(1,000{\sim}2,000Hz)$ was significantly high compared with the others (P=0.034). 2) In total group, the Soeumin's group 3 APQ was significantly low compared with the others (P=0.042). 3) In under 55 year-old group, the Soeumin's center value of center pitch 4$(1,000{\sim}2,000Hz)$ was significantly high compared with the others (P=0.025) 4) In over 55 year-old group, no statistical significance was found between the Taeyangin, Soyangin, Taeumin and Soeumin. 4. Conclusions In under 55 year-old group, Soeumin's voice showed high pitched sound (clearness) at the low frequency (1000-2000Hz). In over 55 year-old group, there is no significant differences. This fits in with that 'Soeumin's voice is 'Yu-tone' born by 'Shang-tone', very short and high.' 'Yu-tone' corresponds to 'Ra' and witch is highest among Gong, Shang, Gao, Chi and Yu. This is related with the appearance that the Soeumin's voice is weak, thin and high tone. Therefore it is supposed that Soeumin adult men's voices are thick, and there are vibrations of the ending. It is accepted one of the Soeumin's characters like as a mild tremor of limbs and deep breath caused by Soeumin's Qi-deficiency. This outcome accords with the theory that Soeumin's Qi is less than the Other constitutions.

• Korean Journal of Occupational Health Nursing
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• v.14 no.1
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• pp.56-70
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• 2005

Objectives: The purpose of this study is to develop a linking model between industrial injury insurance organs and local organizations providing social welfare health services, for the activation of medical rehabilitation services for industrial injury patients. Method: Research design for this study was a multi-step research through literature review, field research, and group interviews with persons in charge, to compare local society-oriented medical rehabilitation programs. The term of researches Sep.1 ~ Nov. 30, 2004. Results: 1. Home nurses from Workers Accident Medical Corporation have been taken to be adequate to case managers, who link industrial accident insurance institutions to local society services for the activation of medical rehabilitation services for industrial injury patients. They have been chosen for case managers because they have richer understanding and experiences of objects of industrial accidents than any other specialists, and because they have proved to be able to provide direct home services as a specialist. We have established the center for case management affairs within the workers accident general hospital, organized the committee for case management with doctors in charge, doctors in rehabilitation, rehabilitation consultants, social welfare workers, physical therapists, and nurses, determined objects of case managements from those of long-term recuperation, and constructed a course of case management containing from case management plans to evaluation. 2. We have made files of community resources, and organized the council of industrial accident administration to have it in charge of the adjustment and linking of services in case management affairs. 3. Because there are inequality of community resources between areas, differences in experiences in and bases for linking, and disparity of core organizations with active linking in the system of linking between public and civil sectors, we have taken a system of linking between parallel organs to be the core. In our linking model, workers accident general hospital, hospitals designated for industrial injury, and rehabilitation hospitals are linked in parallel, inadequate long-term recuperation managers are trusted to an workers accident medical corporations through examination by the examination committee in Korea Labor Welfare Corporation, and are dealt with by the committee for case management. Of the hospitals designated for industrial accidents, those running a home caring center provide home caring services for the handicapped at home from industrial injury. 4. Workers Accident Medical Corporation take part in medical rehabilitation, and Korea Labor Welfare Corporation in vocational/social rehabilitation. Furthermore, in the model, the latter should construct a system for job opportunities through Internet portals and provide cyber vocational consultation and introduction. Conclusion: Improvement of systems is needed to apply the linking model to practical affairs. Because this model is centered for practical affairs, it should be put under the analysis of effects, and evaluation of its adequacy to practical application, and its effects and efficiency through experimental running in the 8 workers accident general hospital in Korea.

