• International Journal of Oncology
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• 제54권4호
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• pp.1327-1336
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• 2019

Endothelial progenitor cells (EPCs) are bone marrow (BM)-derived progenitor cells that can differentiate into mature endothelial cells, contributing to vasculogenesis in the blood vessel formation process. Runt-related transcription factor 3 (RUNX3) belongs to the Runt domain family and is required for the differentiation of specific immune cells and neurons. The tumor suppressive role of RUNX3, via the induction of apoptosis and cell cycle arrest in a variety of cancers, and its deletion or frequent silencing by epigenetic mechanisms have been studied extensively; however, its role in the differentiation of EPCs is yet to be investigated. Therefore, in the present study, adult BM-derived hematopoietic stem cells (HSCs) were isolated from Runx3 heterozygous (Rx3^+/-) or wild-type (WT) mice. The differentiation of EPCs from the BM-derived HSCs of Rx3^+/- mice was found to be significantly increased compared with those of the WT mice, as determined by the number of small or large colony-forming units. The migration and tube formation abilities of Rx3^+/- EPCs were also observed to be significantly increased compared with those of WT EPCs. Furthermore, the number of circulating EPCs, defined as CD34⁺/vascular endothelial growth factor receptor 2 (VEGFR2)⁺ cells, was also significantly increased in Rx3^+/- mice. Hypoxia-inducible factor (HIF)-1α was upregulated in Rx3^+/- EPCs compared with WT EPCs, even under normoxic conditions. Furthermore, in a hindlimb ischemic mouse models, the recovery of blood flow was observed to be highly stimulated in Rx3^+/- mice compared with WT mice. Also, in a Lewis lung carcinoma cell allograft model, the tumor size in Rx3^+/- mice was significantly larger than that in WT mice, and the EPC cell population (CD34⁺/VEGFR2⁺ cells) recruited to the tumor was greater in the Rx3^+/- mice compared with the WT mice. In conclusion, the present study revealed that Runx3 inhibits vasculogenesis via the inhibition of EPC differentiation and functions via the suppression of HIF-1α activity.

• 생물환경조절학회지
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• 제28권3호
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• pp.255-264
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• 2019

본 연구에서는 현장 온실농가에서 수명이 다하여 교체작업이 이루어진 총 4종의 다겹보온자재를 채취하여 해당 사용기간별 보온성의 변화를 비교하기 위해 여기서 고안된 Hot box 시험이 실시되었다. 4종의 다겹보온자재는 마트지, 부직포, PE폼 및 화학솜 등이 주요 재료로서 다겹보온자재별로 이 재료들이 서로 다르게 조합된 형태였다. 이 4종의 다겹보온자재를 시편($70{\times}70cm$)으로 제작하여 Hot box 시험을 통해서 대상시편별로 온도 하강률, 열관류율 및 열전도저항 등이 측정되었다. 그 결과를 요약하면 다음과 같다. 본 연구에서 사용된 다겹보온자재들에 대하여 적절한 보온성능을 기대할 수 있는 사용기간은 약 5년 정도로 예상되었다. 다겹보온자재의 재료조합에 대하여 다겹의 PE폼을 적용하여 상대적으로 보온성을 높일 수 있으나 다겹보온자재 내에서 공기 단열층을 형성하는 화학솜에 비해 보온성능에 대한 기여가 현저히 낮은 것으로 판단되었다. 다겹보온자재에 대하여 적절한 보온성능을 기대하기 위해서는 기본적으로 화학솜과 같은 공기 단열층을 형성하는 기능이 있는 재료가 다겹보온자재에 포함되어야 될 것으로 판단되었다. 본 연구에서 고안된 Hot box 시험을 통해 다겹보온 자재의 온도 하강률, 열관류율 및 열전도저항 등이 적절하게 측정되었다. 그러나 본 연구는 사용이 완료된 다겹보온자재의 채취 어려움으로 총 4종의 다겹보온자재만 고려되었으며, 이는 비교적 적은 사례로 통해 얻어진 결과라 할 수 있으며, 본 연구의 한계이다. 향후 관련 연구를 통해 더 많은 사례들이 조사 및 보완되어야 될 것이다.

