• 제목/요약/키워드: Multi-Objective

검색결과 2,150건 처리시간 0.03초

Deep Learning-Assisted Diagnosis of Pediatric Skull Fractures on Plain Radiographs

  • Jae Won Choi;Yeon Jin Cho;Ji Young Ha;Yun Young Lee;Seok Young Koh;June Young Seo;Young Hun Choi;Jung-Eun Cheon;Ji Hoon Phi;Injoon Kim;Jaekwang Yang;Woo Sun Kim
    • Korean Journal of Radiology
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    • 제23권3호
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    • pp.343-354
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    • 2022
  • Objective: To develop and evaluate a deep learning-based artificial intelligence (AI) model for detecting skull fractures on plain radiographs in children. Materials and Methods: This retrospective multi-center study consisted of a development dataset acquired from two hospitals (n = 149 and 264) and an external test set (n = 95) from a third hospital. Datasets included children with head trauma who underwent both skull radiography and cranial computed tomography (CT). The development dataset was split into training, tuning, and internal test sets in a ratio of 7:1:2. The reference standard for skull fracture was cranial CT. Two radiology residents, a pediatric radiologist, and two emergency physicians participated in a two-session observer study on an external test set with and without AI assistance. We obtained the area under the receiver operating characteristic curve (AUROC), sensitivity, and specificity along with their 95% confidence intervals (CIs). Results: The AI model showed an AUROC of 0.922 (95% CI, 0.842-0.969) in the internal test set and 0.870 (95% CI, 0.785-0.930) in the external test set. The model had a sensitivity of 81.1% (95% CI, 64.8%-92.0%) and specificity of 91.3% (95% CI, 79.2%-97.6%) for the internal test set and 78.9% (95% CI, 54.4%-93.9%) and 88.2% (95% CI, 78.7%-94.4%), respectively, for the external test set. With the model's assistance, significant AUROC improvement was observed in radiology residents (pooled results) and emergency physicians (pooled results) with the difference from reading without AI assistance of 0.094 (95% CI, 0.020-0.168; p = 0.012) and 0.069 (95% CI, 0.002-0.136; p = 0.043), respectively, but not in the pediatric radiologist with the difference of 0.008 (95% CI, -0.074-0.090; p = 0.850). Conclusion: A deep learning-based AI model improved the performance of inexperienced radiologists and emergency physicians in diagnosing pediatric skull fractures on plain radiographs.

Laying hen responses to multi-strain Bacillus-based probiotic supplementation from 25 to 37 weeks of age

  • Elijah Ogola Oketch;Myunghwan Yu;Jun Seon Hong;Nuwan Chamara Chaturanga;Eunsoo Seo;Hans Lee;Rafael Gustavo Hermes;Natasja Smeets;Apichaya Taechavasonyoo;Susanne Kirwan;Raquel Rodriguez-Sanchez;Jung Min Heo
    • Animal Bioscience
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    • 제37권8호
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    • pp.1418-1427
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    • 2024
  • Objective: This study aimed to investigate the efficacy of Bacillus-based probiotics supplemented at two different levels to modulate the productive performance, egg quality, tibia traits, and specific cecal bacteria counts of Hy-Line Brown layers from 25 to 37 weeks of age. Methods: A total of 216 twenty-five-week-old hens were randomly distributed into 3 experimental diets with 12 replicates of 6 birds per cage. Diets included basal diet supplemented with 0 (CON), 3×108 (PRO1), or 3×109 (PRO2) colony-forming unit (CFU) of the test probiotic containing Bacillus subtilis PB6, Bacillus subtilis FXA, and Bacillus licheniformis G3 per kilogram of feed. Results: Improved egg weights and mass at 29 weeks; and feed intake at 31 weeks (p<0.10) were noticed with the probiotic-supplemented PRO1 and PRO2 diets. Considering egg quality, the shell thickness, Haugh units, and yolk color were improved; but yolk cholesterol was lowered (p<0.05) with PRO1 and PRO2 diets at 29 weeks. At both 33 and 37 weeks, the egg-breaking strength, shell color and thickness, albumen height, Haugh units, and yolk color were improved; but yolk cholesterol was similarly lowered (p<0.05) with the PRO1 and PRO2 diets. Improved tibia Ca, ash, weights, and density; and raised cecal counts of Bifidobacteria and Lactobacilli (p<0.05) were noticed with PRO1 and PRO2 diets. Improved tibia P but reduced Clostridia counts (p<0.10) were also observed with the PRO1 and PRO2 diets. Conclusion: Probiotic supplementation of Bacillus subtilis PB6, Bacillus subtilis FXA, and Bacillus licheniformis G3 at 3×108 CFU/kg of feed is adequate to significantly improve egg quality, lower yolk cholesterol, enhance several tibia traits, and raise the populations of beneficial cecal bacteria. Modest improvements in several productive parameters and tibia P but reduced Clostridia were also observed; and could warrant further investigation of probiotic effects beyond the current test period.