• Korean Journal of Acupuncture
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• v.27 no.2
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• pp.95-105
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• 2010

Objectives : The purpose of this study is to investigate the effect of Bacillus-fermented Scutellariae Radix acupuncture solution (SB) on interleukin(IL) production in mouse macrophage stimulatedby lipopolysaccaride(LPS). Methods : Productions of interleukins were measured y High-throughput Multiplex Bead based Assay with Bio-plex Suspension Array System based on $xMAP^{(R)}$(multi-analyte profiling beads) technology. To begin with, cell culture supernatant was obtained after treatment with LPS(1 ${\mu}g/mL$) and SB for 24 hour. Then, it was incubated with the antibody-conj${\mu}g$ated beads for 30 minutes. And detection antibody was added and incubated for 30 minutes. After incubating for 30 minutes, Strepavidin-conjugated Phycoerythrin(SAPE) was then added. Incubating for another 30 minutes, the level of SAPE fluorescence was analyzed on Bio-plex Suspension Array System. Results : The results of the experiment are as follows. SB significantly inhibited the LPS-induced production of IL-3($9.15{\pm}0.35$ pg/mL) by $6.92{\pm}0.05,\;7.21{\pm}0.11,\;6.96{\pm}0.33,\;and\;7.45{\pm}0.74$ pg/mL at the concentration of 25, 50, 100, and 200 ${\mu}g/mL$ in mouse macrophage RAW 264.7 cells (p<0.05). SB significantly inhibited the LPS-induced production of IL-5($7.30{\pm}0.48$ pg/mL) by $6.50{\pm}0.29,\;6.30{\pm}0.25,\;6.30{\pm}0.25,\;and\;5.80{\pm}0.25$ pg/mL at the concentration of 25, 50 100, and 200 ${\mg}g/mL$ in RAW 264.7 cells (p<0.05). SB significantly inhibited the LPS-induced productiion of IL-9($17.26{\pm}0.19$ pg/mL) by $15.01{\pm}0.43$ pg/mL at the concentration of 25 ${\mu}g/mL$ in RAW 264.7 cells(p<0.05). SB significantly inhibited the LPS-induced productioh of IL-13($187.80{\pm}2.90$ pg/mL) by $152.80{\pm}4.25,\;172.80{\pm}3.97,\;162.10{\pm}6.67,\;and\;165.30{\pm}11.80$ pg/mL at the concentration fo 25, 50, 100, and 200 ${\mu}g/mL$ in RAW 264.7 cells(p<0.05). SB significantly inhibited the LPS-induced production of IL-17($18.30{\pm}0.95$ pg/mL) by $13.30{\pm}1.25,\;13.80{\pm}1.11,\;13.30{\pm}0.75,\;and\;14.00{\pm}1.08$ pg/mL at the concentration of 25, 50 100, and 200 ${\mu}g/mL$ in RAW 264.7 cells(p<0.05). SB significantly inhibited the LPS-induced production of IL-23($43.90{\pm}0.83$ pg/mL by $39.50{\pm}1.26,\;38.00{\pm}1.78,\;and\;39.60{\pm}2.49$ pg/mL at the concentration of 25, 100, and 200 ${\mu}g/mL$ in RAW 264.7 cells(p<0.05). Conclusions : These results suggest that SB has anti-inflammatory activity related with its inhibition of IL-3, IL-5, IL-13, IL-17, and IL-23 production in macrophages.

• Journal of Preventive Medicine and Public Health
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• v.45 no.6
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• pp.394-401
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• 2012

