• Biomolecules & Therapeutics
• /
• v.27 no.1
• /
• pp.71-77
• /
• 2019

Previous studies have shown that spinosin was implicated in the modulation of sedation and hypnosis, while its effects on learning and memory deficits were rarely reported. The aim of this study is to investigate the effects of spinosin on the improvement of cognitive impairment in model mice with Alzheimer's disease (AD) induced by $A{\beta}_{1-42}$ and determine the underlying mechanism. Spontaneous locomotion assessment and Morris water maze test were performed to investigate the impact of spinosin on behavioral activities, and the pathological changes were assayed by biochemical analyses and histological assay. After 7 days of intracerebroventricular (ICV) administration of spinosin ($100{\mu}g/kg/day$), the cognitive impairment of mice induced by $A{\beta}_{1-42}$ was significantly attenuated. Moreover, spinosin treatment effectively decreased the level of malondialdehyde (MDA) and $A{\beta}_{1-42}$ accumulation in hippocampus. $A{\beta}_{1-42}$ induced alterations in the expression of brain derived neurotrophic factor (BDNF) and B-cell lymphoma-2 (Bcl-2), as well as inflammatory response in brain were also reversed by spinosin treatment. These results indicated that the ameliorating effect of spinosin on cognitive impairment might be mediated through the regulation of oxidative stress, inflammatory process, apoptotic program and neurotrophic factor expression,suggesting that spinosin might be beneficial to treat learning and memory deficits in patients with AD via multi-targets.

• Progress in Medical Physics
• /
• v.31 no.4
• /
• pp.135-144
• /
• 2020

Purpose: Gafchromic films for proton dosimetry are dependent on linear energy transfers (LETs), resulting in dose underestimation for high LETs. Despite efforts to resolve this problem for single-energy beams, there remains a need to do so for multi-energy beams. Here, a bimolecular reaction model was applied to correct the under-response of spread-out Bragg peaks (SOBPs). Methods: For depth-dose measurements, a Gafchromic EBT3 film was positioned in water perpendicular to the ground. The gantry was rotated at 15° to avoid disturbances in the beam path. A set of films was exposed to a uniformly scanned 112-MeV pristine proton beam with six different dose intensities, ranging from 0.373 to 4.865 Gy, at a 2-cm depth. Another set of films was irradiated with SOBPs with maximum energies of 110, 150, and 190 MeV having modulation widths of 5.39, 4.27, and 5.34 cm, respectively. The correction function was obtained using 150.8-MeV SOBP data. The LET of the SOBP was then analytically calculated. Finally, the model was validated for a uniform cubic dose distribution and compared with multilayered ionization chamber data. Results: The dose error in the plateau region was within 4% when normalized with the maximum dose. The discrepancy of the range was <1 mm for all measured energies. The highest errors occurred at 70 MeV owing to the steep gradient with the narrowest Bragg peak. Conclusions: With bimolecular model-based correction, an EBT3 film can be used to accurately verify the depth dose of scanned proton beams and could potentially be used to evaluate the depth-dose distribution for patient plans.

• The Korean Journal of Physiology and Pharmacology
• /
• v.27 no.1
• /
• pp.49-59
• /
• 2023

Metabolic syndrome (MetS) involves multi-factorial conditions linked to an elevated risk of type 2 diabetes mellitus and cardiovascular disease. Pre-metabolic syndrome (pre-MetS) possesses two MetS components but does not meet the MetS diagnostic criteria. Although cardiac autonomic derangements are evident in MetS, there is little information on their status in pre-MetS subjects. In this study, we sought to examine cardiac autonomic functions in pre-MetS and to determine which MetS component is more responsible for impaired cardiac autonomic functions. A total of 182 subjects were recruited and divided into healthy controls (n=89) and pre-MetS subjects (n=93) based on inclusion and exclusion criteria. We performed biochemical profiles on fasting blood samples to detect pre-MetS. Using standardized protocols, we evaluated anthropometric data, body composition, baroreflex sensitivity (BRS), heart rate variability (HRV), and autonomic function tests (AFTs). We further examined these parameters in pre-MetS subjects for each MetS component. Compared to healthy controls, we observed a significant cardiac autonomic dysfunction (CAD) through reduced BRS, lower overall HRV, and altered AFT parameters in pre-MetS subjects, accompanied by markedly varied anthropometric, clinical and biochemical parameters. Furthermore, all examined BRS, HRV, and AFT parameters exhibited an abnormal trend and significant correlation toward hyperglycemia. This study demonstrates CAD in pre-MetS subjects with reduced BRS, lower overall HRV, and altered AFT parameters. Hyperglycemia was considered an independent determinant of alterations in all the examined BRS, HRV, and AFT parameters. Thus, hyperglycemia may contribute to CAD in pre-MetS subjects before progressing to MetS.

