• Nuclear Medicine and Molecular Imaging
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• 제42권2호
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• pp.98-111
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• 2008

This review introduces advances in clinical and pre-clinical single photon emission computed tomography (SPECT) and positron emission tomography (PET) providing noninvasive functional images of biological processes. Development of new collimation techniques such as multi-pinhole and slit-slat collimators permits the improvement of system spatial resolution and sensitivity of SPECT. Application specific SPECT systems using smaller and compact solid-state detector have been customized for myocardial perfusion imaging with higher performance. Combined SPECT/CT providing improved diagnostic and functional capabilities has been introduced. Advances in PET and CT instrumentation have been incorporated in the PET/CT design that provide the metabolic information from PET superimposed on the anatomic information from CT. Improvements in the sensitivity of PET have achieved by the fully 3D acquisition with no septa and the extension of axial field-of-view. With the development of faster scintillation crystals and electronics, time-of-flight (TOF) PET is now commercially available allowing the increase in the signal-to-noise ratio by incorporation of TOF information into the PET reconstruction process. Hybrid PET/SPECT/CT systems has become commercially available for molecular imaging in small animal models. The pre-clinical systems have improved spatial resolution using depth-of-interaction measurement and new collimators. The recent works on solid state detector and dual modality nuclear medicine instrumentations incorporating MRI and optical imagers will also be discussed.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.461-463
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• 2002

Image quality and selection of optimized window for good quality reconstruction in coronary angiography using multi-detector row CT (MDCT) have not been studied by heart rate and its variation. Therefore, the effect of heart rate and its variation was systemically analyzed. Eighty-three patients were undergone contrast-enhanced coronary angiography using MDCT. In this study, sixty cases were enrolled. Two radiologists graded image quality as follows: 4, excellent; 3, good; 2, fair; l, bad. The starting points of the reconstruction window were chosen at seventy and forty percent of R wave interval. Optimized window was scored as 1 when 40% reconstruction was better quality than 70%, as 2 when 40% reconstruction is same as 70%, and as 3 when 70% reconstruction was better than 40%. Regression analysis was performed. The range of variation of beats per minute (BPM) was well correlated with image quality (r=-0.55, p=0.000), however correlation with optimized window percentage was not statistically significant (p=0.969). By contraries, median value of BPM was comparatively well correlated with optimized window grade (r=-0.24, p=0.086). Median value of BPM was not well correlated with image quality (r=0.l70, p=0.l97). Image quality is more affected by variation of heart rate (VHR) than by higher heart rate. Selection of optimized reconstruction window for good image quality is mainly affected by heart rate and there is a tendency that systolic phase reconstruction is better in image quality than diastolic reconstruction in higher heart rate.

• 대한영상의학회지
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• 제84권5호
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• pp.1047-1065
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• 2023

다중검출기컴퓨터단층촬영(multi-detector CT; 이하 MDCT)은 높은 정확도를 가진 진단도구로서 충수염과 그 합병증을 평가하기 위해 보편적으로 사용된다. MDCT 소견에 근거한 충수염의 진단은 영상 소견이 전형적인 모습과 일치하지 않을 때 어려울 수 있다. 비전형적인 충수염에는 충수 및 맹장의 위치이상을 동반하는 경우, 합병증이 나타난 경우 그리고 충수염을 모방하거나 유발하는 병리학적 소견을 동반한 경우 등 다양한 스펙트럼의 질환이 포함된다. 본 임상화보는 비전형적이고 복잡한 충수염 및 충수염과 유사한 상태의 다양한 스펙트럼을 위치이상, 드문 합병증 및 종양, 반응성 충수염, 충수게실염, IgG4 연관 질환을 포함한 병리학적 이상의 관점에서 설명했다. 본 임상화보를 통해 독자들은 다양한 스펙트럼의 비전형적 충수염 MDCT 소견에 더 익숙해질 수 있다.

• 대한의용생체공학회:의공학회지
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• 제28권3호
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• pp.332-337
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• 2007

In the early twenty-first century, minimally invasive surgery is the mainstay of various kinds of surgical fields. Surgeons gave percutaneously surgical treatment of the screw directly using a fluoroscopic view in the past. The latest date, they began to operate the fractured carpal bone surgery using Computerized Tomography (CT). Carpal bones composed of wrist joint consist of eight small bones which have hexahedron and sponge shape. Because of these shape, it is difficult to grasp the shape of carpal bones using only CT image data. Although several image segmentation studies have been conducted with carpal bone CT image data, more studies about carpal bone using CT data are still required. Especially, to apply the software implemented from the studies to clinical fIeld, the outcomes should be user friendly and very accurate. To satisfy those conditions, we propose modified multi-seed region growing segmentation method which uses simple threshold and the canny edge detector for finding edge information more accurately. This method is able to use very easily and gives us high accuracy and high speed for extracting the edge information of carpal bones. Especially, using multi-seed points, multi-bone objects of the carpal bone are extracted simultaneously.

