• Biomolecules & Therapeutics
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• 제12권2호
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• pp.114-121
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• 2004

This study was undertaken to evaluate the general pharmacological properties of CJ-11828, an amlodipine adipate, in experimental animals and in vitro system. CJ-11828 had no effects on general behavior, motor coordination, writhing syndromes, pentetrazol-induced chemoshock and electric shock in mice at dose levels of 3,10, anti 30 mg/kg, po. But there were decrease of body temperature, prolongation of sleeping time, and inhibition of intestinal activity in mice treated with CJ-11828 at doses of 10 and 30 mg/kg, po. CJ-11828 decreased the blood pressure in coscuous fog at the dose level of 2mg/kg, po, but it was expected as a result of pharmacological activity of CJ-11828. Any effect on respiratory system was not observed in conscious rat at doses of 3,10, and 30 mg/kg, po. The slight decrease in spontaneous motor activity was observed in mice treated with CJ-11828 at high dose, 30 mg/kg. In vitro experiments, CJ-11828 had no effect on agonists-induced contraction of isolated guinea pig ileum at 0.1, 1, and 10 ${\mu}$M. Based on these results, it was concluded that CJ-11828 had no pharmacological effect ill these studies even up to the 36-fold anticipated clinical dose, 3 mg/kg.

• 대한인간공학회:학술대회논문집
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• 대한인간공학회 1994년도 춘계학술대회논문집
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• pp.49-51
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• 1994

The aims of this study were first to determine the influence of vibration displacement amplitude $(200{\mu}m, 300{\mu}m peak-to-peak)$ at selected frequencies (40-200Hz) on a commonly observed but often undesired motor response elicited bylocal vibratory stimulation, the Tonic Vibration Reflex (TVR). Second, to determine the degree of synchronization of motor unit (MU) activity with vibratory stimuli. Vibration was applied to the distal tendons of the hand flexor muscles. Changes in root- mean-square electromyographic (EMG) activity of the finger and wrist flexor muscles were analyzed both as a function of their initial contraction level (0%, 10%, 20% of the maximal voluntarycontraction: MVC) and as a function of the vibration parameters. The results indicate that the TVR increased with the initial muscle contraction up to 10% MVC: The TVR increased with vibration frequency up to 100-150 Hz and decreases beyond; A significant increase of the TVR with vibration displacement amplitude was observed only for the wrist flexor muscle; MU synchronization at vibration frequency (VF) was found more often in the low frequency range $(f{\leq}100 Hz)$ and tended todecrease beyond; In the high frequency range $(f{\geq}120 Hz)$, MU activity at subharmonic frequency was predominant; The "cut-off" frequency of the synchronization with VF was neither affected by the vibration displacement amplitude nor initial muscle contraction level. The surface EMG turned out to be a useful means to analyze MU synchronization since it is noninvasive, and it can be easily used for analysis of different muscle contraction levels, while single MU technique might have some difficulties at high muscle contraction levels. Furthermore, these results indicate that high frequencyvibration (f>150 Hz) tends to induce less muscle/tendon stress and MU synchronization. Such remarks are of importance for the design of hand-held vibrating tools.ing tools.

• Physical Therapy Rehabilitation Science
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• 제11권1호
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• pp.24-31
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• 2022

Objective: This study attempted to find out if it changes the child's ability to perform daily life activities when visiting the familiar environment and daily living space of children with cerebral palsy and conducting a home activity support program for children and parents. Design: Randomized Controlled Trial Methods: Among 22 children aged 3 to 12 years old, they were assigned to the intervention group and control group. Of these, 12 boys and 10 girls participated in the study. Gross motor function measure and upper extremity function evaluation were used to measure the physical function of children with cerebral palsy, and self-care skills, mobility and social functions were evaluated in the pediatric evaluation of disability inventory. In addition, a parenting sense of competence was used to find out the efficacy of parents in raising children. After the pre-evaluation, basic rehabilitation treatment and intervention programs were applied to the intervention group, and only basic rehabilitation treatment was performed to the control group, and post-evaluation was performed 8 weeks later. Results: As a result of the study, among the items that measured the gross motor function, upper limb function, and daily life performance ability of the intervention group in the difference between the intervention group and the control group, statistically improved in personal processing and movement (p<0.05). In addition, the parenting sense of competence children in the intervention group was statistically significant (p<0.05). Conclusions: The home activity support program will help strengthen the ability of cerebral palsy children to perform daily life as a way to set mutually agreed goals with their families or children and achieve them in a familiar environment.