• Advances in nano research
• /
• v.15 no.3
• /
• pp.215-224
• /
• 2023

Nonlinearity plays an important role in control systems and the application of design. For this reason, in addition to linear vibrations, nonlinear vibrations of the stepped nanobeam are also discussed in this manuscript. This study investigated the vibrations of stepped nanobeams according to Eringen's nonlocal elasticity theory. Eringen's nonlocal elasticity theory was used to capture the nanoscale effect. The nanoscale stepped Euler Bernoulli beam is considered. The equations of motion representing the motion of the beam are found by Hamilton's principle. The equations were subjected to nondimensionalization to make them independent of the dimensions and physical structure of the material. The equations of motion were found using the multi-time scale method, which is one of the approximate solution methods, perturbation methods. The first section of the series obtained from the perturbation solution represents a linear problem. The linear problem's natural frequencies are found for the simple-simple boundary condition. The second-order part of the perturbation solution is the nonlinear terms and is used as corrections to the linear problem. The system's amplitude and phase modulation equations are found in the results part of the problem. Nonlinear frequency-amplitude, and external frequency-amplitude relationships are discussed. The location of the step, the radius ratios of the steps, and the changes of the small-scale parameter of the theory were investigated and their effects on nonlinear vibrations under simple-simple boundary conditions were observed by making comparisons. The results are presented via tables and graphs. The current beam model can assist in designing and fabricating integrated such as nano-sensors and nano-actuators.

• Journal of The Korean Astronomical Society
• /
• v.56 no.2
• /
• pp.277-286
• /
• 2023

It is difficult to distinguish the pure signal produced by an orbiting planetary companion around giant stars from other possible sources, such as stellar spots, pulsations, or certain activities. Since 2003, we have obtained radial (RV) data from evolved stars using the high-resolution, fiber-fed Bohyunsan Observatory Echelle Spectrograph (BOES) at the Bohyunsan Optical Astronomy Observatory (BOAO). Here, we report the results of RV variations in the binary star HD 135438. We found two significant periods: 494.98 d with eccentricity of 0.23 and 8494.1 d with eccentricity of 0.83. Considering orbital stability, it is impossible to have two companions in such close orbits with high eccentricity. To determine the nature of the changes in the RV variability, we analyzed indicators of stellar spot and stellar chromospheric activity to find that there are no signals related to the significant period of 494.98 d. However, we calculated the upper limits of rotation period of the rotational velocity and found this to be 478-536 d. One possible interpretation is that this may be closely related to the rotational modulation of an orbital inclination at 67-90 degrees. The other signal corresponding to the period of 8494.1 d is probably associated with a stellar companion orbiting the giant star. A Markov Chain Monte Carlo (MCMC) simulation considering a single companion indicates that HD 135438 system hosts a stellar companion with 0.57^+0.017 _-0.017 M_⊙ with an orbital period of 8498 d.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.37 no.4
• /
• pp.400-406
• /
• 2024

Next-generation wide-bandgap semiconductors such as SiC, GaN, and Ga2O3 are being considered as potential replacements for current silicon-based power devices due to their high mobility, larger size, and production of high-quality wafers at a moderate cost. In this study, we investigate the gradual modulation of chemical composition in multi-stacked metal oxide semiconductor thin films to enhance the performance and bias stability of thin-film transistors (TFTs). It demonstrates that adjusting the Ga ratio in the indium gallium oxide (IGO) semiconductor allows for precise control over the threshold voltage and enhances device stability. Moreover, employing multiple deposition techniques addresses the inherent limitations of solution-processed amorphous oxide semiconductor TFTs by mitigating porosity induced by solvent evaporation. It is anticipated that solution-processed indium gallium oxide (IGO) semiconductors, with a Ga ratio exceeding 50%, can be utilized in the production of oxide semiconductors with wide band gaps. These materials hold promise for power electronic applications necessitating high voltage and current capabilities.

• The Journal of the Acoustical Society of Korea
• /
• v.28 no.8
• /
• pp.768-773
• /
• 2009

This paper demonstrates the digital communication in air using the parametric array. The stepped-plate transducer which is suitable for high-power and high-efficient radiation is used to generate the difference frequency wave with the parametric array. The primary frequencies are selected to 83 kHz and 122 kHz and the resulting difference frequency wave at the frequency of 39 kHz is used for the communication. The modulation method is selected to On-Off Keying method. The waveform and signal-to-noise ratio (SNR) is measured and analyzed to see the characteristics of the digital communication using the parametric array. The proper distance for the communication using parametric array is about 3 m. The measured beam width of the 3dB SNR reduction was $14^{\circ}$. The possibility of the communication in air using the parametric array is confirmed and the high directional characteristic of the communication using the parametric array is expected to have the advantages for the multi path and the security problems.

