• 대한인간공학회지
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• 제31권6호
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• pp.725-731
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• 2012

Objective: The aim of this study is to investigate visual feedback effects and human performance in the foot mouse control. Background: Generally, computer mouse tasks are controlled by visual feedback. In order to understand the characteristics of a foot mouse control, it is important to investigate the patterns of visual feedback involved in foot-mouse control tasks. Human performance of foot mouse control is also an important factor to understand the foot mouse control. Method: Three types of mouse control were determined to investigate visual feedback effects and human performance in the foot mouse control. Visual feedback effects in the foot mouse control were compared with those of a typical hand mouse. The cursor movement speed and mental workload were measured in the three types of tasks and two types of mouses. Results: Mouse control tasks with an element of homing-in to the target were more quickly performed by the hand mouse than the foot mouse. Mental workload was also higher in the foot mouse than the hand mouse. However, in the steering movement, human performance of the foot mouse control was not lower than that of the hand mouse control. Visual feedback in the foot mouse control was less required than in the hand mouse control. Conclusion: The foot mouse was not efficient in the most mouse control tasks, compared to the hand mouse. However, the foot mouse was efficient in the steering movement, moving a cursor within a path with lateral constraints. Application: The results of this study might help to develop the foot mouse.

• 한국식품영양과학회지
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• 제29권3호
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• pp.525-530
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• 2000

상품가치가 없는 비상품구로부터 추출한 OWE를 mouse의 피부암 및 위장암 저해 효과에 관한 실험을 한 결과 피부암의 경우 control구에서는 6주부터 종양이 발생하여 23주에는 mouse 당 2.9개의 종양이 발생하였으나 20mg OWE 처리구에서는 8주부터 종양이 발생하여 23주에는 mouse 당 1.3개의 종양이 발생하여 control에 비해 55.2%의 종양 억제효과가 있었다. 20mg quercetin 처리에서는 6주부터 종양이 발생하기 시작하여 23주에는 mouse 당 1.2개의 종양이 발생하였다. 처리별 암 발생율은 20mg OWE 처리에서 85.7%, 20mg quercetin 처리에서는 76.2%의 발생율을 보여 control의 95.2%에 비해 낮은 암발생율을 보였다. 위장암의 경우 control에서는 mouse 당 9.2개의 종양이 발생하였고, 50mg OWE 및 25mg OWE 처리에서는 각 6.1, 6.3개의 종양이 발생하여 control에 비해 각각 33.7%, 31.5%의 종양억제효과가 있었다. 그리고 25mg quercetin 처리에서는 mouse 당 5.3개의 종양이 발생하였다. 처리별 암발생율은 50mg OWE 및 25 mg OWE 처리에서 각 88.2%, 94.1%, 25mg quercetin 처리에서 83.3%의 발생율을 보여 control 100%에 비해 낮은 암발생율을 보였다.

• 대한인간공학회지
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• 제35권3호
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• pp.175-184
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• 2016

Objective: In this study, two types of foot-controlled mouse devices are compared with a hand mouse in the input tasks requiring repetitively switching between a keyboard and a mouse. Background: Foot-controlled mouse devices have been developed for persons with impairments in the mobility of their hands. However, some researchers insisted that the foot-controlled mouse devices could be effectively used by the persons with no limits to their hand mobility. There are needs to investigate the efficiency of the foot-controlled mouse devices, when they are used by the nondisabled people. Method: Participants conducted the input tasks, requiring repetitive switches between a keyboard and a computer mouse. The used computer mouse devices were two types of foot-controlled mouse and a typical hand mouse. Participants performed three types of input task for five days and three types of task performance were measured; the number of completed input tasks within a given practice time, subjective satisfaction level and the time wasted for the mouse control. Results: For five days, the performance of input tasks sharply increased in input tasks by foot-controlled mouse devices rather than a hand mouse. After five days, the level of satisfaction on the foot-controlled mouse devices approached to about 76% of a hand mouse satisfaction level. The control time of the foot-controlled mouse devices also approached to about 109% of a hand mouse control time. Conclusion: After only five-day practice, the input task performance by foot-controlled mouse devices approached to that of a hand mouse. This result may suggest that the foot-controlled mouse devices can be effectively used as an alternative input device for the nondisabled people, if input tasks are easy and enough practice time is provided. Application: The results of this study might help to design foot-controlled mouse devices and to expend the usage of them.

