• Nuclear Medicine and Molecular Imaging
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• 제42권2호
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• pp.98-111
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• 2008

This review introduces advances in clinical and pre-clinical single photon emission computed tomography (SPECT) and positron emission tomography (PET) providing noninvasive functional images of biological processes. Development of new collimation techniques such as multi-pinhole and slit-slat collimators permits the improvement of system spatial resolution and sensitivity of SPECT. Application specific SPECT systems using smaller and compact solid-state detector have been customized for myocardial perfusion imaging with higher performance. Combined SPECT/CT providing improved diagnostic and functional capabilities has been introduced. Advances in PET and CT instrumentation have been incorporated in the PET/CT design that provide the metabolic information from PET superimposed on the anatomic information from CT. Improvements in the sensitivity of PET have achieved by the fully 3D acquisition with no septa and the extension of axial field-of-view. With the development of faster scintillation crystals and electronics, time-of-flight (TOF) PET is now commercially available allowing the increase in the signal-to-noise ratio by incorporation of TOF information into the PET reconstruction process. Hybrid PET/SPECT/CT systems has become commercially available for molecular imaging in small animal models. The pre-clinical systems have improved spatial resolution using depth-of-interaction measurement and new collimators. The recent works on solid state detector and dual modality nuclear medicine instrumentations incorporating MRI and optical imagers will also be discussed.

• 대한약침학회지
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• 제17권1호
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• pp.20-26
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• 2014

Objectives: The study aimed to determine changes in laboratory data for cancer patients receiving Korean medicine (KM) care, with a focus on patients' functional status, cancer-coagulation factors and cancer immunity. Methods: We conducted an observational study of various cancer patients in all stages admitted to the East-West Cancer Center (EWCC), Dunsan Korean Hospital of Daejeon University, from Mar. 2011 to Aug. 2011. All patients were under the center's multi-modality Korean-medicine-based inpatient cancer care program. The hospitalization stay at EWCC ranged from 9 to 34 days. A total of 80 patients were followed in their routine hematologic laboratory screenings performed before and after hospitalization. Patients were divided into three groups depending on the status of their treatment: prevention of recurrence and metastasis group, KM treatment only group, and combination of conventional and KM treatment group. The lab reports included natural killer cell count (CD16 + CD56), fibrinogen, white blood cell (WBC), lymphocytes, monocytes, neutrophil, red blood cell (RBC), hemoglobin, platelet, Erythrocyte Sedimentation Rate (ESR), and Eastern Cooperative Oncology Group (ECOG) performance status. Results: With a Focus on patients' functional status, cancer-coagulation factors and cancer immunity, emphasis was placed on the NK cell count, fibrinogen count, and ECOG scores. Data generally revealed decreased fibrinogen count, fluctuating NK cell count and decreased ECOG, meaning improved performance status in all groups. The KM treatment only group showed the largest decrease in mean fibrinogen count and the largest increase in mean NK cell count. However, the group's ECOG score showed the smallest decrease, which may be due to the concentration of late-cancer-stage patients in that particular group. Conclusions: Multi-modality KM inpatient care may have positive effect on lowering the cancer coagulation factor fibrinogen, but its correlation with the change in the NK cell count is not clear.

• 대한인간공학회지
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• 제26권4호
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• pp.1-7
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• 2007

Navigation system or way finding in Wearable computer help disabled and impaired persons and it is impossible to be safe and efficient for drivers as well as pedestrian. Wearable computing situation must be multi-tasking simultaneously and users need minimal attention. In this paper, we used virtual environment as real way-finding similarly. The direction cues of navigation system are investigated as visual only, visual & auditory, and visual & speech. In the paper, the trial demonstrates the difference of performance in detection of directing and performance of motor and subjective satisfaction of user.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2627-2630
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• 2013

Background: Ovarian cancer continues to pose a major challenge to physicians and radiologists. It is the third most common gynecologic malignancy and estimated to be fifth leading cancer cause of death in women, constituting 23% of all gynecological malignancies. Multi-detector computed tomography (MDCT) appears to offer an excellent modality in diagnosing ovarian cancer based on combination of its availability, meticulous technique, efficacy and familiarity of radiologists and physicians. The aim of this study was to compute sensitivity, specificity, positive and negative predictive values and diagnostic accuracy of 64-slice MDCT in classifying ovarian masses; 95% confidence intervals were reported. Materials and Methods: We prospectively designed a cross-sectional analytical study to collect data from July 2010 to August 2011 from a tertiary care hospital in Karachi, Pakistan. A sample of 105 women aged between 15-80 years referred for 64-MDCT of abdomen and pelvis with clinical suspicion of malignant ovarian cancer, irrespective of stage of disease, were enrolled by non-probability purposive sampling. All patients who were already known cases of histologically proven ovarian carcinoma and having some contraindication to radiation or iodinated contrast media were excluded. Results: Our prospective study reports sensitivity, specificity; positive and negative predictive values with 95%CI and accuracy were computed. Kappa was calculated to report agreement among the two radiologists. For reader A, MDCT was found to have 92% (0.83, 0.97) sensitivity and 86.7% (0.68, 0.96) specificity, while PPV and NPV were 94.5% (0.86, 0.98) and 86.7% (0.63, 0.92), respectively. Accuracy reported by reader A was 90.5%. For reader B, sensitivity, specificity, PPV and NPV were 94.6% (0.86, 0.98) 90% (0.72, 0.97) 96% (0.88, 0.99) and 87.1% (0.69, 0.95) respectively. Accuracy computed by reader B was 93.3%. Excellent agreement was found between the two radiologists with a significant kappa value of 0.887. Conclusion: Based on our study results, we conclude MDCT is a reliable imaging modality in diagnosis of ovarian masses accurately with insignificant interobserver variability.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제30권2호
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• pp.150-156
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• 2004