• 대한감각통합치료학회지
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• 제16권1호
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• pp.25-34
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• 2018

목적 : 본 연구는 학령전기 지적장애아동에게 제공한 그룹감각통합치료가 소근육 기능, 상호작용 및 놀이에 미치는 영향을 알아보고자 한다. 연구방법 : 지적장애 등록을 한 만3~5세 아동 4명을 대상으로 주 1회 90분씩, 총 12회기 실시하였다. 그룹감각통합치료는 평행놀이와 또래놀이 중심의 대근육 활동과 주제에 맞는 미술활동과 감각놀이로 구성하였다. 결과측정은 Erhardt Developmental Prehension Assessment(EDPA)와 또래놀이 상호작용 평점척도(Penn Interactive Peer Play Scale; PIPPS), 놀이다움(The Test of Playfulness; ToP)를 사용하여 대상자의 사전사후 소근육 기능과 상호작용, 놀이를 평가하였다. 측정 결과는 윌콕슨 순위 검정(Wilcoxon matched-pair signed rank test)을 사용하여 소근육 기능과 상호작용, 놀이의 중재 전후로 차이를 비교하여 분석하였다. 결과 : 그룹감각통합치료 후, 소근육 기능은 통계학적으로 유의한 차이를 보이지 않았으나, 상호작용과 놀이에서는 유의한 차이가 있었다(p<.05). 결론 : 그룹감각통합치료는 상호작용과 놀이능력 향상에 유용한 치료적 접근방법이라는 것을 알 수 있었으며, 지속적인 그룹 활동을 통하여 일상생활에서의 다양한 상황에 대한 일반화가 진행되길 기대한다.

• 대한물리의학회지
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• 제11권3호
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• pp.125-131
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• 2016

PURPOSE: The objective of this research is to investigate the effectiveness of mental practice on function and muscle activation of upper extremity (UE) in stroke patients. METHODS: The mental practice was conducted on 12 subjects for 10 minutes and the related existing work treatment for 20 minutes. The evaluation for the function of UE proceeded with Fugl-Meyer assessment of motor function (FMA) and muscle activity analysis instrument. Furthermore we analyzed patients' reaching activity by two stages, reaching phase and returning to original position phase. RESULTS: According to the research results, the subjects' upper limb function improved in all of the measured items and the total scores after the mental practice (p<.05). In muscle activity, CCR value was used to efficiently analyze the patients' reaching activity in the two stages of reaching stage and returning to the original position phase. While the elbow movement only had a bit of positive change (1.1%) in the reaching stage, both the shoulder (-12.3%) and elbow (-18.2%) movements had a positive change in the returning to original position phase. CONCLUSION: This research confirmed that the mental practice is effective for the enhancement of UE function for stroke patients. The result of this research can contribute to the progress of mental practice in clinical environment.

• 대한물리치료과학회지
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• 제27권1호
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• pp.18-25
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• 2020

Purpose: The purpose of this study was to investigate the improve on brain activity during action observation training for cerebral palsy of diplegia. Design: Randomized controlled trial. Methods: 18 subjects were divide into two groups: action observation training group and a control group. Action observation group practiced repeatedly the action with their motor skill and control group practiced conventional physical therapy. The subjects participated in eighteen 30-min sessions, 3 day a week, for 6week. To confirm the effects on brain activity were evaluated. Results: The results show that the Mu-rhythm was statistically significant increase on the C3 of the action observation training group (p<0.05). Conclusion: The action observation training improves brain activity of a cerebral palsy with diplegia. These results suggest that the action observation training is feasible and beneficial for improving brain activation for the cerebral palsy with diplegia. In the future, I think we need to be actively utilized to the action observation training program in the clinical with the neuromuscular development treatment. And the study on the various the action observation training program that can improve the function of the children with cerebral palsy is thought necessary.