• International Journal of Control, Automation, and Systems
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• 제5권2호
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• pp.147-154
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• 2007

This paper describes a 'gyro-mouse', which provides a new human-computer interface (HCI) for persons who are disabled in their upper extremities, for handling the mouse-click and mouse-move function. We adopted the artificial neural network to recognize a quick-nodding pattern of the disabled person as the gyro-mouse click. The performance of our gyro-mouse was evaluated by three indices that include 'click recognition rate', 'error in cursor position control', and 'click rate per minute' on a target box appearing at random positions. Although it turned out that the average error in cursor positioning control was 1.4-1.5 times larger than that of optical mouse control, and the average click rate per minute was 40% of the optical mouse, the overall click recognition rate was 93%. Moreover, the click rate per minute increased from 35.2% to 44% with repetitive trials. Hence, our suggested gyro-mouse system can be used to provide a new user interface tool especially for those persons who do not have full use of their upper extremities.

• 한국멀티미디어학회논문지
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• 제20권4호
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• pp.671-685
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• 2017

We propose a finger detection algorithm for computer mouse control to control the most commonly actions of a computer mouse(left, right and double click, scroll up and down then we add open and close, minimize and maximize a window, control the mouse.) We use a built-in web camera to control the mouse tasks. We detected, segment, then recognize the hand in our previous papers [1, 2]. The user will be able to interact with the computer with the number of fingers detected.

• Interdisciplinary Bio Central
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• 제2권4호
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• pp.15.1-15.5
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• 2010

RIKEN BioResource Center (BRC) has collected, preserved, conducted quality control of, and distributed mouse resources since 2002 as the core facility of the National BioResource Project by the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. Our mouse resources include over 5,000 strains such as humanized disease models, fluorescent reporters, and knockout mice. We have developed novel mouse strains such as tissue-specific Cre-drivers and optogenetic strains that are in high demand by the research community. We have removed all our specified pathogens from the deposited mice and used our quality control tests to examine their genetic modifications and backgrounds. RIKEN BRC is a founding member of the Federation of International Mouse Resources and the Asian Mouse Mutagenesis and Resource Association, and provides mouse resources to the one-stop International Mouse Strain Resource database. RIKEN BRC also participates in the International Gene Trap Consortium, having registered 713 gene-trap clones and their sequences in a public library, and is an advisory member of the CREATE (Coordination of resources for conditional expression of mutated mouse alleles) consortium which represents major European and international mouse database holders for the integration and dissemination of Cre-driver strains. RIKEN BRC provides training courses in the use of advanced technologies for the quality control and cryopreservation of mouse strains to promote the effective use of mouse resources worldwide.

• Applied Biological Chemistry
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• 제40권6호
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• pp.490-494
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• 1997

Benzo[a]pyrene (BP)으로 유발한 mouse의 전위암 형성에 대한 astaxanthin 함유 난황 (astaxanthin-containing egg yolk : AEY)의 영향을 연구하였다. Female ICR mouse (6-7 주령, 5 mice/cage, 20 mice/treatment)에게 물과 사료를 자유로이 공급하면서 일주일간 적응시킨 후 다음과 같이 처리를 하였다. BP (2 mg/0.2 ml corn oil)를 각 mouse에 경구투여하기 4 일과 2 일 전에 50 mg AEY, 100 mg AEY, 150 mg AEY, 또는 150 mg control egg yolk (CEY)을 함유하는 phosphate-buffered saline (PBS) 0.2 ml를 경구투여하였다. Control mouse는 0.2 ml PBS와 BP 만 경구투여하였다. 이 과정을 4회 반복하였다. BP를 경구투여 한 일주일 후부터 몸무게와 사료섭취량을 매주 기록하였으며 24주 후에 생존한 모든 mouse에 대해 전위암 생성을 조사하였다. AEY를 처리한 mouse에서는 control mouse나 CEY 처리 mouse에 비해 mouse 당 암의 수가 1/3 정도로 감소되었다. 이와 같은 AEY의 항암효과는 AEY의 처리량에 비례하였다. AEY 처리에 따른 암발생율은 control이나 CEY 처리에 비해 감소되었으나 150 mg AEY 처리에서만 유의성이 있는 감소를 보였다. AEY 처리에 따른 몸무게나 사료 소비량의 감소현상은 볼 수 없었다. 따라서 이 결과는 AEY가 BP로 유발한 mouse의 전위암 발생을 억제함을 암시한다.

