• Genomics & Informatics
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• 제21권3호
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• pp.42.1-42.23
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• 2023

Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, one of the most deadly infections in humans. The emergence of multidrug-resistant and extensively drug-resistant Mtb strains presents a global challenge. Mtb has shown resistance to many frontline antibiotics, including rifampicin, kanamycin, isoniazid, and capreomycin. The only licensed vaccine, Bacille Calmette-Guerin, does not efficiently protect against adult pulmonary tuberculosis. Therefore, it is urgently necessary to develop new vaccines to prevent infections caused by these strains. We used a subtractive proteomics approach on 23 virulent Mtb strains and identified a conserved membrane protein (MmpL4, NP_214964.1) as both a potential drug target and vaccine candidate. MmpL4 is a non-homologous essential protein in the host and is involved in the pathogen-specific pathway. Furthermore, MmpL4 shows no homology with anti-targets and has limited homology to human gut microflora, potentially reducing the likelihood of adverse effects and cross-reactivity if therapeutics specific to this protein are developed. Subsequently, we constructed a highly soluble, safe, antigenic, and stable multi-subunit vaccine from the MmpL4 protein using immunoinformatics. Molecular dynamics simulations revealed the stability of the vaccine-bound Tolllike receptor-4 complex on a nanosecond scale, and immune simulations indicated strong primary and secondary immune responses in the host. Therefore, our study identifies a new target that could expedite the design of effective therapeutics, and the designed vaccine should be validated. Future directions include an extensive molecular interaction analysis, in silico cloning, wet-lab experiments, and evaluation and comparison of the designed candidate as both a DNA vaccine and protein vaccine.

• 대한방사선기술학회지:방사선기술과학
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• 제41권2호
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• pp.123-128
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• 2018

Recently, the use of contrast agents has been increasing as a broader range of tests and dynamic tests have become common due to the development of equipment and imaging techniques such as Multi-Detector CT. However, the side effects of using contrast agents have been reduced by the development of non-ionic contrast agents, but they are still occurring often. The purpose of this study was to propose a method to minimize the side effect of contrast agent by using the amount of contrast agent injected to the brain angiography test to suppress excessive use of contrast agent and analyze the amount of contrast agent. Patients who were prescribed Brain Angiography due to cerebrovascular disease, According to the results of the comparison of the results obtained by dividing into 4 groups of 10ml each according to the amount of contrast medium injected with contrast agent according to the BMI of the patient, BA and SNR were not different between groups, and even if the amount of contrast injection was reduced, there was no problem in the evaluation of CT angiography through 3D reconstruction. This result shows that even if the contrast medium is injected into the blood vessels of the patient first and then the contrast medium is used as the physiological saline solution, the contrast medium is reduced by 40% it can be expected to minimize.

• 인터넷정보학회논문지
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• 제2권4호
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• pp.41-53
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• 2001

고가용 E-Business 모델을 위해 구축된 다중 분산 웹 클러스터 모델은 구조적 특성상 내부 시스템 노드들이 노출되어 있으며, 불법적인 3자에 의한 고의적인 방해와 공격으로 정상적인 작업수행이 불가능할 가능성을 지니고 있다. 따라서 구성된 시스템 노드들을 보호하고 불법적인 사용자로부터의 정보유출과 부당한 서비스 요구를 효과적으로 대응할 수 있는 보안 시스템이 필요하다. 제안한 분산 침입 탐지 시스템은 SC-Server의 공유메모리를 기반으로 SC-Agent간의 유기적인 제어를 통하여 개방된 네트워크 상에 분산되어 있는 시스템 노드에 대한 불법적인 요구나 자원 접근을 탐지하는 기술이다. 분산 침입 탐지시스템은 불법적인 침입을 탐지하기 위하여 일차적으로 Detection Agent를 이용한 작업요구 패킷의 검사를 수행하며, 이후 작업이 진행되었을 때 Monitoring Agent를 통하여 작업과정을 관찰하며 허용되지 않는 자원의 접근 및 요구가 발생하였을 때, 다른 시스템 노드와의 긴밀한 협조작업을 통해 침입여부를 판단한다.

• 한국방송∙미디어공학회:학술대회논문집
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• 한국방송공학회 2009년도 추계학술대회
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• pp.165-172
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• 2009

Integrated management model (SNMP/SMI) for lubiquitous egacy remote communication network or service make possible combination of various architecture. However, legacy management system cannot be applied some problems such as inefficient, complexly, implement and large network by reason of integration of voice and data, wired and wireless, and service area between service provider. For improve this, supplied JMX(Java Management eXtensions) on network management technology from SUN. JMX is integrated architecture for existing network management and monitoring. In this paper, we design and implement for integrated network management through multi-protocol agent using JMX.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2009년도 추계학술대회 논문집
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• pp.331-335
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• 2009

A novel multi-staged waste pyrolysis & gasification system of pilot scale (~1 ton/day) is designed and constructed in Korea Institute of Industrial Technology. The pyrolysis & gasification system is composed of pyrolysis & gasification system, syngas reformer, syngas cleaning system, gas engine power generation system and co-combustion system. For each unit process, experimental approaches have been conducted to find optimal design and operating conditions. As a result, We can produce syngas with a calorific value of ~4000 kcal/$Nm^3$ and cold gas efficiency of the system is more than 55 % in case of waste plastic and oxygen as a gasifying agent.

