• Reproductive and Developmental Biology
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• v.35 no.4
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• pp.503-510
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• 2011

Cellular uptake of nanoparticles for stem cell labeling and tracking is a critical technique for biomedical therapeutic applications. However, current techniques suffer from low intracellular labeling efficiency and cytotoxic effects, which has led to great interest in the development of a new labeling strategy. Using silica-coated nanoparticles conjugated with rhodamine B isothiocyanate (RITC) (SR), we tested the cellular uptake efficiency, biocompatibility, proliferation or differentiation ability with murine bone marrow derived hematopoietic stem/progenitor cells. The bone marrow hematopoietic cells showed efficient uptake with SR with dose or time dependent manner and also provided a higher uptake on hematopoietic stem/progenitor cells. Biocompatibility tests revealed that the SR had no deleterious effects on cell cytotoxicity, proliferation, or multi-differentiation capacities in vitro and in vivo. SR nanoparticles are advantageous over traditional labeling techniques as they possess a high level of cellular internalization without limiting the biofunctionality of the cells. Therefore, SR provides a useful alternative for gene or drug delivery into hematopoietic stem/progenitor cells for basic research and clinical applications.

• Journal of Information Technology Applications and Management
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• v.14 no.2
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• pp.151-168
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• 2007

The corporate credit rating represents an assessment of the relative level of risk associated with the timely payments required by the debt obligation. In this study, the corporate credit rating model employs artificial intelligence methods including Neural Network (NN) and Case-Based Reasoning (CBR). At first we suggest three classification models, as partitioned neural networks, all of which convert multi-group classification problems into two group classification ones: Ordinal Pairwise Partitioning (OPP) model, binary classification model and simple classification model. The experimental results show that the partitioned NN outperformed the conventional NN. In addition, we put to use CBR that is widely used recently as a problem-solving and learning tool both in academic and business areas. With an advantage of the easiness in model design compared to a NN model, the CBR model proves itself to have good classification capability through the highest hit ratio in the corporate credit rating.

• Proceedings of the KIPE Conference
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• 2005.07a
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• pp.651-654
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• 2005

In this paper, an efficient switching pattern to equalize the size of transformer is proposed for a multi-level inverter employing cascaded transformers. It is based on the prior selected harmonic elimination PWM(SHEPWM) method. Because the maximum magnetic flux imposed on each transformer becomes exactly equal each to each, all transformers can be designed with the same size regardless of their position. Therefore, identical full-bridge inverter units can be utilized, thus improving modularity and manufacturability. The fundamental idea of the proposed switching pattern is illustrated and the analyzed theoretically. The validity of the proposed switching strategy is verified by experimental results.

• Proceedings of the Korea Database Society Conference
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• 1998.09a
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• pp.395-405
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• 1998

최근 멀티미디어 기술의 발전으로 인해 영상을 효율적으로 검색할 수 있는 영상 데이터베이스 시스템이 정보화 사회의 중요한 핵심 기술로 대두되고 있다. 본 논문에서는 내용기반 영상 데이터 검색을 위한 영상 특징 추출 방법으로 색상 정보와 모양 정보를 고려하는 다단계 영상 검색 시스템을 제안하였다. 1단계에서는 색상 정보론 얻기 위해서는 Striker 등이 제시한 색상 분포 특성을 이용한 색인 방법의 문제점을 보완하고 확장해서 지역 색상 분포 특성을 고려한 색인 방법을 사용하여 1차로 영상을 대분류한다. 2단계에서는 1단계에서 대분류된 집단 영상들에 대하여 2차로 모양 정보를 이용하여 사용자가 질의한 영상과 유사한 영상을 최종적으로 검색한다. 모양 정보를 얻기 위해서는 기존 불변 모멘트의 문제점인 많은 연산량과, Jain 등이 제시한 방향 히스토그램 인터섹션 방법에서 제기된 회전에 민감하다는 문제점을 해결하기 위해 물체의 윤곽선에 해당하는 화소들만을 대상으로 연산을 수행하는 향상된 불변 모멘트(Improved Moment Invariants : IMI)를 이용한다. 실험 영상으로 300개의 자동차 영상을 사용하여 기존 방법들과의 비교 실험을 통해 향상된 검색 결과를 얻을 수 있었다.

• The Journal of Information Technology and Database
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• v.5 no.1
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• pp.85-96
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• 1998

최근 멀티미디어 기술의 발전으로 인해 영상을 효율적으로 검색할 수 있는 영상 데이터베이스 시스템이 정보화 사회의 중요한 핵심 기술로 대두되고 있다. 본 논문에서는 내용기반 영상 데이터 검색을 위한 영상 특징 추출 방법으로 색상 정보와 모양 정보를 고려하는 다단계 영상 검색 시스템을 제안하였다. 제안된 시스템에서는 2단계로 이루어진다. 1단계에서는 색상 정보를 위해서 Striker 등이 제시한 색상 분포 특성을 이용한 색인 방법의 문제점을 보완하고 확장하여 지역 색상 분포 특성을 고려한 색인 방법을 사용하여 1차로 영상을 대 분류한다. 2단계에서는 1단계에서 대 분류된 집단 영상들에 대하여 2차로 모양 정보를 이용하여 사용자가 질의한 영상과 유사한 영상을 최종적으로 검색한다. 모양 정보를 위해서는 기존 불변 모멘트의 문제점인 많은 연산량과, Jain 등이 제시한 방향 히스토그램 인터섹션 방법에서 제기된 회전에 민감하다는 문제점을 해결하기 위해 물체의 윤곽선에 해당하는 화소들만을 대상으로 연산을 수행하는 향상된 불변 모멘트(Improved Moment Invariants: IMI)를 이용한다. 실험 영상으로 300개의 상표 영상을 사용하여 기존 방법들과의 비교 실험을 통해 향상된 검색 결과를 얻을 수 있었다.