감각통합치료가 발달지연 아동의 침 흘림과 놀이에 미치는 효과: 단일사례연구 (Effect of Sensory Integration Therapy with Oral Activity on Drooling and Play in Children with Developmental Disorder: Single-Subject Research)

  • 박소희;홍은경
    • 대한감각통합치료학회지
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    • 제21권3호
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    • pp.54-64
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    • 2023
  • 목적 : 본 연구는 구강감각의 감각조절장애가 있는 발달지연 아동을 대상으로 구강활동을 포함한 감각통합 치료를 적용하여 침 흘림과 구강장난감을 활용한 놀이에 대한 효과를 알아보고자 하였다. 연구방법 : 연구대상은 2세 8개월의 구강감각의 감각조절장애가 있는 발달지연 남아 2명이었다. 단일대상연구 ABA' 중 대상자간 중다기초설계(multiple-baseline design across subjects)를 사용하였다. 목표행동은 목표성취도 척도(Goal Attainment Scale; GAS)를 사용하여 침 흘림과 구강 장난감을 활용한 놀이 대한 관심과 집중으로 측정하였다. 중재기(B) 10회기 동안 구강활동과 고유-전정 중심의 감각통합치료를 아동에게 적용하였다. 결과 : 침 흘림은 기초선 기간에 평균 목표행동 값(GAS)이 A 아동 0.25점, B 아동-0.5점에서 중재 기간에는 A 아동 1.88점, B 아동 1.4점으로 향상했고 유지기 동안 평균은 A, B 아동 모두 3점이었다. 놀이에 대한 기초선 기간에 평균 목표행동 값은 A 아동은 -0.75점, B 아동은 0.75점에서 중재 기간 A 아동은 1.9점, B 아동은 1.1점이었고 유지기 동안 평균은 A 아동 1.33점, B 아동 2점이었다. 결론 : 구강활동을 포함한 고유-전정감각 중심의 감각통합치료는 구강감각의 감각조절문제가 있는 아동에게 침 흘림과 구강장난감을 활용한 놀이에 효과가 있는 것으로 보인다.

MRI Assessment of Complete Response to Preoperative Chemoradiation Therapy for Rectal Cancer: 2020 Guide for Practice from the Korean Society of Abdominal Radiology