Objectives: Diabetes and obesity each increases mortality, but recent papers have shown that lean Asian persons were at greater risk for mortality than were obese persons. The objective of this study is to determine whether an interaction exists between body mass index (BMI) and diabetes, which can modify the risk of death by cardiovascular disease (CVD). Methods: Subjects who were over 20 years of age, and who had information regarding BMI, past history of diabetes, and fasting blood glucose levels (n=16 048), were selected from the Korea Multi-center Cancer Cohort study participants. By 2008, a total of 1290 participants had died; 251 and 155 had died of CVD and stroke, respectively. The hazard for deaths was calculated with hazard ratio (HR) and 95% confidence interval (95% CI) by Cox proportional hazard model. Results: Compared with the normal population, patients with diabetes were at higher risk for CVD and stroke deaths (HR, 1.84; 95% CI, 1.33 to 2.56; HR, 1.82; 95% CI, 1.20 to 2.76; respectively). Relative to subjects with no diabetes and normal BMI (21 to 22.9 $kg/m^2$), lean subjects with diabetes (BMI <21 $kg/m^2$) had a greater risk for CVD and stroke deaths (HR, 2.83; 95% CI, 1.57 to 5.09; HR, 3.27; 95% CI, 1.58 to 6.76; respectively), while obese subjects with diabetes (BMI ${\geq}25kg/m^2$) had no increased death risk (p-interaction <0.05). This pattern was consistent in sub-populations with no incidence of hypertension. Conclusions: This study suggests that diabetes in lean people is more critical to CVD deaths than it is in obese people.

• Korean Journal of Environmental Biology
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• v.31 no.4
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• pp.419-428
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• 2013

The objectives of this research were to determine ecological characteristics and chemical gradients in two different loach populations-Misgurnus anguillicaudatus ($M_a$) and Koreocobitis rotundicaudata ($K_r$). Eight chemical parameters were compared to test the chemical preferences between the two species. The population of Kr occurred more in better water quality, compared to the $M_a$-population. The $M_a$-population co-occurred more with tolerant species (TS) and omnivores, whereas the $K_r$-population co-occurred more with sensitive species (SS) and insectivores. The differences in the tolerance and trophic composition matched well with the result of stream health assessment, based on the multi-metric model of Index of Biological Integrity (IBI). The IBI value in habitat with the $M_a$-population was "19.6" (range: 8~40) indicating a fair condition, and the IBI values of $K_r$-population was 29.4 (range: 12~40) indicating good condition. Similar results were found in physical habitat health analysis (QHEI). Overall, data analysis showed that the $M_a$-population belong to the tolerant species and $K_r$-population belong to sensitive species in the tolerance classification.

• The Journal of Korean Medical History
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• v.28 no.2
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• pp.37-45
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• 2015

Objectives : A quantitative analysis on the vocabulary in the English translation version of Donguibogam. Methods : This study quantitatively analyzed the English-translated texts of Donguibogam with the Corpus-based analysis, and compared the quantitative results analyzing the texts of original Donguibogam. Results : As the results from conducting the corpus analysis on the English-translation version of Donguibogam, it was found that the number of total words (Token) was about 1,207,376, and the all types of used words were about 20.495 and the TTR (Type/Token Rate) was 1.69. The accumulation rate reaching to the high-ranking 1000 words was 83.54%, and the accumulation rate reaching to the high-ranking 2000 words was 90.82%. As the words having the high-ranking frequency, the function words like 'the, and of, is' mainly appeared, and for the content words, the words like 'randix, qi, rhizoma and water' were appeared in multi frequencies. As the results from comparing them with the corpus analysis results of original version of Donguibogam, it was found that the TTR was higher in the English translation version than that of original version. The compositions of function words and contents words having high-ranking frequencies were similar between the English translation version and the original version of Donguibogam. The both versions were also similar in that their statements in the parts of 'Remedies' and 'Acupuncture' showed higher composition rate of contents words than the rate of function words. Conclusions : The vocabulary in the English translation version of Donguibogam showed that this book was a book keeping the complete form of sentence and an Korean medical book at the same time. Meanwhile, the English translation version of Donguibogam had some problems like the unification of vocabulary due to several translators, and the incomplete delivery of word's meanings from the Chinese character-culture area to the English-culture area, and these problems are considered as the matters to be considered in a work translating Korean old medical books in English.