• 천문학회보
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• 제40권1호
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• pp.67.4-68
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• 2015

We present a multi-wavelength observational study of a low-mass star-forming region, L1251-C, with observational results at wavelengths from the near-infrared to the millimeter. Spitzer Space Telescope observations confirmed that IRAS 22343+7501 is a small group of protostellar objects. The extended emission to east-west direction with its intensity peak at the center of L1251A has been detected at 350 and 850 mm with the CSO and JCMT telescopes, tracing dense envelope materials around L1251A. The single-dish data from the KVN and TRAO telescopes show inconsistencies between the intensity peaks of several molecular line emission and that of the continuum emission, suggesting complex distributions of molecular abundances around L1251A. The SMA interferometer data, however, show intensity peaks of CO 2-1 and $^{13}CO$ 2-1 located at the position of IRS 1, which is both the brightest source in IRAC image and the weakest source in the 1.3 mm dust continuum map. IRS 1 is the strongest candidate for being the driving source of a newly detected the compact CO 2-1 outflow. Over the whole region ($14^{\prime}{\times}14^{\prime}$) of L125l-C, 3 Class I and 16 Class II sources have been detected, including three YSOs in L1251A. A comparison with the average projected distance among 19 YSOs in L1251-C and that among 3 YSOs in L1251A suggests L1251-C is an example of low-mass cluster formation, where protostellar objects are forming in a small group.

• 한국산학기술학회논문지
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• 제19권8호
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• pp.25-31
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• 2018

본 연구에서는 카울 모듈의 성형 시 최적 설계 공정을 유한요소해석을 통해 도출하는 방안을 제시하였다. 소재 인장시험 및 성형성 평가와 같은 기계적 물성 평가를 통해 성형 해석의 주름 및 크랙 발생을 사전에 파악하고 이를 개선하기 위한 공정 설계 변경을 통해 최적 설계 방안을 도출하였다. 또한 제진성 향상이 필요한 카울 로워 패널에 패치워크를 적용을 통해 카울 모듈의 강성 증대 및 제진 특성 향상을 고유진동수 측정 시험과 해석을 통해 확인하였다. 해석 결과, 실러 패치워크 기술 적용에 따른 1차 고유진동수가 향상됨을 알 수 있었고, 이는 강성 및 제진특성 증대와 관련있다고 볼 수 있다. 실러 패치워크 적용 시 공정수 감소를 위해 성형 전 로워 패널 블랭크에 패치워크 블랭크를 점용접으로 접합시켜 성형하므로, 성형 후 패치워크 패널의 위치가 점용접 조건에 따라 달라진다. 이를 위해 점용접 위치에 따른 성형 해석을 실시하여 결과를 바탕으로 최적 공정 설계를 도출하였다. 스탬핑 공법을 이용한 타부품의 적용을 위해 성형 해석 기법을 구축하여 다양한 제품 설계에 도움이 될 것으로 판단된다.

• 한국위성정보통신학회논문지
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• 제11권4호
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• pp.107-113
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• 2016

본 논문에서는 5.9 GHz에서 동작하는 광대역의 Butler Matrix에 기반한 차량 간 통신(V2X)용 안테나의 설계법이 제시된다. V2X가, 교통 시스템의 지능화, 모바일 통신 기능의 다각화, 주파수 자원의 포화문제 해소, 신호 송수신의 효율성을 극대화를 위한 빔 형성 및 빔 조향 안테나를 필요로 함에 따라, 부피가 크지 않으면서 요구사항을 충족할 수 있는 Butler Matrix 급전부와 그에 연결된 방사체를 구현한다. 기본적인 Butler Matrix를 구성하는 협대역 부품들과 방사체가 먼저 설계된 다음, 안테나 시스템의 차량 장착시에 발생될 주파수 천이에 대해 영향을 크게 받지 않기 위한 광대역용 Butler matrix의 구성품들이 설계된다. 협대역과 광대역 구조들의 성능들이 서로 비교되어, 빔 형성 및 빔 조향의 공통된 성능을 보이는 동시에, 주파수 영역에서 대역폭 관점에서의 차별성이 도시된다.