  • Seong Ho Park;Seung Hyun Cho;Sang Hyun Choi;Jong Keon Jang;Min Ju Kim;Seung Ho Kim;Joon Seok Lim;Sung Kyoung Moon;Ji Hoon Park;Nieun Seo;Korean Society of Abdominal Radiology Study Group for Rectal Cancer
    • Korean Journal of Radiology
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    • 제21권7호
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    • pp.812-828
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    • 2020
  • Objective: To provide an evidence-based guide for the MRI interpretation of complete tumor response after neoadjuvant chemoradiation therapy (CRT) for rectal cancer using visual assessment on T2-weighted imaging (T2) and diffusion-weighted imaging (DWI). Materials and Methods: PubMed MEDLINE, EMBASE, and Cochrane Library were searched on November 28, 2019 to identify articles on the following issues: 1) sensitivity and specificity of T2 or DWI for diagnosing pathologic complete response (pCR) and the criteria for MRI diagnosis; 2) MRI alone vs. MRI combined with other test(s) in sensitivity and specificity for pCR; and 3) tests to select patients for the watch-and-wait management. Eligible articles were selected according to meticulous criteria and were synthesized. Results: Of 1615 article candidates, 55 eligible articles (for all three issues combined) were identified. Combined T2 and DWI performed better than T2 alone, with a meta-analytic summary sensitivity of 0.62 (95% confidence interval [CI], 0.43-0.77; I2 = 80.60) and summary specificity of 0.89 (95% CI, 0.80-0.94; I2 = 92.61) for diagnosing pCR. The criteria for the complete response on T2 in most studies had the commonality of remarkable tumor decrease to the absence of mass-like or nodular intermediate signal, although somewhat varied, as follows: (near) normalization of the wall; regular, thin, hypointense scar in the luminal side with (near) normal-appearance or homogeneous intermediate signal in the underlying wall; and hypointense thickening of the wall. The criteria on DWI were the absence of a hyperintense signal at high b-value (≥ 800 sec/mm2) in most studies. The specific algorithm to combine T2 and DWI was obscure in half of the studies. MRI combined with endoscopy was the most utilized means to select patients for the watch-and-wait management despite a lack of strong evidence to guide and support a multi-test approach. Conclusion: This systematic review and meta-analysis provide an evidence-based practical guide for MRI assessment of complete tumor response after CRT for rectal cancer.

The Effects of a Vasodilator on Transluminal Attenuation Gradient at Coronary Computed Tomography Angiography

  • Moon Sung Kim;Eun-Ju Kang;Hyun Jin Kim;Moo Hyun Kim;Ki-Nam Lee
    • Korean Journal of Radiology
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    • 제21권12호
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    • pp.1285-1293
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    • 2020
  • Objective: To evaluate the effects of vasodilators on contrast enhancement and transluminal attenuation gradient (TAG) of coronary arteries at coronary computed tomography angiography (CCTA). Materials and Methods: We retrospectively reviewed CCTA scans of patients who underwent double-acquisition CCTA; CCTA without a vasodilator, and CCTA during a intravenous (IV) infusion of nitrate. Among them, we enrolled 19 patients who had no significant atherosclerotic lesions or coronary spasms. In the control group, 28 patients were enrolled who showed normal coronary arteries on CCTA, which was acquired by a conventional method (sublingual vasodilator). We measured the TAG and Hounsfield units for each of the three major epicardial coronary arteries (reported as 'ProxHU') and then compared the results between the nitrate administration methods (CT without vasodilator [CTpre], CT with IV vasodilator [CTiv], and CT with sublingual vasodilator [CTsub]). Results: The mean TAG showed a significant difference between the coronary arteries (right coronary artery [RCA] > left anterior descending artery [LAD] > left circumflex artery [LCX], p < 0.05), while there was no difference in ProxHU of each coronary artery in all three types of nitrate administration methods (p > 0.05). The TAG of CTpre group showed steeper slope than those of vasodilator groups (CTiv and CTsub) on LAD and LCX ([LAD: CTpre = -22.1 ± 6.66, CTiv = -16.76 ± 5.78, and CTsub = -16.47 ± 5.78, p = 0.005], [LCX: CTpre = -31.26 ± 17.43, CTiv = -23.74 ± 14.06, and CTsub = -20.94 ± 12.15, p = 0.051]), while that of RCA showed no significant differences (p = 0.600). When comparing proxHU, CTiv showed higher proxHU than that of CTpre or CTsub, especially on LCX (CTpre = 426.7 ± 68.3, CTiv = 467.9 ± 84.9, and CTsub = 404.9 ± 63.3, p = 0.013). ProxHU showed a negative correlation with TAG on all three of methods (r = -0.280, p < 0.001). Conclusion: TAG in CCTA was significantly affected by vasodilator administration. Both TAG and ProxHU of coronary arteries tend to increase with vasodilator administration on CCTA.