• 한국의학물리학회지:의학물리
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• 제21권2호
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• pp.137-144
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• 2010

64 multi-detector computed tomography (MDCT)에서 두개부의 과도한 선량이 문제가 되어 고정관류기법과 관전류 자동노출조절(automatic exposure control, AEC) 기법을 이용하여 선량 감소 정도를 비교 평가하고자 한다. 연구에 사용한 장비는 Siemens사의 SOMATOM Definition 64 multi-detector CT를 이용했으며, Whole body phantom (KUPBU-50, Kyoto Kagaku CO. Ltd)의 두개부를 사용했다. 실험 protocol은 helical scan 방식을 적용하여 120 kVp, rotation time은 1 sec, slice thickness와 increment는 각각 5 mm, FOV는 250 mm, matrix size는 $512{\times}512$, collimation은 $64{\times}0.625\;mm$, pitch는 1로 조사하였다. 선량감소효과의 측정방법은 관전류를 350 mAs로 고정한 방법과 AEC 기법을 적용한 방법으로 나누어 평가하였으며, 영상품질은 CT number의 표준편차를 이용하여 영상의 잡음을 측정하였다. 이 때 두개부(craniofacial bone)는 머리덮개뼈(calvaria) 끝부분에서 눈썹활(superciliary ridge)까지를 1구역, 논썹활 아래부터 코가시점(acanthion)까지를 2구역, 그리고 코가시점 아래부터 턱(mentum)끝까지를 3구역으로 정의하여 측정하였다. 고정관류기법에서 구역별로 CTDIvol은 57.7 mGy였으며, DLP는 $640.2\;mGy{\cdot}cm$로 동일하였다. AEC 기법을 적용한 1구역은 CTDIvol: 30.7 mGy, DLP: $340.7\;mGy{\cdot}cm$, 2구역은 CTDIvol: 46.5 mGy, DLP: $515.0\;mGy{\cdot}cm$, 그리고 3구역은 CTDIvol: 30.3 mGy, DLP: $337.0\;mGy{\cdot}cm$으로 나타났다. 영상품질을 나타내는 CT number의 표준편차는 1구역에서 고정 관류기법은 2.6, AEC 기법은 3.0, 2구역에서 고정 관류기법은 3.1, AEC 기법은 3.4, 3구역에서 고정 관류기법은 2.7, AEC 기법은 3.2으로 측정되었다. 64 MDCT에서의 AEC 기법은 기존의 고정관류법에 비해 안구, 이하선 그리고 갑상선 부위에 대해 큰 선량 감소효과가 나타났으며, 두개부의 방사선량을 감소시키는데 매우 유용한 기법으로 사료된다.

• Korean Journal of Radiology
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• 제24권10호
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• pp.1006-1016
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• 2023

Objective: Computed tomography (CT) is an established method for the diagnosis, staging, and treatment of multiple myeloma. Here, we investigated the potential of photon-counting detector computed tomography (PCD-CT) in terms of image quality, diagnostic confidence, and radiation dose compared with energy-integrating detector CT (EID-CT). Materials and Methods: In this prospective study, patients with known multiple myeloma underwent clinically indicated whole-body PCD-CT. The image quality of PCD-CT was assessed qualitatively by three independent radiologists for overall image quality, edge sharpness, image noise, lesion conspicuity, and diagnostic confidence using a 5-point Likert scale (5 = excellent), and quantitatively for signal homogeneity using the coefficient of variation (CV) of Hounsfield Units (HU) values and modulation transfer function (MTF) via the full width at half maximum (FWHM) in the frequency space. The results were compared with those of the current clinical standard EID-CT protocols as controls. Additionally, the radiation dose (CTDIvol) was determined. Results: We enrolled 35 patients with multiple myeloma (mean age 69.8 ± 9.1 years; 18 [51%] males). Qualitative image analysis revealed superior scores (median [interquartile range]) for PCD-CT regarding overall image quality (4.0 [4.0-5.0] vs. 4.0 [3.0-4.0]), edge sharpness (4.0 [4.0-5.0] vs. 4.0 [3.0-4.0]), image noise (4.0 [4.0-4.0] vs. 3.0 [3.0-4.0]), lesion conspicuity (4.0 [4.0-5.0] vs. 4.0 [3.0-4.0]), and diagnostic confidence (4.0 [4.0-5.0] vs. 4.0 [3.0-4.0]) compared with EID-CT (P ≤ 0.004). In quantitative image analyses, PCD-CT compared with EID-CT revealed a substantially lower FWHM (2.89 vs. 25.68 cy/pixel) and a significantly more homogeneous signal (mean CV ± standard deviation [SD], 0.99 ± 0.65 vs. 1.66 ± 0.5; P < 0.001) at a significantly lower radiation dose (mean CTDIvol ± SD, 3.33 ± 0.82 vs. 7.19 ± 3.57 mGy; P < 0.001). Conclusion: Whole-body PCD-CT provides significantly higher subjective and objective image quality at significantly reduced radiation doses than the current clinical standard EID-CT protocols, along with readily available multi-spectral data, facilitating the potential for further advanced post-processing.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.468-470
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• 2002

