• 한국연소학회:학술대회논문집
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• 한국연소학회 2012년도 제45회 KOSCO SYMPOSIUM 초록집
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• pp.97-99
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• 2012

A pressure-based BOIK model considering Shock to Detonation Transition(SDT) and damage due to external fragment or bullet stimuli impact on energetic materials and analytical approach for determination of free parameters are proposed. The rate of product mass fraction(${\lambda}$) consists of ignition term that represents the initiation due to shock compression and growth term that describes propagation of detonation wave and strain term representing the morphological deformation induced by external impact.

• 한국수의병리학회:학술대회논문집
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• 한국수의병리학회 2003년도 추계학술대회초록집
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• pp.7-7
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• 2003

Histological examination of biopsy or postmortem lung tissue from patients with asthma usually reveals thickened airway walls. This change is called airway remodeling, which is characterized by airway eosinophilia, hyperplasia of goblet cells and smooth muscle, and subepithelial fibrosis [1,2]. In this study, we investigated the time-course functional, morphological, biochemical changes of remodeling in a ovalbumin (OVA)-induced murine chronic asthma model. (omitted)

• 한국정밀공학회지
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• 제27권1호
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• pp.134-141
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• 2010

This study analyzed the regional morphological and mechanical characteristics of vertebrae by using micro-computed tomography (micro-CT) and micro finite element analysis (FEA). For the present study, the $12^{th}$ human thoracic vertebral bones (an 85-years female and a 48-years male) were used. These were scanned by using micro-CT. Structural parameters were evaluated from the acquired 20 image data for fifteen $4{\times}4mm^2$ regions (five regions in respective layers of superior, middle and inferior part) in the thoracic vertebral trabecular bones. $4{\times}4{\times}4mm^3$ cubic finite element models of each regions were created at $70{\mu}m$ voxel resolution to investigate effective modulus ($E^+$). The present study indicated that there were significant differences in morphological and elastic mechanical characteristics of each region. There are close relationship between effective modulus and structural model index (SMI) in the bone of the 48-years male and between effective modulus and bone volume fraction (BV/TV) in the bone of the 85-years female. In addition, the effective modulus of central regions is about 80% stiffer than that of lateral regions at transverse plane. These findings may be likely to explain the previous result that a change of loading distribution of the vertebral trabecular bones is caused by spinal curvature and nucleus pulpous degeneration of the intervertebral disc.

• Reproductive and Developmental Biology
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• 제35권2호
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• pp.143-149
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• 2011

Arthritis is a common disease in aged people, and is clinically divided into rheumatoid arthritis (RA) and osteoarthritis (OA). Although common symptoms such as pain are present, the underlying pathological mechanisms are slightly different. Therefore, the objectives of the present study were to compare joint damage induced by RA and OA by analyzing the major morphological and molecular differences, and to propose a suitable therapeutic intervention based on the pathophysiological conditions of bones and joints. For the RA animal model, 8-week-old DBA1/J mice were immunized with bovine type II collagen emulsified in complete Freund's adjuvant (CFA). Normal C57BL/6 mice (over 2 years of age) were used for OA. The clinical arthritis score was calculated using a subjective scoring system, and paw thicknesses were measured using calipers. The serum TNF ${\alpha}$ level was analyzed using an ELISA kit. Micro-CT was used to identify pathological characteristics and morphological changes. In collagen-induced RA mice, there were increased ankle joint volumes and clinical scores (p<0.01). The concentration of TNF ${\alpha}$ was significantly increased from 3 to 7 weeks after immunization. Micro-CT images showed trabecular bone destruction, pannus formation, and subchondral region destruction in RA mice. OA among aged mice showed narrowed joint spaces and breakdown of articular cartilage. This study suggests that a careful therapeutic intervention between RA and OA is required, and it should be based on morphological alteration of bone and joint.

• 한국정보기술학회논문지
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• 제15권12호
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• pp.165-171
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• 2017

본 논문은 서포터 생성 기법으로 형태학적 기하학 연산을 대신하여 층 단면 영상에 형태학적 영상 처리를 적용함으로 서포터를 생성하는 방법을 제안하였다. 기하학적 연산 비용은 일반적으로 형태에 의존적이지만 본 방법은 영상 내의 형태에 무관하게 적용된다. 돌출부에 대한 외부 서포터 영역을 얻는 방법으로 2개의 층 단면 영상에 대한 형태학적 영상 처리 방법 및 처리 과정의 예를 보였다. 내부 서포터 영역에 대하여 하나의 층 단면으로부터 침식과 열림을 통해 얻는 과정을 나타내었다. 그리고 이러한 서포터 영역을 얻고 서포터 구조를 통한 서포터를 생성하였다. 이어서 제작한 DLP 프린터에 서포터 구조를 가진 조형물을 제작하였다. 또, 서포터 형태에 따라 조형되는 소재의 특성이 조형에 주는 변화를 통해 소재에 따른 개별적인 서포터 구조를 통한 서포터 생성 방법의 필요성을 확인하였다.