2024 대한민국 디지털 비즈니스 트렌드 인식조사: 학계와 산업계의 다양한 목소리를 들어보다 (2024 Korea Digital Business Trend Study: Listening to Voices from Academia and Industry)

  • 신하진;안현철;김태경;이정
    • 경영정보학연구
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    • 제26권1호
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    • pp.315-335
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    • 2024
  • 본 연구는 한국의 디지털 비즈니스 환경을 분석하여 2024년에 주목할 디지털 비즈니스 트렌드를 예측하였다. 이 연구는 국내외 ICT 시장 전망을 종합적으로 검토하고, 다양한 전문가들의 의견을 수렴하여 객관적이고 심도 있는 분석을 제공한다. 특히, 다차원적인 접근을 통해 실제 비즈니스 환경에 적용 가능한 실질적인 트렌드를 도출하였으며, 국내 디지털 비즈니스의 특성을 고려한 전략적 시사점을 제시하며 한국 기업들이 글로벌 비즈니스 환경에 적응하고 경쟁력을 강화할 수 있는 방향을 제시한다. 연구 과정에서 국내외 주요 시장조사기관의 보고서를 수집 및 분석하여 초기에 20개의 예비 후보 트렌드를 도출했다. 이후 산업계 및 학계 전문가 10명과의 심층 인터뷰를 통해 이들 20개 트렌드와 전년도에 선정된 10대 트렌드 중에서 총 15개의 최종 후보 트렌드를 선별했다. 마지막 단계로, 학계 및 산업계 전문가 209명을 대상으로 한 대규모 설문조사를 통해 최종적으로 2024년 주목해야 할 국내 디지털 비즈니스 트렌드 11개를 선정했다. 이처럼 국내 디지털 비즈니스 리더들에게 과학적으로 수렴된 다양한 의견을 바탕으로 국내 비즈니스 환경에 적합한 디지털 비즈니스 트렌드 전망을 제시한 본 연구는 한국의 IT 트렌드를 비즈니스 관점에서 이해하고 국제적인 트렌드와의 차이를 이해하는 일에 기여할 수 있을 것이다.

장기간 SPOT/VEGETATION 정규화 식생지수를 이용한 지면 변화 탐지 개선에 관한 연구 (The Study of Land Surface Change Detection Using Long-Term SPOT/VEGETATION)

  • 염종민;한경수;김인환
    • 한국지리정보학회지
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    • 제13권4호
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    • pp.111-124
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    • 2010
  • 지표면의 환경변화를 관측하는 것은 토지사용과 기후변화, 기상연구, 농업, 지표면의 에너지 균형 및 환경시스템에 매우 중요한 연구로 이용되어지고 있다. 최근 위성영상을 이용한 변화탐지는 국지 단위 환경변화 탐지를 위해 그 필요성이 높아지고 있는 실정이며, 특히 잦은 개발과 변화로 주기적인 탐지가 필요한 도심지역의 변화탐지는 국토환경변화 및 지역계획 연구에 대한 효율적인 의사결정 지원이 가능하므로 그 활용성이 매우 높아지고 있다. 이러한 배경으로, 위성 영상을 이용한 원격탐사 자료를 활용한 분석은 비교적 짧은 시간에 광범위한 지역의 영상 정보를 취득할 수 있기 때문에 국토 환경변화 관리 분야에서의 적용 가능성이 높다. 본 연구에서는 인공위성 자료를 활용하여 변화탐지를 수행할 때 공간정보 추출의 정확성을 높이는 기술 개발을 위해 시계열자료의 통계적 분석을 통한 변화탐지기법 개발을 수행하였다. 전처리된 자료를 이용하여 정규화 식생지수를 산출하고 K-mean clustering 무감독 분류를 통해 처리된 데이터를 연구영역의 10년간 자료를 이용한 평균 정규화 식생지수 값과 표준편차 값을 계산하여 각각의 화소별 상대적인 변화량을 측정하여 변화 정도를 탐지하였다. 일반적으로 변화 탐지 수행 시, 태양광 채널을 이용할 경우 기하학적 특성에 의해 발생하는 방향성 효과를 보정하여야 한다. 본 연구에서는 대기 보정과 방향성 보정이 수행된 중 저해상도 정규화 식생지수를 이용하여 객관적인 변화 임계치 값을 결정하였다. 연구결과 반사도 값의 차이를 이용한 변화탐지보다 객관적이고 명확하게 변화지역을 탐지할 수 있었다.