• Korean Journal of Remote Sensing
• /
• v.14 no.3
• /
• pp.213-222
• /
• 1998

Electro-Optical Camera(EOC) is the main payload of the KOrea Multi-Purpose SATellite(KOMPSAT) with the mission of cartography to build up a digital map of Korean territory including a Digital Terrain Elevation Map(DTEM). This instalment which comprises EOC Sensor Assembly and EOC Electronics Assembly produces the panchromatic images of 6.6 m GSD with a swath wider than 17 km by push-broom scanning and spacecraft body pointing in a visible range of wavelength, 510~730 nm. The high resolution panchromatic image is to be collected for 2 minutes during 98 minutes of orbit cycle covering about 800 km along ground track, over the mission lifetime of 3 years with the functions of programmable gain/offset and on-board image data storage. The image of 8 bit digitization, which is collected by a full reflective type F8.3 triplet without obscuration, is to be transmitted to Ground Station at a rate less than 25 Mbps. EOC was elaborated to have the performance which meets or surpasses its requirements of design phase. The spectral response, the modulation transfer function, and the uniformity of all the 2592 pixel of CCD of EOC are illustrated as they were measured for the convenience of end-user. The spectral response was measured with respect to each gain setup of EOC and this is expected to give the capability of generating more accurate panchromatic image to the users of EOC data. The modulation transfer function of EOC was measured as greater than 16 % at Nyquist frequency over the entire field of view, which exceeds its requirement of larger than 10 %. The uniformity that shows the relative response of each pixel of CCD was measured at every pixel of the Focal Plane Array of EOC and is illustrated for the data processing.

• Journal of Advanced Navigation Technology
• /
• v.6 no.1
• /
• pp.44-51
• /
• 2002

This paper describes the performance evaluation and analysis of an Orthogonal Frequency-Division Multiplexing (OFDM) system having the least Inter Symbol Interference (ISI) in a multi-path fading channel environment. Wireless Local Area Network (W-LAN) in accordance with IEEE 802.11a and IEEE 802.11b provides high-speed transmission to universities, businesses and other various places. In addition, service providers can offer a public W-LAN service on restricted areas such as a subway. The proliferation of W-LAN has led to greater W-LAN service demands, but problems are also on the rise in offering a good W-LAN service. In particular, urban areas with high radio wave interference and many buildings are vulnerable to deteriorated QoS including disconnected data and errors. For example, when high-speed data is transmitted in such areas, the relatively high frequency generates ISI between Access Points (AP) and Mobile Terminals (such as a notebook computer), leading to a frequency selective fading channel environment. Consequently, it is difficult to expect a goodW-LAN service. The simulation proves that the OFDM system enables W-LAN to implement QoS in high-speed data transmission in a multi-path fading channel environment. The enhanced OFDM performance with 52 sub-carriers is verified via data modulation methods such as BPSK, QPSK and 16QAM based on IEEE 802.11a and punched convolutional codes with code rate of 1/2 and 3/4 and constraint length of 7. Especially, the simulation finds that the OFDM system has better performance and there is no data disconnection even in a mobile environment by applying a single tap equalizer and a decision feedback equalizer to a mobile channel environment with heavy fading influence. Given the above result, the OFDM system is an ideal solution to guarantee QoS of the W-LAN service in a high-speed mobile environment.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.10
• /
• pp.4353-4358
• /
• 2014

Background: PI3/AKT and NF-kB signaling pathways are constitutively active in acute myeloid leukemia and cross-talk between the two has been shown in various cancers. However, their role in acute myeloid leukemia has not been completely explored. We therefore used cell penetrating inhibitor peptides to define the contributions of AKT and NF-kB to survival and multi drug resistance (MDR) in HL-60 cells. Materials and Methods: Inhibition of AKT and NF-kB activity by AKT inhibitor peptide and NBD inhibitor peptide, respectively, resulted in decreased expression of mRNA for the MDR1 gene as assessed by real time PCR. In addition, treatment of HL-60 cells with AKT and NBD inhibitor peptides led to inhibition of cell viability and induction of apoptosis in a dose dependent manner as detected by flow cytometer. Results: Finally, co-treatment of HL-60 cells with sub-optimal doses of AKT and NBD inhibitor peptides led to synergistic apoptotic responses in AML cells. Conclusions: These data support a strong biological link between NF-kB and PI3-kinase/AKT pathways in the modulation of antiapoptotic and multi drug resistant effects in AML cells. Synergistic targeting of these pathways using NF-kB and PI3-kinase/AK inhibitor peptides may have a therapeutic potential for AML and possibly other malignancies with constitutive activation of these pathways.