• 한국환경성돌연변이발암원학회지
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• 제21권1호
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• pp.44-50
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• 2001

To identify nongenotoxic carcinogen determined as negative by ICH guideline-recommended standard genotoxicity test battery; Ames test, chromosome aberration assay, mouse lymphoma $tk^{+/-}$ assay, in vivo micronucleus assay, we picked bisphenol A as a model compound. In this study, we applied in vitro BalB/c 3T3 cell transformation assay and Syrian hamster embryo (SHE) cell transfarmation assay. Bisphenol A was treated upto $769.2 ug/m{\ell}$ in BalB/c 3T3 cells and upto $125 ug/m{\ell}$ in SHE cells. bisphenol A didn't induced morphological transformation both with one stage treatment protocol and with two stage treatment protocol. But, treated far 48 hr, Bisphenol A induced morphological transformation significantly in SHE cells.

• 한국정보처리학회논문지
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• 제6권10호
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• pp.2707-2715
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• 1999

Recently, there have been researches to automate processing and analysing images in the medical field using image processing technique, a fast communication network, and high performance hardware. In this paper, we propose a system to be able to analyze morphological abnormality of red-blood cells for peripheral blood image using image processing techniques. To do this, we segment red-blood cells in the blood image acquired from microscope with CCD camera and then extract UNL fourier features to classify them into 15 classes. We reduce the number of multi-variate features using PCA to construct a more efficient classifier. Our system has the best performance in recognition rate, compared with two other algorithms, LVQ3 and k-NN. So, we show that it can be applied to a pathological guided system.

• 한국지하수토양환경학회:학술대회논문집
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• 한국지하수토양환경학회 1998년도 총회 및 춘계 학술발표회 논문집
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• pp.87-90
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• 1998

본 연구의 목적은 방향족 화합물의 생분해능이 우수한 토양 방선균을 분리하여 방선균에 의한 방향족 화합물의 생분해 기작 및 생분해 특성을 연구하는 것이다. 본 연구실에서는 phenol을 model compound로 실험한 결과, 일반 토양에서 분리한 많은 방선균들이 비록 농노의 차이를 보이기는 하지만 phenol의 생분해능을 갖고 있었다. 그러나 이들 대다수의 방선균들을 낮은 농도의 phenol에서만 일정 기간 성장을 하며, morphological differentiation 및 포자의 형성과 같은 일반적인 방선균의 성장 특성은 전혀 관찰되지 않았다. 이들 중 몇 종류의 분리된 방선균들 낮은 농도에서의 우수한 성장은 물론이고 상당히 높은 농도 (7mM)에서도 phenol을 유일한 탄소 및 에너지원으로 사용하여 성장하며 정상적인 morphological differentiation을 진행시킴이 관찰되었다. 특히 PD001로 명명된 phenol 분해능이 우수한 방선균에서는 일반적인 방선균 성장 온도 (3$0^{\circ}C$) 보다 높은 45$^{\circ}C$의 고온에서 더 빠른 성장을 보이는 고온성 방선균의 특징도 관찰되었다.

• 한국컴퓨터정보학회논문지
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• 제20권8호
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• pp.15-21
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• 2015

This study proposed a Sasang constitution classification system that can increase the objectivity and reliability of Sasang constitution diagnosis using the image of frontal face, in order to solve problems in the subjective classification of Sasang constitution based on Sasang constitution specialists' experiences. For classification, characteristics indicating the shapes of the eyes, nose, mouth and chin were defined, and such characteristics were extracted using the morphological statistic analysis of face images. Then, Sasang constitution was classified through a SVM (Support Vector Machine) classifier using the extracted characteristics as its input, and according to the results of experiment, the proposed system showed a correct recognition rate of 93.33%. Different from existing systems that designate characteristic points directly, this system showed a high correct recognition rate and therefore it is expected to be useful as a more objective Sasang constitution classification system.

• 한국정보통신학회논문지
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• 제4권1호
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• pp.123-130
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• 2000

본 논문은 고정된 카메라에서 얻어진 연속 영상으로부터 능동 윤곽선 모델을 이용하여 이동 물체의 윤곽선을 추출하는 방법을 제안한다. 주위 환경 변화에 강인한 처리를 위해 적응 배경 모델을 사용하였다. 물체 분할 모델은 얻어진 배경 영상과 현재 영상의 차영상으로부터 국부 영상의 임계값 이상의 화소를 찾아 연결한 영역을 분할하며, 형태학적 필터에 의하여 이동 물체의 경계 부분에서 발생하는 잡음을 제거하였다 분할된 이동 물체 윤곽선은 능동 윤곽선 모델을 이용하여 보다 정확한 이동 물체의 경계를 추출한다. 제안한 방법을 사용하여 도로 영상에서 실험한 결과를 보였다.