• 한국환경성돌연변이발암원학회지
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• 제18권1호
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• pp.22-25
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• 1998

Anticarcinogenic activity of astaxanthin-containing egg yolks (designate AEY) was investigated for 7,12-dimethylbenz[a]anthracene (DMBA)-induced two stage mouse epidermal carcinogenesis. Female ICR mouse (6-7 weeks of age) were house in a humidity-and-temperature-controlled facility and subjected to feed and water ad libitum. AEY (10 mg/0.2 ml acetone) was painted on the back of mice 7 days, 3 days and 5 min before DMBA treatment (50 nmole/0.2 ml acetone). One week later after DMBA treatment, 6 ${\mu}g$ tetradecanoyl 12-phorbol 13-O-acetate (TPA) dissolved in 0.2 ml acetone was applied on the mouse twice weekly over a period of 22 weeks. No sample was given to control mice. Control egg yolk (CEY) and astaxanthin-containing oil (designate AO) from Phaffia rhodozyma were used as positive controls. Mouse treated with AEY exhibited 10 tumors per mouse whereas control mouse exhibited 15 tumors per mouse, the fact that 33% reduction of tumor per mouse by AEY treatment. Tumor incidence was also reduced to 15% by AEY treatment when compared to that of control group. Such effects were also seen in CEY and AO treatment groups, but leaser extent. AO gave reduction of food intake and body weights relative to those of AEY and CEY, indicating toxicity of AO. These results suggest that AEY exhibits anticarcinogenic activity for DMBA-induced mouse epidermal carcinogenesis.

• 산업공학
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• 제17권1호
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• pp.113-120
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• 2004

The increased use of computers has introduced a variety kind of human-computer interfaces. Mouse is one of the useful interface tools to place the cursor on the desired position on the monitor. This paper suggested a foot controlled isotonic mouse which was similar to the ordinary hand-controlled mouse except that positioning was controlled by the right foot and the clicking was performed by the left foot. Experimental results showed that both the index of difficulty(IOD) and the display-control gain(DC gain) varied the total movement time in a target acquisition task on the monitor. The present authors also drew the optimal display-control gain of the foot-controlled isotonic mouse over the index of difficulty of 1.0 to 3.0. The optimal display-control gain, i. e., 0.256, could be used when designing a foot-controlled isotonic mouse.

• 대한한의학회지
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• 제23권4호
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• pp.169-185
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• 2002

Objectives: This study was carried out to investigate 1he effects of Sasammaickmoondong-tang(SME) on colonic mucosal lesions induced by indomethacin in mouse. Methods: The normal group is 1hat no inflammation elicitated mouse. Control group is that gastro-inflammation elicitated mouse. Sample group is that SME administered mouse after gastro-inflammation elicitation. Results: In the common morphology and histochemical change, control group was observed various injury-mucous surface cell, micro-villi, paneth cell, surface epithelial cell, goblet cell-by hemorrhagic erosion, while sample group was as same as normal group. In the immunohistochemical change, 1he distributions of COX-1, Bcl-2, and BrdU treated with SME noticeably increased than control group(P<0.05). The distributions of TUNEL, $NF-{\kappa}B$, COX-2, $IL-2R-\alpha$, NK-1.1, ICAM-1, and CD11b/18 treated with SME noticeably decreased than control group(P<0.05). And the distribution of SBA was as same as normal group. Conclusions: According to the above results, it is supposed that Sasammaickmoondong-tang is applicable to colonic mucosal lesions.