We have designed X-ray detection system and multi-channel data acquisition system for Spiral CT application. X-ray detection system consists of scintillator and photodiode. Scintillator converts X-ray into visible light. Photodiode converts visible light into electrical signal. The multi-channel data acquisition system consists of analog, digital, master and backplane board. Analog board detects electrical signal and amplifies signal by 140dB. Digital board consists of MUX(Multiplex) which routes multi-channel analog signal to preamplifier, and ADC(Analog to Digital Converter) which converts analog signal into digital signal. Master board supplies the synchronized clock and transmits the digital data to image reconstructor. Backplane provides electrical power, analog output and clock signal. The system converts the projected X-ray signal over the detector array with large gain, samples the data in each channel sequentially, and the sampled data are transmitted to host computer in a given time frame. To meet the timing limitation, this system is very flexible since it is implemented by FPGA(Field Programmable Gate Array). This system must have a high-speed operation with low noise and high SNR(signal to noise ratio), wide dynamic range to get a high resolution image.

• 재활복지공학회논문지
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• 제10권3호
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• pp.237-242
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• 2016

slip-ring 기술을 가진 spiral CT의 주요 장점으로는 X-ray 튜브의 연속적인 회전에 의해 환자에 대한 정보의 손실 없이 데이터를 연속적으로 획득할 수 있다는 것이다. 또한, X-선량의 인체 흡수의 감소를 위해서, 고시그널 저노이즈 및 빠른 데이터 획득 시간을 갖는 시스템이 요구되어 진다. 본 연구에서, CT 적용을 위해 다채널 포토센서 및 데이터 획득 시스템이 개발되어 졌다. 포토센서의 모듈은 16채널 CdWO4 크리스탈 및 실리콘 베이스의 포토다이오드가 사용되었다. 또한, 포토센서로 부터의 입력 신호에 대한 전기적인 증폭을 위해, 트랜스 임피던스 스위치 인테그레이터가 사용되었다. 스위치 인테그레이터는 CT 적용에 대해 적합한 시그널 밴드와 노이즈 퍼포먼스를 갖고 있다. 데이터 획득과 20 bit ADC 의 컨트롤은 FPGA를 이용하였고, 코딩은 VHDL을 사용하였다. CdWO4 기반의 실리콘 포토센서와 고SNR 및 좁은 시그널 밴드를 가진 증폭단 및 FPGA기반의 디지털 하드웨어는 CT적용 이외에 하드웨어 변경 없이 다른 분야에서도 이용 가능하다.

• Imaging Science in Dentistry
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• 제42권1호
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• pp.25-33
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• 2012

Purpose : This study was performed to determine the accuracy of linear measurements on three-dimensional (3D) images using multi-detector computed tomography (MDCT) and cone-beam computed tomography (CBCT). Materials and Methods : MDCT and CBCT were performed using 24 dry skulls. Twenty-one measurements were taken on the dry skulls using digital caliper. Both types of CT data were imported into OnDemand software and identification of landmarks on the 3D surface rendering images and calculation of linear measurements were performed. Reproducibility of the measurements was assessed using repeated measures ANOVA and ICC, and the measurements were statistically compared using a Student t-test. Results : All assessments under the direct measurement and image-based measurements on the 3D CT surface rendering images using MDCT and CBCT showed no statistically difference under the ICC examination. The measurements showed no differences between the direct measurements of dry skull and the image-based measurements on the 3D CT surface rendering images (P>.05). Conclusion : Three-dimensional reconstructed surface rendering images using MDCT and CBCT would be appropriate for 3D measurements.

• Imaging Science in Dentistry
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• 제34권3호
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• pp.159-164
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• 2004

Purpose: To compare alveolar bony height of pantomograph with bony height of thin slice, multiplanar reformatted (MPR) Computed Tomograph. Materials and Methods : Panoramic radiograms of 12 young adult patients had been taken by one radologic technitian and the measurements were corrected by magnification ratio (1.20). The slice thickness of Multi-detector Computed Tomography (CT) was at least 1mm for the accuracy. The raw CT datas were imported into the V-works 4.0 (CyberMed Corp., Seoul, Korea) and transformed to MPR images. Pantomographic measurements of alveolar bone were compared to CT values by average mean bony height measurements for the accuracy. Inter-, and Intra-observer variability was evaluated. Results : There was no significant differences between height measurement of pantomography and that of CT (P>0.05). There were no significant differences in either inter-or intra-observer measurements (P>0.05). Conclusion : Pantomography showed relatively high accuracy and precision in measuring alveolar bony height.