정지궤도 천리안위성 해양관측센서 GOCI의 Tasseled Cap 변환계수 산출연구 (A Study of Tasseled Cap Transformation Coefficient for the Geostationary Ocean Color Imager (GOCI))

  • 신지선;박욱;원중선
    • 대한원격탐사학회지
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    • 제30권2호
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    • pp.275-292
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    • 2014
  • 이 연구에서는 Geostationary Ocean Color Imager(GOCI) 센서에 적용할 수 있는 고유의 Tasseled Cap Transformation(TCT) 계수를 제시하고 있다. TCT는 다중밴드 센서 자료로부터 지표의 특성을 분석하는 전통적인 영상변환 방법 중 하나로 새로운 다중밴드 광학센서가 관측을 시작하는 경우 센서의 특성 차이로 인하여 각각의 육상관측 위성센서에 적합한 TCT 계수들이 장기 분석을 통하여 수립되어야 한다. GOCI 센서는 해양관측이 주 목적으로 개발되었으나 영상의 상당 부분은 육지를 관측하고 있으며 밴드 구성은 육지관측에도 일반적으로 이용되는 Visible-Near InfraRed(VNIR) 영역의 정보를 포함하고 있다. 또한 GOCI 센서의 높은 시간 해상도는 지표의 일별 변화의 관측에도 유용하게 사용될 수 있다. 이러한 장점을 이용하여 GOCI 센서에 대한 고유한 TCT가 제공된다면 GOCI 센서의 관측범위 내에서 준 실시간으로 지표변화에 대한 분석과 해석이 가능할 것이다. TCT는 일반적으로 "Brightness", "Greenness", "Wetness"의 세 가지 정보를 포함하지만, ShortWave InfraRed(SWIR) 파장대역이 없는 GOCI 센서의 경우에는 "Wetness"의 정보를 얻을 수 없다. GOCI 센서의 높은 시간 해상도의 활용을 극대화하기 위해서는 "Wetness"의 정보가 제공되어야 한다. "Wetness"의 정보를 얻기 위해 GOCI 주성분 분석(Principal Component Analysis: PCA) 공간을 MODIS TCT 공간에 선형 회귀하는 방법이 사용되었다. 이 연구에서 산출된 GOCI TCT 계수는 정지궤도의 특성에 의해 관측 시간대별로 다른 변환계수를 가질 수 있다. 이 차이를 알아보기 위하여 GOCI TCT 자료와 MODIS TCT 자료 사이의 상관관계가 비교되었다. 그 결과, "Brightness"와 "Greenness"는 4시 자료, "Wetness"는 2시 자료의 변환계수가 선택되었다. 최종적으로 산출된 변환계수의 적절성을 평가하기 위하여 GOCI TCT 자료는 MODIS TCT 영상 및 여러 육상 파라미터들과 비교되었다. GOCI TCT 영상은 MODIS TCT 영상보다 지표 피복의 분류가 더 세밀하게 표현되었으며, GOCI TCT 공간의 지표 피복 분포도 유의미한 결과를 보여줬다. 또한 GOCI TCT의 "Brightness", "Greenness", "Wetness" 자료는 Albedo($R^2$ = 0.75), Normalized Difference Vegetation Index(NDVI) ($R^2$ = 0.97), Normalized Difference Moisture Index(NDMI) ($R^2$ = 0.77)와 각각 비교적 높은 상관관계가 나타났다. 이러한 결과들은 적절한 TCT 계수의 산출이 이루어졌다는 것을 보여준다.