The etiology of the obstructive sleep apnea includes the various factors such as anatomical abnormality in upper airway, craniofacial structure, obesity and personal habit. To establish reasonable treatment plan, multi-department approach is should be emphasized because the treatment modality is depend on the result of analysis for degree & site of obstruction and various behavioral factors. In Sleep Clinic in Keimyung University Medical Center, the standard of care for sleep apnea patient was established according to the Standard of practice committee of Americal Sleep Disorders Association. After one year experience of comprehensive approach for sleep apnea we could achieve following recommendation for the treatment. 1) The multi-department examination and diagnosis could prevent unnessesary treatment because the treatment plan could be established under comprehensive discussion. 2) Determination of the site of obstruction is important for treatment planning. However, no single determinant could be found. We expect multi-department approach can reduce the mistake in detection of obstruction. 3) Further evaluation of treatmet outcome should be succeeded to establish Korean standard of care for sleep apnea treatment.

• Nuclear Medicine and Molecular Imaging
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• 제42권2호
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• pp.153-163
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• 2008

다중영상기기는 1990년대 초에 처음 개발되어 현재 주요 영상 장비 회사에서 상품으로 개발되어 판매되고 있다. 단순한 소프트웨어적인 정합과 융합을 통해 해부학적 영상과 기능적 영상의 상호 보완하는 단계에서 발전하여 하드웨어적으로 정합하는 하드웨어의 개발은 새로운 연구의 시작이다. 다중영상기기의 발전 이전에는 해부학적 구조를 보여주는 영상 장비와 기능적 영상을 표현하는 장비가 각각 고 분해능과 고 해상도로 많은 발전을 이루어 왔다. 현재는 각 영상 장비의 특징을 살려 효과적으로 결합시킨 다중영상기기의 개발이 활발하게 이루어지고 있다. 다중영상기기는 단순하게 두 장비를 결합시키는 개념에서 기능적 영상에서 필요한 감쇠 보정을 하면서 동시에 해부학적 위치를 융합 영상 형태로 표현하는 새로운 영상 장비로 발전하고 있다 다중영상기기의 특징을 살릴 수 있는 프로토콜이 개발되고 하드웨어적으로도 상호 보완적으로 결합되고 있다. 실제로 PET/CT와 같은 다중영상기기는 임상적으로 중요한 역할을 하고 있으며 PET 영상기기를 대체하고 있다. PET/CT 스캐너는 PET에서 나오는 기능적 영상과 CT에서 나오는 해부학적 영상뿐만 아니라 융합 영상을 함께 보여 주므로 임상적으로 유용한 정보를 제공하고 있다. 현재 SPECT/CT는 아직 보급이 많이 되지 않았으나 PET/CT와 같이 임상적으로 유용한 SPECT와 CT 장비가 결합된 상품들이 나오고 있어 그 시장이 점점 성장할 것으로 기대된다. 다중영상기기는 각각의 단독 영상장비에서 갖고 있는 문제뿐만 아니라 두 영상 장비를 결합시키므로 인해 새로운 문제들이 발생하고 있다. 대표적으로 호흡에 의한 움직임, 조영제의 영향, 금속 물질의 영향과 환자의 피폭에 관한 문제가 있다. 이를 해결하기 위해 새로운 프로토콜과 프로세싱 방법이 개발되고 있다. 뇌를 동시에 촬영할 수 있는 PET/MR의 개발은 뇌 과학에 많은 발전을 줄 것으로 기대된다. PET/MR의 개발은 PET/CT 에서 촬영한 영상의 일부분을 대체할 것으로 예상된다. MR 영상이 CT 영상보다 우수한 분해능을 보이는 분야에서는 PET/MR을 이용한 검사와 연구가 활발하게 진행될 것으로 보인다. 해부학적 영상과 기능적 영상을 결합시킨 융합 영상을 함께 제공하는 다중영상기기는 환자의 질병을 진단뿐만 아니라 치료 후의 효과를 보는데 있어서 중요한 역할을 할 것으로 기대된다. 또 앞으로 검사 목적에 맞는 다양한 다중영상기기의 개발이 이루어질 것으로 기대된다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집C
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• pp.537-542
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• 2001

