• Asian Pacific Journal of Cancer Prevention
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• v.17 no.2
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• pp.743-748
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• 2016

Background: $K^-Ras$ activation is an early event in colorectal carcinogenesis and associated mutations have been reported in about 40% of colorectal cancer patients. These mutations have always been responsible for enhancing malignancy and silencing them is associated with attenuation of tumorigenicity. Among downstream effectors are the RAF/MEK/ERK and the PI3K/Akt signaling pathways. PI3K/Akt signaling leads to reduction of apoptosis, stimulated cell growth and enhanced proliferation. Ellagic acid (EA), a naturally occurring antioxidant, has recently emerged as a promising anti-cancer agent. Purpose: To evaluate the impact of cellular genetic makeup of two colon cancer cell lines with different genetic backgrounds, HCT-116 ($K^-Ras^-/p53^+$) and Caco-2 ($K^-Ras^+/p53^-$), on response to potential anti-tumour effects of EA. In addition, the influence of $K^-Ras$ silencing in HCT-116 cells was investigated. Materials and Methods: Cellular proliferation, morphology and cell cycle analysis were carried out in addition to Western blotting for detecting total Akt and p-Akt (at Thr308 and Ser473) in the presence and absence of different concentrations of EA. Cell proliferation was also assessed in cells transfected with different concentrations of $K^-Ras$ siRNA or incubated with ellagic acid following transfection. Results: The results of the present study revealed that EA exerts anti-proliferative and dose-dependent pro-apoptotic effects. Cytostatic and cytotoxic effects were also observed. p-Akt (at Thr308 and Ser473) was downregulated. Moreover, EA treatment was found to (i) reduce $K^-Ras$ protein expression; (ii) in cells transfected with siRNA and co-treated with EA, pronounced anti-proliferative effects as well as depletion of p-Akt (at Thr308) were detected. Conclusions: Cellular genetic makeup ($K^-Ras^-/p53^-$) was not likely to impose limitations on targeting EA in treatment of colon cancer. EA had a multi-disciplinary pro-apoptotic anti-proliferative approach, having inhibited Akt phosphorylation, induced cell cycle arrest and showed an anti-proliferative potential in HCT-116 cells (expressing mutant $K^-Ras$).

• The Journal of Korean Academic Society of Nursing Education
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• v.5 no.2
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• pp.267-284
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• 1999

The purpose of this study are 1. Evaluate the degree of knowledge of Vaginal Birth After Cesarean(VBAC) of Korean nurses. 2. To gather and develop educational material for VBAC. The sample was surveyed Korean Nurses knowledge about VBAC, from November 1998 through March 1999. For the data analysis, the SPSS computer program percentage and frequency were used for descriptive statistics. The x2 and the t-test were used to compare the results of the two sample groups. Open questions asked in the survey were sorted out by content, then displayed in chart form. For the education material, the Internet was the main source of information. Information on the Internet was provided by professional doctors and prenatal educational nurses. The results of the survey are as follows: 1. Out of 97 Nurses 15.3% answered that cesarean deliveries do not need to be performed after previous cesarean sections : however. 46.4% answered that cesarean sections must be performed after previous cesarean sections. 2. Of the nurses surveyed 14% had no knowledge or had never heard of VBAC. 3 Nurses did not have questions from patients concerning VBAC was 34.7%. This led to the conclusion that patients either do not have knowledge about VBAC or patients have no interest in the trial of labor. 4, Nurses indicated that their information about VBAC originated from other people's experiences (31%), Nursing School (25%), Media information (9%), and through literature review (6%). This data led to the conclusion that the knowledge about VBAC may not be extensive enough to counsel and guide patients who are willing to endure the trial of labor. 5. Nurses preferred hospital education programs to develop their knowledge concerning VBAC. Based upon survey, the conclusion was made that General Nurses and Maternity Nurses did not have knowledge about VBAC success rates and the possibility of a trial of labor. In order for nurses to help patients make decisions concerning VBAC, nurses have to gam more knowledge through hospital educational programs. Further more, the study suggests that through hospital educational programs, the possibility and importance of VBAC must be emphasized to nurses who work in maternity areas. Second, through prenatal educational programs, the possibility and importance of VBAC must be explained and emphasized to patients who had previous cesarean sections. Third, the clinical pathways of VBAC need to be developed. Fourth, each hospital needs to develop multi-disciplinary teams, consis-ting of obstetricians, risk management/quality management, staff registered nurses, and the director for perinatal services. This team can review cesarean section rates and help to increase the practice of VBAC.

• 대한공업교육학회지
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• v.34 no.1
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• pp.196-209
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• 2009

The purpose of this study was to analyze engineering basic competencies about the time completed a course and educational needs of engineering college graduates. Survey method using questionnaire was the major research method of this study. A survey of 807 engineering college graduates was carried out. Questionnaire were made of the level of engineering basic competencies of engineering college graduates, its priorities of actual vocation and level of engineering basic competencies of major. Major results of the study, some recommendations for future researches were made as follows: The level of engineering basic competencies of engineering college graduates was 3.3 average(5 full marks). Engineering basic competencies that educational needs were high respectively, were an ability to communicate effectively, an ability to design a system, component, or process to meet desired needs, an ability to function on multi-disciplinary teams, an ability to understand global culture and cooperate internationally, an ability to design and conduct experiment as well as to analyze and interpret data, and an ability to engage in life-long learning.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1987.05a
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• pp.6-6
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• 1987