• Geomechanics and Engineering
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• 제9권3호
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• pp.373-395
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• 2015

Comprehensive results from cyclic plate loading at a diameter of 300 mm supported by layers of geocell are presented. The plate load tests were performed in a test pit measuring $2000{\times}2000mm$ in plane and 700 mm in depth. To simulate half and full traffic loadings, fifteen loading and unloading cycles were applied to the loading plate with amplitudes of 400 and 800 kPa. The optimum embedded depth of the first layer of geocell beneath the loading plate and the optimum vertical spacing of geocell layers, based on plate settlement, are both approximately 0.2 times loading plate diameter. The results show that installation of the geocell layers in the foundation bed, increase the resilient behavior in addition to reduction of accumulated plastic and total settlement of pavement system. Efficiency of geocell reinforcement was decreased by increasing the number of the geocell layers for all applied stress levels and number of cycles of applied loading. The results of the testing reveal the ability of the multiple layers of geocell reinforcement to 'shakedown' to a fully resilient behavior after a period of plastic settlement except when there is little or no reinforcement and the applied cyclic pressure are large. When shakedown response is observed, then both the accumulated plastic settlement prior to a steady-state response being obtained and the resilient settlements thereafter are reduced. The use of four layers of geocell respectively decreases the total and residual plastic settlements about 53% and 63% and increases the resilient settlement 145% compared with the unreinforced case. The inclusion of the geocell layers also reduces the vertical stress transferred down through the pavement by distributing the load over a wider area. For example, at the end of the load cycle of the applied pressure of 800 kPa, the transferred pressure at the depth of 510 mm is reduced about 21.4%, 43.9%, 56.1% for the reinforced bases with one, two, and three layers of geocell, respectively, compared to the stress in the unreinforced bed.

• 반도체디스플레이기술학회지
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• 제3권3호
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• pp.1-4
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• 2004

Fabrication and electrical and mechanical properties of piezoelectric micro bending actuators (PMBA) using sol-gel-multi-coated thick PZT films and MEMS processes were investigated. PMBA could be used for design and fabrication of micro fluidic devices, for example, micro-pumps, micro dispensers, and so on. PMBA were fabricated using 2 um thick PZT films on Pt (350 nm)/$SiO_2$ (500 nm)/Si ($300\mu\textrm{m}$) substrates and MEMS processes. 7 types of PMBA were fabricated with areas of silicon diaphragms, PZT films and top electrodes. When the sizes of silicon diaphragms, PZT films and Pt top electrodes were reduced from 3000$\times$$1389\mu\textrm{m}$, 4000$\times$$1000\mu\textrm{m}$ and 4000$\times$$900\mu\textrm{m}$ down to 14%, 14% and 11 % of them, respectively, the center displacements of PMBA were decreased from 0.68 um to 0.10 um at 5 Hz and 12 Vpp. So, PMBA with large areas showed larger displacements than PMBA with small areas and experimental results were also good agreement with the plate and shell theory.