• 지능정보연구
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• 제12권1호
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• pp.139-161
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• 2006

본 논문에서는 새로운 조합경매(combinational auction)모형인 다자간 최적화 경매모형(N-Bilateral Optimized Combinatorial Auction; N-BOCA)을 제시하였다. N-BOCA는 다수의 공급자 및 다수의 구매자간 최적화된 거래를 지원하는 조합경매모형이다. 특히 아키텍처, 거래규약, 거래전략 세가지 관점에서 N-BOCA 시스템을 설계하였다. 경매시장 참여자인 경매자들과 입찰자들은 특정 아키텍처 및 거래규약하에서 최적 거래 대상자 선정을 위한 다양한 전략을 가지게 되며 이러한 거래전략에 따른 유연한 의사결정 모델링 지원을 필요로 한다. 이에 본 논문에서는 최적의 입찰 및 경매자 선정을 위한 Integer Programming 모형 기반의 에이전트 시스템을 제시하였다. 아울러 N-BOCA모형의 유용성을 입증하기 위해 프로토타입과 실험결과를 제시하였다. 실험결과, 기존의 일대다 조합경매 모형 대비 높은 거래 성과를 나타내었다.

• 한국항해항만학회지
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• 제28권10호
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• pp.917-923
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• 2004

공간정도의 생산과 수요가 본격화되고 있으나 공간정보의 본질과 응용특성을 고려한 공간정보모델링체계에 대해서는 특성화된 연구가 충분히 수행되고 있지 않다. 특히, 기존의 모델링기법들은 대부분 정보의 표현과 분석기능을 대상으로 개발되었으므로 보다 고차원적인 의사결정지원과 자율적인 업무수행을 위한 이론적 모델의 개발에 대한 논의가 최근의 지식정보화환경에서 더욱 요구되고 있다. 본 논문에서는 공간정보시스템을 모델링하기 위한 여러 기반개념들과 모델링 유형에 대한 고찰을 통해, 기존 모델링 방법에 대한 문제점을 분석하여 효율적인 공간적 업무수행을 위한 요구사항을 도출한다. 또한, 도출된 공간정보모델링의 요구사항에 적합한 이론적인 접근방안으로서 에이전트 기반의 공간모델링 프레임워크를 제안하며, 이러한 프레임워크를 해양지리정보분야에 적용하기 위한 고려사항도 함께 제시한다.

• Carbon letters
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• 제8권3호
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• pp.184-190
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• 2007

Carbon Nano Tubes could be either metallic or semi-conducting in nature, depending on their diameter. Its photocatalytic behavior has given an impetus to use it as an anti-microbial agent. More than 95% Escherichia coli and Staphylococcus aureus bacteria got killed when exposed to Carbon Nano Tubes for 30 minutes in presence of sunlight. Carbon Nano Tubes are supposed to have smooth surface on to which it accumulates positive charges when exposed to light. The surface that is non illuminated has negative charge. At the cellular level microorganisms produce negative charges on the cell membrane, Therefore damaging effect of multi walled carbon nano tubes (exposed to light) on the microorganisms is possible. In this paper, photo catalytic killing of microbes by multi walled carbon nano tubes is reported. Killing was due to damage in the cell membrane, as seen in SEM micrographs. Moreover biochemical analysis of membrane as well as total cellular proteins by SDS PAGE showed that there was denaturation of membrane proteins as well as total proteins of both the microbes studied. The killed microbes that showed a decrease in number of protein bands (i.e. due to breaking down of proteins) also showed an increase in level of free amino acids in microbes. This further confirmed that proteins got denatured or broken down into shorter units of amino acids. Increased level of free amino acids was recorded in both the microbes treated with multi walled carbon nano tubes and sunlight.

• 한국자동차공학회논문집
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• 제16권4호
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• pp.165-172
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• 2008

Urea-SCR, the selective catalytic reduction using urea as reducing agent, has been investigated for about 10 years in detail and today is a well established technique for deNOx of stationary diesel engines. In the case of the SCR-catalyst a non-uniform velocity and $NH_3$ profile will cause an inhomogeneous conversion of the reducing agent $NH_3$, resulting in a local breakthrough of $NH_3$ or increasing NOx emissions. Therefore, this work investigates the effect of flow and $NH_3$ non-uniformities on the deNOx performance and $NH_3$ slip in a Urea-SCR exhaust system. From the results of this study, it is found that flow and $NH_3$ distribution within SCR monolith is strongly related with deNOx performance of SCR catalyst. It is also found that multi-hole injector shows better $NH_3$ uniformity at the face of SCR monolith face than one hole injector.

• 정보와 통신
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• 제34권2호
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• pp.12-19
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• 2017

The LED technology advancement introduce cuttingedge technology on Internet of Things (IoT) to connect the physical world to the digital realm, using digital smart lighting infrastructure called Internet of light (IoL). This paper proposes an Integrated IoT agent on networked smart LED lighting controller called IoL Filed Gateway using lighting infrastructure in which a lighting system that can connect to a network and can be monitored and controlled from a centralized system or via the cloud. The IoL Field Gateway defines new world of smart connected intelligence, lighting can become an integral and responsive part of everyday human life environments. The proposed connected lighting gateway uses the concept of multi-hop ad hoc network using visible light communication (VLC) with RF wireless technologies and Wired PLC (Power Line Communication). This connectivity and intelligence integrated into LED-based luminaires form the backbone of smart buildings and cities and make the Internet of Things (IoT) vision feasible and enables the lighting administrator can control numerous lightings easily and visitors can get visual information from the lightings with their smart devices. The proposed IoL gateway design is emulated on Arduino based HW platform with VLC, RF, and PLC connectivity and evaluated with four sensor interface.