• 한국전문물리치료학회지
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• 제28권4호
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• pp.273-279
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• 2021

Background: Lunge exercises are lower extremity rehabilitation and strengthening exercises for patients and athletes. Most studies have shown the effectiveness of the forward and backward lunge exercises for treating patellofemoral pain and anterior cruciate ligament injuries (by increasing lower extremity muscle activity) and improving kinematics. Objects: However, it is not known how the two different lunge movements affect trunk muscle activities in healthy individuals. The purpose of this study was to investigate the electromyographic activity of the rectus abdominis and erector spinae muscles during forward and backward lunge exercises in healthy participants. Methods: Twelve healthy participants were recruited. Electromyographic activity of the rectus abdominis and erector spinae was recorded using surface electrodes during forward and backward lunges, and subsequently normalized to the respective reference voluntary isometric contractions of each muscle. Results: Activity of the erector spinae was significantly higher than that of the rectus abdominis during all stages of the backward lunge (p < 0.05). The activity of the erector spinae was significantly greater during the backward than forward lunge at all stages (p < 0.05). Conclusion: Backward lunging is better able to enhance trunk motor control and activate the erector spinae muscles.

• 한국보건간호학회지
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• 제33권1호
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• pp.20-32
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• 2019

Objectives: This study identified biopsychosocial factors associated with metabolic syndrome among Korean men and women aged over 40 years. Methods: Secondary data from the 2010-2016 Korean National Health and Nutrition Examination Survey were used for this study. Based on the biopsychosocial model, psychosocial factors (stress, depression, smoking, binge alcohol consumption, physical activity) were assessed with control of biomedical (age, body mass index, family history of hypertension, dyslipidemia, type 2 diabetes mellitus, and cardiovascular disease) and biosocial factors (educational level and economic status). Data from 8,624 men and 7,321 women were analyzed by logistic regression analysis using a complex sample procedure. Results: Among men, current or past smoking habits (Adjusted Odds Ratio [AOR]: 1.349; 95% Confidence Interval [CI]: 1.155-1.575, p<.001) and binge alcohol consumption (AOR: 1.570, CI: 1.389-1.774, p<.001) were associated with metabolic syndrome. In addition, moderate (AOR: 1.205, CI: 1.038-1.400, p=.014) and low levels of physical activity (AOR: 1.296, CI: 1.109-1.514, p=.001) were associated with metabolic syndrome. Among women, low level of physical activity (AOR: 1.276, CI: 1.017-1.602, p=.036) was associated with metabolic syndrome. Conclusion: Gender specific interventions such as encouraging physical activity and prevention of smoking and excessive alcohol drinking are important to prevention of metabolic syndrome.

• 대한안전경영과학회지
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• 제15권4호
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• pp.261-267
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• 2013

In automobile company it is needed to establish the collaborative relationship between the assembly company and the part manufacturing company. In this paper we established the improvement for the procurement logistics and logistics in assembly company and thus we derived the near optimal procurement cycle through the simple EXCEL simulation and the improved inventory management method for H automobile company in CHINA. At this time we adopted the pull manufacturing process instead of push manufacturing process. We resulted that the manufacturing activity of both companies was stabilized and the usage of storage area in assembly company was reduced by 50%, especially it was reduced by 100% in the case of directly delivering the parts to assembly line through the third party logistics company.

• Journal of Ginseng Research
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• 제14권2호
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• pp.171-177
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• 1990

Using an ethopharmacological technique, we demonstrated that saponin fraction from red ginseng root possessed a potent psychotropic actions on either intermale or maternal aggression models. A series of experiments clearly indicated that one of psychoactive ingredient is ginsenoside Rbl. Although a drug-induced debilitation of motor performance remains a possible cause of the antiaggressive affect of the drug. ginsenoside Rbl did not alter the locomotor activity of the mice during agonistic confrontations. Thus. one can eliminate the possibility that the psychotropic effect of ginsenoside Rbl might be concealed by a drug-induced impairment of motor performance. More recently, we developed a nevi model for copulatory disorder and introduced into the behavioral analysis of drug action. Male mice which has been housed individually from weaning for 5 weeks failed to manifest copulatory behavior when they encountered with the sexually receptive females. Daily administration of crude ginseng saponin during isolation housing period prevented the development of copulatory disorder, whereas both ginsenoside Rbl and Rgl were ineffective. A further experiment may be needed to explore active ingredient of ginseng saponins.