만성중이염은 현재 그 빈도가 줄어드는 추세에 있으나 아직도 이과 영역에서 큰 비중을 차지하는 질환이다. 또한 청력개선, 정상구조의 보존, 병변 제거의 목적을 위하여 대부분 수술적 요법이 필요하게 된다. 이에 저자들은 본 병원에서 시행한 만성 중이염 451예, 남자 238예, 여자 213예. 진주종성 중이염 170예, 비진주종성 중이염 273예에 대한 수술시 소견에 대한 임상 통계적 관찰을 한 바, 다음과 같은 결과를 얻었다. 1) 관찰대상을 술식별로 분류하면 진주종성 중이염과 비진주종성 중이염의 비가 $\circled1$ Myningoplasty ; 19.1% : 0%, $\circled2$ Tympanoplasty without mastoidectomy ; 34.5% : 14.4%, $\circled3$ Tympanoplasty with mastoidectomy ; 3.0% :12.1% 이었다. 2) 고막천공부위는, 진주종성 중이염과 비진주종성 중이염의 비가 변연부천공이 10.1% : 5.5%, 상고실천공이 38.8% : 1.4%, 중심부천증이 12.9% : 47.3%, 전천공이 32.5% : 39.6%, 고막유착이 5.6% : 6.2% 을 보였다. 3) 이소골의 상태는 진주종성중이염과 비진주종성 중이염의 비가, 모든 이소골의 손실은 26.6% : 4.3%, 모든 이소골이 정상에 가까운 예는 16.6% : 69.3%, 가장 병변이 심했던 침골 이상은 76.9% : 24.8% 를 보였다. 4) 중이강 점막소견은 진주종성 중이염과 비진주종성 중이염의 비가, 정상에 가까운 예가 16.7% : 47.0%, 병적 소견을 보인 예가 83.3% : 53.0% 이었다. 5) 진주종성 중이염과, 비진주종성 중이염에서의 안면신경관노출은 2.2% : 0.3%, 뇌막노출은 9.5% : 2.9%, 횡정맥동노출은 5.0% : 1.1%, 미로누공은 1.7% : 0% 이었다.lant, engineering service business can be said "The Software of Total Industry." Engineering service is what is called a higher business which offers specialized engineering know-how and experience. Engineering service compaines offer Its specialized knowledge and experience to government, industry and commerce. Whether the task is to modernize plant equipment, to design a building or to manage construction, an engineering company will develop and implement the most appropriate and cost effective solution. Clients use the engineering service of firm knowing that the engineer′s professional judgement is not influenced or biased by other commercial affiliations. While benefiting from the diverse experience that professional engineers can apply to a specific problem, government and industry also reduce the need for permanent in-house engineering staff. Engineering firms may be specialized or multi-disciplinary.도말표본에서와 같이 제 14 일 이전에는 호중구가, 그 이후에는 단핵구가 주종을 이루었다.>18.9dB

• The Southeast Asian review
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• v.28 no.2
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• pp.47-84
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• 2018

Domestic debates on 'international development' has hitherto been rather more focused on the narrow topic of Official Development Assistance (ODA) - therefore, practical and practice-oriented enquiries for the former's effective implementation have dominated the field as a result. However, such lack of foundational debates on 'development' has rendered the field inept to respond to the rapidly changing development landscape since the new millennium both globally and in Southeast Asia. With this particular problematique in mind, the paper argues for the utility of critical Southeast Asian studies in enriching theoretical debates in Korea's international development studies. In doing so, we analysed the trend of academic research published since 2000, of which theme concern international development with a specific geographical focus on Southeast Asia. The result shows that such publication and the thematic issues have witnessed rapid quantitative growth since 2007 - while the nature of the publications still clearly remained practical and practice-oriented for effective execution of ODA. We therefore propose the critical Southeast Asian studies to overcome the problematique above by emphasising more inter-/multi-disciplinary approaches that challenge the hegemonic paradigm in the field.

• Journal of Gastric Cancer
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• v.9 no.4
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• pp.186-192
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• 2009

Purpose: The aim of this study was to analyze the trend of the literature reported in the Journal of Korean Gastric Cancer Association (JKGCA) and the Journal of Korean Surgical Society (JKSS) in order to suggest new directions for the future studies on gastric cancer. Materials and Methods: The papers published in the Journal of Korean Gastric Cancer Association (JKGCA) and the Journal of Korean Surgical Society (JKSS) between 2001 and 2008 were compared and summarized in terms of the following categories, retrospective study, prospective study, case report, biomolecular study, genetic study, tumor marker study, review article, and report. Results: For recent 8 years, while the number of review articles in JKSS had initially increased, gradually fallen down and recently increased again, only a few (only 6 publications) in JKGCA have been published. The number of case reports in JKSS has gradually increased and fallen down. On the other hand, a few of case reports (1~3 publications) has been annually published in JKSS. Uniquely, reports were published only in JKGCA with the noticeable increase during the period from 2004 to 2005. For retrospective studies, in JKGCA the number started off very high and decreased, and finally increased again (U-shaped), whereas it had a bell-shaped trend in JKSS. The number of prospective studies in JKGCA had a bell-shaped trend, but the one in JKSS continued to decrease. Few papers of molecular biologic study, tumor marker study and genetic study had been published in both journals. Conclusion: We concluded that the transition from retrospective studies to prospective studies as well as a comprehensive multi-disciplinary team management of a clinical research would represent a desirable strategy in gastric cancer research.