In recent engineering, the designer has become more and more dependent on computer simulation. But defining exact model using computer simulation is too expensive and time consuming in the complicate systems. Thus, designers often use approximation models, which express the relation between design variables and response variables. These models are called metamodel. In this paper, we introduce one of the metamodel, named Kriging. This model employs an interpolation scheme and is developed in the fields of spatial statistics and geostatistics. This class of interpolating model has flexibility to model response data with multiple local extreme. By reason of this multi modality, we can't use any gradient-based optimization algorithm to find global extreme value of this model. Thus we have to introduce global optimization algorithm. To do this, we introduce DE(Differential Evolution). DE algorithm is developed by Ken Price and Rainer Storn, and it has recently proven to be an efficient method for optimizing real-valued multi-modal objective functions. This algorithm is similar to GA(Genetic Algorithm) in populating points, crossing over, and mutating. But it introduces vector concept in populating process. So it is very simple and easy to use. Finally, we show how we determine Kriging metamodel and find global extreme value through two mathematical examples.

• 대한기계학회논문집A
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• 제31권6호
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• pp.686-693
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• 2007

To perceive body movement, the nervous system uses multi-sensory cues such as vision, vestibular signals, and somatosensation. Among the multi-sensory modality, the previous researchers reported that the lower limb somatosensation plays an important role on maintaining postural balance. In this study, we examined the contribution of somatosensory cues to linear motion perception by measuring the detection threshold of the direction of linear motion with and without lower limb somatosensory constraints. Six healthy male volunteers participated in randomly ordered 33 single sinusoidal acceleration trials with the stimulus at 0.25Hz with peak magnitude ranged from 0 to 8mG. After each stimulus, subjects reported their perceived direction of motion by button press. Results showed that the reduced lower limb somatosensation significantly increased perception threshold. Without constraints, mean threshold was $0.82{\pm}0.23mG$, while it was $1.23{\pm}0.35mG$ with reduced lower limb somatosensation. The results suggest that without visual cues, perception of the movement direction strongly depends on the lower limb somatosensory information.

• Nuclear Engineering and Technology
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• 제56권8호
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• pp.3425-3434
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• 2024

The main features of the loading pattern optimization (LPO) problem, such as high-dimensionality, multi-modality, and non-linearity, make it difficult to achieve a truly optimal configuration. In recent years, metaheuristic methods have been successfully used to solve this problem. In this research, a discrete golden eagle optimization (DGEO) algorithm has been developed to solve the LPO problem in the first cycle of VVER-1000 reactor core. To evaluate the proposed algorithm, a linear multi-purpose fitness function has been used to improve the safety parameters of the reactor core by obtaining a flatter power distribution during the first cycle, and also to enhance the economic parameters by increasing the cycle length and reducing the cost of fuel recycling. For this purpose, a FORTRAN program has been written to map the DGEO algorithm for the LPO problem using the PMAX and PARCS core calculation code to compute the fitness function in each iteration. To speed up the calculations, parallel computing has been applied in the written program. The results demonstrated that the loading pattern, which is suggested by the DGEO algorithm, enhances all the safety and economic parameters in the fitness function. Thus, the DGEO algorithm is highly reliable for the LPO problems in the VVER 1000 reactor core.

• 정보과학회 논문지
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• 제43권11호
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• pp.1281-1297
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• 2016

최근 스마트 기기의 보급으로 자유롭게 비디오 컨텐츠를 생성하고 이를 빠르고 편리하게 공유할 수 있는 네트워크 환경이 갖추어지면서, 퍼스널 비디오가 급증하고 있다. 그러나, 퍼스널 비디오는 비디오라는 특성 상 멀티 모달리티로 구성되어 있으면서 데이터가 시간의 흐름에 따라 변화하기 때문에 이벤트 분류를 할 때 이에 대한 고려가 필요하다. 본 논문에서는 비디오 내의 멀티 모달리티들로부터 고수준의 특징을 추출하여 시간 순으로 재배열한 것을 바탕으로 모달리티 사이의 연관관계를 Deep Neural Network(DNN)으로 학습하여 퍼스널 비디오 이벤트를 분류하는 방법을 제안한다. 제안하는 방법은 비디오에 내포된 이미지와 오디오를 시간적으로 동기화하여 추출한 후 GoogLeNet과 Multi-Layer Perceptron(MLP)을 이용하여 각각 고수준 정보를 추출한다. 그리고 이들을 비디오에 표현된 시간순으로 재 배열하여 비디오 한 편당 하나의 특징으로 재 생성하고 이를 바탕으로 학습한 DNN을 이용하여 퍼스널 비디오 이벤트를 분류한다.