중학교 "환경" 교과의 교수.학습 및 평가 방법 연구 (A Study on Teaching-Learning and Evaluation Methods of Environmental Studies in the Middle School)

  • 남상준
    • 한국환경교육학회지:환경교육
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    • 제7권1호
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    • pp.1-17
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    • 1994
  • This study was performed to determine appropriate teaching-learning and evaluation methods for Environmental Studies. To promote the relevance of our study to the needs of the schools and concerned educational communities of environmental education, we reviewed related literature, conducted questionnaire surveys, interviewed related teachers and administrator, held meetings with experts, and field-tested our findings. For selecting and developing teaching-learning methods of Environmental Studies, findings of educational research in general are considered. moreover, principles of environmental education, general aim of environmental education, orientations of environmental education, and developmental stages of middle school students in educational psychology were attended. In addition, relevance to the purpose of the Environmental Studies curriculum, appropriateness for value inquiry as well as knowledge inquiry, small group centered class organization, social interaction centered teaching-learning process, regional environmental situation, significance of personal environment, evaluation methods of Environmental Studies, multi- and inter-disciplinary contents of the Environmental Studies textbook, suitability to the evaluation methods of Environmental Studies, and emphasis on the social interaction in teaching-learning process were regarded. It was learned the Environmental Studies can be taught most effectively in via of holding discussion sessions, conducting actual investigation, doing experiment-practice, doing games and plate, role-playing and carrying out simulation activities, and doing inquiry. These teaching-learning methods were field-tested and proved appropriate methods for the subject. For selecting and developing evaluation method of Environmental Studies, such principles and characteristics of Environmental Studies as objective domains stated in the Environmental Studies curriculum, diversity of teaching-learning organization, were appreciated. We categorized nine evaluation methods: the teacher may conduct questionnaire surveys, testings, interviews, non-participatory observations; they may evaluate student's experiment-practice performances, reports preparation ability, ability to establish a research project, the teacher may ask the students to conduct a self-evaluation, or reciprocal evaluation. To maximize the effect of these methods, we further developed an application system. It considered three variables, that is, evaluates, evaluation objectives domains, and evaluation agent, and showed how to choose the most appropriate methods and, when necessary, how to combine uses of different methods depending on these variables. A sample evaluation instrument made on the basis of this application system was developed and tested in the classes. The system proved effective. Pilot applications of the teaching-learning methods and evaluation method were made simultaneously; and the results and their implications are as follows. Discussion program was applied in a lesson dealing with the problems of waste disposal, in which students showed active participation and creative thinking. The evaluation method used in this lesson was a multiple-choice written test for knowledge and skills. It was shown that this evaluation method and device are effective in helping students' revision of the lesson and in stimulating their creative interpretations and responces. Pupils showed great interests in the actual investigation program, and this programme was proved to be effective in enhancing students' participation. However, it was also turned out that there must be pre-arranged plans for the objects, contents and procedures of survey if this program is to effective. In this lesson, non-participatory observation methods were used with a focus on the attitudes of students. A scaled reported in general description rather than in grade. Experiment-practice programme was adopted in a lesson for purifying contaminated water and in this lesson, instruction objectives were properly established, the teaching-learning process was clearly specified and students were highly motivated. On the other hand, however, it was difficult to control the class when some groups of students require more times to complete their experiment, and sometimes different results. As regards to evaluation, performance observation test were used for assessing skills and attitudes. If teachers use well-prepared Likert scale, evaluation of all groups within a reasonablely short period of time will be possible. The most effective and successful programme in therms of students' participation and enjoyment, was the 'ah-nah-bah-dah-market' program, which is kind of game of the flea market. For better organized program of this kind, however, are essential, In this program, students appraise their own attitudes and behavior by responding to a written questionnaire. In addition, students were asked to record any anecdotes relating to self-appraisal of changes on one's own attitudes and behaviours. Even after the lesson, students keep recording those changes on letters to herself. Role-playing and simulation game programme was applied to a case of 'NIMBY', in which students should decide where to located a refuse dumping ground. For this kind of programme to e successful, concepts and words used in the script should be appropriate for students' intellectual levels, and students should by adequately introduced into the objective and the procedures of the lessons. Written questionnaire was used to assess individual students' attitudes after the lesson, but in order to acquire information on the changes of students' attitudes and skills, pre-test may have to be made. Doing inquiry programme, in which advantages in which students actually investigated the environmental influence of the areas where school os located, had advantages in developing students' ability to study the environmental problems and to present the results of their studies. For this programme to be more efficient, areas of investigation should be clearly divided and alloted to each group so that repetition or overlap in areas of study and presentation be avoided, and complementary wok between groups bee enhanced. In this programme, teacher assessed students' knowledge and attitudes on the basis of reports prepared by each group. However, there were found some difficults in assessing students' attitudes and behaviours solely on the grounds of written report. Perhaps, using a scaled checklist assessing students' attitudes while their presentation could help to relieve the difficulties.