• 지역사회간호학회지
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• 제12권3호
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• pp.647-660
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• 2001

Forming health care management model in small-scale enterprises was the purpose of this study. For the purpose, we tried to investigate the characteristics of small-scale enterprises and analyzed the pattern of their health care management. The results are as follow: 1. The strength of health managing agency and technical supporting program lies in team approach by specialized manpower. However, if the liaison between each part of the organization is not smooth, the overall management will be very difficult. 2. Small scale enterprises are characterized by their short life after the establishment, use of rental building, lack of welfare facilities, weakness in sanitary management and aggregation of factories of similar type of industry. Because of these characteristics, it is very difficult to solve problem basically, such as improvement of working environment. Therefore, it is important to focus on health education and community based approach. 3. Many workers in small-scale factories are in middle and old age. They have health problems mainly related to personal habits. Implementation of an appropriate health promotion program is needed. 4. The number of workplaces, which should be managed by health managing agent. is increasing rapidly. But the number of health managing agent is limited. In the aspect of the requirement of manpower and equipment, training personal agent is more urgent than founding institutional agent. 5. The uniform method of health management hampers the choice of employer and workers. The types of provision of health management should be diversified. 6. For an efficient management, a frequent visit of personal agent and the following referral to a specialist should be done. The specialists in charge of secondary management are from the field of occupational medicine, occupational hygiene, ergonomics, etc. 7. The health management of small-scale facilities should have six components. They are community-based approach, multi-disciplinary cooperative system, program based on the need of recipient, forming partnership of employer and worker, change of lifestyle, and evidence-based program.

• 한국미생물·생명공학회지
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• 제40권3호
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• pp.169-179
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• 2012

미생물에 의한 탄산칼슘침전은 생물 화학적으로 풍화, 침식된 시멘트 건축구조물 표면의 미학적 복원 및 수분침투 방지를 목적으로 응용되었다. 이 기술의 두드러진 장점이 보고된 후 유럽과 미국을 중심으로 미생물을 이용한 건축공학적 응용가능성에 대한 연구가 활발히 이루어져 왔다. 견고하고 원재료와의 호환성이 뛰어난 이 기술은 다양한 탄산칼슘형성세균의 선별 또는 배양 및 적용방법의 개발로 그 관심이 촉발되었다. 본 총설의 목적은 친환경적 건축소재에 대한 관심이 높아지고 그 필요성이 대두되고 있는 현 시점에서 미생물 탄산칼슘형성 매카니즘과 그 관련 기술들을 검토해 보고자 한다. 본론에선 시멘트 건축물 표면코팅 효과에 대한 방법론적 연구사례들을 조사하였고, 시멘트 구조물의 내구성 증진을 위한 미생물의 첨가에 대한 연구사례들도 함께 살펴보았다. 부가적으로 향후 미생물의 다기능성을 이용한 자기수복 스마트 콘크리트 개발에 대한 개념을 살펴보고 그 미래를 전망하였다.

• 소성∙가공
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• 제21권1호
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• pp.49-57
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• 2012

It is difficult to estimate the properties of multilayered sheet because they are composed of one or more different materials. Plastic deformation behavior of the multilayered sheet is quite different as compared to each material individually. The deformation behavior of multilayered sheet should be investigated in order to prevent forming defects and to predict the properties of the formed part. In this study, the mechanical properties and formability of stainless steel-aluminum-magnesium multilayered sheet were investigated. The multilayered sheet needs to be deformed at an elevated temperature because of its poor formability at room temperature. Uniaxial tensile tests were performed at various temperatures and strain rates. Fracture patterns changed mainly at a temperature of $200^{\circ}C$. Uniform and total elongation of multilayered sheet increased to values greater than those of each material when deformed at $250^{\circ}C$. The limiting drawing ratio (LDR) was obtained using a circular cup deep drawing test to measure the formability of the multilayered sheet. A maximum value for the LDR of about 2 was achieved at $250^{\circ}C$, which is the appropriate forming temperature for the Mg alloy. Fracture patterns on a circular cup and thickness of formed part were predicted by a rigid-viscoplastic FEM analysis. Two kinds of modeling techniques were used to simulate deep drawing process of multilayered sheet. A single-layer FE-model, which combines the three different layers into a macroscopic single layer, predicted well the thickness distribution of the drawn cup. In contrast, the location and the time of fracture were estimated better with a multi-layer FE model, which used different material properties for each of the three layers.