• Proceedings of the KIEE Conference
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• summer
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• pp.1528-1530
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• 2004

In this paper, an efficient switching pattern to equalize the size of transformer is proposed for a multi-level inverter employing cascaded transformers. It is based on the prior selected harmonic elimination PWM(SHEPWM) method. Because the maximum magnetic flux imposed on each transformer becomes exactly equal each to each, all transformers can be designed with the same size regardless of their position. Therefore, identical full-bridge inverter units can be utilized, thus improving modularity and manufacturability. The fundamental idea of the proposed switching pattern is illustrated and then analyzed theoretically. The validity of the proposed switching strategy is verified by experimental results.

• Asia pacific journal of information systems
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• v.1 no.1
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• pp.63-86
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• 1991

In this paper, our concern is the artificial neural network-based patten classification, when can resolve the difficulties in the Autoregressive Moving Average(ARMA) model identification problem To effectively classify a time series into an approriate ARMA model, we adopt the Multi-layered Backpropagation Network (MLBPN) as a pattern classifier, and Extended Sample Autocorrelation Function (ESACF) as a feature extractor. To improve the classification power of MLBPN's we suggest an integrated neural network system which consists of an AR Network and many small-sized MA Networks. The output of AR Network which will gives the MA order. A step-by-step training strategy is also suggested so that the learned MLBPN's can effectively ESACF patterns contaminated by the high level of noises. The experiment with the artificially generated test data and real world data showed the promising results. Our approach, combined with a statistical parameter estimation method, will provide a way to the automation of ARMA modeling.

• Journal of Power Electronics
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• v.18 no.2
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• pp.558-572
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• 2018

In addition to its modular nature, a Hybrid Modular Multilevel Converter (HMMC) assembled from half-bridge and full-bridge sub-modules, is able to block DC faults with a minimum number of switching devices, which makes it attractive for high power applications. This paper introduces a control strategy based on the Root-Least Square (RLS) algorithm to estimate the capacitor voltages instead of using direct measurements. This action eliminates the need for voltage transducers in the HMMC sub-modules and the associated communication link with the central controller. In addition to capacitor voltage balancing and suppression of circulating currents, a fault tolerant control unit (FTCU) is integrated into the proposed strategy to modify the parameters of the HMMC controller. On advantage of the proposed FTCU is that it does not need extra components. Furthermore, a fault detection unit is adapted by utilizing a hybrid estimation scheme to detect sub-module faults. The behavior of the suggested technique is assessed using PSCAD offline simulations. In addition, it is validated using a real-time digital simulator connected to a real time controller under various normal and fault conditions. The proposed strategy shows robust performance in terms of accuracy and time response since it succeeds in stabilizing the HMMC under faults.

• Journal of Power Electronics
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• v.14 no.2
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• pp.271-281
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• 2014

Fluctuating wind conditions necessitate the use of a variable speed wind turbine (VSWT) with a AC/DC/AC converter scheme in order to harvest the maximum power from the wind and to decouple the synchronous generator voltage and frequency from the grid voltage and frequency. In this paper, a combination of a three phase diode bridge rectifier (DBR) and a modified topology of the diode clamped multilevel inverter (DCMLI) has been considered as an AC/DC/AC converter. A control strategy has been proposed for the DCMLI to achieve the objective of grid interface of a wind power system together with local load compensation. A novel fixed frequency current control method is proposed for the DCMLI based on the level shifted multi carrier PWM for achieving the required control objectives with equal and uniform switching frequency operation for better control and thermal management with the modified DCMLI. The condition of the controller gain is derived to ensure the operation of the DCMLI at the fixed frequency of the carrier. The converter current injected into the distribution grid is controlled in accordance with the wind power availability. In addition, load compensation is performed as an added facility in order to free the source currents being fed from the grid of harmonic distortion, unbalance and a low power factor even though the load may be unbalanced, non-linear and of a poor power factor. The results are validated using PSCAD/EMTDC simulation studies.

• Journal of Korea Game Society
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• v.6 no.3
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• pp.13-22
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• 2006

Games such as sports, RTS, RPG, which teams of players play, require advanced artificial intelligence technology for team management. The existing artificial intelligence enables an intelligent agent to have the autonomy solving problem by itself, but to lack interaction and cooperation between agents. This paper presents "Level Unified Approach Method" with effective role allocation and autonomy in multiagent system. This method allots sub-goals to agents using role information to accomplish a global goal. Each agent makes a decision and takes actions by itself in dynamic environments. Global goal of Team coordinates to allocated role in tactics approach. Each agent leads interactive cooperation by sharing state information with another using Databoard, As each agent has planning capacity, an agent takes appropriate actions for playing allocated roles in dynamic environments. This cooperation and interactive operation between agents causes a collision problem, so it approaches at tactics side for controlling this problem. Our experimental result shows that "Level Unified Approach Method" has better performance than existing rental approach method or de-centralized approach method.