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Prospective Multi-Center Korean Registry of Transcatheter Arterial Chemoembolization with Drug-Eluting Embolics for Nodular Hepatocellular Carcinoma: A Two-Year Outcome Analysis

  • Myungsu Lee;Jin Wook Chung;Kwang-Hun Lee;Jong Yun Won;Ho Jong Chun;Han Chu Lee;Jin Hyoung Kim;In Joon Lee;Saebeom Hur;Hyo-Cheol Kim;Yoon Jun Kim;Gyoung Min Kim;Seung-Moon Joo;Jung Suk Oh
    • Korean Journal of Radiology
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    • 제22권10호
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    • pp.1658-1670
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    • 2021
  • Objective: To assess the two-year treatment outcomes of chemoembolization with drug-eluting embolics (DEE) for nodular hepatocellular carcinoma (HCC). Materials and Methods: This study was a prospective, multicenter, registry-based, single-arm trial conducted at five university hospitals in Korea. Patients were recruited between May 2011 and April 2013, with a target population of 200. A DC Bead loaded with doxorubicin was used as the DEE agent. Patients were followed up for two years. Per-patient and per-lesion tumor response analysis, per-patient overall survival (OS) and progression-free survival (PFS) analysis, and per-lesion tumor control analysis were performed. Results: The final study population included 152 patients, with 207 target lesions for the per-lesion analysis. At one-month, six-month, one-year, and two-year per-patient assessments, complete response (CR) rates were 40.1%, 43.0%, 33.3%, and 19.6%, respectively. The objective response (OR) rates were 91.4%, 55.4%, 35.1%, and 19.6%, respectively. The cumulative two-year OS rate was 79.7%. The cumulative two-year PFS rate was 22.4% and the median survival was 9.3 months. In multivariable analysis, the Child-Pugh score (p = 0.019) was an independent predictor of OS, and tumor multiplicity (p < 0.001), tumor size (p = 0.020), and Child-Pugh score (p = 0.006) were independent predictors of PFS. In per-lesion analysis, one-month, six-month, one-year and two-year CR rates were 57.5%, 58.5%, 45.2%, and 33.3%, respectively, and the OR rates were 84.1%, 65.2%, 46.6%, and 33.3%, respectively. The cumulative two-year per-lesion tumor control rate was 36.2%, and the median time was 14.1 months. The Child-Pugh score (p < 0.001) was the only independent predictor of tumor control. Serious adverse events were reported in 11 patients (7.2%). Conclusion: DEE chemoembolization for nodular HCCs in the Korean population showed acceptable survival, tumor response, and safety profiles after a two-year follow-up. Good liver function (Child-Pugh score A5) was a key predictor of per-patient OS, PFS, and per-lesion tumor control.