• Nutrition Research and Practice
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• v.10 no.1
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• pp.56-66
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• 2016

BACKGROUND/OBJECTIVES: Despite successes recorded in combating iodine deficiency, more than 2 billion people are still at risk of iodine deficiency disorders. Rural landlocked and mountainous areas of developing countries are the hardest hit, hence the need to explore and advance novel strategies such as biofortification. SUBJECTS/METHODS: We evaluated adoption, purchase, and consumption of iodine biofortified vegetable legumes (IBVL) using the theory of protection motivations (PMT) integrated with an economic valuation technique. A total of 1,200 participants from three land-locked locations in East Africa were recruited via multi-stage cluster sampling, and data were collected using two, slightly distinct, questionnaires incorporating PMT constructs. The survey also elicited preferences for iodine biofortified foods when offered at a premium or discount. Determinants of protection motivations and preferences for iodine biofortified foods were assessed using path analysis modelling and two-limit Tobit regression, respectively. RESULTS: Knowledge of iodine, iodine-health link, salt iodization, and biofortification was very low, albeit lower at the household level. Iodine and biofortification were not recognized as nutrient and novel approaches, respectively. On the other hand, severity, fear, occupation, knowledge, iodine status, household composition, and self-efficacy predicted the intention to consume biofortified foods at the household level; only vulnerability, self-efficacy, and location were the most crucial elements at the school level. In addition, results demonstrated a positive willingness-to-pay a premium or acceptance of a lesser discount for biofortification. Furthermore, preference towards iodine biofortified foods was a function of protection motivations, severity, vulnerability, fear, response efficacy, response cost, knowledge, iodine status, gender, age. and household head. CONCLUSIONS: Results lend support for prevention of iodine deficiency in unprotected populations through biofortification; however 'threat' appraisal and socio-economic predictors are decisive in designing nutrition interventions and stimulating uptake of biofortification. In principle, the contribution is threefold: 1) Successful application of the integrated model to guide policy formulation; 2) Offer guidance to stakeholders to identify and tap niche markets; 3) stimulation of rural economic growth around school feeding programmes.

• Journal of the Korean Association of Geographic Information Studies
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• v.12 no.3
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• pp.13-20
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• 2009

Techniques for change detection using satellite images enable efficient detection of natural and artificial changes in use of land through multi-phase images. As for change detection, different results are made based on methods of calibration of satellite images, types of input data, and techniques in change analysis. Thus, an analytic technique that is appropriate to objectives of a study shall be applied as results are different based on diverse conditions even when an identical satellite and an identical image are used for change detection. In this study, Normalized Difference Vegetation Index (NDVI) and Principal Component Analysis (PCA) were conducted after geometric calibration of satellite images which went through absolute and relative radiometric calibrations and change detection analysis was conducted using Image Difference (ID) and Image Rationing (IR). As a result, ID-NDVI showed excellent accuracy in change detection related to vegetation. ID-PCA showed 90% of accuracy in all areas. IR-NDVI had 90% of accuracy while it was 70% and below as for paddies and dry fields${\rightarrow}$grassland. IR-PCA had excellent change detection over all areas.

• Journal of health informatics and statistics
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• v.43 no.4
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• pp.245-254
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• 2018

Objectives: This paper examines how serious the appearance concerns of adolescents is in South Korean society by delving into the formation and changes of adolescents' appearance concerns. Methods: We conducted a secondary analysis of the data of multi-year tracing surveys which the National Youth Policy Institute opened to the public. The repeated Measures ANOVA, the paired t-test, and a chi-squared test were applied against the data. Results: It was found that about one out of ten adolescents experienced concerns that began as early as the upper grades of elementary school, reached its peak in middle school, and decreased afterwards. On the other hand, some of them faced enduring appearance concerns and seemed to suffer from it. One interesting finding is that adolescents once relieved from the concerns were free from it permanently. We also found that there were considerable differences between male and female adolescents in terms of the level of concerns they experienced, their peak periods, and other characteristics. Conclusions: Appearance concerns changes dynamically according to development of adolescence. Appearance concerns was less prevalent among adolescents than predicted, and it seemed considerably fluid. Our study not only confirms but also challenges some important findings of previous studies.